Motif ID: HIF1A.p2

Z-value: 2.466


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)



Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_38720881 3.360 NM_138435
FAM83F
family with sequence similarity 83, member F
chrX_-_13866366 2.528


chrX_-_13866565 2.421 NM_001001994
GPM6B
glycoprotein M6B
chrX_-_13866451 2.357 GPM6B
glycoprotein M6B
chr3_-_185025989 2.251 NM_024871
MAP6D1
MAP6 domain containing 1
chr13_-_43259032 1.982 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr19_-_51608665 1.838 NM_032040
CCDC8
coiled-coil domain containing 8
chr2_-_96174502 1.759 DUSP2
dual specificity phosphatase 2
chr11_+_69602055 1.654 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr1_+_231816372 1.512 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr4_-_41848874 1.481 BEND4
BEN domain containing 4
chr10_-_88720908 1.478 LOC100133190
hypothetical LOC100133190
chr4_+_321607 1.419 ZNF141
zinc finger protein 141
chr6_+_73388713 1.418 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr19_-_63550712 1.403 A1BG
alpha-1-B glycoprotein
chr4_+_321587 1.379 NM_003441
ZNF141
zinc finger protein 141
chr2_-_96174865 1.373 NM_004418
DUSP2
dual specificity phosphatase 2
chr1_+_13899272 1.372 NM_001135610
PRDM2
PR domain containing 2, with ZNF domain
chr5_+_17270781 1.368 BASP1
brain abundant, membrane attached signal protein 1
chr5_+_3649167 1.351 NM_024337
IRX1
iroquois homeobox 1
chr19_-_19599973 1.348 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr2_-_225615556 1.344 NM_014689
DOCK10
dedicator of cytokinesis 10
chr12_+_52618815 1.321 NM_017410
HOXC13
homeobox C13
chr21_+_25856311 1.288 MIR155HG
MIR155 host gene (non-protein coding)
chr4_-_10068055 1.141 NM_053042
ZNF518B
zinc finger protein 518B
chr1_-_180840016 1.129 NM_002928
RGS16
regulator of G-protein signaling 16
chr5_+_17270474 1.103 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr11_+_65357972 1.086 NM_152760
SNX32
sorting nexin 32
chr1_+_231816540 1.085 KCNK1
potassium channel, subfamily K, member 1
chr3_-_180651874 1.068 GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr3_-_129024665 1.067 NM_001003794
MGLL
monoglyceride lipase
chr2_+_222997456 1.054 SGPP2
sphingosine-1-phosphate phosphatase 2
chr10_+_112247614 1.035 NM_004419
DUSP5
dual specificity phosphatase 5
chr2_+_222997529 1.034 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr5_-_49772940 0.997 EMB
embigin
chr8_+_95722448 0.982 ESRP1
epithelial splicing regulatory protein 1
chr5_-_49772973 0.978 NM_198449
EMB
embigin
chr13_+_24152548 0.968 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr3_-_129023850 0.964 NM_007283
MGLL
monoglyceride lipase
chr12_+_52806103 0.960 LOC400043
hypothetical LOC400043
chr4_+_183302105 0.929 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr12_-_21701985 0.925 NM_001174097
LDHB
lactate dehydrogenase B
chr11_+_13646806 0.923 FAR1
fatty acyl CoA reductase 1
chr3_-_180652024 0.919 NM_021629
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr12_-_21702021 0.918 LDHB
lactate dehydrogenase B
chr12_-_21702036 0.909 LDHB
lactate dehydrogenase B
chr12_-_21702000 0.901 LDHB
lactate dehydrogenase B
chr11_+_13646727 0.900 NM_032228
FAR1
fatty acyl CoA reductase 1
chr3_+_113534710 0.890 CD200
CD200 molecule
chr10_+_17312654 0.868 VIM
vimentin
chr11_-_66092534 0.868 NM_003793
CTSF
cathepsin F
chr1_+_222870573 0.867 CNIH3
cornichon homolog 3 (Drosophila)
chr11_+_20341835 0.852 NM_001098520
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr22_+_16020241 0.851 CECR4
cat eye syndrome chromosome region, candidate 4 (non-protein coding)
chr11_+_20341806 0.850 NM_006410
NM_001098521
HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

chr17_-_7996409 0.849 NM_002616
PER1
period homolog 1 (Drosophila)
chr1_+_222870798 0.848 NM_152495
CNIH3
cornichon homolog 3 (Drosophila)
chr11_-_124871258 0.847 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr1_-_35957030 0.844 C1orf216
chromosome 1 open reading frame 216
chr4_-_143987053 0.819 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr1_-_208046011 0.818 NM_006147
IRF6
interferon regulatory factor 6
chr12_-_21702046 0.811 NM_002300
LDHB
lactate dehydrogenase B
chrX_-_135161185 0.808 NM_001173517
NM_024597
MAP7D3

MAP7 domain containing 3

chr10_+_3099708 0.807 NM_002627
PFKP
phosphofructokinase, platelet
chr16_-_674357 0.801 NM_001005920
JMJD8
jumonji domain containing 8
chr18_+_42167904 0.801 RNF165
ring finger protein 165
chr1_+_148521852 0.800 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr8_+_1937711 0.795 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr1_-_35956979 0.789 C1orf216
chromosome 1 open reading frame 216
chr13_+_35903966 0.789 NM_001111046
NM_001111047
CCNA1

cyclin A1

chr5_+_110587546 0.777 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr16_-_674318 0.775 JMJD8
jumonji domain containing 8
chr8_+_22479115 0.774 NM_001018003
SORBS3
sorbin and SH3 domain containing 3
chr11_+_20341900 0.767 NM_001098522
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr19_-_14951349 0.761 SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr8_-_72918697 0.759 MSC
musculin
chrX_+_64804235 0.759 NM_002444
MSN
moesin
chr1_+_158017380 0.753 NM_017823
DUSP23
dual specificity phosphatase 23
chr3_-_36961539 0.749 NM_014831
TRANK1
tetratricopeptide repeat and ankyrin repeat containing 1
chr17_-_69151821 0.739 NM_001144952
SDK2
sidekick homolog 2 (chicken)
chr15_-_90999606 0.727 NM_207446
FAM174B
family with sequence similarity 174, member B
chr21_-_41140457 0.725 DSCAM
Down syndrome cell adhesion molecule
chr11_+_107304344 0.720 NM_017516
RAB39
RAB39, member RAS oncogene family
chr1_+_191357906 0.711 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr16_+_22733307 0.700 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chrX_-_47394808 0.699 ELK1
ELK1, member of ETS oncogene family
chrX_+_16714452 0.698 NM_001168683
NM_018360
TXLNG

taxilin gamma

chrX_-_47394937 0.697 NM_001114123
NM_005229
ELK1

ELK1, member of ETS oncogene family

chrX_-_152804731 0.697 L1CAM
L1 cell adhesion molecule
chr15_-_81744469 0.694 NM_001717
BNC1
basonuclin 1
chr19_-_53516962 0.686 CCDC114
coiled-coil domain containing 114
chr1_+_12046020 0.683 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr1_-_158182006 0.679 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr22_+_43476710 0.675 NM_181333
PRR5
proline rich 5 (renal)
chr7_+_2525922 0.674 NM_001040167
NM_001040168
LFNG

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr16_-_30504309 0.672 NM_152458
ZNF785
zinc finger protein 785
chr1_+_67546143 0.662 IL12RB2
interleukin 12 receptor, beta 2
chr1_-_158161877 0.653 TAGLN2
transgelin 2
chr1_-_158161902 0.652 NM_003564
TAGLN2
transgelin 2
chr3_-_16530132 0.648 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr1_+_199975563 0.643 NM_001167738
NAV1
neuron navigator 1
chr10_-_43390014 0.640 NM_001099282
NM_001099283
NM_001099284
ZNF239


zinc finger protein 239


chr12_+_129922589 0.640 RAN
RAN, member RAS oncogene family
chr16_-_53520208 0.638 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr5_-_43432969 0.637 CCL28
chemokine (C-C motif) ligand 28
chr8_+_49083522 0.628 NM_003350
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr4_-_2905649 0.625 NM_001120
MFSD10
major facilitator superfamily domain containing 10
chr5_+_49998677 0.623 PARP8
poly (ADP-ribose) polymerase family, member 8
chr16_-_80602546 0.623 NM_145168
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
chrX_+_64804259 0.618 MSN
moesin
chr11_+_32808045 0.617 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr19_+_1022208 0.614 HMHA1
histocompatibility (minor) HA-1
chr2_-_227371698 0.611 NM_005544
IRS1
insulin receptor substrate 1
chr20_-_57015698 0.606 NM_001336
CTSZ
cathepsin Z
chrX_+_102356659 0.606 NM_001080425
NM_001127688
BEX4

brain expressed, X-linked 4

chr12_+_129922570 0.599 RAN
RAN, member RAS oncogene family
chr22_+_43527101 0.597 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr2_-_235070431 0.593 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr8_-_97342971 0.592 NM_015942
MTERFD1
MTERF domain containing 1
chr10_+_80672842 0.589 ZMIZ1
zinc finger, MIZ-type containing 1
chr7_+_27102197 0.585


chr13_-_19633182 0.578 NM_021954
GJA3
gap junction protein, alpha 3, 46kDa
chr9_+_123501186 0.578 DAB2IP
DAB2 interacting protein
chr14_-_87529212 0.563 GALC
galactosylceramidase
chr8_-_75396016 0.561 NM_020647
JPH1
junctophilin 1
chrX_-_51256166 0.560 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr7_-_27102049 0.556 NM_005522
NM_153620
HOXA1

homeobox A1

chr16_+_55180767 0.555 NM_005954
MT3
metallothionein 3
chr1_-_164402575 0.553 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr3_-_69517913 0.552 FRMD4B
FERM domain containing 4B
chr14_-_87529222 0.548 GALC
galactosylceramidase
chr17_-_2561676 0.546 NM_015229
KIAA0664
KIAA0664
chr15_+_46957556 0.544 NM_014335
EID1
EP300 interacting inhibitor of differentiation 1
chr3_+_23219707 0.542 NM_152653
UBE2E2
ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
chr18_+_32131628 0.536 NM_025135
FHOD3
formin homology 2 domain containing 3
chr5_-_127447197 0.535 FLJ33630
hypothetical LOC644873
chr3_-_16529996 0.535 RFTN1
raftlin, lipid raft linker 1
chr13_-_35818491 0.534 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr17_-_10042579 0.534 NM_201433
GAS7
growth arrest-specific 7
chr9_+_111442888 0.531 NM_001037293
PALM2
paralemmin 2
chr11_+_65311104 0.531 NM_004561
OVOL1
ovo-like 1(Drosophila)
chr17_+_44927591 0.528 NM_002507
NGFR
nerve growth factor receptor
chr21_-_41140908 0.524 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr22_+_43476755 0.523 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr9_+_92603884 0.520 SYK
spleen tyrosine kinase
chr13_-_35818396 0.518 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr4_+_78298326 0.516 CCNG2
cyclin G2
chrX_+_24077649 0.512 NM_001178086
NM_001178095
NM_001178084
NM_001178085
NM_003410
ZFX




zinc finger protein, X-linked




chr20_+_55718718 0.511


chr4_+_5104140 0.510 STK32B
serine/threonine kinase 32B
chr8_+_145718702 0.509


chrX_-_102452461 0.508 NM_001168399
NM_001168400
NM_001168401
NM_032621
BEX2



brain expressed X-linked 2



chr16_+_88305743 0.508 LOC100128881
hypothetical LOC100128881
chr4_-_2905448 0.507 MFSD10
major facilitator superfamily domain containing 10
chr1_+_199519202 0.501 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr14_-_87529600 0.498 NM_000153
NM_001037525
GALC

galactosylceramidase

chr22_-_16020153 0.497 CECR5
cat eye syndrome chromosome region, candidate 5
chr9_-_109291575 0.492 KLF4
Kruppel-like factor 4 (gut)
chr11_+_125279481 0.490 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr7_-_87687302 0.487 NM_003130
SRI
sorcin
chr19_-_36531958 0.483 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr3_-_69518119 0.481 NM_015123
FRMD4B
FERM domain containing 4B
chr1_+_182622987 0.481 C1orf21
chromosome 1 open reading frame 21
chr11_-_63770716 0.479 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr9_+_111582317 0.479 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr22_-_16020076 0.479 CECR5
cat eye syndrome chromosome region, candidate 5
chr5_+_176493488 0.478 NSD1
nuclear receptor binding SET domain protein 1
chr1_+_45565126 0.477 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr17_-_8000362 0.476 PER1
period homolog 1 (Drosophila)
chr3_+_52694975 0.474 NM_014366
NM_206825
NM_206826
GNL3


guanine nucleotide binding protein-like 3 (nucleolar)


chr20_-_49073023 0.474 NM_002237
KCNG1
potassium voltage-gated channel, subfamily G, member 1
chr2_-_253982 0.472 SH3YL1
SH3 domain containing, Ysc84-like 1 (S. cerevisiae)
chr19_+_43502380 0.471 KCNK6
potassium channel, subfamily K, member 6
chr3_+_23219490 0.471 UBE2E2
ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
chr7_+_117611321 0.468 NM_016200
NAA38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr2_-_254037 0.465 NM_001159597
NM_015677
SH3YL1

SH3 domain containing, Ysc84-like 1 (S. cerevisiae)

chr3_+_120904555 0.465 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr19_-_60587414 0.461 NM_001190764
LOC388564
hypothetical protein LOC388564
chr6_+_72949092 0.460 RIMS1
regulating synaptic membrane exocytosis 1
chr2_-_119322228 0.459 NM_001426
EN1
engrailed homeobox 1
chr19_+_40337846 0.459 FXYD5
FXYD domain containing ion transport regulator 5
chr3_+_114414064 0.458 NM_033254
BOC
Boc homolog (mouse)
chr1_+_181025494 0.457 NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr8_-_72918938 0.453 MSC
musculin
chr22_-_41913002 0.450 TTLL12
tubulin tyrosine ligase-like family, member 12
chr11_+_65311142 0.450 OVOL1
ovo-like 1(Drosophila)
chr7_+_154720547 0.448 INSIG1
insulin induced gene 1
chr7_-_87687276 0.448 SRI
sorcin
chr1_-_173428455 0.448 NM_001162895
NM_014656
NM_001162893
NM_001162894
KIAA0040



KIAA0040



chr4_-_122063118 0.447 NM_018699
PRDM5
PR domain containing 5
chr22_+_48971067 0.445 TRABD
TraB domain containing
chr21_-_31853160 0.444 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chr1_-_35957314 0.443 NM_152374
C1orf216
chromosome 1 open reading frame 216
chr8_-_9046460 0.442 PPP1R3B
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr1_+_117253882 0.439 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr9_+_92603894 0.439 SYK
spleen tyrosine kinase
chr10_+_105334704 0.437 NEURL
neuralized homolog (Drosophila)
chr7_+_148613304 0.435 LOC155060
AI894139 pseudogene
chr1_+_67545634 0.435 NM_001559
IL12RB2
interleukin 12 receptor, beta 2
chrX_+_64804318 0.434 MSN
moesin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.28 4.96e-08 GO:0044260 cellular macromolecule metabolic process
1.22 5.74e-08 GO:0044237 cellular metabolic process
1.17 1.44e-05 GO:0008152 metabolic process
1.22 3.93e-05 GO:0043170 macromolecule metabolic process
1.17 1.21e-04 GO:0044238 primary metabolic process
1.30 9.47e-04 GO:0044267 cellular protein metabolic process
2.25 2.04e-03 GO:0006913 nucleocytoplasmic transport
2.23 2.82e-03 GO:0051169 nuclear transport
1.50 2.22e-02 GO:0046907 intracellular transport
1.08 3.42e-02 GO:0009987 cellular process
1.30 4.05e-02 GO:0006464 protein modification process
1.29 4.75e-02 GO:0043412 macromolecule modification

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.18 3.36e-24 GO:0044424 intracellular part
1.17 1.69e-22 GO:0005622 intracellular
1.22 3.29e-19 GO:0043227 membrane-bounded organelle
1.22 3.40e-19 GO:0043231 intracellular membrane-bounded organelle
1.19 1.57e-17 GO:0043226 organelle
1.19 4.84e-17 GO:0043229 intracellular organelle
1.28 7.12e-13 GO:0005634 nucleus
1.19 1.53e-12 GO:0005737 cytoplasm
1.22 3.27e-09 GO:0044444 cytoplasmic part
1.21 4.69e-07 GO:0044446 intracellular organelle part
1.20 1.33e-06 GO:0044422 organelle part
1.05 5.19e-06 GO:0044464 cell part
1.05 5.41e-06 GO:0005623 cell
1.34 3.87e-05 GO:0044428 nuclear part
1.34 9.27e-05 GO:0005829 cytosol
1.31 1.75e-04 GO:0070013 intracellular organelle lumen
1.30 2.55e-04 GO:0031974 membrane-enclosed lumen
2.03 3.22e-04 GO:0005635 nuclear envelope
1.30 5.00e-04 GO:0043233 organelle lumen
1.30 1.03e-03 GO:0031090 organelle membrane
1.53 2.10e-03 GO:0031967 organelle envelope
1.51 2.79e-03 GO:0031975 envelope
1.33 5.12e-03 GO:0012505 endomembrane system
1.47 8.87e-03 GO:0044432 endoplasmic reticulum part
1.29 1.09e-02 GO:0031981 nuclear lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 4.14e-04 GO:0005515 protein binding
1.21 7.98e-03 GO:0003676 nucleic acid binding
1.30 1.51e-02 GO:0016740 transferase activity
1.25 2.73e-02 GO:0000166 nucleotide binding
1.14 2.76e-02 GO:0003824 catalytic activity