Motif ID: SREBF1,2.p2

Z-value: 1.128


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2



Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_34107087 3.966 HMOX1
heme oxygenase (decycling) 1
chr10_-_14090459 3.086 FRMD4A
FERM domain containing 4A
chr22_+_34107051 3.040 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr17_+_75851984 2.726


chr17_+_73638430 2.681 NM_152468
TMC8
transmembrane channel-like 8
chr14_-_93512818 2.577 ASB2
ankyrin repeat and SOCS box containing 2
chr19_+_55614006 2.491 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr12_-_47604930 2.424 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr13_+_48582389 2.278 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr2_+_143603439 2.216 ARHGAP15
Rho GTPase activating protein 15
chr9_-_37566248 2.213 NM_012166
FBXO10
F-box protein 10
chr13_-_31900218 2.166 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr12_+_56284867 2.138 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chr19_-_15436333 2.083 NM_022904
RASAL3
RAS protein activator like 3
chr10_-_98021144 1.895 NM_001114094
NM_013314
BLNK

B-cell linker

chr22_+_40724674 1.822 NM_152613
WBP2NL
WBP2 N-terminal like
chr11_-_60475558 1.818 NM_016582
SLC15A3
solute carrier family 15, member 3
chr1_-_152797707 1.727 NM_017582
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr8_+_75066117 1.704 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr17_-_7078446 1.697 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chrX_+_128741578 1.651 SASH3
SAM and SH3 domain containing 3
chrX_+_128741562 1.631 NM_018990
SASH3
SAM and SH3 domain containing 3
chr11_+_59979857 1.568 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr17_-_7078304 1.543 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr1_-_152797820 1.521 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr12_+_52733927 1.482 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr4_+_177223978 1.474 NM_170710
NM_181265
WDR17

WD repeat domain 17

chr7_+_101861007 1.469 ORAI2
ORAI calcium release-activated calcium modulator 2
chr1_-_152797767 1.463 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr1_+_181871830 1.427 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr3_-_126414252 1.409 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr3_+_44878380 1.402 NM_144638
TMEM42
transmembrane protein 42
chr2_+_219751230 1.375 FAM134A
family with sequence similarity 134, member A
chr9_-_133574928 1.364 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr1_-_152797760 1.351 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr20_-_4743768 1.335 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr17_-_7078399 1.333 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr11_+_120828275 1.323 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr19_+_54149843 1.314 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr11_+_120828058 1.309 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr19_+_54149941 1.297 BAX
BCL2-associated X protein
chr14_-_93512647 1.282 ASB2
ankyrin repeat and SOCS box containing 2
chr1_+_111544469 1.269


chr14_-_19999475 1.269 NM_001100814
NM_144568
TMEM55B

transmembrane protein 55B

chr10_-_105427898 1.256 SH3PXD2A
SH3 and PX domains 2A
chr3_-_113763049 1.251 NM_022488
ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr15_-_70455153 1.241 HEXA
hexosaminidase A (alpha polypeptide)
chr19_+_1018293 1.239 HMHA1
histocompatibility (minor) HA-1
chr4_+_177224142 1.237 WDR17
WD repeat domain 17
chr19_+_54149963 1.236 BAX
BCL2-associated X protein
chr5_-_150517499 1.234 ANXA6
annexin A6
chr22_+_23153529 1.225 NM_000675
ADORA2A
adenosine A2a receptor
chr15_+_86983038 1.197 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr5_+_244625 1.187 NM_001080478
LRRC14B
leucine rich repeat containing 14B
chr22_-_35232979 1.182 FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr5_-_150517454 1.182 ANXA6
annexin A6
chr7_+_101860958 1.175 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr13_-_32757835 1.170 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr19_+_1018536 1.165 HMHA1
histocompatibility (minor) HA-1
chr15_-_70455355 1.145 NM_000520
HEXA
hexosaminidase A (alpha polypeptide)
chr22_-_36907638 1.131 NM_001004426
NM_003560
PLA2G6

phospholipase A2, group VI (cytosolic, calcium-independent)

chr12_+_64869181 1.096 NM_001142523
NM_007199
IRAK3

interleukin-1 receptor-associated kinase 3

chr19_+_14405100 1.080 NM_002741
PKN1
protein kinase N1
chr2_-_55090759 1.079 NM_007008
RTN4
reticulon 4
chr11_-_16992524 1.071 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr1_-_153477673 1.068 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr3_-_49370755 1.058 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr22_-_35233032 1.041 NM_024955
NM_001102371
FOXRED2

FAD-dependent oxidoreductase domain containing 2

chr16_+_639278 1.039 NM_145294
WDR90
WD repeat domain 90
chr7_-_29995809 1.034 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr2_+_227898163 1.032 MFF
mitochondrial fission factor
chr2_-_25328452 1.027 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr2_+_208284610 1.022 CCNYL1
cyclin Y-like 1
chr3_-_49370682 1.021 GPX1
glutathione peroxidase 1
chr12_+_64869271 1.020 IRAK3
interleukin-1 receptor-associated kinase 3
chr12_-_107551783 1.002 NM_003006
SELPLG
selectin P ligand
chr8_+_109525050 0.981 TTC35
tetratricopeptide repeat domain 35
chr11_+_9642226 0.978 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr12_-_107551744 0.970 SELPLG
selectin P ligand
chr2_+_208284691 0.965 CCNYL1
cyclin Y-like 1
chr2_+_208284484 0.963 NM_001142300
NM_152523
CCNYL1

cyclin Y-like 1

chr16_-_66072477 0.959 NM_004691
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chrX_+_55760774 0.953 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr16_-_87570716 0.947 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr1_-_153477511 0.946 GBA
glucosidase, beta, acid
chr12_-_107551694 0.944 SELPLG
selectin P ligand
chr2_+_219751207 0.941 FAM134A
family with sequence similarity 134, member A
chr11_-_71491916 0.937 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr11_+_9642182 0.935 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr11_+_9642229 0.934 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr11_+_9642200 0.929 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr17_-_44043361 0.926 NM_004502
HOXB7
homeobox B7
chr1_-_24386324 0.923 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr17_+_45527507 0.922 NM_002611
PDK2
pyruvate dehydrogenase kinase, isozyme 2
chr7_+_17304707 0.910 NM_001621
AHR
aryl hydrocarbon receptor
chr12_+_120840829 0.907 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr16_+_55580910 0.903 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr14_-_19999324 0.903 TMEM55B
transmembrane protein 55B
chr8_+_109525010 0.901 NM_014673
TTC35
tetratricopeptide repeat domain 35
chr1_-_197173159 0.899 LOC100131234
familial acute myelogenous leukemia related factor
chrX_-_114703273 0.886


chr12_+_64869296 0.886 IRAK3
interleukin-1 receptor-associated kinase 3
chr8_+_67507271 0.881 NM_144650
ADHFE1
alcohol dehydrogenase, iron containing, 1
chr8_+_21937533 0.875 NPM2
nucleophosmin/nucleoplasmin 2
chr12_-_56432292 0.869 CDK4
cyclin-dependent kinase 4
chr17_-_3407780 0.867 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr19_+_14405216 0.862 PKN1
protein kinase N1
chr14_-_23752507 0.860 CHMP4A
chromatin modifying protein 4A
chr11_-_71491942 0.850 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr14_+_23711044 0.847 NM_001048205
NM_005132
REC8

REC8 homolog (yeast)

chr9_-_21984379 0.841 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr3_-_113763449 0.834 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr5_-_150517528 0.831 NM_001155
ANXA6
annexin A6
chr17_+_1574782 0.830 NM_001163809
WDR81
WD repeat domain 81
chr2_+_219751192 0.823 FAM134A
family with sequence similarity 134, member A
chr20_-_2769120 0.821 FAM113A
family with sequence similarity 113, member A
chr11_-_36267510 0.817 COMMD9
COMM domain containing 9
chr12_+_52713098 0.816 NM_018953
HOXC5
homeobox C5
chr10_+_106018915 0.811 GSTO2
glutathione S-transferase omega 2
chr9_-_21984329 0.809 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr14_-_34661156 0.808 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr14_-_23752498 0.808 CHMP4A
chromatin modifying protein 4A
chr8_+_11599119 0.805 NM_002052
GATA4
GATA binding protein 4
chr3_-_113763217 0.804 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr17_-_41018291 0.797


chr12_-_57600564 0.796 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr3_-_113763454 0.796 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr17_-_53764867 0.784


chr10_-_100196624 0.782 HPS1
Hermansky-Pudlak syndrome 1
chr3_+_51403760 0.780 NM_013286
RBM15B
RNA binding motif protein 15B
chr2_+_215885063 0.772 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr3_-_51950919 0.772 NM_004704
RRP9
ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
chr14_-_34661190 0.768 NM_017917
PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr14_-_63830830 0.766 NM_001040275
NM_001437
ESR2

estrogen receptor 2 (ER beta)

chr4_+_54660954 0.766 NM_133267
GSX2
GS homeobox 2
chr12_+_115660468 0.764 NM_001109903
NM_032814
RNFT2

ring finger protein, transmembrane 2

chr8_-_54918389 0.763 NM_015941
NM_213619
ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

chr11_+_7491789 0.756 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr3_-_113763425 0.752 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr15_-_32398220 0.748 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr1_-_210939929 0.737 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr6_-_90178685 0.735 NM_021244
RRAGD
Ras-related GTP binding D
chr6_+_151815114 0.734 NM_024573
C6orf211
chromosome 6 open reading frame 211
chr1_-_210939727 0.734


chr13_-_45654327 0.726 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_224253678 0.721 NM_152608
C1orf55
chromosome 1 open reading frame 55
chr17_-_44022595 0.718 HOXB3
homeobox B3
chr19_-_9908014 0.716 NM_058164
OLFM2
olfactomedin 2
chr11_+_7491576 0.715 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr5_-_150118747 0.714 NM_001135643
NM_016221
DCTN4

dynactin 4 (p62)

chr2_-_182253457 0.714 NM_002500
NEUROD1
neurogenic differentiation 1
chr14_+_23710924 0.712 REC8
REC8 homolog (yeast)
chr14_-_23752476 0.709 CHMP4A
chromatin modifying protein 4A
chr2_-_158008763 0.703 NM_004288
CYTIP
cytohesin 1 interacting protein
chr4_+_91267706 0.702 NM_001145065
FAM190A
family with sequence similarity 190, member A
chr20_+_56861430 0.701 NM_001077490
NM_080425
GNAS

GNAS complex locus

chr3_+_134775946 0.700 NM_001134423
CDV3
CDV3 homolog (mouse)
chr8_+_133856738 0.694 NM_016018
NM_032205
NM_198513
PHF20L1


PHD finger protein 20-like 1


chr2_-_219791638 0.693 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr18_+_54958095 0.689 NM_033280
SEC11C
SEC11 homolog C (S. cerevisiae)
chr9_-_21984414 0.688 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr17_-_60346042 0.684 LRRC37A3
leucine rich repeat containing 37, member A3
chr17_+_1574583 0.684 NM_001163811
WDR81
WD repeat domain 81
chr11_-_71491983 0.684 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr4_-_647424 0.681


chr10_+_69314714 0.679 SIRT1
sirtuin 1
chr20_+_33823318 0.679 NM_016436
PHF20
PHD finger protein 20
chr2_-_219791902 0.677 NM_005689
ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr17_-_44043278 0.671 HOXB7
homeobox B7
chr1_-_165211128 0.668 NM_199351
ILDR2
immunoglobulin-like domain containing receptor 2
chr17_+_52410466 0.662 NM_021626
SCPEP1
serine carboxypeptidase 1
chr13_-_45654296 0.649 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr14_+_75114692 0.649 NM_017791
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr12_-_57600336 0.648 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr1_-_210939820 0.648 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr7_-_50103335 0.636 NM_001159878
NM_007009
ZPBP

zona pellucida binding protein

chr14_+_34661497 0.635 NM_014672
KIAA0391
KIAA0391
chr1_-_224253610 0.635 C1orf55
chromosome 1 open reading frame 55
chr10_-_100196647 0.633 HPS1
Hermansky-Pudlak syndrome 1
chr17_-_33043514 0.631 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr2_+_241903395 0.630 NM_001008491
NM_006155
SEPT2

septin 2

chr20_+_37024383 0.627 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr9_-_19117462 0.626 PLIN2
perilipin 2
chr13_-_49057707 0.626 NM_018191
RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr4_-_23500706 0.624 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr9_+_115151632 0.624 NM_017688
BSPRY
B-box and SPRY domain containing
chr17_-_73636386 0.624 NM_001127198
TMC6
transmembrane channel-like 6
chr8_+_98725505 0.623 NM_178812
MTDH
metadherin
chr14_-_38971370 0.621 NM_203301
FBXO33
F-box protein 33
chr12_-_101835183 0.620 PAH
phenylalanine hydroxylase
chr12_+_6703686 0.616 NM_001164093
COPS7A
COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chrX_+_10084984 0.610 NM_001830
CLCN4
chloride channel 4
chr19_+_18069596 0.607 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr17_+_6856521 0.603 NM_001004333
RNASEK-C17ORF49
RNASEK
RNASEK-C17orf49 read-through transcript
ribonuclease, RNase K
chr3_+_49002774 0.603 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr5_+_41940216 0.600 NM_175921
C5orf51
chromosome 5 open reading frame 51
chr19_+_7493436 0.599 NM_020533
MCOLN1
mucolipin 1
chr17_-_44026042 0.598 NM_002147
HOXB5
homeobox B5
chr8_-_54918325 0.597 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr11_+_107304344 0.596 NM_017516
RAB39
RAB39, member RAS oncogene family

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 8.94e-06 GO:0044237 cellular metabolic process
1.20 3.26e-04 GO:0044238 primary metabolic process
1.32 3.55e-04 GO:0006807 nitrogen compound metabolic process
1.33 4.81e-04 GO:0034641 cellular nitrogen compound metabolic process
1.18 5.78e-04 GO:0008152 metabolic process
1.35 7.29e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.10 6.58e-03 GO:0009987 cellular process
2.94 1.05e-02 GO:0000041 transition metal ion transport
4.95 1.44e-02 GO:0015682 ferric iron transport
4.95 1.44e-02 GO:0033572 transferrin transport
1.23 1.66e-02 GO:0044260 cellular macromolecule metabolic process
1.31 4.89e-02 GO:0044249 cellular biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 3.04e-13 GO:0044424 intracellular part
1.15 1.53e-12 GO:0005622 intracellular
1.21 2.08e-11 GO:0043227 membrane-bounded organelle
1.21 3.78e-11 GO:0043231 intracellular membrane-bounded organelle
1.22 1.62e-10 GO:0005737 cytoplasm
1.18 2.98e-10 GO:0043226 organelle
1.30 4.29e-10 GO:0044446 intracellular organelle part
1.29 6.51e-10 GO:0044422 organelle part
1.18 6.58e-10 GO:0043229 intracellular organelle
1.28 1.30e-09 GO:0044444 cytoplasmic part
1.50 1.25e-08 GO:0043233 organelle lumen
1.50 1.32e-08 GO:0031974 membrane-enclosed lumen
2.49 5.21e-08 GO:0005773 vacuole
1.49 7.03e-08 GO:0070013 intracellular organelle lumen
1.50 8.11e-08 GO:0044428 nuclear part
1.64 2.71e-07 GO:0005654 nucleoplasm
1.51 1.42e-06 GO:0031981 nuclear lumen
2.42 5.48e-06 GO:0000323 lytic vacuole
2.42 5.48e-06 GO:0005764 lysosome
1.23 1.05e-05 GO:0005634 nucleus
1.43 2.67e-05 GO:0005829 cytosol
2.75 5.66e-05 GO:0044437 vacuolar part
2.79 6.37e-05 GO:0005774 vacuolar membrane
1.72 1.92e-04 GO:0044451 nucleoplasm part
1.28 3.30e-04 GO:0032991 macromolecular complex
3.86 7.80e-04 GO:0016605 PML body
2.27 9.44e-04 GO:0016604 nuclear body
2.82 1.30e-03 GO:0005765 lysosomal membrane
2.54 1.83e-02 GO:0005770 late endosome
5.40 2.07e-02 GO:0033176 proton-transporting V-type ATPase complex
1.73 2.21e-02 GO:0005768 endosome
1.25 2.65e-02 GO:0043234 protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 1.08e-07 GO:0005488 binding
1.20 2.19e-06 GO:0005515 protein binding
1.81 2.68e-02 GO:0003712 transcription cofactor activity
1.80 2.88e-02 GO:0000988 protein binding transcription factor activity
1.80 2.88e-02 GO:0000989 transcription factor binding transcription factor activity
2.04 4.49e-02 GO:0003713 transcription coactivator activity