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ENCODE cell lines, expression (Ernst 2011)

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Results for ZBTB49

Z-value: 0.92

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Transcription factors associated with ZBTB49

Gene Symbol Gene ID Gene Info
ZBTB49
ENSG00000168826.11 ZBTB49

Activity profile of ZBTB49 motif

Sorted Z-values of ZBTB49 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB49

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_-_49604545 4.77 ENST00000371175.4
ENST00000229810.7
 RHAG
 Rh-associated glycoprotein
chrX_-_151903184 4.18 ENST00000357916.4
ENST00000393869.3
 MAGEA12
 melanoma antigen family A, 12
chrX_-_151903101 3.47 ENST00000393900.3
 MAGEA12
 melanoma antigen family A, 12
chrX_+_30265256 2.93 ENST00000397548.2
 MAGEB1
 melanoma antigen family B, 1
chrX_+_151903253 2.43 ENST00000452779.2
ENST00000370291.2
 CSAG1
 chondrosarcoma associated gene 1
chrX_+_52780318 1.90 ENST00000375515.3
ENST00000276049.6
 SSX2B
 synovial sarcoma, X breakpoint 2B
chr22_+_21996549 1.86 ENST00000248958.4
 SDF2L1
 stromal cell-derived factor 2-like 1
chrX_+_9431324 1.74 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
 TBL1X
 transducin (beta)-like 1X-linked
chr7_-_103629963 1.34 ENST00000428762.1
ENST00000343529.5
ENST00000424685.2
 RELN
 reelin
chr1_+_182808474 1.05 ENST00000367549.3
 DHX9
 DEAH (Asp-Glu-Ala-His) box helicase 9
chr21_-_26979786 0.85 ENST00000419219.1
ENST00000352957.4
ENST00000307301.7
 MRPL39
 mitochondrial ribosomal protein L39
chrX_+_101854096 0.84 ENST00000246174.2
ENST00000537008.1
ENST00000541409.1
 ARMCX5
 armadillo repeat containing, X-linked 5
chr12_+_53835539 0.84 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
 PRR13
 proline rich 13
chr12_+_53835383 0.81 ENST00000429243.2
 PRR13
 proline rich 13
chr7_-_44613494 0.78 ENST00000431640.1
ENST00000258772.5
 DDX56
 DEAD (Asp-Glu-Ala-Asp) box helicase 56
chr4_-_2243839 0.77 ENST00000511885.2
ENST00000506763.1
ENST00000514395.1
ENST00000502440.1
ENST00000243706.4
ENST00000443786.2
 POLN
HAUS3
 polymerase (DNA directed) nu
HAUS augmin-like complex, subunit 3
chr8_-_99129338 0.74 ENST00000520507.1
 HRSP12
 heat-responsive protein 12
chr11_+_117857063 0.73 ENST00000227752.3
ENST00000541785.1
ENST00000545409.1
 IL10RA
 interleukin 10 receptor, alpha
chr3_+_39424828 0.70 ENST00000273158.4
ENST00000431510.1
 SLC25A38
 solute carrier family 25, member 38
chr8_-_99129384 0.68 ENST00000521560.1
ENST00000254878.3
 HRSP12
 heat-responsive protein 12
chr7_+_99006232 0.65 ENST00000403633.2
 BUD31
 BUD31 homolog (S. cerevisiae)
chr9_-_123676827 0.59 ENST00000546084.1
 TRAF1
 TNF receptor-associated factor 1
chr8_-_59572093 0.59 ENST00000427130.2
 NSMAF
 neutral sphingomyelinase (N-SMase) activation associated factor
chr10_+_94352956 0.57 ENST00000260731.3
 KIF11
 kinesin family member 11
chrX_+_101854426 0.56 ENST00000536530.1
ENST00000473968.1
ENST00000604957.1
ENST00000477663.1
ENST00000479502.1
 ARMCX5
 armadillo repeat containing, X-linked 5
chr1_+_26869597 0.55 ENST00000530003.1
 RPS6KA1
 ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr17_+_80009741 0.52 ENST00000578552.1
ENST00000320548.4
ENST00000581578.1
ENST00000583885.1
ENST00000583641.1
ENST00000581418.1
ENST00000355130.2
ENST00000306823.6
ENST00000392358.2
 GPS1
 G protein pathway suppressor 1
chr11_+_4116005 0.51 ENST00000300738.5
 RRM1
 ribonucleotide reductase M1
chr14_+_35591858 0.49 ENST00000603544.1
 KIAA0391
 KIAA0391
chr10_+_64893039 0.48 ENST00000277746.6
ENST00000435510.2
 NRBF2
 nuclear receptor binding factor 2
chr11_+_4116054 0.48 ENST00000423050.2
 RRM1
 ribonucleotide reductase M1
chr5_+_154238149 0.47 ENST00000519430.1
ENST00000520671.1
ENST00000521583.1
ENST00000518028.1
ENST00000519404.1
ENST00000519394.1
ENST00000518775.1
 CNOT8
 CCR4-NOT transcription complex, subunit 8
chr6_-_43655511 0.47 ENST00000372133.3
ENST00000372116.1
ENST00000427312.1
 MRPS18A
 mitochondrial ribosomal protein S18A
chr18_-_11148587 0.45 ENST00000302079.6
ENST00000580640.1
ENST00000503781.3
 PIEZO2
 piezo-type mechanosensitive ion channel component 2
chr8_-_82024290 0.43 ENST00000220597.4
 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
chr4_-_53525406 0.42 ENST00000451218.2
ENST00000441222.3
 USP46
 ubiquitin specific peptidase 46
chr18_+_32558208 0.40 ENST00000436190.2
 MAPRE2
 microtubule-associated protein, RP/EB family, member 2
chr9_-_116102530 0.40 ENST00000374195.3
ENST00000341761.4
 WDR31
 WD repeat domain 31
chr8_+_24151553 0.39 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
 ADAM28
 ADAM metallopeptidase domain 28
chr12_+_53835508 0.38 ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
ENST00000541275.1
 PRR13
PCBP2
 proline rich 13
poly(rC) binding protein 2
chr2_+_95691445 0.37 ENST00000353004.3
ENST00000354078.3
ENST00000349807.3
 MAL
 mal, T-cell differentiation protein
chr22_-_19166343 0.36 ENST00000215882.5
 SLC25A1
 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr3_+_196594727 0.35 ENST00000445299.2
ENST00000323460.5
ENST00000419026.1
 SENP5
 SUMO1/sentrin specific peptidase 5
chr1_-_151319283 0.34 ENST00000392746.3
 RFX5
 regulatory factor X, 5 (influences HLA class II expression)
chr2_+_95691417 0.34 ENST00000309988.4
 MAL
 mal, T-cell differentiation protein
chr8_+_24151620 0.34 ENST00000437154.2
 ADAM28
 ADAM metallopeptidase domain 28
chr5_-_77590480 0.33 ENST00000519295.1
ENST00000255194.6
 AP3B1
 adaptor-related protein complex 3, beta 1 subunit
chr7_+_148936732 0.33 ENST00000335870.2
 ZNF212
 zinc finger protein 212
chr15_-_55489097 0.32 ENST00000260443.4
 RSL24D1
 ribosomal L24 domain containing 1
chrX_+_64887512 0.32 ENST00000360270.5
 MSN
 moesin
chr15_-_25684110 0.31 ENST00000232165.3
 UBE3A
 ubiquitin protein ligase E3A
chr2_+_27237615 0.30 ENST00000458529.1
ENST00000402218.1
 MAPRE3
 microtubule-associated protein, RP/EB family, member 3
chr10_+_88428370 0.29 ENST00000372066.3
ENST00000263066.6
ENST00000372056.4
ENST00000310944.6
ENST00000361373.4
ENST00000542786.1
 LDB3
 LIM domain binding 3
chr2_+_89890533 0.29 ENST00000429992.2
 IGKV2D-40
 immunoglobulin kappa variable 2D-40
chr5_+_154238096 0.29 ENST00000517568.1
ENST00000524105.1
ENST00000285896.6
 CNOT8
 CCR4-NOT transcription complex, subunit 8
chr19_-_59070239 0.29 ENST00000595957.1
ENST00000253023.3
 UBE2M
 ubiquitin-conjugating enzyme E2M
chr5_+_154238042 0.28 ENST00000519211.1
ENST00000522458.1
ENST00000519903.1
ENST00000521450.1
ENST00000403027.2
 CNOT8
 CCR4-NOT transcription complex, subunit 8
chr14_+_35591928 0.23 ENST00000605870.1
ENST00000557404.3
 KIAA0391
 KIAA0391
chr19_+_18669809 0.21 ENST00000602094.1
 KXD1
 KxDL motif containing 1
chr10_+_88428206 0.19 ENST00000429277.2
ENST00000458213.2
ENST00000352360.5
 LDB3
 LIM domain binding 3
chr22_-_29196030 0.19 ENST00000405219.3
 XBP1
 X-box binding protein 1
chr19_-_6481776 0.18 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
 DENND1C
 DENN/MADD domain containing 1C
chr8_+_99129513 0.18 ENST00000522319.1
ENST00000401707.2
 POP1
 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
chr5_+_154237778 0.17 ENST00000523698.1
ENST00000517876.1
ENST00000520472.1
 CNOT8
 CCR4-NOT transcription complex, subunit 8
chr14_+_79746249 0.17 ENST00000428277.2
 NRXN3
 neurexin 3
chr3_+_52232102 0.16 ENST00000469224.1
ENST00000394965.2
ENST00000310271.2
ENST00000484952.1
 ALAS1
 aminolevulinate, delta-, synthase 1
chr19_+_17862274 0.11 ENST00000596536.1
ENST00000593870.1
ENST00000598086.1
ENST00000598932.1
ENST00000595023.1
ENST00000594068.1
ENST00000596507.1
ENST00000595033.1
ENST00000597718.1
 FCHO1
 FCH domain only 1
chrX_-_153210107 0.09 ENST00000369997.3
ENST00000393700.3
ENST00000412763.1
 RENBP
 renin binding protein
chr10_-_12084770 0.08 ENST00000357604.5
 UPF2
 UPF2 regulator of nonsense transcripts homolog (yeast)
chr14_-_35591433 0.08 ENST00000261475.5
ENST00000555644.1
 PPP2R3C
 protein phosphatase 2, regulatory subunit B'', gamma
chr16_-_28621353 0.06 ENST00000567512.1
 SULT1A1
 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr22_-_29196546 0.06 ENST00000403532.3
ENST00000216037.6
 XBP1
 X-box binding protein 1
chr1_+_8021954 0.06 ENST00000377491.1
ENST00000377488.1
 PARK7
 parkinson protein 7
chr9_-_97401782 0.06 ENST00000375326.4
 FBP1
 fructose-1,6-bisphosphatase 1
chr14_+_35591735 0.04 ENST00000604948.1
ENST00000605201.1
ENST00000250377.7
ENST00000321130.10
ENST00000534898.4
 KIAA0391
 KIAA0391
chr17_-_3195876 0.03 ENST00000323404.1
 OR3A1
 olfactory receptor, family 3, subfamily A, member 1
chr2_-_48982708 0.02 ENST00000428232.1
ENST00000405626.1
ENST00000294954.7
 LHCGR
 luteinizing hormone/choriogonadotropin receptor
chr15_+_93749295 0.02 ENST00000599897.1
 AC112693.2
 AC112693.2
chr20_-_32700075 0.02 ENST00000374980.2
 EIF2S2
 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.4 1.3 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.3 1.7 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.2 1.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 1.0 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 0.6 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 0.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.7 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 0.4 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.1 0.4 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.5 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 1.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.4 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.1 0.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.9 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.2 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.3 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.0 0.8 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.6 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.1 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.0 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.8 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.3 GO:0030742 GTP-dependent protein binding(GO:0030742)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 1.0 GO:0005726 perichromatin fibrils(GO:0005726)
0.2 0.8 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.1 1.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.8 GO:0070652 HAUS complex(GO:0070652)
0.1 1.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.5 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 2.0 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.8 GO:0031143 pseudopodium(GO:0031143)
0.0 0.7 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.5 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.2 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.5 GO:0008180 COP9 signalosome(GO:0008180)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.8 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.6 REACTOME KINESINS Genes involved in Kinesins
0.0 0.8 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0035378 carbon dioxide transmembrane transport(GO:0035378)
0.3 1.3 GO:0097476 NMDA glutamate receptor clustering(GO:0097114) spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.2 1.0 GO:0035549 positive regulation of interferon-beta secretion(GO:0035549)
0.2 1.7 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 0.8 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 0.3 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.1 0.4 GO:0006842 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.1 0.7 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.1 0.7 GO:0015816 glycine transport(GO:0015816)
0.1 0.2 GO:0035470 positive regulation of vascular wound healing(GO:0035470) regulation of lactation(GO:1903487)
0.1 0.3 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.6 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 0.7 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.3 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.1 0.3 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 0.6 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.4 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.3 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.0 1.0 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 1.2 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 0.5 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.2 GO:0016078 tRNA catabolic process(GO:0016078)
0.0 0.6 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.0 0.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.1 GO:0006050 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.0 0.5 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 1.3 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.0 1.7 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.8 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.1 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.0 0.2 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.2 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events