ENCODE cell lines, expression (Ernst 2011)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
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Gene Symbol	Gene ID	Gene Info
ZNF35 Links Ensembl NCBI GeneCards UniProt	ENSG00000169981.6	ZNF35

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZNF35	hg19_v2_chr3_+_44690211_44690267	0.04	8.7e-01	Click!

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Promoter	Score	Transcript	Gene	Gene Info
chr3_-_148939835	1.46	ENST00000264613.6	CP	ceruloplasmin (ferroxidase)
chrX_+_9431324	0.89	ENST00000407597.2 ENST00000424279.1 ENST00000536365.1 ENST00000441088.1 ENST00000380961.1 ENST00000415293.1	TBL1X	transducin (beta)-like 1X-linked
chr4_+_68424434	0.82	ENST00000265404.2 ENST00000396225.1	STAP1	signal transducing adaptor family member 1
chr9_+_42671887	0.73	ENST00000456520.1 ENST00000377391.3	CBWD7	COBW domain containing 7
chr12_+_51318513	0.70	ENST00000332160.4	METTL7A	methyltransferase like 7A
chr10_-_52645379	0.68	ENST00000395489.2	A1CF	APOBEC1 complementation factor
chr10_-_52645416	0.65	ENST00000374001.2 ENST00000373997.3 ENST00000373995.3 ENST00000282641.2 ENST00000395495.1 ENST00000414883.1	A1CF	APOBEC1 complementation factor
chr6_-_133084580	0.65	ENST00000525270.1 ENST00000530536.1 ENST00000524919.1	VNN2	vanin 2
chr12_+_25205446	0.63	ENST00000557489.1 ENST00000354454.3 ENST00000536173.1	LRMP	lymphoid-restricted membrane protein
chr1_+_214161272	0.55	ENST00000498508.2 ENST00000366958.4	PROX1	prospero homeobox 1
chr12_+_54891495	0.55	ENST00000293373.6	NCKAP1L	NCK-associated protein 1-like
chr12_+_25205666	0.53	ENST00000547044.1	LRMP	lymphoid-restricted membrane protein
chr7_-_87342564	0.49	ENST00000265724.3 ENST00000416177.1	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr6_+_32812568	0.42	ENST00000414474.1	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9
chr8_-_95274536	0.40	ENST00000297596.2 ENST00000396194.2	GEM	GTP binding protein overexpressed in skeletal muscle
chr12_-_102872317	0.36	ENST00000424202.2	IGF1	insulin-like growth factor 1 (somatomedin C)
chr12_+_4382917	0.35	ENST00000261254.3	CCND2	cyclin D2
chr7_+_123488124	0.33	ENST00000476325.1	HYAL4	hyaluronoglucosaminidase 4
chrM_+_4431	0.32	ENST00000361453.3	MT-ND2	mitochondrially encoded NADH dehydrogenase 2
chr15_+_35270552	0.28	ENST00000391457.2	AC114546.1	HCG37415; PRO1914; Uncharacterized protein
chrX_-_138724677	0.25	ENST00000370573.4 ENST00000338585.6 ENST00000370576.4	MCF2	MCF.2 cell line derived transforming sequence
chr3_-_49066811	0.25	ENST00000442157.1 ENST00000326739.4	IMPDH2	IMP (inosine 5'-monophosphate) dehydrogenase 2
chr3_-_58523010	0.25	ENST00000459701.2 ENST00000302819.5	ACOX2	acyl-CoA oxidase 2, branched chain
chr1_-_169599353	0.24	ENST00000367793.2 ENST00000367794.2 ENST00000367792.2 ENST00000367791.2 ENST00000367788.2	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)
chr3_+_69985792	0.22	ENST00000531774.1	MITF	microphthalmia-associated transcription factor
chr4_+_129730947	0.22	ENST00000452328.2 ENST00000504089.1	PHF17	jade family PHD finger 1
chr2_-_191878162	0.22	ENST00000540176.1	STAT1	signal transducer and activator of transcription 1, 91kDa
chr17_+_41561317	0.21	ENST00000540306.1 ENST00000262415.3 ENST00000605777.1	DHX8	DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr6_-_135271219	0.21	ENST00000367847.2 ENST00000367845.2	ALDH8A1	aldehyde dehydrogenase 8 family, member A1
chr5_-_58571935	0.15	ENST00000503258.1	PDE4D	phosphodiesterase 4D, cAMP-specific
chr12_-_22487618	0.15	ENST00000404299.3 ENST00000396037.4	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr5_-_39203093	0.15	ENST00000515010.1	FYB	FYN binding protein
chr14_-_31889782	0.14	ENST00000543095.2	HEATR5A	HEAT repeat containing 5A
chr1_-_12677714	0.13	ENST00000376223.2	DHRS3	dehydrogenase/reductase (SDR family) member 3
chr7_+_80231466	0.12	ENST00000309881.7 ENST00000534394.1	CD36	CD36 molecule (thrombospondin receptor)
chr21_-_42219065	0.10	ENST00000400454.1	DSCAM	Down syndrome cell adhesion molecule
chr4_-_89744365	0.10	ENST00000513837.1 ENST00000503556.1	FAM13A	family with sequence similarity 13, member A
chr18_+_74240610	0.09	ENST00000578092.1 ENST00000578613.1 ENST00000583578.1	LINC00908	long intergenic non-protein coding RNA 908
chr13_+_109248500	0.08	ENST00000356711.2	MYO16	myosin XVI
chr17_-_42295870	0.07	ENST00000526094.1 ENST00000529383.1 ENST00000530828.1	UBTF	upstream binding transcription factor, RNA polymerase I
chr7_+_74072288	0.07	ENST00000443166.1	GTF2I	general transcription factor IIi
chr3_+_29323043	0.07	ENST00000452462.1 ENST00000456853.1	RBMS3	RNA binding motif, single stranded interacting protein 3
chr7_+_27282319	0.05	ENST00000222761.3	EVX1	even-skipped homeobox 1
chr19_-_12833164	0.04	ENST00000356861.5	TNPO2	transportin 2
chr13_-_41240717	0.03	ENST00000379561.5	FOXO1	forkhead box O1
chr7_-_83824169	0.03	ENST00000265362.4	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr3_+_69985734	0.02	ENST00000314557.6 ENST00000394351.3	MITF	microphthalmia-associated transcription factor
chr19_-_13617247	0.01	ENST00000573710.2	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	0.5	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.9	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.2	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.1	GO:0042231	interleukin-13 biosynthetic process(GO:0042231)
0.3	1.0	GO:1902938	regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.1	0.5	GO:1902044	regulation of Fas signaling pathway(GO:1902044)
0.1	0.3	GO:0006788	heme oxidation(GO:0006788)
0.1	0.2	GO:0046586	regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.0	0.3	GO:0060700	regulation of ribonuclease activity(GO:0060700)
0.0	0.2	GO:0010269	response to selenium ion(GO:0010269)
0.0	0.2	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0	0.2	GO:0017062	respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0	0.7	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.0	0.6	GO:0043090	amino acid import(GO:0043090)
0.0	0.1	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	1.5	GO:0070268	cornification(GO:0070268)
0.0	0.1	GO:0070315	G1 to G0 transition involved in cell differentiation(GO:0070315)
0.0	0.3	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.0	0.0	GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.3	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.1	0.3	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.1	0.4	GO:1990111	spermatoproteasome complex(GO:1990111)
0.1	0.4	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.5	GO:0031209	SCAR complex(GO:0031209)
0.0	0.4	GO:0051233	spindle midzone(GO:0051233)
0.0	1.2	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	0.9	GO:0005876	spindle microtubule(GO:0005876)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.0	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.2	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.2	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.1	GO:0070847	core mediator complex(GO:0070847)
0.0	0.0	GO:0097454	Schwann cell microvillus(GO:0097454)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.0	GO:1903135	cupric ion binding(GO:1903135)
0.1	0.3	GO:0004392	heme oxygenase (decyclizing) activity(GO:0004392)
0.1	0.2	GO:0004947	bradykinin receptor activity(GO:0004947)
0.1	0.2	GO:0035473	lipase binding(GO:0035473)
0.0	0.3	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0	0.1	GO:0050509	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.0	0.2	GO:0047144	2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0	0.6	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0004102	choline O-acetyltransferase activity(GO:0004102)
0.0	1.5	GO:0097110	scaffold protein binding(GO:0097110)
0.0	0.5	GO:0005123	death receptor binding(GO:0005123)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	1.0	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	2.1	REACTOME SIGNALING BY ILS	Genes involved in Signaling by Interleukins

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	0.2	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	1.1	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.2	1.3	GO:0016554	cytidine to uridine editing(GO:0016554)
0.2	0.6	GO:0046619	optic placode formation involved in camera-type eye formation(GO:0046619)
0.1	0.5	GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
0.1	0.4	GO:1901842	negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1	0.4	GO:1904073	trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1	0.5	GO:1901529	positive regulation of anion channel activity(GO:1901529)
0.1	0.6	GO:0015939	pantothenate metabolic process(GO:0015939)
0.1	1.5	GO:0006825	copper ion transport(GO:0006825)
0.1	0.2	GO:0072308	negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
0.0	0.2	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.0	GO:0021824	cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.0	0.2	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0	0.2	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0	0.1	GO:2000332	lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0	0.2	GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0	0.2	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.3	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.1	GO:0014886	transition between slow and fast fiber(GO:0014886)
0.0	0.3	GO:0030207	chondroitin sulfate catabolic process(GO:0030207)
0.0	0.1	GO:0048842	positive regulation of axon extension involved in axon guidance(GO:0048842)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.1	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	1.0	PID GLYPICAN 1PATHWAY	Glypican 1 network

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.5	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1	0.8	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1	0.6	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	0.5	GO:0090554	phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1	0.2	GO:0042806	fucose binding(GO:0042806)
0.1	0.6	GO:0050692	DBD domain binding(GO:0050692)
0.1	0.2	GO:0003938	IMP dehydrogenase activity(GO:0003938)
0.0	0.2	GO:0016402	pristanoyl-CoA oxidase activity(GO:0016402)
0.0	0.3	GO:0004415	hyalurononglucosaminidase activity(GO:0004415)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
0.0	0.2	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.4	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.2	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	1.3	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0001165	RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)