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ENCODE cell lines, expression (Ernst 2011)
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Results for YY1_YY2
Z-value: 1.28
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Transcription factors associated with YY1_YY2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| YY1 | hg19_v2_chr14_+_100705322_100705360 | -0.80 | 2.1e-04 | Click! |
| YY2 | hg19_v2_chrX_+_21874105_21874105 | 0.10 | 7.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of YY1_YY2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_149688896 | 4.53 |
ENST00000239940.7 |
PFN2 |
profilin 2 |
| chr3_-_149688502 | 4.50 |
ENST00000481767.1 ENST00000475518.1 |
PFN2 |
profilin 2 |
| chr3_-_149688655 | 4.24 |
ENST00000461930.1 ENST00000423691.2 ENST00000490975.1 ENST00000461868.1 ENST00000452853.2 |
PFN2 |
profilin 2 |
| chr2_-_190044480 | 3.04 |
ENST00000374866.3 |
COL5A2 |
collagen, type V, alpha 2 |
| chr12_-_91539918 | 2.35 |
ENST00000548218.1 |
DCN |
decorin |
| chr5_-_16936340 | 2.28 |
ENST00000507288.1 ENST00000513610.1 |
MYO10 |
myosin X |
| chr2_-_175870085 | 2.25 |
ENST00000409156.3 |
CHN1 |
chimerin 1 |
| chr17_-_3571934 | 2.25 |
ENST00000225525.3 |
TAX1BP3 |
Tax1 (human T-cell leukemia virus type I) binding protein 3 |
| chr15_+_63340647 | 2.12 |
ENST00000404484.4 |
TPM1 |
tropomyosin 1 (alpha) |
| chrX_-_153236819 | 2.09 |
ENST00000354233.3 |
HCFC1 |
host cell factor C1 (VP16-accessory protein) |
Gene Ontology Analysis
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.4 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.3 | 13.4 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 5.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 5.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 5.4 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 4.1 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 4.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.3 | 3.6 | GO:0046972 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.0 | 2.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.2 | 2.7 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.9 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.7 | 12.3 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 7.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 4.4 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.2 | 4.3 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.2 | 4.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 3.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 3.4 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 3.4 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.0 | 3.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 7.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 6.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 5.8 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 5.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 4.6 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 3.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.9 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 2.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.3 | 13.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 4.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 3.9 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 3.9 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.1 | 3.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 2.5 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 2.4 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.1 | 2.4 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 2.4 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 13.2 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 1.4 | 10.9 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.2 | 6.0 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 1.1 | 4.4 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.8 | 4.1 | GO:2000542 | negative regulation of gastrulation(GO:2000542) |
| 0.2 | 3.9 | GO:0033622 | integrin activation(GO:0033622) |
| 0.3 | 3.4 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.2 | 3.0 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 3.0 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.0 | 3.0 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |