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ENCODE cell lines, expression (Ernst 2011)

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Results for ZFHX3

Z-value: 0.54

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Transcription factors associated with ZFHX3

Gene Symbol Gene ID Gene Info
ZFHX3
ENSG00000140836.10 ZFHX3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZFHX3hg19_v2_chr16_-_73093597_73093597,
hg19_v2_chr16_-_73082274_73082274		0.292.7e-01Click!

Activity profile of ZFHX3 motif

Sorted Z-values of ZFHX3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_+_22696314 1.34 ENST00000532398.1
ENST00000433790.1
 GAS2
 growth arrest-specific 2
chr4_-_155511887 0.92 ENST00000302053.3
ENST00000403106.3
 FGA
 fibrinogen alpha chain
chr9_-_123812542 0.80 ENST00000223642.1
 C5
 complement component 5
chr17_-_64225508 0.71 ENST00000205948.6
 APOH
 apolipoprotein H (beta-2-glycoprotein I)
chr12_-_91546926 0.61 ENST00000550758.1
 DCN
 decorin
chr5_+_118690466 0.58 ENST00000503646.1
 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
chr19_+_926000 0.57 ENST00000263620.3
 ARID3A
 AT rich interactive domain 3A (BRIGHT-like)
chrX_-_110655306 0.56 ENST00000371993.2
 DCX
 doublecortin
chr17_+_41052808 0.55 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
 G6PC
 glucose-6-phosphatase, catalytic subunit
chr1_+_192544857 0.52 ENST00000367459.3
ENST00000469578.2
 RGS1
 regulator of G-protein signaling 1
chr14_+_95027772 0.47 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
 SERPINA4
SERPINA5
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr4_+_100495864 0.44 ENST00000265517.5
ENST00000422897.2
 MTTP
 microsomal triglyceride transfer protein
chr12_+_59989791 0.43 ENST00000552432.1
 SLC16A7
 solute carrier family 16 (monocarboxylate transporter), member 7
chr5_+_95066823 0.42 ENST00000506817.1
ENST00000379982.3
 RHOBTB3
 Rho-related BTB domain containing 3
chr8_-_70745575 0.41 ENST00000524945.1
 SLCO5A1
 solute carrier organic anion transporter family, member 5A1
chr22_-_30970560 0.39 ENST00000402369.1
ENST00000406361.1
 GAL3ST1
 galactose-3-O-sulfotransferase 1
chr10_-_75226166 0.36 ENST00000544628.1
 PPP3CB
 protein phosphatase 3, catalytic subunit, beta isozyme
chrX_-_32173579 0.35 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
 DMD
 dystrophin
chr19_-_46234119 0.32 ENST00000317683.3
 FBXO46
 F-box protein 46
chr17_-_26697304 0.32 ENST00000536498.1
 VTN
 vitronectin
chrX_+_9431324 0.32 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
 TBL1X
 transducin (beta)-like 1X-linked
chr2_-_60780607 0.32 ENST00000537768.1
ENST00000335712.6
ENST00000356842.4
 BCL11A
 B-cell CLL/lymphoma 11A (zinc finger protein)
chr2_-_60780702 0.32 ENST00000359629.5
 BCL11A
 B-cell CLL/lymphoma 11A (zinc finger protein)
chr19_-_36304201 0.31 ENST00000301175.3
 PRODH2
 proline dehydrogenase (oxidase) 2
chr2_-_60780536 0.30 ENST00000538214.1
 BCL11A
 B-cell CLL/lymphoma 11A (zinc finger protein)
chr15_+_58724184 0.25 ENST00000433326.2
 LIPC
 lipase, hepatic
chrX_+_84258832 0.21 ENST00000373173.2
 APOOL
 apolipoprotein O-like
chr17_-_60142609 0.21 ENST00000397786.2
 MED13
 mediator complex subunit 13
chr3_-_114477787 0.20 ENST00000464560.1
 ZBTB20
 zinc finger and BTB domain containing 20
chr1_-_160549235 0.20 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
 CD84
 CD84 molecule
chr7_-_100026280 0.19 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
 ZCWPW1
 zinc finger, CW type with PWWP domain 1
chr20_-_33735070 0.18 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
 EDEM2
 ER degradation enhancer, mannosidase alpha-like 2
chr12_+_59989918 0.18 ENST00000547379.1
ENST00000549465.1
 SLC16A7
 solute carrier family 16 (monocarboxylate transporter), member 7
chr14_+_39703084 0.16 ENST00000553728.1
 RP11-407N17.3
 cTAGE family member 5 isoform 4
chr8_+_98900132 0.16 ENST00000520016.1
 MATN2
 matrilin 2
chr12_-_101801505 0.15 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
 ARL1
 ADP-ribosylation factor-like 1
chr19_+_50016610 0.12 ENST00000596975.1
 FCGRT
 Fc fragment of IgG, receptor, transporter, alpha
chr3_-_49066811 0.12 ENST00000442157.1
ENST00000326739.4
 IMPDH2
 IMP (inosine 5'-monophosphate) dehydrogenase 2
chr6_-_116447283 0.11 ENST00000452729.1
ENST00000243222.4
 COL10A1
 collagen, type X, alpha 1
chr6_+_28317685 0.10 ENST00000252211.2
ENST00000341464.5
ENST00000377255.3
 ZKSCAN3
 zinc finger with KRAB and SCAN domains 3
chr19_+_54466179 0.10 ENST00000270458.2
 CACNG8
 calcium channel, voltage-dependent, gamma subunit 8
chr7_-_44580861 0.09 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
 NPC1L1
 NPC1-like 1
chrX_+_1710484 0.09 ENST00000313871.3
ENST00000381261.3
 AKAP17A
 A kinase (PRKA) anchor protein 17A
chr4_-_100356291 0.09 ENST00000476959.1
ENST00000482593.1
 ADH7
 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr16_+_87636474 0.08 ENST00000284262.2
 JPH3
 junctophilin 3
chr7_+_100026406 0.08 ENST00000414441.1
 MEPCE
 methylphosphate capping enzyme
chr2_+_185463093 0.08 ENST00000302277.6
 ZNF804A
 zinc finger protein 804A
chr20_-_21494654 0.07 ENST00000377142.4
 NKX2-2
 NK2 homeobox 2
chr3_+_69812701 0.07 ENST00000472437.1
 MITF
 microphthalmia-associated transcription factor
chr11_-_61687739 0.06 ENST00000531922.1
ENST00000301773.5
 RAB3IL1
 RAB3A interacting protein (rabin3)-like 1
chr21_+_40824003 0.05 ENST00000452550.1
 SH3BGR
 SH3 domain binding glutamic acid-rich protein
chr12_-_7818474 0.05 ENST00000229304.4
 APOBEC1
 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr12_+_53835508 0.05 ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
ENST00000541275.1
 PRR13
PCBP2
 proline rich 13
poly(rC) binding protein 2
chr22_+_39101728 0.04 ENST00000216044.5
ENST00000484657.1
 GTPBP1
 GTP binding protein 1
chr16_-_15474904 0.03 ENST00000534094.1
 NPIPA5
 nuclear pore complex interacting protein family, member A5
chr1_+_159557607 0.03 ENST00000255040.2
 APCS
 amyloid P component, serum
chr12_-_2944184 0.01 ENST00000337508.4
 NRIP2
 nuclear receptor interacting protein 2
chr11_+_8040739 0.01 ENST00000534099.1
 TUB
 tubby bipartite transcription factor
chr4_-_100356551 0.00 ENST00000209665.4
 ADH7
 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr20_+_42187608 0.00 ENST00000373100.1
 SGK2
 serum/glucocorticoid regulated kinase 2

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.6 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:1903860 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.3 0.8 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 1.2 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.5 GO:0061107 seminal vesicle development(GO:0061107)
0.1 0.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.5 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.1 0.6 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.6 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 0.2 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1 0.3 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.6 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.4 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.4 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 0.4 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.1 GO:0021779 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.2 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.1 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0 0.1 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.1 GO:0040031 snRNA modification(GO:0040031)
0.0 0.1 GO:2000773 negative regulation of cellular senescence(GO:2000773)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.7 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.6 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.3 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.4 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.5 GO:0032190 acrosin binding(GO:0032190)
0.0 0.4 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.1 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.0 0.3 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.8 GO:0008009 chemokine activity(GO:0008009)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.4 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.4 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0036024 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.1 0.8 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.3 GO:0071062 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 0.9 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.6 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.7 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.4 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.2 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0030314 junctional membrane complex(GO:0030314)