Motif ID: NKX2-1,4.p2

Z-value: 0.796


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_36059084-0.543.0e-02Click!
NKX2-4chr20_-_213260460.332.1e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_1298493 0.724 FKBP1A
FK506 binding protein 1A, 12kDa
chr16_+_70654625 0.615 NM_020995
HPR
haptoglobin-related protein
chr1_+_180836050 0.588


chr7_+_94377145 0.575 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr5_-_88004891 0.543 LOC645323
hypothetical LOC645323
chr11_+_66152309 0.536


chr5_+_139485703 0.514 NM_001007189
C5orf53
chromosome 5 open reading frame 53
chr2_+_38009405 0.514 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr20_+_56455866 0.506 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr10_+_70650064 0.494 NM_025130
HKDC1
hexokinase domain containing 1
chr5_-_13997588 0.483 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr10_-_13584950 0.475 NM_001100912
NM_152751
BEND7

BEN domain containing 7

chr4_-_185963859 0.472 ACSL1
acyl-CoA synthetase long-chain family member 1
chr8_-_30826074 0.450 NM_031271
TEX15
testis expressed 15
chr7_-_107230867 0.450 NM_000111
SLC26A3
solute carrier family 26, member 3
chr1_-_41398126 0.447 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr3_+_38238080 0.446 OXSR1
oxidative-stress responsive 1
chr1_+_150749943 0.436 NM_178438
LCE5A
late cornified envelope 5A
chr6_+_155579788 0.428 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr1_+_32489426 0.424 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr2_+_161701711 0.422 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr4_-_184478920 0.416 NM_001111319
CLDN22
claudin 22
chr3_+_171560104 0.399 NM_001145097
SKIL
SKI-like oncogene
chr4_-_174774368 0.394 NM_006792
MORF4
mortality factor 4
chr4_+_22303645 0.387 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr5_+_150008030 0.384 SYNPO
synaptopodin
chr14_+_63752424 0.377 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr19_+_45797413 0.367 LTBP4
latent transforming growth factor beta binding protein 4
chr1_+_146827470 0.366 NM_173638
NBPF15
neuroblastoma breakpoint family, member 15
chr20_+_35266581 0.364 RPN2
ribophorin II
chr3_+_46386636 0.356 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr2_-_100125402 0.354 NM_002285
AFF3
AF4/FMR2 family, member 3
chr15_-_29734833 0.346 NM_130901
OTUD7A
OTU domain containing 7A
chr1_+_61642287 0.344 NFIA
nuclear factor I/A
chr9_+_102380156 0.337 NM_001018116
MURC
muscle-related coiled-coil protein
chr2_-_37397669 0.331 NM_005813
PRKD3
protein kinase D3
chr1_-_201465395 0.330 NM_003465
CHIT1
chitinase 1 (chitotriosidase)
chr1_+_24522116 0.329 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr22_-_37211467 0.328 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr22_-_27787793 0.323 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr10_-_49152918 0.322 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr8_-_7207899 0.306 NM_001164457
ZNF705G
zinc finger protein 705G
chr17_-_31353196 0.298 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr2_+_28892366 0.295 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr12_+_108310906 0.295 NM_001101421
MYO1H
myosin IH
chr17_+_20048890 0.292 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr1_+_159817752 0.286 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr9_+_114671635 0.285 SNX30
sorting nexin family member 30
chr6_+_132901119 0.284 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr7_+_38984133 0.282 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr10_+_86121526 0.278 FAM190B
family with sequence similarity 190, member B
chr12_+_54132264 0.277 NM_054105
OR6C2
olfactory receptor, family 6, subfamily C, member 2
chr1_-_178100204 0.270


chr15_+_38430517 0.268 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr11_+_34599227 0.261 EHF
ets homologous factor
chr4_+_37638450 0.260 NM_006607
PTTG2
pituitary tumor-transforming 2
chr6_+_31059463 0.258 NM_001010909
MUC21
mucin 21, cell surface associated
chr1_+_210864411 0.252 NM_153606
FAM71A
family with sequence similarity 71, member A
chr1_+_145116168 0.251


chr11_+_34599163 0.250 NM_012153
EHF
ets homologous factor
chr5_+_156752739 0.246 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr8_-_6901661 0.244 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chr5_-_150663519 0.239 NM_001145017
NM_181774
SLC36A3

solute carrier family 36 (proton/amino acid symporter), member 3

chr19_+_16691786 0.234 NM_001007525
NWD1
NACHT and WD repeat domain containing 1
chr19_-_6621078 0.233 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr5_-_121842680 0.233


chr19_+_50144267 0.233 APOC2
apolipoprotein C-II
chr19_-_15906669 0.231 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr2_-_242205556 0.229 NM_001164356
THAP4
THAP domain containing 4
chr10_+_90511142 0.223 NM_001102469
LIPN
lipase, family member N
chr19_+_4720144 0.223 C19orf30
chromosome 19 open reading frame 30
chr1_+_172683834 0.221 NM_005684
GPR52
G protein-coupled receptor 52
chr3_-_58538110 0.220 FAM107A
family with sequence similarity 107, member A
chr8_-_7308438 0.217 NM_016512
NM_058200
NM_058201
NM_058202
NM_058203
SPAG11B




SPAG11A
sperm associated antigen 11B




sperm associated antigen 11A
chr6_+_30212488 0.215 NM_138700
TRIM40
tripartite motif containing 40
chr2_-_26717713 0.215 NM_001029881
CIB4
calcium and integrin binding family member 4
chr6_-_50045296 0.211 NM_001037729
DEFB113
defensin, beta 113
chr1_-_21478571 0.211 NM_001113347
ECE1
endothelin converting enzyme 1
chr17_-_7434113 0.210 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr11_+_124294355 0.208 NM_001037558
HEPN1
hepatocellular carcinoma, down-regulated 1
chr1_+_38033666 0.206 NM_152496
MANEAL
mannosidase, endo-alpha-like
chr3_-_51971915 0.205 NM_033010
PCBP4
poly(rC) binding protein 4
chr15_+_38437703 0.205 NM_033510
DISP2
dispatched homolog 2 (Drosophila)
chr4_-_68793928 0.203 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr1_-_201586910 0.203 NM_002023
FMOD
fibromodulin
chrX_+_128966844 0.201 NM_021946
BCORL1
BCL6 corepressor-like 1
chr9_-_111230926 0.199 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr3_+_63403792 0.199 NM_144642
SYNPR
synaptoporin
chr5_-_134810696 0.198 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr9_+_6231677 0.197 NM_033439
IL33
interleukin 33
chr1_-_89364273 0.197 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr15_-_48192804 0.196 ATP8B4
ATPase, class I, type 8B, member 4
chr12_+_76749199 0.196 NM_014903
NAV3
neuron navigator 3
chr1_+_169747788 0.195 PRRC2C
proline-rich coiled-coil 2C
chr4_+_102954005 0.194 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr19_+_43847049 0.194


chr16_+_70646008 0.192 NM_001126102
NM_005143
HP

haptoglobin

chr16_-_70306198 0.191 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr10_+_123744131 0.191 TACC2
transforming, acidic coiled-coil containing protein 2
chr8_-_110726921 0.190 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr1_-_229627412 0.188 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr6_+_43373986 0.186 SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr5_-_39306465 0.184 FYB
FYN binding protein
chr6_-_152681171 0.184 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr7_+_29840865 0.183 NM_001080529
WIPF3
WAS/WASL interacting protein family, member 3
chr4_-_107508040 0.181 NM_001195138
LOC100507096
GTPase IMAP family member-like
chr6_-_11887265 0.180 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr3_+_188397967 0.177 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr17_+_63338500 0.176 BPTF
bromodomain PHD finger transcription factor
chr2_+_28469172 0.176 FOSL2
FOS-like antigen 2
chr5_-_58918031 0.175 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_156590109 0.173 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chr15_-_40537002 0.173 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr1_+_159899528 0.172 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr18_+_6824431 0.169 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr8_+_22909305 0.167 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr15_-_53350383 0.167 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr5_+_66160359 0.167 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_-_143706300 0.167 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr11_+_59979857 0.167 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr17_-_53335748 0.167 NM_017949
CUEDC1
CUE domain containing 1
chr3_+_187840842 0.166 NM_014375
FETUB
fetuin B
chr10_-_69125932 0.166 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_+_221168388 0.165 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chrX_-_131989963 0.162 NM_031907
USP26
ubiquitin specific peptidase 26
chr5_-_131907071 0.160 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr4_-_24590867 0.159 NM_173463
CCDC149
coiled-coil domain containing 149
chr1_-_156013487 0.158 NM_030764
FCRL2
Fc receptor-like 2
chr7_+_142885087 0.156 NM_176883
TAS2R41
taste receptor, type 2, member 41
chrX_-_108611940 0.155 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr4_-_77147625 0.154 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr11_-_102331643 0.153 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr12_-_12394402 0.151 NM_018050
MANSC1
MANSC domain containing 1
chr1_-_21310462 0.151 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr7_+_143457083 0.150 NM_001001659
OR2A14
olfactory receptor, family 2, subfamily A, member 14
chr16_+_510732 0.150 RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr4_-_46086150 0.148 NM_001114175
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr10_-_28611020 0.147 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr13_-_25687062 0.144 RNF6
ring finger protein (C3H2C3 type) 6
chr1_+_151117421 0.142 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chrX_+_49480643 0.142 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr11_+_89403921 0.139 NM_001195234
TRIM49
TRIM49L2
tripartite motif containing 49
tripartite motif containing 49-like 2
chr2_-_160838397 0.138 RBMS1
RNA binding motif, single stranded interacting protein 1
chr3_-_127810087 0.137 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr12_+_61240542 0.136 MON2
MON2 homolog (S. cerevisiae)
chr15_+_79304694 0.136 NM_172217
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr15_+_40481879 0.136 NM_173088
CAPN3
calpain 3, (p94)
chr9_-_33385265 0.136 AQP7
aquaporin 7
chrX_+_41468351 0.135 NM_080817
GPR82
G protein-coupled receptor 82
chr5_-_101862447 0.135 NM_173488
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr9_+_135994734 0.135 NM_052821
WDR5
WD repeat domain 5
chr8_+_9990471 0.135 NM_001135671
MSRA
methionine sulfoxide reductase A
chr4_-_151993422 0.133


chr13_+_77007809 0.132 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr12_-_7739591 0.130 NM_020634
GDF3
growth differentiation factor 3
chr15_+_37330176 0.129 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr1_+_200698493 0.128 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr1_-_201586808 0.127 FMOD
fibromodulin
chr17_-_32730804 0.125 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr7_-_99170651 0.125 NM_000765
CYP3A7
cytochrome P450, family 3, subfamily A, polypeptide 7
chr1_-_201586872 0.125


chr2_+_28469199 0.120 FOSL2
FOS-like antigen 2
chr1_-_143706196 0.120 PDE4DIP
phosphodiesterase 4D interacting protein
chrX_+_71280758 0.120 NM_207422
FLJ44635
TPT1-like protein
chr1_+_144124547 0.117 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr2_-_56266408 0.117 LOC100129434
hypothetical LOC100129434
chr15_-_70385709 0.116 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr7_+_116182676 0.116


chr1_+_150948146 0.115 NM_178356
LCE4A
late cornified envelope 4A
chr19_-_53950458 0.114 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr5_-_137882303 0.113 ETF1
eukaryotic translation termination factor 1
chr1_+_220953351 0.112 BROX
BRO1 domain and CAAX motif containing
chr1_+_31814709 0.111 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr5_-_37871349 0.111 NM_199231
GDNF
glial cell derived neurotrophic factor
chr9_+_115246831 0.110 NM_144488
RGS3
regulator of G-protein signaling 3
chr1_-_201321711 0.110 MYOG
myogenin (myogenic factor 4)
chr1_-_43168247 0.109 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr16_-_69876262 0.109 FTSJD1
FtsJ methyltransferase domain containing 1
chr15_-_76313896 0.108 NM_015162
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr19_+_55488632 0.107 MYH14
myosin, heavy chain 14, non-muscle
chr3_-_148607096 0.107 NM_032153
ZIC4
Zic family member 4
chr5_+_145297490 0.106 SH3RF2
SH3 domain containing ring finger 2
chr4_-_72868598 0.106 NM_000583
GC
group-specific component (vitamin D binding protein)
chr1_+_40977092 0.105 NFYC
nuclear transcription factor Y, gamma
chr7_-_96471544 0.105 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr18_+_54013575 0.104 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr4_-_77547481 0.103 NM_001042784
CCDC158
coiled-coil domain containing 158
chr2_-_217433018 0.102 NM_003284
TNP1
transition protein 1 (during histone to protamine replacement)
chr5_-_160211623 0.102 NM_025153
ATP10B
ATPase, class V, type 10B
chr4_+_86968069 0.102 ARHGAP24
Rho GTPase activating protein 24
chr8_-_134156437 0.101 SLA
Src-like-adaptor
chr1_-_58920315 0.101


chr10_-_91092410 0.100 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr1_-_108032645 0.099 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr12_+_5473558 0.099 NM_002527
NTF3
neurotrophin 3
chr3_-_143230124 0.099 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr11_+_5732498 0.098 NM_001005175
OR52N4
olfactory receptor, family 52, subfamily N, member 4
chr13_+_110637173 0.098 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr4_-_77176163 0.098 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr6_+_73133152 0.097 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.22 8.03e-04 GO:0061061 muscle structure development
1.36 1.84e-03 GO:0032501 multicellular organismal process
3.40 9.89e-03 GO:0007517 muscle organ development
2.29 3.84e-02 GO:0001775 cell activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.92 8.80e-04 GO:0044421 extracellular region part
1.99 4.35e-03 GO:0005615 extracellular space

Nothing significant found in function category.