Motif ID: LHX3,4.p2

Z-value: 1.023


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
LHX3chr9_-_138236775-0.322.3e-01Click!
LHX4chr1_+_178466064-0.087.7e-01Click!


Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_60962318 1.625 NM_001145014
RFPL4A
ret finger protein-like 4A
chr3_-_69254226 1.251 NM_198271
LMOD3
leiomodin 3 (fetal)
chr5_+_6799100 1.209 NM_001171806
PAPD7
PAP associated domain containing 7
chr8_-_131483395 1.025 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr15_+_32048380 1.024 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr6_+_73133152 0.980 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr15_+_100175888 0.976 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr8_+_124032830 0.965 ZHX2
zinc fingers and homeoboxes 2
chr12_-_7547552 0.881 NM_004244
NM_203416
CD163

CD163 molecule

chr6_+_155579788 0.867 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr12_-_41269679 0.839 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr5_-_16795336 0.796 MYO10
myosin X
chr1_-_93919789 0.790 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr7_+_129771865 0.783 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr1_+_156991133 0.778 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr8_+_17440664 0.777 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chrX_+_7147471 0.740 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr1_+_242281199 0.733 ZNF238
zinc finger protein 238
chr7_+_128802719 0.728 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr6_-_25679197 0.728


chr2_-_99238001 0.719 NM_175735
LYG2
lysozyme G-like 2
chr9_-_111230926 0.713 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_-_150398327 0.703 NM_001122965
RPTN
repetin
chr16_-_70168449 0.700 NM_000353
TAT
tyrosine aminotransferase
chr5_-_88155360 0.678 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr20_-_49747397 0.656 ATP9A
ATPase, class II, type 9A
chr1_+_242281175 0.655 NM_205768
ZNF238
zinc finger protein 238
chrX_-_55074125 0.631 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr1_-_159191184 0.623 NM_080878
ITLN2
intelectin 2
chr6_-_50045296 0.619 NM_001037729
DEFB113
defensin, beta 113
chr6_+_29663661 0.619 NM_007160
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr3_+_196933422 0.615 NM_152673
MUC20
mucin 20, cell surface associated
chr7_-_27133163 0.605 NM_153631
HOXA3
homeobox A3
chr11_-_111636792 0.580 NM_001145024
C11orf34
chromosome 11 open reading frame 34
chr9_+_674193 0.578


chr4_-_170314382 0.577 SH3RF1
SH3 domain containing ring finger 1
chr10_+_685887 0.570 C10orf108
chromosome 10 open reading frame 108
chr1_+_242283129 0.568 NM_006352
ZNF238
zinc finger protein 238
chr3_+_46386636 0.567 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr1_-_195818927 0.563 DENND1B
DENN/MADD domain containing 1B
chr14_+_69307914 0.561 SRSF5
serine/arginine-rich splicing factor 5
chr7_-_86433139 0.548 NM_152748
KIAA1324L
KIAA1324-like
chrX_-_110542040 0.543 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr11_+_33306652 0.539 HIPK3
homeodomain interacting protein kinase 3
chr5_-_137502975 0.536 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr22_+_21817512 0.528 NM_004914
RAB36
RAB36, member RAS oncogene family
chr11_-_114593838 0.510 CADM1
cell adhesion molecule 1
chr21_-_34820916 0.502 NM_203418
RCAN1
regulator of calcineurin 1
chrX_-_43717864 0.498 NM_000266
NDP
Norrie disease (pseudoglioma)
chr2_-_224574860 0.494 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr2_-_166638376 0.494 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr10_+_21924265 0.491 MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr6_+_161043214 0.489 NM_000301
NM_001168338
PLG

plasminogen

chr8_+_22900863 0.477 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr9_+_27099138 0.472 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr8_-_7207899 0.472 NM_001164457
ZNF705G
zinc finger protein 705G
chr3_+_46628928 0.469 NM_001195442
LOC100132146
hypothetical LOC100132146
chr1_-_203592538 0.464 NM_018203
KLHDC8A
kelch domain containing 8A
chr6_-_2580296 0.464 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr2_+_178893216 0.463 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr20_+_56919233 0.463 GNAS
GNAS complex locus
chr8_-_7710547 0.462 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chrX_-_15242589 0.461 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr17_-_36347197 0.460 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr10_-_48426868 0.458 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr3_+_152934393 0.452 NM_207365
AADACL2
arylacetamide deacetylase-like 2
chr7_-_122627235 0.450 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr1_+_42773146 0.444 NM_001080850
CCDC30
coiled-coil domain containing 30
chr17_-_36877002 0.434 NM_002278
KRT32
keratin 32
chr11_+_124294355 0.428 NM_001037558
HEPN1
hepatocellular carcinoma, down-regulated 1
chr4_-_68511738 0.417 NM_001114387
NM_182606
TMPRSS11A

transmembrane protease, serine 11A

chr6_-_31196174 0.416 NM_001264
CDSN
corneodesmosin
chr7_+_147918589 0.414 NM_145304
C7orf33
chromosome 7 open reading frame 33
chr11_-_5819702 0.412 NM_001005167
OR52E6
olfactory receptor, family 52, subfamily E, member 6
chr13_+_52500830 0.409 NM_006418
OLFM4
olfactomedin 4
chr4_-_26100986 0.402 NM_000730
CCKAR
cholecystokinin A receptor
chr7_-_38279757 0.400 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr9_+_129066576 0.399 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr18_+_28023984 0.397 NM_005925
MEP1B
meprin A, beta
chr11_+_89403921 0.396 NM_001195234
TRIM49
TRIM49L2
tripartite motif containing 49
tripartite motif containing 49-like 2
chr6_+_136214495 0.394 NM_018945
PDE7B
phosphodiesterase 7B
chr5_+_36642424 0.394 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr20_-_29441946 0.394 NM_153289
NM_153323
NM_173460
DEFB119


defensin, beta 119


chr5_-_111121691 0.394 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr10_-_33264491 0.390 NM_033668
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr4_+_169789327 0.389 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr6_-_152681171 0.388 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr9_-_14076901 0.388 NFIB
nuclear factor I/B
chr5_+_36642213 0.387 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr1_-_67039518 0.387 NM_005478
INSL5
insulin-like 5
chr8_+_7340777 0.386 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr13_-_109600709 0.385 COL4A1
collagen, type IV, alpha 1
chr2_-_87102453 0.384 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr16_-_71650034 0.384 NM_001164766
ZFHX3
zinc finger homeobox 3
chr5_-_160044844 0.383 ATP10B
ATPase, class V, type 10B
chr6_+_144654565 0.382 NM_007124
UTRN
utrophin
chr3_+_11269384 0.381 NM_000861
HRH1
histamine receptor H1
chr15_+_22832198 0.381 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr15_-_31147376 0.380 NM_001103184
FMN1
formin 1
chr16_+_2749934 0.380


chr6_-_29635680 0.379 NM_006398
UBD
ubiquitin D
chr5_-_37220702 0.378 C5orf42
chromosome 5 open reading frame 42
chr21_-_30460841 0.376 NM_012131
CLDN17
claudin 17
chr6_-_29120930 0.375 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chrX_+_135558001 0.373 NM_000074
CD40LG
CD40 ligand
chr5_+_127012611 0.373 NM_001048252
CTXN3
cortexin 3
chr12_+_100394787 0.370 NM_152323
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr10_+_63478974 0.367 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr2_-_175170674 0.364 WIPF1
WAS/WASL interacting protein family, member 1
chrX_-_44945025 0.359 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr1_+_166516901 0.353 NM_005149
TBX19
T-box 19
chr4_+_187227302 0.351 NM_003265
TLR3
toll-like receptor 3
chr16_-_3783475 0.350 CREBBP
CREB binding protein
chr10_+_24795446 0.347 KIAA1217
KIAA1217
chr2_+_135312655 0.347 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr2_-_56266408 0.346 LOC100129434
hypothetical LOC100129434
chr3_+_153074118 0.343 NM_033050
SUCNR1
succinate receptor 1
chr1_+_200775864 0.342 NM_001197131
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr11_+_89032112 0.340 NM_153696
FOLH1B
folate hydrolase 1B
chr7_+_111908143 0.338 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr3_-_127810087 0.336 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr11_-_117628211 0.334 NM_198275
MPZL3
myelin protein zero-like 3
chr19_-_40995564 0.333 PRODH2
proline dehydrogenase (oxidase) 2
chr5_+_145296313 0.332 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr11_-_18913121 0.329 NM_147199
MRGPRX1
MAS-related GPR, member X1
chr4_-_54119102 0.329 LNX1
ligand of numb-protein X 1
chr3_-_11598829 0.325 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chrX_-_138875342 0.323 NM_001013403
CXorf66
chromosome X open reading frame 66
chr1_-_163680941 0.323 NM_006917
RXRG
retinoid X receptor, gamma
chr3_-_15538164 0.320 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr12_+_54172413 0.320 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr5_+_95092384 0.318 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr6_+_152053323 0.317 NM_001122742
ESR1
estrogen receptor 1
chr15_+_94670160 0.316 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr13_+_97856148 0.315


chr6_-_66346417 0.314 NM_198283
EYS
eyes shut homolog (Drosophila)
chr4_+_166350620 0.311 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr19_-_40995606 0.310 PRODH2
proline dehydrogenase (oxidase) 2
chr19_+_21116666 0.309 NM_133473
ZNF431
zinc finger protein 431
chr12_-_52281050 0.308 NM_001130059
ATF7
activating transcription factor 7
chrX_-_18600108 0.308 NM_000330
RS1
retinoschisin 1
chr15_+_55298908 0.307 NM_207040
TCF12
transcription factor 12
chrX_-_62697473 0.306 LOC92249
hypothetical LOC92249
chr11_+_59979857 0.306 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr11_+_61794205 0.306 NM_002411
SCGB2A2
secretoglobin, family 2A, member 2
chr17_-_36346240 0.305 KRT23
keratin 23 (histone deacetylase inducible)
chr1_-_157014048 0.304 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chr6_-_50097606 0.303 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chr3_+_45902999 0.303 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr14_-_105997732 0.302 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_+_24795465 0.301 KIAA1217
KIAA1217
chr21_-_30510113 0.300 NM_199328
CLDN8
claudin 8
chr18_+_59767567 0.299 NM_001123366
HMSD
histocompatibility (minor) serpin domain containing
chr1_-_152845399 0.298 NM_001193495
ADAR
adenosine deaminase, RNA-specific
chr5_-_124108672 0.298 NM_020747
ZNF608
zinc finger protein 608
chr19_-_56612653 0.295 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr2_+_158559936 0.291 NM_001135098
UPP2
uridine phosphorylase 2
chr3_+_115099007 0.286 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr7_+_137795387 0.286 NM_003852
NM_015905
TRIM24

tripartite motif containing 24

chr3_+_150675117 0.279 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr4_+_123311207 0.276 NM_015312
KIAA1109
KIAA1109
chrX_-_138552517 0.276 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chr4_+_3341521 0.275 NM_198227
RGS12
regulator of G-protein signaling 12
chr8_+_22266256 0.272 PIWIL2
piwi-like 2 (Drosophila)
chr11_-_89181390 0.271 NM_020358
TRIM49
tripartite motif containing 49
chr5_+_179065282 0.271 CANX
calnexin
chr9_+_117955890 0.269 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr15_-_64108718 0.269


chr9_-_15240113 0.268 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr4_-_54119159 0.265 NM_032622
LNX1
ligand of numb-protein X 1
chr1_+_119759076 0.265 NM_001166120
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chrX_+_50044279 0.265 NM_033031
NM_033670
CCNB3

cyclin B3

chr11_-_47472648 0.264 NM_198700
CELF1
CUGBP, Elav-like family member 1
chr13_+_108046500 0.264 NM_015011
MYO16
myosin XVI
chr18_+_27210737 0.264 NM_001134453
NM_177986
DSG4

desmoglein 4

chr21_-_35174742 0.263 RUNX1
runt-related transcription factor 1
chr1_+_111634996 0.262 NM_021797
NM_201653
CHIA

chitinase, acidic

chr6_-_38671741 0.260 NM_001172418
NM_152733
BTBD9

BTB (POZ) domain containing 9

chr20_+_56455866 0.260 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chrX_+_107174855 0.259 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr11_-_85115105 0.258 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr9_-_4142182 0.256 NM_152629
GLIS3
GLIS family zinc finger 3
chr5_+_71538456 0.255 MAP1B
microtubule-associated protein 1B
chr3_+_171022403 0.255 NM_001080460
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chrX_+_55666557 0.253 NM_198451
FOXR2
forkhead box R2
chr1_-_155336223 0.253 NM_001004341
ETV3L
ets variant 3-like
chr2_-_206790871 0.252 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr9_+_123369219 0.251 NM_032552
DAB2IP
DAB2 interacting protein
chr2_+_216695062 0.247 XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr7_-_139408808 0.246 PARP12
poly (ADP-ribose) polymerase family, member 12
chr7_+_18296569 0.245 HDAC9
histone deacetylase 9
chrX_+_70682204 0.243 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr4_+_111616630 0.242 NM_001977
ENPEP
glutamyl aminopeptidase (aminopeptidase A)
chr12_-_10870134 0.237 NM_023921
TAS2R10
taste receptor, type 2, member 10
chrX_+_55951280 0.236


chr1_+_13903936 0.233 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr6_-_24985432 0.233 NM_015864
FAM65B
family with sequence similarity 65, member B
chr8_-_62764839 0.232 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr16_+_3473476 0.232 NAT15
N-acetyltransferase 15 (GCN5-related, putative)
chr19_+_9157269 0.232 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.36 6.57e-05 GO:0007608 sensory perception of smell
2.16 7.40e-04 GO:0007606 sensory perception of chemical stimulus
1.74 1.24e-02 GO:0007600 sensory perception

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.51 3.62e-05 GO:0005576 extracellular region
1.26 3.72e-03 GO:0005886 plasma membrane
2.71 3.73e-03 GO:0005882 intermediate filament
1.26 5.41e-03 GO:0071944 cell periphery
2.34 3.73e-02 GO:0045111 intermediate filament cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.12 1.17e-08 GO:0004930 G-protein coupled receptor activity
2.48 3.67e-06 GO:0004984 olfactory receptor activity
1.60 1.54e-05 GO:0004872 receptor activity
1.63 2.95e-04 GO:0004888 transmembrane receptor activity
1.46 5.52e-04 GO:0004871 signal transducer activity
1.46 5.52e-04 GO:0060089 molecular transducer activity
6.29 1.00e-02 GO:0001608 nucleotide receptor activity, G-protein coupled
6.29 1.00e-02 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
13.11 4.31e-02 GO:0004969 histamine receptor activity