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ENCODE cell lines, expression (Ernst 2011)

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Results for VAX1_GSX2

Z-value: 1.06

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Transcription factors associated with VAX1_GSX2

Gene Symbol Gene ID Gene Info
VAX1
ENSG00000148704.8 VAX1
GSX2
ENSG00000180613.6 GSX2

Activity profile of VAX1_GSX2 motif

Sorted Z-values of VAX1_GSX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of VAX1_GSX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_+_125133315 2.72 ENST00000223423.4
ENST00000362012.2
 PTGS1
 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_+_125132803 2.50 ENST00000540753.1
 PTGS1
 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_+_157154578 2.48 ENST00000295927.3
 PTX3
 pentraxin 3, long
chr1_+_192778161 2.36 ENST00000235382.5
 RGS2
 regulator of G-protein signaling 2, 24kDa
chr1_-_68698222 2.31 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
 WLS
 wntless Wnt ligand secretion mediator
chr7_-_81399329 2.15 ENST00000453411.1
ENST00000444829.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr7_-_81399438 1.95 ENST00000222390.5
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr8_-_41166953 1.75 ENST00000220772.3
 SFRP1
 secreted frizzled-related protein 1
chr4_-_25865159 1.66 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
 SEL1L3
 sel-1 suppressor of lin-12-like 3 (C. elegans)
chr12_-_10022735 1.54 ENST00000228438.2
 CLEC2B
 C-type lectin domain family 2, member B
chr1_-_68698197 1.53 ENST00000370973.2
ENST00000370971.1
 WLS
 wntless Wnt ligand secretion mediator
chr12_-_6233828 1.30 ENST00000572068.1
ENST00000261405.5
 VWF
 von Willebrand factor
chr7_-_81399411 1.21 ENST00000423064.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr3_+_62304712 1.17 ENST00000494481.1
 C3orf14
 chromosome 3 open reading frame 14
chr12_+_26348246 1.15 ENST00000422622.2
 SSPN
 sarcospan
chr7_+_100770328 1.13 ENST00000223095.4
ENST00000445463.2
 SERPINE1
 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr12_+_29376673 1.10 ENST00000547116.1
 FAR2
 fatty acyl CoA reductase 2
chr11_-_27722021 1.09 ENST00000356660.4
ENST00000418212.1
ENST00000533246.1
 BDNF
 brain-derived neurotrophic factor
chr12_+_29376592 1.09 ENST00000182377.4
 FAR2
 fatty acyl CoA reductase 2
chr22_-_32651326 1.09 ENST00000266086.4
 SLC5A4
 solute carrier family 5 (glucose activated ion channel), member 4
chr3_+_62304648 1.07 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
 C3orf14
 chromosome 3 open reading frame 14
chr1_-_36789755 0.99 ENST00000270824.1
 EVA1B
 eva-1 homolog B (C. elegans)
chr3_+_50273625 0.99 ENST00000536647.1
 GNAI2
 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr7_-_81399355 0.97 ENST00000457544.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr15_-_37393406 0.92 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
 MEIS2
 Meis homeobox 2
chr4_-_169239921 0.92 ENST00000514995.1
ENST00000393743.3
 DDX60
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr7_+_120628731 0.84 ENST00000310396.5
 CPED1
 cadherin-like and PC-esterase domain containing 1
chr2_+_102953608 0.84 ENST00000311734.2
ENST00000409584.1
 IL1RL1
 interleukin 1 receptor-like 1
chr7_-_99716952 0.84 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
 TAF6
 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_+_158978768 0.83 ENST00000447473.2
 IFI16
 interferon, gamma-inducible protein 16
chr1_+_81771806 0.80 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
 LPHN2
 latrophilin 2
chr11_+_5710919 0.72 ENST00000379965.3
ENST00000425490.1
 TRIM22
 tripartite motif containing 22
chr3_+_158519654 0.68 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
 MFSD1
 major facilitator superfamily domain containing 1
chr5_-_143550159 0.66 ENST00000448443.2
ENST00000513112.1
ENST00000519064.1
ENST00000274496.5
 YIPF5
 Yip1 domain family, member 5
chr11_-_33774944 0.63 ENST00000532057.1
ENST00000531080.1
 FBXO3
 F-box protein 3
chr2_+_44502597 0.62 ENST00000260649.6
ENST00000409387.1
 SLC3A1
 solute carrier family 3 (amino acid transporter heavy chain), member 1
chr15_+_64680003 0.62 ENST00000261884.3
 TRIP4
 thyroid hormone receptor interactor 4
chr11_-_33913708 0.61 ENST00000257818.2
 LMO2
 LIM domain only 2 (rhombotin-like 1)
chr14_+_61654271 0.60 ENST00000555185.1
ENST00000557294.1
ENST00000556778.1
 PRKCH
 protein kinase C, eta
chr1_-_202897724 0.59 ENST00000435533.3
ENST00000367258.1
 KLHL12
 kelch-like family member 12
chr14_+_104182105 0.59 ENST00000311141.2
 ZFYVE21
 zinc finger, FYVE domain containing 21
chr14_+_104182061 0.58 ENST00000216602.6
 ZFYVE21
 zinc finger, FYVE domain containing 21
chr11_+_24518723 0.56 ENST00000336930.6
ENST00000529015.1
ENST00000533227.1
 LUZP2
 leucine zipper protein 2
chr4_-_164534657 0.56 ENST00000339875.5
 MARCH1
 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr1_+_84630645 0.55 ENST00000394839.2
 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
chr15_-_55563072 0.54 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
 RAB27A
 RAB27A, member RAS oncogene family
chr1_-_151965048 0.52 ENST00000368809.1
 S100A10
 S100 calcium binding protein A10
chr17_-_66951474 0.51 ENST00000269080.2
 ABCA8
 ATP-binding cassette, sub-family A (ABC1), member 8
chr7_-_14029283 0.51 ENST00000433547.1
ENST00000405192.2
 ETV1
 ets variant 1
chr12_+_26348429 0.51 ENST00000242729.2
 SSPN
 sarcospan
chr5_-_55412774 0.50 ENST00000434982.2
 ANKRD55
 ankyrin repeat domain 55
chr11_-_102651343 0.50 ENST00000279441.4
ENST00000539681.1
 MMP10
 matrix metallopeptidase 10 (stromelysin 2)
chrX_+_107334895 0.50 ENST00000372232.3
ENST00000345734.3
ENST00000372254.3
 ATG4A
 autophagy related 4A, cysteine peptidase
chr15_-_55562582 0.49 ENST00000396307.2
 RAB27A
 RAB27A, member RAS oncogene family
chr5_-_139726181 0.47 ENST00000507104.1
ENST00000230990.6
 HBEGF
 heparin-binding EGF-like growth factor
chr15_+_84115868 0.46 ENST00000427482.2
 SH3GL3
 SH3-domain GRB2-like 3
chrX_-_18690210 0.45 ENST00000379984.3
 RS1
 retinoschisin 1
chr12_-_57039739 0.43 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
 ATP5B
 ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chrX_-_23926004 0.41 ENST00000379226.4
ENST00000379220.3
 APOO
 apolipoprotein O
chr8_+_54764346 0.41 ENST00000297313.3
ENST00000344277.6
 RGS20
 regulator of G-protein signaling 20
chr1_-_77685084 0.40 ENST00000370812.3
ENST00000359130.1
ENST00000445065.1
ENST00000370813.5
 PIGK
 phosphatidylinositol glycan anchor biosynthesis, class K
chr2_+_210517895 0.40 ENST00000447185.1
 MAP2
 microtubule-associated protein 2
chr15_-_42264702 0.39 ENST00000220325.4
 EHD4
 EH-domain containing 4
chr15_-_55562479 0.38 ENST00000564609.1
 RAB27A
 RAB27A, member RAS oncogene family
chr11_+_59824060 0.38 ENST00000395032.2
ENST00000358152.2
 MS4A3
 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr17_-_33446735 0.38 ENST00000460118.2
ENST00000335858.7
 RAD51D
 RAD51 paralog D
chr3_+_101504200 0.36 ENST00000422132.1
 NXPE3
 neurexophilin and PC-esterase domain family, member 3
chr11_+_59824127 0.35 ENST00000278865.3
 MS4A3
 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr3_-_99569821 0.35 ENST00000487087.1
 FILIP1L
 filamin A interacting protein 1-like
chr1_-_67266939 0.32 ENST00000304526.2
 INSL5
 insulin-like 5
chr4_+_144354644 0.31 ENST00000512843.1
 GAB1
 GRB2-associated binding protein 1
chr10_-_92681033 0.31 ENST00000371697.3
 ANKRD1
 ankyrin repeat domain 1 (cardiac muscle)
chr11_-_71823266 0.30 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
 ANAPC15
 anaphase promoting complex subunit 15
chr6_-_110501200 0.30 ENST00000392586.1
ENST00000419252.1
ENST00000392589.1
ENST00000392588.1
ENST00000359451.2
 WASF1
 WAS protein family, member 1
chr10_+_47894023 0.29 ENST00000358474.5
 FAM21B
 family with sequence similarity 21, member B
chrX_+_21958674 0.28 ENST00000404933.2
 SMS
 spermine synthase
chr11_+_65554493 0.28 ENST00000335987.3
 OVOL1
 ovo-like zinc finger 1
chr1_-_150669500 0.28 ENST00000271732.3
 GOLPH3L
 golgi phosphoprotein 3-like
chr2_+_198380289 0.27 ENST00000233892.4
ENST00000409916.1
 MOB4
 MOB family member 4, phocein
chr5_-_9630463 0.27 ENST00000382492.2
 TAS2R1
 taste receptor, type 2, member 1
chr3_-_164796269 0.26 ENST00000264382.3
 SI
 sucrase-isomaltase (alpha-glucosidase)
chr15_+_89631381 0.25 ENST00000352732.5
 ABHD2
 abhydrolase domain containing 2
chr4_+_110736659 0.24 ENST00000394631.3
ENST00000226796.6
 GAR1
 GAR1 ribonucleoprotein
chr9_-_95166884 0.24 ENST00000375561.5
 OGN
 osteoglycin
chr21_-_15918618 0.23 ENST00000400564.1
ENST00000400566.1
 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
chr3_+_138340067 0.23 ENST00000479848.1
 FAIM
 Fas apoptotic inhibitory molecule
chr6_+_34204642 0.23 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
 HMGA1
 high mobility group AT-hook 1
chr15_+_58430567 0.23 ENST00000536493.1
 AQP9
 aquaporin 9
chr12_+_28410128 0.23 ENST00000381259.1
ENST00000381256.1
 CCDC91
 coiled-coil domain containing 91
chr10_+_70661014 0.22 ENST00000373585.3
 DDX50
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr2_-_44588624 0.22 ENST00000438314.1
ENST00000409936.1
 PREPL
 prolyl endopeptidase-like
chrX_-_16887963 0.22 ENST00000380084.4
 RBBP7
 retinoblastoma binding protein 7
chr1_-_54411255 0.22 ENST00000371377.3
 HSPB11
 heat shock protein family B (small), member 11
chr5_-_94890648 0.22 ENST00000513823.1
ENST00000514952.1
ENST00000358746.2
 TTC37
 tetratricopeptide repeat domain 37
chr7_+_77428149 0.21 ENST00000415251.2
ENST00000275575.7
 PHTF2
 putative homeodomain transcription factor 2
chr4_-_103749313 0.21 ENST00000394803.5
 UBE2D3
 ubiquitin-conjugating enzyme E2D 3
chr3_+_152552685 0.21 ENST00000305097.3
 P2RY1
 purinergic receptor P2Y, G-protein coupled, 1
chr4_-_103749179 0.21 ENST00000502690.1
 UBE2D3
 ubiquitin-conjugating enzyme E2D 3
chr15_+_89631647 0.21 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
 ABHD2
 abhydrolase domain containing 2
chr2_-_44588679 0.20 ENST00000409411.1
 PREPL
 prolyl endopeptidase-like
chr5_+_174151536 0.20 ENST00000239243.6
ENST00000507785.1
 MSX2
 msh homeobox 2
chr8_-_86290333 0.20 ENST00000521846.1
ENST00000523022.1
ENST00000524324.1
ENST00000519991.1
ENST00000520663.1
ENST00000517590.1
ENST00000522579.1
ENST00000522814.1
ENST00000522662.1
ENST00000523858.1
ENST00000519129.1
 CA1
 carbonic anhydrase I
chr4_-_103749205 0.20 ENST00000508249.1
 UBE2D3
 ubiquitin-conjugating enzyme E2D 3
chr11_-_71823796 0.20 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
 ANAPC15
 anaphase promoting complex subunit 15
chr4_-_39979576 0.20 ENST00000303538.8
ENST00000503396.1
 PDS5A
 PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr21_-_35899113 0.19 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
 RCAN1
 regulator of calcineurin 1
chr12_-_71031220 0.19 ENST00000334414.6
 PTPRB
 protein tyrosine phosphatase, receptor type, B
chr7_-_14028488 0.18 ENST00000405358.4
 ETV1
 ets variant 1
chr12_+_20963647 0.18 ENST00000381545.3
 SLCO1B3
 solute carrier organic anion transporter family, member 1B3
chr2_-_44588694 0.18 ENST00000409957.1
 PREPL
 prolyl endopeptidase-like
chr7_-_99717463 0.18 ENST00000437822.2
 TAF6
 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr8_-_86253888 0.18 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
 CA1
 carbonic anhydrase I
chr19_+_19303008 0.18 ENST00000353145.1
ENST00000421262.3
ENST00000303088.4
ENST00000456252.3
ENST00000593273.1
 RFXANK
 regulatory factor X-associated ankyrin-containing protein
chr4_-_103749105 0.18 ENST00000394801.4
ENST00000394804.2
 UBE2D3
 ubiquitin-conjugating enzyme E2D 3
chr13_-_36050819 0.17 ENST00000379919.4
 MAB21L1
 mab-21-like 1 (C. elegans)
chr7_+_77428066 0.17 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
 PHTF2
 putative homeodomain transcription factor 2
chr4_+_70796784 0.17 ENST00000246891.4
ENST00000444405.3
 CSN1S1
 casein alpha s1
chr14_-_70883708 0.17 ENST00000256366.4
 SYNJ2BP
 synaptojanin 2 binding protein
chr9_-_95166841 0.16 ENST00000262551.4
 OGN
 osteoglycin
chr17_-_64187973 0.16 ENST00000583358.1
ENST00000392769.2
 CEP112
 centrosomal protein 112kDa
chr12_+_20963632 0.16 ENST00000540853.1
ENST00000261196.2
 SLCO1B3
 solute carrier organic anion transporter family, member 1B3
chr17_-_46690839 0.16 ENST00000498634.2
 HOXB8
 homeobox B8
chr17_+_48823975 0.16 ENST00000513969.1
ENST00000503728.1
 LUC7L3
 LUC7-like 3 (S. cerevisiae)
chr1_-_109618566 0.15 ENST00000338366.5
 TAF13
 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr22_+_23154239 0.15 ENST00000390315.2
 IGLV3-10
 immunoglobulin lambda variable 3-10
chr11_+_66276550 0.15 ENST00000419755.3
 CTD-3074O7.11
 Bardet-Biedl syndrome 1 protein
chr16_-_66764119 0.15 ENST00000569320.1
 DYNC1LI2
 dynein, cytoplasmic 1, light intermediate chain 2
chr11_-_71823715 0.15 ENST00000545944.1
ENST00000502597.2
 ANAPC15
 anaphase promoting complex subunit 15
chr8_-_62602327 0.15 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
 ASPH
 aspartate beta-hydroxylase
chr1_-_197115818 0.14 ENST00000367409.4
ENST00000294732.7
 ASPM
 asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr3_+_130569429 0.14 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
 ATP2C1
 ATPase, Ca++ transporting, type 2C, member 1
chr6_-_38670897 0.14 ENST00000373365.4
 GLO1
 glyoxalase I
chr12_-_10978957 0.14 ENST00000240619.2
 TAS2R10
 taste receptor, type 2, member 10
chr6_+_26440700 0.14 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
 BTN3A3
 butyrophilin, subfamily 3, member A3
chr6_+_29429217 0.13 ENST00000396792.2
 OR2H1
 olfactory receptor, family 2, subfamily H, member 1
chr12_-_10959892 0.13 ENST00000240615.2
 TAS2R8
 taste receptor, type 2, member 8
chr5_+_176811431 0.13 ENST00000512593.1
ENST00000324417.5
 SLC34A1
 solute carrier family 34 (type II sodium/phosphate contransporter), member 1
chr1_+_16370271 0.12 ENST00000375679.4
 CLCNKB
 chloride channel, voltage-sensitive Kb
chr5_+_140579162 0.11 ENST00000536699.1
ENST00000354757.3
 PCDHB11
 protocadherin beta 11
chr21_-_43346790 0.11 ENST00000329623.7
 C2CD2
 C2 calcium-dependent domain containing 2
chr3_+_149191723 0.11 ENST00000305354.4
 TM4SF4
 transmembrane 4 L six family member 4
chr19_+_48949030 0.11 ENST00000253237.5
 GRWD1
 glutamate-rich WD repeat containing 1
chr3_+_138340049 0.11 ENST00000464668.1
 FAIM
 Fas apoptotic inhibitory molecule
chr10_-_28571015 0.11 ENST00000375719.3
ENST00000375732.1
 MPP7
 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr11_+_46958248 0.10 ENST00000536126.1
ENST00000278460.7
ENST00000378618.2
ENST00000395460.2
ENST00000378615.3
ENST00000543718.1
 C11orf49
 chromosome 11 open reading frame 49
chr4_-_103748880 0.10 ENST00000453744.2
ENST00000349311.8
 UBE2D3
 ubiquitin-conjugating enzyme E2D 3
chr10_+_96443378 0.10 ENST00000285979.6
 CYP2C18
 cytochrome P450, family 2, subfamily C, polypeptide 18
chr18_-_54305658 0.09 ENST00000586262.1
ENST00000217515.6
 TXNL1
 thioredoxin-like 1
chr1_+_160160283 0.09 ENST00000368079.3
 CASQ1
 calsequestrin 1 (fast-twitch, skeletal muscle)
chr3_-_141747950 0.08 ENST00000497579.1
 TFDP2
 transcription factor Dp-2 (E2F dimerization partner 2)
chr1_+_160160346 0.08 ENST00000368078.3
 CASQ1
 calsequestrin 1 (fast-twitch, skeletal muscle)
chr19_-_58951496 0.08 ENST00000254166.3
 ZNF132
 zinc finger protein 132
chr7_+_55433131 0.08 ENST00000254770.2
 LANCL2
 LanC lantibiotic synthetase component C-like 2 (bacterial)
chr1_+_12834984 0.08 ENST00000357726.4
 PRAMEF12
 PRAME family member 12
chr12_+_81110684 0.08 ENST00000228644.3
 MYF5
 myogenic factor 5
chr2_+_11682790 0.07 ENST00000389825.3
ENST00000381483.2
 GREB1
 growth regulation by estrogen in breast cancer 1
chr2_-_3521518 0.07 ENST00000382093.5
 ADI1
 acireductone dioxygenase 1
chr1_-_207226313 0.07 ENST00000367084.1
 YOD1
 YOD1 deubiquitinase
chr11_-_13517565 0.06 ENST00000282091.1
ENST00000529816.1
 PTH
 parathyroid hormone
chr2_+_169757750 0.06 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
 G6PC2
 glucose-6-phosphatase, catalytic, 2
chr3_+_111717511 0.05 ENST00000478951.1
ENST00000393917.2
 TAGLN3
 transgelin 3
chr6_+_110501344 0.05 ENST00000368932.1
 CDC40
 cell division cycle 40
chr17_-_2996290 0.05 ENST00000331459.1
 OR1D2
 olfactory receptor, family 1, subfamily D, member 2
chrX_-_13835147 0.05 ENST00000493677.1
ENST00000355135.2
 GPM6B
 glycoprotein M6B
chr4_+_41614909 0.05 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
 LIMCH1
 LIM and calponin homology domains 1
chr11_+_33061543 0.05 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
 TCP11L1
 t-complex 11, testis-specific-like 1
chr12_-_10605929 0.04 ENST00000347831.5
ENST00000359151.3
 KLRC1
 killer cell lectin-like receptor subfamily C, member 1
chr19_+_50016610 0.04 ENST00000596975.1
 FCGRT
 Fc fragment of IgG, receptor, transporter, alpha
chr18_+_46065393 0.04 ENST00000256413.3
 CTIF
 CBP80/20-dependent translation initiation factor
chr1_-_190446759 0.04 ENST00000367462.3
 BRINP3
 bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr17_-_45266542 0.04 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
 CDC27
 cell division cycle 27
chr5_+_66300446 0.04 ENST00000261569.7
 MAST4
 microtubule associated serine/threonine kinase family member 4
chr20_-_50722183 0.04 ENST00000371523.4
 ZFP64
 ZFP64 zinc finger protein
chr8_+_9413410 0.04 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
 TNKS
 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr10_-_61900762 0.04 ENST00000355288.2
 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
chr1_-_205325850 0.04 ENST00000537168.1
 KLHDC8A
 kelch domain containing 8A
chrX_-_77225135 0.03 ENST00000458128.1
 PGAM4
 phosphoglycerate mutase family member 4
chr15_-_64665911 0.03 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
 CTD-2116N17.1
 Uncharacterized protein
chr12_-_10607084 0.03 ENST00000408006.3
ENST00000544822.1
ENST00000536188.1
 KLRC1
 killer cell lectin-like receptor subfamily C, member 1
chr3_+_186353756 0.03 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
 FETUB
 fetuin B
chr17_-_10372875 0.03 ENST00000255381.2
 MYH4
 myosin, heavy chain 4, skeletal muscle
chr15_-_65903407 0.03 ENST00000395644.4
ENST00000567744.1
ENST00000568573.1
ENST00000562830.1
ENST00000569491.1
ENST00000561769.1
 VWA9
 von Willebrand factor A domain containing 9
chr16_+_69345243 0.03 ENST00000254950.11
 VPS4A
 vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr1_-_1710229 0.03 ENST00000341991.3
 NADK
 NAD kinase
chr2_-_169887827 0.03 ENST00000263817.6
 ABCB11
 ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr1_+_186369704 0.02 ENST00000574641.1
 OCLM
 oculomedin
chr17_-_3030875 0.02 ENST00000328890.2
 OR1G1
 olfactory receptor, family 1, subfamily G, member 1
chr1_+_117544366 0.02 ENST00000256652.4
ENST00000369470.1
 CD101
 CD101 molecule
chr6_+_110501621 0.02 ENST00000368930.1
ENST00000307731.1
 CDC40
 cell division cycle 40
chr16_+_6069072 0.02 ENST00000547605.1
ENST00000550418.1
ENST00000553186.1
 RBFOX1
 RNA binding protein, fox-1 homolog (C. elegans) 1
chr18_+_22040620 0.02 ENST00000426880.2
 HRH4
 histamine receptor H4
chr12_+_106751436 0.02 ENST00000228347.4
 POLR3B
 polymerase (RNA) III (DNA directed) polypeptide B
chr15_+_62853562 0.01 ENST00000561311.1
 TLN2
 talin 2
chr2_-_208031943 0.01 ENST00000421199.1
ENST00000457962.1
 KLF7
 Kruppel-like factor 7 (ubiquitous)
chr14_-_104181771 0.01 ENST00000554913.1
ENST00000554974.1
ENST00000553361.1
ENST00000555055.1
ENST00000555964.1
ENST00000556682.1
ENST00000445556.1
ENST00000553332.1
ENST00000352127.7
 XRCC3
 X-ray repair complementing defective repair in Chinese hamster cells 3
chr18_-_19997878 0.01 ENST00000391403.2
 CTAGE1
 cutaneous T-cell lymphoma-associated antigen 1
chr6_+_28317685 0.01 ENST00000252211.2
ENST00000341464.5
ENST00000377255.3
 ZKSCAN3
 zinc finger with KRAB and SCAN domains 3
chr8_-_97273807 0.01 ENST00000517720.1
ENST00000287025.3
ENST00000523821.1
 MTERFD1
 MTERF domain containing 1
chr12_-_10955226 0.01 ENST00000240687.2
 TAS2R7
 taste receptor, type 2, member 7
chr16_-_1464688 0.01 ENST00000389221.4
ENST00000508903.2
ENST00000397462.1
ENST00000301712.5
 UNKL
 unkempt family zinc finger-like

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 5.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 1.0 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 1.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.9 REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.4 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.6 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.3 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.9 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 1.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.4 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 2.2 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.8 6.3 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.7 2.2 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.6 1.7 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.5 2.5 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.4 1.1 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.4 1.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.3 2.4 GO:0010519 negative regulation of phospholipase activity(GO:0010519) regulation of adrenergic receptor signaling pathway(GO:0071877)
0.3 5.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 1.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.2 0.9 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.2 0.5 GO:0051697 protein delipidation(GO:0051697)
0.1 0.8 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 0.5 GO:0051541 elastin metabolic process(GO:0051541)
0.1 0.6 GO:0097338 response to clozapine(GO:0097338)
0.1 0.6 GO:1990822 L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822)
0.1 0.3 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.3 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 1.2 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.1 0.6 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 0.2 GO:0051795 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.1 0.4 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.2 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.4 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.4 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.6 GO:0014029 neural crest formation(GO:0014029)
0.0 0.2 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.1 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 1.1 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.5 GO:0009642 response to light intensity(GO:0009642)
0.0 0.3 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.6 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.2 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 0.5 GO:0001765 membrane raft assembly(GO:0001765)
0.0 0.7 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.6 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0 0.2 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.1 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
0.0 1.2 GO:0006458 'de novo' protein folding(GO:0006458)
0.0 0.4 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.1 GO:0009438 methylglyoxal metabolic process(GO:0009438)
0.0 0.1 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.2 GO:0070884 calcineurin-NFAT signaling cascade(GO:0033173) inositol phosphate-mediated signaling(GO:0048016) regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.2 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.4 GO:0006907 pinocytosis(GO:0006907)
0.0 0.3 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.0 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.0 0.5 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.2 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.6 GO:1901998 toxin transport(GO:1901998)
0.0 0.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.1 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.0 GO:0061738 late endosomal microautophagy(GO:0061738)
0.0 0.6 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 0.9 GO:0008542 visual learning(GO:0008542)
0.0 0.1 GO:1901419 regulation of response to alcohol(GO:1901419)
0.0 0.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 1.2 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.2 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.7 GO:0070206 protein trimerization(GO:0070206)
0.0 0.4 GO:0042407 cristae formation(GO:0042407)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 2.5 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.9 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.6 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.7 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.6 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.3 PID EPO PATHWAY EPO signaling pathway
0.0 0.4 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.4 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 3.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 2.2 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.4 GO:0061617 MICOS complex(GO:0061617)
0.1 0.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.4 GO:0033063 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 7.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 0.4 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.1 0.2 GO:0055087 Ski complex(GO:0055087)
0.1 1.0 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 5.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.7 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0090661 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 1.0 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.2 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.1 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.7 GO:0031526 brush border membrane(GO:0031526)
0.0 0.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.7 GO:0015030 Cajal body(GO:0015030)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.7 2.2 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.4 1.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.3 2.5 GO:0001849 complement component C1q binding(GO:0001849)
0.3 3.8 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.3 0.8 GO:0002113 interleukin-33 binding(GO:0002113)
0.3 1.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.2 1.2 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.1 5.9 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.4 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.6 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.1 0.6 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.1 0.3 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.3 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 2.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.4 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.5 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 0.2 GO:0015254 glycerol channel activity(GO:0015254) urea channel activity(GO:0015265)
0.1 1.4 GO:0031489 myosin V binding(GO:0031489)
0.1 0.2 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.4 GO:0004064 arylesterase activity(GO:0004064)
0.0 1.3 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 1.0 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.4 GO:0000150 recombinase activity(GO:0000150)
0.0 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.6 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.1 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.0 0.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.1 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.6 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.2 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)