Motif ID: HNF4A_NR2F1,2.p2

Z-value: 7.381


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF4Achr20_+_424634190.893.3e-06Click!
NR2F2chr15_+_94670160-0.421.0e-01Click!
NR2F1chr5_+_92946348-0.165.6e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_69950782 13.948 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr9_-_126309510 13.896 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr6_+_131190237 12.879 NM_001195597
LOC285733
hypothetical LOC285733
chr9_-_14858974 12.809 FREM1
FRAS1 related extracellular matrix 1
chr17_+_24394281 12.607 PIPOX
pipecolic acid oxidase
chr5_-_42847716 11.814 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr14_-_23847000 11.534 CIDEB
cell death-inducing DFFA-like effector b
chr2_+_241193492 11.439 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr1_-_167822248 11.437 F5
coagulation factor V (proaccelerin, labile factor)
chr14_-_23847024 11.143 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_23846993 10.926 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_23846904 10.874 CIDEB
cell death-inducing DFFA-like effector b
chr12_+_51783554 10.854 SOAT2
sterol O-acyltransferase 2
chr10_-_101831579 10.684 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr12_+_51783540 10.679 NM_003578
SOAT2
sterol O-acyltransferase 2
chr14_-_93924873 9.971 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr16_-_86527608 9.875 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr2_-_74606819 9.781 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr6_+_31731647 9.649 NM_019101
APOM
apolipoprotein M
chr9_-_129752687 9.522 NM_203305
FAM102A
family with sequence similarity 102, member A
chr6_+_31731667 9.485 APOM
apolipoprotein M
chr6_+_32090516 9.369 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr13_+_112825113 9.135 NM_000504
F10
coagulation factor X
chr10_+_102722275 8.813 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr16_+_21152516 8.702 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr1_-_167822334 8.612 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr17_-_31353196 8.395 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr3_-_52454082 8.389 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr16_-_51138306 8.289 NM_001080430
TOX3
TOX high mobility group box family member 3
chr20_-_3097070 7.851 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr1_-_153537810 7.800 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr17_-_31352643 7.770 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr12_+_119900931 7.724 NM_000545
HNF1A
HNF1 homeobox A
chr1_-_159459814 7.659 APOA2
apolipoprotein A-II
chr17_-_31352720 7.533 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr22_+_43451600 7.465 PRR5
proline rich 5 (renal)
chr12_-_7935010 7.366 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr6_+_32021793 7.365 CFB
complement factor B
chr19_-_55708936 7.363 NM_001114598
ASPDH
aspartate dehydrogenase domain containing
chr1_-_172153087 7.352 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr1_-_172153024 7.225 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr20_+_35406497 7.066 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr17_+_24394043 7.036 NM_016518
PIPOX
pipecolic acid oxidase
chr2_+_27573206 6.958 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr2_-_238164042 6.937 RAB17
RAB17, member RAS oncogene family
chr20_+_55569542 6.854 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr12_+_119900677 6.848 HNF1A
HNF1 homeobox A
chr11_-_116213511 6.831 NM_000039
APOA1
apolipoprotein A-I
chr8_+_21972631 6.807 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr17_-_7023378 6.673 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr17_-_33178987 6.591 HNF1B
HNF1 homeobox B
chr2_+_242398954 6.516 NEU4
sialidase 4
chr2_+_11597530 6.423 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr1_-_176205672 6.353 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr11_+_60858611 6.293 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr17_-_33179118 6.273 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr6_+_32021742 6.160 CFB
complement factor B
chr1_-_1346465 6.124 NM_001145210
LOC441869
hypothetical protein LOC441869
chr1_-_159459999 6.111 NM_001643
APOA2
apolipoprotein A-II
chr17_+_35147697 6.041 NM_005310
GRB7
growth factor receptor-bound protein 7
chr2_+_218992053 6.005 NM_007127
VIL1
villin 1
chr16_+_464844 5.987 NM_001142272
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr1_-_176205970 5.790 SEC16B
SEC16 homolog B (S. cerevisiae)
chr16_+_29597965 5.768 QPRT
quinolinate phosphoribosyltransferase
chr11_+_110675175 5.720 NM_001136105
C11orf93
chromosome 11 open reading frame 93
chr6_+_32057779 5.606 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr10_+_101532544 5.575 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr13_+_49658016 5.564


chr19_-_63715135 5.551 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr17_-_68769613 5.549 NM_001129885
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr1_-_149611768 5.490 NM_003944
SELENBP1
selenium binding protein 1
chr3_-_121883647 5.472 HGD
homogentisate 1,2-dioxygenase
chr13_+_112808102 5.469 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr4_-_9632192 5.463 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr6_+_32021831 5.463 CFB
complement factor B
chr2_+_219354692 5.448 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr2_-_88208650 5.426 NM_001443
FABP1
fatty acid binding protein 1, liver
chr3_-_195553297 5.418 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr5_+_133870175 5.392


chr1_-_110108048 5.364 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr16_-_16224791 5.347 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr6_+_32003380 5.318 C2
complement component 2
chr6_+_30238961 5.285 NM_033229
TRIM15
tripartite motif containing 15
chr1_-_228916559 5.276 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr20_+_31059038 5.251 NM_025227
BPIL1
bactericidal/permeability-increasing protein-like 1
chr10_+_60607232 5.202 NM_001143774
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr11_+_46697345 5.199 F2
coagulation factor II (thrombin)
chr7_-_100630912 5.187 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr8_+_21972804 5.117 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr17_+_4638966 5.116 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr8_-_82769761 5.101 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr1_-_153537362 5.076 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr19_+_46640902 4.982 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr11_+_46697335 4.964 F2
coagulation factor II (thrombin)
chr14_-_93924663 4.951 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr11_-_116168316 4.911 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr10_+_101532450 4.868 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chrX_+_152565849 4.859 DUSP9
dual specificity phosphatase 9
chr17_+_38259620 4.848 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr11_+_46697312 4.845 NM_000506
F2
coagulation factor II (thrombin)
chr17_-_71352090 4.825 UNC13D
unc-13 homolog D (C. elegans)
chr2_+_10009242 4.793 NM_198182
GRHL1
grainyhead-like 1 (Drosophila)
chr2_-_233586145 4.776 NGEF
neuronal guanine nucleotide exchange factor
chr17_+_4621924 4.696 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr17_-_71352017 4.694 UNC13D
unc-13 homolog D (C. elegans)
chr20_+_34937928 4.650 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr7_-_50600536 4.632 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr11_+_74548472 4.588 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr2_-_233586164 4.570 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr19_-_15906669 4.540 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr3_-_42892195 4.538 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr16_+_55963883 4.502 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr12_+_56114724 4.493 NM_005538
INHBC
inhibin, beta C
chr17_+_72958207 4.482 NM_001113496
SEPT9
septin 9
chr2_+_113648036 4.403 PSD4
pleckstrin and Sec7 domain containing 4
chr13_-_112392051 4.394 LOC440149
hypothetical LOC440149
chr17_-_6958773 4.365 NM_001181
NM_080912
NM_080913
ASGR2


asialoglycoprotein receptor 2


chr6_+_32003180 4.356 NM_000063
NM_001145903
C2

complement component 2

chr8_-_71478560 4.341 NM_006540
NCOA2
nuclear receptor coactivator 2
chr6_-_29635456 4.297 UBD
ubiquitin D
chr22_+_43451351 4.287 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr3_-_58497913 4.268 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr17_+_69939130 4.239 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr17_+_38306339 4.207 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr2_-_238164452 4.207 NM_022449
RAB17
RAB17, member RAS oncogene family
chr1_-_11029882 4.203 MASP2
mannan-binding lectin serine peptidase 2
chr1_+_1351370 4.199 NM_001146685
TMEM88B
transmembrane protein 88B
chr2_-_208702760 4.189 NM_020989
CRYGC
crystallin, gamma C
chr15_+_83228895 4.188 NM_004213
NM_201651
SLC28A1

solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

chr16_-_11277806 4.163 NM_002762
PRM2
protamine 2
chr17_+_35147738 4.162 GRB7
growth factor receptor-bound protein 7
chr16_+_31619427 4.148 KIAA0664L3
KIAA0664-like 3
chr16_+_31619415 4.138 KIAA0664L3
KIAA0664-like 3
chr10_+_114123828 4.089 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_-_198784590 4.044 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr11_-_64520964 4.023 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr7_+_101704145 4.000 CUX1
cut-like homeobox 1
chr16_-_45339605 3.986 NM_182493
MYLK3
myosin light chain kinase 3
chr6_+_32021687 3.977 NM_001710
CFB
complement factor B
chr11_-_60819110 3.956 VWCE
von Willebrand factor C and EGF domains
chr1_-_228916958 3.944 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr20_-_47963682 3.936 NM_001135773
SPATA2
spermatogenesis associated 2
chr4_+_100714995 3.922 MTTP
microsomal triglyceride transfer protein
chr15_+_38082041 3.916 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr17_+_72958330 3.906 SEPT9
septin 9
chr11_+_696607 3.894 EPS8L2
EPS8-like 2
chr1_+_226404037 3.881 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr17_-_6958695 3.875 ASGR2
asialoglycoprotein receptor 2
chr6_-_31853027 3.868 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr17_-_71352182 3.868 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr2_+_242398832 3.866 NM_001167600
NM_001167601
NEU4

sialidase 4

chr16_+_29819647 3.842 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr21_+_41616590 3.841 FAM3B
family with sequence similarity 3, member B
chr11_-_16992524 3.819 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr1_+_20751518 3.789 NM_207334
FAM43B
family with sequence similarity 43, member B
chr19_-_4491078 3.773 LRG1
leucine-rich alpha-2-glycoprotein 1
chr19_+_4104593 3.678 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr7_-_86942910 3.670 NM_000443
NM_018849
NM_018850
ABCB4


ATP-binding cassette, sub-family B (MDR/TAP), member 4


chr11_+_22644732 3.661 NM_001143830
GAS2
growth arrest-specific 2
chr1_-_24307514 3.657 MYOM3
myomesin family, member 3
chr6_+_32021899 3.656 CFB
complement factor B
chr12_-_120781002 3.630 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr10_+_114123765 3.610 ACSL5
acyl-CoA synthetase long-chain family member 5
chr5_+_132237253 3.601 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr2_+_47449951 3.600 EPCAM
epithelial cell adhesion molecule
chr19_-_56561391 3.588 ETFB
electron-transfer-flavoprotein, beta polypeptide
chr10_-_74384485 3.566 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr19_+_7566698 3.554 NM_001080429
NM_020902
KIAA1543

KIAA1543

chr19_-_19142053 3.553 MEF2B
myocyte enhancer factor 2B
chr10_-_74384569 3.544 PLA2G12B
phospholipase A2, group XIIB
chr11_-_60819273 3.541 NM_152718
VWCE
von Willebrand factor C and EGF domains
chr20_-_52120710 3.515 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr7_+_142692165 3.504 NM_153345
TMEM139
transmembrane protein 139
chr20_-_32363268 3.497 NM_001161766
AHCY
adenosylhomocysteinase
chr20_+_42417502 3.488 HNF4A
hepatocyte nuclear factor 4, alpha
chr20_+_42593849 3.486 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr5_-_16791346 3.477 MYO10
myosin X
chr17_+_7180571 3.454 NM_014716
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr19_-_56561444 3.442 NM_001985
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr17_+_73638430 3.439 NM_152468
TMC8
transmembrane channel-like 8
chr17_-_53847937 3.404 RNF43
ring finger protein 43
chr1_-_11029737 3.381 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr8_-_144887876 3.370 NM_198488
FAM83H
family with sequence similarity 83, member H
chr9_-_35804982 3.358


chr19_+_876984 3.358 NM_005224
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr8_+_144706699 3.346 NM_001166237
GSDMD
gasdermin D
chr1_+_203740391 3.336 CDK18
cyclin-dependent kinase 18
chr11_+_2881080 3.311 SLC22A18
solute carrier family 22, member 18
chr1_+_153366928 3.308 NM_004428
NM_182685
EFNA1

ephrin-A1

chr17_+_50699965 3.300 HLF
hepatic leukemia factor
chr4_-_1156959 3.294 NM_001128325
SPON2
spondin 2, extracellular matrix protein
chr1_+_38033666 3.294 NM_152496
MANEAL
mannosidase, endo-alpha-like
chr20_-_52120421 3.289 BCAS1
breast carcinoma amplified sequence 1
chr17_-_23721351 3.279 VTN
vitronectin
chr2_+_219780192 3.269 ZFAND2B
zinc finger, AN1-type domain 2B
chr8_-_110773195 3.266 NM_001099743
NM_001099744
SYBU

syntabulin (syntaxin-interacting)

chr3_+_187813405 3.266 AHSG
alpha-2-HS-glycoprotein
chr19_-_4491024 3.261 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr11_+_63412562 3.256 NM_017490
MARK2
MAP/microtubule affinity-regulating kinase 2
chr20_+_42417752 3.252 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 2.76e-04 GO:0055114 oxidation-reduction process
1.49 4.19e-04 GO:0006082 organic acid metabolic process
1.26 5.25e-04 GO:0042221 response to chemical stimulus
1.49 7.61e-04 GO:0019752 carboxylic acid metabolic process
1.49 7.61e-04 GO:0043436 oxoacid metabolic process
1.47 1.08e-03 GO:0042180 cellular ketone metabolic process
1.11 3.27e-03 GO:0008152 metabolic process
1.26 5.48e-03 GO:0044281 small molecule metabolic process
1.23 1.64e-02 GO:0065008 regulation of biological quality
1.62 2.81e-02 GO:0032787 monocarboxylic acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 6.18e-05 GO:0000267 cell fraction
1.44 6.24e-05 GO:0005626 insoluble fraction
1.42 3.06e-04 GO:0005624 membrane fraction
1.45 5.69e-04 GO:0044429 mitochondrial part
1.54 6.95e-04 GO:0005740 mitochondrial envelope
1.30 9.51e-04 GO:0005739 mitochondrion
1.11 1.93e-03 GO:0044444 cytoplasmic part
1.63 2.68e-03 GO:0005743 mitochondrial inner membrane
1.39 6.13e-03 GO:0031967 organelle envelope
1.57 6.42e-03 GO:0019866 organelle inner membrane
1.38 6.73e-03 GO:0031975 envelope
1.49 7.59e-03 GO:0031966 mitochondrial membrane
1.08 1.42e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.51 2.46e-05 GO:0016491 oxidoreductase activity