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ENCODE cell lines, expression (Ernst 2011)

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Results for UUGUUCG

Z-value: 0.33

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miRNA associated with seed UUGUUCG

NamemiRBASE accession
hsa-miR-375
MIMAT0000728

Activity profile of UUGUUCG motif

Sorted Z-values of UUGUUCG motif

Network of associatons between targets according to the STRING database.

First level regulatory network of UUGUUCG

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_81071684 0.70 ENST00000220244.3
ENST00000394685.3
ENST00000356249.5
 KIAA1199
 KIAA1199
chr1_-_57045228 0.58 ENST00000371250.3
 PPAP2B
 phosphatidic acid phosphatase type 2B
chr4_-_157892498 0.54 ENST00000502773.1
 PDGFC
 platelet derived growth factor C
chr11_-_115375107 0.50 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
 CADM1
 cell adhesion molecule 1
chr11_+_101981169 0.48 ENST00000526343.1
ENST00000282441.5
ENST00000537274.1
ENST00000345877.2
 YAP1
 Yes-associated protein 1
chr1_-_225840747 0.38 ENST00000366843.2
ENST00000366844.3
 ENAH
 enabled homolog (Drosophila)
chr10_-_126849068 0.37 ENST00000494626.2
ENST00000337195.5
 CTBP2
 C-terminal binding protein 2
chr12_-_76425368 0.35 ENST00000602540.1
 PHLDA1
 pleckstrin homology-like domain, family A, member 1
chr17_+_38599693 0.34 ENST00000542955.1
ENST00000269593.4
 IGFBP4
 insulin-like growth factor binding protein 4
chr7_+_17338239 0.31 ENST00000242057.4
 AHR
 aryl hydrocarbon receptor
chr8_-_122653630 0.28 ENST00000303924.4
 HAS2
 hyaluronan synthase 2
chr9_-_21335356 0.27 ENST00000359039.4
 KLHL9
 kelch-like family member 9
chr10_-_735553 0.27 ENST00000280886.6
ENST00000423550.1
 DIP2C
 DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr3_-_114790179 0.26 ENST00000462705.1
 ZBTB20
 zinc finger and BTB domain containing 20
chr11_+_12695944 0.26 ENST00000361905.4
 TEAD1
 TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr1_-_120612240 0.24 ENST00000256646.2
 NOTCH2
 notch 2
chr16_+_86544113 0.22 ENST00000262426.4
 FOXF1
 forkhead box F1
chr7_-_27183263 0.21 ENST00000222726.3
 HOXA5
 homeobox A5
chr1_-_240775447 0.21 ENST00000318160.4
 GREM2
 gremlin 2, DAN family BMP antagonist
chr14_-_30396948 0.20 ENST00000331968.5
 PRKD1
 protein kinase D1
chr4_-_120550146 0.20 ENST00000354960.3
 PDE5A
 phosphodiesterase 5A, cGMP-specific
chr17_+_27369918 0.19 ENST00000323372.4
 PIPOX
 pipecolic acid oxidase
chr2_+_223725652 0.19 ENST00000357430.3
ENST00000392066.3
 ACSL3
 acyl-CoA synthetase long-chain family member 3
chrX_+_73641286 0.17 ENST00000587091.1
 SLC16A2
 solute carrier family 16, member 2 (thyroid hormone transporter)
chr14_-_70883708 0.16 ENST00000256366.4
 SYNJ2BP
 synaptojanin 2 binding protein
chr14_+_67707826 0.15 ENST00000261681.4
 MPP5
 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr9_-_110251836 0.14 ENST00000374672.4
 KLF4
 Kruppel-like factor 4 (gut)
chr14_-_55878538 0.14 ENST00000247178.5
 ATG14
 autophagy related 14
chr1_-_21377447 0.14 ENST00000374937.3
ENST00000264211.8
 EIF4G3
 eukaryotic translation initiation factor 4 gamma, 3
chr4_+_184020398 0.14 ENST00000403733.3
ENST00000378925.3
 WWC2
 WW and C2 domain containing 2
chr4_+_72204755 0.13 ENST00000512686.1
ENST00000340595.3
 SLC4A4
 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr14_+_74486043 0.13 ENST00000464394.1
ENST00000394009.3
 CCDC176
 coiled-coil domain containing 176
chr9_-_16870704 0.12 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
 BNC2
 basonuclin 2
chr18_+_19749386 0.12 ENST00000269216.3
 GATA6
 GATA binding protein 6
chr16_+_56965960 0.12 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
 HERPUD1
 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr11_+_44117741 0.12 ENST00000395673.3
ENST00000343631.3
 EXT2
 exostosin glycosyltransferase 2
chr13_+_73632897 0.12 ENST00000377687.4
 KLF5
 Kruppel-like factor 5 (intestinal)
chr2_+_46926048 0.11 ENST00000306503.5
 SOCS5
 suppressor of cytokine signaling 5
chr11_-_86666427 0.10 ENST00000531380.1
 FZD4
 frizzled family receptor 4
chr4_-_141677267 0.10 ENST00000442267.2
 TBC1D9
 TBC1 domain family, member 9 (with GRAM domain)
chr11_+_68080077 0.10 ENST00000294304.7
 LRP5
 low density lipoprotein receptor-related protein 5
chr8_-_116681221 0.08 ENST00000395715.3
 TRPS1
 trichorhinophalangeal syndrome I
chrX_+_95939711 0.08 ENST00000373049.4
ENST00000324765.8
 DIAPH2
 diaphanous-related formin 2
chr9_+_115983808 0.07 ENST00000374210.6
ENST00000374212.4
 SLC31A1
 solute carrier family 31 (copper transporter), member 1
chr10_+_111967345 0.07 ENST00000332674.5
ENST00000453116.1
 MXI1
 MAX interactor 1, dimerization protein
chr16_+_2587998 0.06 ENST00000441549.3
ENST00000268673.7
 PDPK1
 3-phosphoinositide dependent protein kinase-1
chr16_-_12897642 0.06 ENST00000433677.2
ENST00000261660.4
ENST00000381774.4
 CPPED1
 calcineurin-like phosphoesterase domain containing 1
chr9_+_4679555 0.06 ENST00000381858.1
ENST00000381854.3
 CDC37L1
 cell division cycle 37-like 1
chr15_+_57210818 0.06 ENST00000438423.2
ENST00000267811.5
ENST00000452095.2
ENST00000559609.1
ENST00000333725.5
 TCF12
 transcription factor 12
chr2_+_118846008 0.06 ENST00000245787.4
 INSIG2
 insulin induced gene 2
chr9_-_135819987 0.06 ENST00000298552.3
ENST00000403810.1
 TSC1
 tuberous sclerosis 1
chr10_+_45455207 0.05 ENST00000334940.6
ENST00000374417.2
ENST00000340258.5
ENST00000427758.1
 RASSF4
 Ras association (RalGDS/AF-6) domain family member 4
chr11_+_120207787 0.05 ENST00000397843.2
ENST00000356641.3
 ARHGEF12
 Rho guanine nucleotide exchange factor (GEF) 12
chr15_-_101792137 0.05 ENST00000254190.3
 CHSY1
 chondroitin sulfate synthase 1
chr2_+_204192942 0.05 ENST00000295851.5
ENST00000261017.5
 ABI2
 abl-interactor 2
chr10_+_126490354 0.05 ENST00000298492.5
 FAM175B
 family with sequence similarity 175, member B
chr20_-_524455 0.05 ENST00000349736.5
ENST00000217244.3
 CSNK2A1
 casein kinase 2, alpha 1 polypeptide
chr19_+_19496624 0.05 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
 GATAD2A
 GATA zinc finger domain containing 2A
chr14_-_96830207 0.04 ENST00000359933.4
 ATG2B
 autophagy related 2B
chr20_+_306221 0.04 ENST00000342665.2
 SOX12
 SRY (sex determining region Y)-box 12
chr1_+_2160134 0.04 ENST00000378536.4
 SKI
 v-ski avian sarcoma viral oncogene homolog
chr9_-_38069208 0.04 ENST00000377707.3
ENST00000377700.4
 SHB
 Src homology 2 domain containing adaptor protein B
chr9_+_26956371 0.04 ENST00000380062.5
ENST00000518614.1
 IFT74
 intraflagellar transport 74 homolog (Chlamydomonas)
chr9_-_23821273 0.04 ENST00000380110.4
 ELAVL2
 ELAV like neuron-specific RNA binding protein 2
chr6_-_132834184 0.04 ENST00000367941.2
ENST00000367937.4
 STX7
 syntaxin 7
chr22_+_40390930 0.04 ENST00000333407.6
 FAM83F
 family with sequence similarity 83, member F
chr19_-_7293942 0.03 ENST00000341500.5
ENST00000302850.5
 INSR
 insulin receptor
chr17_+_39845134 0.03 ENST00000591776.1
ENST00000469257.1
 EIF1
 eukaryotic translation initiation factor 1
chr16_+_69458428 0.03 ENST00000512062.1
ENST00000307892.8
 CYB5B
 cytochrome b5 type B (outer mitochondrial membrane)
chr12_-_51420128 0.03 ENST00000262051.7
ENST00000547732.1
ENST00000262052.5
ENST00000546488.1
ENST00000550714.1
ENST00000548193.1
ENST00000547579.1
ENST00000546743.1
 SLC11A2
 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr17_+_14204389 0.03 ENST00000360954.2
 HS3ST3B1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr7_-_558876 0.03 ENST00000354513.5
ENST00000402802.3
 PDGFA
 platelet-derived growth factor alpha polypeptide
chr5_+_95997918 0.03 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
 CAST
 calpastatin
chr14_-_68283291 0.02 ENST00000555452.1
ENST00000347230.4
 ZFYVE26
 zinc finger, FYVE domain containing 26
chr19_+_47421933 0.02 ENST00000404338.3
 ARHGAP35
 Rho GTPase activating protein 35
chr1_+_43148059 0.02 ENST00000321358.7
ENST00000332220.6
 YBX1
 Y box binding protein 1
chr18_+_42260861 0.02 ENST00000282030.5
 SETBP1
 SET binding protein 1
chr12_-_51477333 0.02 ENST00000228515.1
ENST00000548206.1
ENST00000546935.1
ENST00000548981.1
 CSRNP2
 cysteine-serine-rich nuclear protein 2
chr2_-_131850951 0.02 ENST00000409185.1
ENST00000389915.3
 FAM168B
 family with sequence similarity 168, member B
chr9_-_127533519 0.02 ENST00000487099.2
ENST00000344523.4
ENST00000373584.3
 NR6A1
 nuclear receptor subfamily 6, group A, member 1
chrX_+_69664706 0.02 ENST00000194900.4
ENST00000374360.3
 DLG3
 discs, large homolog 3 (Drosophila)
chr17_-_7832753 0.02 ENST00000303790.2
 KCNAB3
 potassium voltage-gated channel, shaker-related subfamily, beta member 3
chr15_-_72410109 0.02 ENST00000564571.1
 MYO9A
 myosin IXA
chr11_-_118047376 0.01 ENST00000278947.5
 SCN2B
 sodium channel, voltage-gated, type II, beta subunit
chr8_-_117768023 0.01 ENST00000518949.1
ENST00000522453.1
ENST00000521861.1
ENST00000518995.1
 EIF3H
 eukaryotic translation initiation factor 3, subunit H
chrX_-_18690210 0.01 ENST00000379984.3
 RS1
 retinoschisin 1
chr1_+_15853308 0.01 ENST00000375838.1
ENST00000375847.3
ENST00000375849.1
 DNAJC16
 DnaJ (Hsp40) homolog, subfamily C, member 16
chr19_-_18392422 0.01 ENST00000252818.3
 JUND
 jun D proto-oncogene
chr2_-_178937478 0.01 ENST00000286063.6
 PDE11A
 phosphodiesterase 11A
chr19_-_17799008 0.01 ENST00000519716.2
 UNC13A
 unc-13 homolog A (C. elegans)
chr3_-_128369643 0.01 ENST00000296255.3
 RPN1
 ribophorin I
chr8_-_38386175 0.01 ENST00000437935.2
ENST00000358138.1
 C8orf86
 chromosome 8 open reading frame 86
chr12_+_56211703 0.00 ENST00000243045.5
ENST00000552672.1
ENST00000550836.1
 ORMDL2
 ORM1-like 2 (S. cerevisiae)
chr11_-_74178582 0.00 ENST00000531854.1
ENST00000526855.1
ENST00000529425.1
ENST00000310128.4
ENST00000532569.1
 KCNE3
 potassium voltage-gated channel, Isk-related family, member 3
chr17_-_617949 0.00 ENST00000401468.3
ENST00000574029.1
ENST00000291074.5
ENST00000571805.1
ENST00000437048.2
ENST00000446250.2
 VPS53
 vacuolar protein sorting 53 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.3 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.1 0.4 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.2 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.1 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.0 0.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.6 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.0 0.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.3 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.2 GO:0036122 BMP binding(GO:0036122)
0.0 0.0 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.1 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.0 0.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 0.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.1 GO:1903349 omegasome membrane(GO:1903349)
0.0 0.1 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.4 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.1 GO:0035749 myelin sheath adaxonal region(GO:0035749) lateral loop(GO:0043219)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.3 GO:0045210 FasL biosynthetic process(GO:0045210)
0.1 0.2 GO:0007439 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.1 0.2 GO:0060535 trachea cartilage morphogenesis(GO:0060535)
0.1 0.2 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.1 0.2 GO:0019474 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.1 0.2 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.1 0.3 GO:1900127 renal water absorption(GO:0070295) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.1 0.5 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
0.0 0.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426) retinal blood vessel morphogenesis(GO:0061304)
0.0 0.1 GO:0071409 negative regulation of muscle hyperplasia(GO:0014740) cellular response to cycloheximide(GO:0071409)
0.0 0.4 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.1 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0 0.0 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.2 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.1 GO:0016240 autophagosome docking(GO:0016240)
0.0 0.5 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.2 GO:0061314 Notch signaling involved in heart development(GO:0061314)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.3 GO:0044342 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) type B pancreatic cell proliferation(GO:0044342)
0.0 0.1 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.0 0.1 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.0 GO:0019087 transformation of host cell by virus(GO:0019087)
0.0 0.1 GO:0072719 cellular response to cisplatin(GO:0072719)
0.0 0.0 GO:0031064 negative regulation of histone deacetylation(GO:0031064)
0.0 0.0 GO:0060283 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)