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ENCODE cell lines, expression (Ernst 2011)

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Results for ZKSCAN1

Z-value: 0.57

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Transcription factors associated with ZKSCAN1

Gene Symbol Gene ID Gene Info
ZKSCAN1
ENSG00000106261.12 ZKSCAN1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN1hg19_v2_chr7_+_99613195_99613206-0.638.5e-03Click!

Activity profile of ZKSCAN1 motif

Sorted Z-values of ZKSCAN1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_4385230 2.35 ENST00000536537.1
 CCND2
 cyclin D2
chr11_-_58343319 1.84 ENST00000395074.2
 LPXN
 leupaxin
chr22_-_37640277 1.23 ENST00000401529.3
ENST00000249071.6
 RAC2
 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr22_-_37640456 0.88 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
 RAC2
 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr2_-_158345462 0.72 ENST00000439355.1
ENST00000540637.1
 CYTIP
 cytohesin 1 interacting protein
chr19_-_55660561 0.69 ENST00000587758.1
ENST00000356783.5
ENST00000291901.8
ENST00000588426.1
ENST00000588147.1
ENST00000536926.1
ENST00000588981.1
 TNNT1
 troponin T type 1 (skeletal, slow)
chr19_+_39138320 0.62 ENST00000424234.2
ENST00000390009.3
ENST00000589528.1
 ACTN4
 actinin, alpha 4
chr1_+_65613340 0.60 ENST00000546702.1
 AK4
 adenylate kinase 4
chr20_-_56265680 0.58 ENST00000414037.1
 PMEPA1
 prostate transmembrane protein, androgen induced 1
chr5_-_134735568 0.48 ENST00000510038.1
ENST00000304332.4
 H2AFY
 H2A histone family, member Y
chr8_-_131028869 0.48 ENST00000518283.1
ENST00000519110.1
 FAM49B
 family with sequence similarity 49, member B
chr1_+_46668994 0.47 ENST00000371980.3
 LURAP1
 leucine rich adaptor protein 1
chrX_+_47441712 0.46 ENST00000218388.4
ENST00000377018.2
ENST00000456754.2
ENST00000377017.1
ENST00000441738.1
 TIMP1
 TIMP metallopeptidase inhibitor 1
chr9_-_112260531 0.42 ENST00000374541.2
ENST00000262539.3
 PTPN3
 protein tyrosine phosphatase, non-receptor type 3
chr20_+_43343517 0.41 ENST00000372865.4
 WISP2
 WNT1 inducible signaling pathway protein 2
chr20_+_43343476 0.40 ENST00000372868.2
 WISP2
 WNT1 inducible signaling pathway protein 2
chr9_+_132934835 0.39 ENST00000372398.3
 NCS1
 neuronal calcium sensor 1
chr5_-_127873659 0.37 ENST00000262464.4
 FBN2
 fibrillin 2
chr1_+_65613217 0.36 ENST00000545314.1
 AK4
 adenylate kinase 4
chr22_+_29702572 0.30 ENST00000407647.2
ENST00000416823.1
ENST00000428622.1
 GAS2L1
 growth arrest-specific 2 like 1
chr15_-_34635314 0.27 ENST00000557912.1
ENST00000328848.4
 NOP10
 NOP10 ribonucleoprotein
chr11_+_70049269 0.26 ENST00000301838.4
 FADD
 Fas (TNFRSF6)-associated via death domain
chr19_+_39138271 0.24 ENST00000252699.2
 ACTN4
 actinin, alpha 4
chr19_-_3062465 0.24 ENST00000327141.4
 AES
 amino-terminal enhancer of split
chr5_+_174151536 0.23 ENST00000239243.6
ENST00000507785.1
 MSX2
 msh homeobox 2
chr22_+_21921994 0.23 ENST00000545681.1
 UBE2L3
 ubiquitin-conjugating enzyme E2L 3
chr14_+_103851712 0.22 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
 MARK3
 MAP/microtubule affinity-regulating kinase 3
chr11_-_118134997 0.22 ENST00000278937.2
 MPZL2
 myelin protein zero-like 2
chr1_-_160549235 0.21 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
 CD84
 CD84 molecule
chr10_+_112679301 0.20 ENST00000265277.5
ENST00000369452.4
 SHOC2
 soc-2 suppressor of clear homolog (C. elegans)
chr5_+_135394840 0.20 ENST00000503087.1
 TGFBI
 transforming growth factor, beta-induced, 68kDa
chr16_+_19125252 0.20 ENST00000566735.1
ENST00000381440.3
 ITPRIPL2
 inositol 1,4,5-trisphosphate receptor interacting protein-like 2
chr19_-_3062881 0.20 ENST00000586742.1
 AES
 amino-terminal enhancer of split
chr15_-_49103235 0.20 ENST00000380950.2
 CEP152
 centrosomal protein 152kDa
chr2_+_74120094 0.19 ENST00000409731.3
ENST00000345517.3
ENST00000409918.1
ENST00000442912.1
ENST00000409624.1
 ACTG2
 actin, gamma 2, smooth muscle, enteric
chr17_-_73150599 0.19 ENST00000392566.2
ENST00000581874.1
 HN1
 hematological and neurological expressed 1
chr17_+_26800756 0.19 ENST00000537681.1
 SLC13A2
 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr20_+_44098385 0.18 ENST00000217425.5
ENST00000339946.3
 WFDC2
 WAP four-disulfide core domain 2
chr20_+_44098346 0.18 ENST00000372676.3
 WFDC2
 WAP four-disulfide core domain 2
chrX_+_109245863 0.18 ENST00000372072.3
 TMEM164
 transmembrane protein 164
chr22_+_33197683 0.18 ENST00000266085.6
 TIMP3
 TIMP metallopeptidase inhibitor 3
chr2_-_183387430 0.18 ENST00000410103.1
 PDE1A
 phosphodiesterase 1A, calmodulin-dependent
chr2_-_37193606 0.18 ENST00000379213.2
ENST00000263918.4
 STRN
 striatin, calmodulin binding protein
chr17_+_26800648 0.17 ENST00000545060.1
 SLC13A2
 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr19_+_10196781 0.17 ENST00000253110.11
 C19orf66
 chromosome 19 open reading frame 66
chr17_-_26220366 0.17 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
 LYRM9
RP1-66C13.4
 LYR motif containing 9
Uncharacterized protein
chr19_-_3063099 0.16 ENST00000221561.8
 AES
 amino-terminal enhancer of split
chr1_-_36615051 0.16 ENST00000373163.1
 TRAPPC3
 trafficking protein particle complex 3
chr6_+_35265586 0.16 ENST00000542066.1
ENST00000316637.5
 DEF6
 differentially expressed in FDCP 6 homolog (mouse)
chr17_-_73150629 0.15 ENST00000356033.4
ENST00000405458.3
ENST00000409753.3
 HN1
 hematological and neurological expressed 1
chr1_-_36615065 0.14 ENST00000373166.3
ENST00000373159.1
ENST00000373162.1
 TRAPPC3
 trafficking protein particle complex 3
chr19_+_13135790 0.13 ENST00000358552.3
 NFIX
 nuclear factor I/X (CCAAT-binding transcription factor)
chr12_+_122326662 0.13 ENST00000261817.2
ENST00000538613.1
ENST00000542602.1
 PSMD9
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr5_-_134734901 0.13 ENST00000312469.4
ENST00000423969.2
 H2AFY
 H2A histone family, member Y
chr15_-_80215984 0.12 ENST00000485386.1
ENST00000479961.1
 ST20
ST20-MTHFS
 suppressor of tumorigenicity 20
ST20-MTHFS readthrough
chr17_+_27071002 0.12 ENST00000262395.5
ENST00000422344.1
ENST00000444415.3
ENST00000262396.6
 TRAF4
 TNF receptor-associated factor 4
chr19_-_19051993 0.12 ENST00000594794.1
ENST00000355887.6
ENST00000392351.3
ENST00000596482.1
 HOMER3
 homer homolog 3 (Drosophila)
chr7_+_87563557 0.11 ENST00000439864.1
ENST00000412441.1
ENST00000398201.4
ENST00000265727.7
ENST00000315984.7
ENST00000398209.3
 ADAM22
 ADAM metallopeptidase domain 22
chr16_+_2076869 0.11 ENST00000424542.2
ENST00000432365.2
 SLC9A3R2
 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr6_+_151815143 0.11 ENST00000239374.7
ENST00000367290.5
 CCDC170
 coiled-coil domain containing 170
chr10_+_102222798 0.11 ENST00000343737.5
 WNT8B
 wingless-type MMTV integration site family, member 8B
chr11_-_73720276 0.10 ENST00000348534.4
 UCP3
 uncoupling protein 3 (mitochondrial, proton carrier)
chr12_+_122326630 0.10 ENST00000541212.1
ENST00000340175.5
 PSMD9
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr4_-_176733897 0.10 ENST00000393658.2
 GPM6A
 glycoprotein M6A
chr3_+_53528659 0.10 ENST00000350061.5
 CACNA1D
 calcium channel, voltage-dependent, L type, alpha 1D subunit
chr2_+_113931513 0.10 ENST00000245796.6
ENST00000441564.3
 PSD4
 pleckstrin and Sec7 domain containing 4
chr16_+_3550924 0.09 ENST00000576634.1
ENST00000574369.1
ENST00000341633.5
ENST00000417763.2
ENST00000571025.1
 CLUAP1
 clusterin associated protein 1
chr19_+_18794470 0.09 ENST00000321949.8
ENST00000338797.6
 CRTC1
 CREB regulated transcription coactivator 1
chr17_+_75372165 0.08 ENST00000427674.2
 SEPT9
 septin 9
chrX_-_15402498 0.08 ENST00000297904.3
 FIGF
 c-fos induced growth factor (vascular endothelial growth factor D)
chr10_-_88281494 0.08 ENST00000298767.5
 WAPAL
 wings apart-like homolog (Drosophila)
chr11_-_73720122 0.08 ENST00000426995.2
 UCP3
 uncoupling protein 3 (mitochondrial, proton carrier)
chr19_+_13135731 0.07 ENST00000587260.1
 NFIX
 nuclear factor I/X (CCAAT-binding transcription factor)
chr1_-_155224751 0.07 ENST00000350210.2
ENST00000368368.3
 FAM189B
 family with sequence similarity 189, member B
chr1_+_32083301 0.06 ENST00000403528.2
 HCRTR1
 hypocretin (orexin) receptor 1
chr2_+_101179152 0.06 ENST00000264254.6
 PDCL3
 phosducin-like 3
chr7_+_87563458 0.06 ENST00000398204.4
 ADAM22
 ADAM metallopeptidase domain 22
chr10_-_112678976 0.06 ENST00000448814.1
 BBIP1
 BBSome interacting protein 1
chr15_+_75494214 0.06 ENST00000394987.4
 C15orf39
 chromosome 15 open reading frame 39
chr15_-_49103184 0.05 ENST00000399334.3
ENST00000325747.5
 CEP152
 centrosomal protein 152kDa
chr19_-_15918936 0.05 ENST00000334920.2
 OR10H1
 olfactory receptor, family 10, subfamily H, member 1
chr2_+_1488435 0.04 ENST00000446278.1
ENST00000469607.1
 TPO
 thyroid peroxidase
chr17_+_18163848 0.04 ENST00000323019.4
ENST00000578174.1
ENST00000395704.4
ENST00000395703.4
ENST00000578621.1
ENST00000579341.1
 MIEF2
 mitochondrial elongation factor 2
chr1_-_177134024 0.04 ENST00000367654.3
 ASTN1
 astrotactin 1
chr10_-_126432619 0.04 ENST00000337318.3
 FAM53B
 family with sequence similarity 53, member B
chr2_+_27070964 0.04 ENST00000288699.6
 DPYSL5
 dihydropyrimidinase-like 5
chr18_+_52495426 0.03 ENST00000262094.5
 RAB27B
 RAB27B, member RAS oncogene family
chr19_+_3178736 0.03 ENST00000246115.3
 S1PR4
 sphingosine-1-phosphate receptor 4
chr19_+_51630287 0.03 ENST00000599948.1
 SIGLEC9
 sialic acid binding Ig-like lectin 9
chr6_+_32944119 0.03 ENST00000606059.1
 BRD2
 bromodomain containing 2
chr11_+_72975578 0.03 ENST00000393592.2
 P2RY6
 pyrimidinergic receptor P2Y, G-protein coupled, 6
chr10_-_112678904 0.03 ENST00000423273.1
ENST00000436562.1
ENST00000447005.1
ENST00000454061.1
 BBIP1
 BBSome interacting protein 1
chr11_+_72975524 0.03 ENST00000540342.1
ENST00000542092.1
 P2RY6
 pyrimidinergic receptor P2Y, G-protein coupled, 6
chr20_-_3644046 0.02 ENST00000290417.2
ENST00000319242.3
 GFRA4
 GDNF family receptor alpha 4
chr4_+_39460689 0.02 ENST00000381846.1
 LIAS
 lipoic acid synthetase
chr3_+_184081213 0.02 ENST00000429568.1
 POLR2H
 polymerase (RNA) II (DNA directed) polypeptide H
chr11_+_72975559 0.02 ENST00000349767.2
 P2RY6
 pyrimidinergic receptor P2Y, G-protein coupled, 6
chr6_-_30640811 0.01 ENST00000376442.3
 DHX16
 DEAH (Asp-Glu-Ala-His) box polypeptide 16
chr3_+_184081175 0.01 ENST00000452961.1
ENST00000296223.3
 POLR2H
 polymerase (RNA) II (DNA directed) polypeptide H
chr3_-_195310802 0.01 ENST00000421243.1
ENST00000453131.1
 APOD
 apolipoprotein D
chr1_-_51796987 0.01 ENST00000262676.5
 TTC39A
 tetratricopeptide repeat domain 39A
chr1_+_209859510 0.01 ENST00000367028.2
ENST00000261465.1
 HSD11B1
 hydroxysteroid (11-beta) dehydrogenase 1
chr19_+_850985 0.00 ENST00000590230.1
 ELANE
 elastase, neutrophil expressed
chr3_+_63898275 0.00 ENST00000538065.1
 ATXN7
 ataxin 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.2 1.8 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.2 0.6 GO:1901837 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
0.2 2.1 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.2 1.0 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.1 2.4 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 1.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 0.5 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.1 0.2 GO:0051795 positive regulation of catagen(GO:0051795)
0.1 0.7 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 0.3 GO:0072683 T cell extravasation(GO:0072683)
0.1 0.6 GO:2000210 positive regulation of anoikis(GO:2000210)
0.1 0.3 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.1 0.2 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.0 0.6 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.2 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.3 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.4 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.2 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.0 0.1 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.1 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.3 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:1990845 adaptive thermogenesis(GO:1990845)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.5 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 0.4 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.1 0.4 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 0.5 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.1 0.6 GO:0000182 rDNA binding(GO:0000182)
0.0 0.7 GO:0031014 troponin T binding(GO:0031014)
0.0 0.4 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.3 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.1 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.0 0.3 GO:0035877 death effector domain binding(GO:0035877)
0.0 0.2 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0016499 orexin receptor activity(GO:0016499)
0.0 0.1 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.1 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.4 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.6 GO:0001740 Barr body(GO:0001740)
0.1 0.3 GO:0098536 deuterosome(GO:0098536)
0.0 0.3 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 1.8 GO:0002102 podosome(GO:0002102)
0.0 0.9 GO:0031143 pseudopodium(GO:0031143)
0.0 0.7 GO:0005861 troponin complex(GO:0005861)
0.0 0.4 GO:0031045 dense core granule(GO:0031045)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 2.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.3 GO:0097342 ripoptosome(GO:0097342)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 2.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix