Motif ID: MAFB.p2

Z-value: 2.957


Transcription factors associated with MAFB.p2:

Gene SymbolEntrez IDGene Name
MAFB 9935 v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MAFBchr20_-_387512890.552.8e-02Click!


Activity profile for motif MAFB.p2.

activity profile for motif MAFB.p2


Sorted Z-values histogram for motif MAFB.p2

Sorted Z-values for motif MAFB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MAFB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_109291575 4.800 KLF4
Kruppel-like factor 4 (gut)
chr4_-_141293572 4.447 MAML3
mastermind-like 3 (Drosophila)
chr15_-_37999519 4.198


chr6_+_45498262 4.160 RUNX2
runt-related transcription factor 2
chr6_+_45498354 3.770 RUNX2
runt-related transcription factor 2
chr2_-_161058120 3.643 RBMS1
RNA binding motif, single stranded interacting protein 1
chr4_-_140696740 3.568 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr15_-_37999717 3.276 GPR176
G protein-coupled receptor 176
chr7_-_27149750 3.050 NM_019102
HOXA5
homeobox A5
chr1_+_66772393 3.022 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr18_-_21185968 3.007 ZNF521
zinc finger protein 521
chr4_-_141294682 2.922 NM_018717
MAML3
mastermind-like 3 (Drosophila)
chr5_+_60663842 2.881 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr8_+_37672427 2.847 NM_025069
ZNF703
zinc finger protein 703
chr7_-_127458231 2.809 NM_022143
LRRC4
leucine rich repeat containing 4
chr3_-_64186151 2.778 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr13_-_76358370 2.769 KCTD12
potassium channel tetramerisation domain containing 12
chr9_-_128924782 2.751 ANGPTL2
angiopoietin-like 2
chr9_-_128924819 2.748 NM_012098
ANGPTL2
angiopoietin-like 2
chr9_-_128924706 2.742 ANGPTL2
angiopoietin-like 2
chr16_+_81218142 2.709 CDH13
cadherin 13, H-cadherin (heart)
chr18_-_21186107 2.668 NM_015461
ZNF521
zinc finger protein 521
chr16_+_81218074 2.647 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr2_-_227371698 2.559 NM_005544
IRS1
insulin receptor substrate 1
chr15_-_46724360 2.499 FBN1
fibrillin 1
chr2_-_192767494 2.493 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr12_+_26239755 2.459 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr9_-_25668230 2.366 TUSC1
tumor suppressor candidate 1
chr1_+_64012154 2.364 NM_001083592
NM_005012
ROR1

receptor tyrosine kinase-like orphan receptor 1

chr9_-_109291866 2.331 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr5_+_92946348 2.323 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr3_+_112273352 2.308 PVRL3
poliovirus receptor-related 3
chr11_-_35503720 2.280 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr20_+_19903778 2.256 RIN2
Ras and Rab interactor 2
chr8_+_32525269 2.252 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr7_+_33911636 2.248 NM_133468
BMPER
BMP binding endothelial regulator
chr6_-_132314004 2.203 NM_001901
CTGF
connective tissue growth factor
chr8_+_60194328 2.187


chr7_-_27190882 2.169 HOXA11
homeobox A11
chr8_+_106400322 2.126 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr18_-_24010944 2.087 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr5_-_146813343 2.075 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr5_+_66160359 2.048 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr12_-_26166485 2.042 BHLHE41
basic helix-loop-helix family, member e41
chr9_-_34448477 2.021 NM_001184940
NM_001184941
NM_001184942
NM_001184943
NM_001184944
NM_001184945
NM_147202
C9orf25






chromosome 9 open reading frame 25






chr2_+_109112428 2.018 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr3_-_188945921 1.995 BCL6
B-cell CLL/lymphoma 6
chr9_-_16717887 1.975 BNC2
basonuclin 2
chr15_+_72006015 1.913 LOXL1
lysyl oxidase-like 1
chr1_+_199884152 1.912 NAV1
neuron navigator 1
chr10_+_52504239 1.910 NM_006258
PRKG1
protein kinase, cGMP-dependent, type I
chr5_+_129268352 1.897 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr6_-_75972286 1.887 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr2_-_161058550 1.877 NM_002897
NM_016836
RBMS1

RNA binding motif, single stranded interacting protein 1

chr3_+_106568243 1.877 ALCAM
activated leukocyte cell adhesion molecule
chr7_+_27190688 1.864


chr5_-_72779585 1.853 FOXD1
forkhead box D1
chr2_-_68400516 1.850 NM_001111101
NM_015463
CNRIP1

cannabinoid receptor interacting protein 1

chrX_-_34585287 1.843 NM_031442
TMEM47
transmembrane protein 47
chr19_-_45888259 1.835 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr10_+_59942874 1.831 NM_001080512
BICC1
bicaudal C homolog 1 (Drosophila)
chr5_+_42459568 1.817 NM_000163
GHR
growth hormone receptor
chr11_-_88864061 1.817 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr20_-_22978141 1.815 NM_000361
THBD
thrombomodulin
chr14_+_85066265 1.812 FLRT2
fibronectin leucine rich transmembrane protein 2
chr12_+_62524778 1.792 NM_020762
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
chr1_+_182622987 1.792 C1orf21
chromosome 1 open reading frame 21
chr1_-_72521079 1.790


chr16_+_85158357 1.785 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr15_+_41597097 1.772 NM_002373
MAP1A
microtubule-associated protein 1A
chr3_-_87122936 1.769 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr4_-_111763655 1.762 NM_000325
PITX2
paired-like homeodomain 2
chr8_-_108579270 1.758 NM_001146
ANGPT1
angiopoietin 1
chr4_-_111763356 1.756 PITX2
paired-like homeodomain 2
chr3_-_87122958 1.752 VGLL3
vestigial like 3 (Drosophila)
chr15_-_53667800 1.736 PYGO1
pygopus homolog 1 (Drosophila)
chr13_-_25523164 1.731 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr11_-_10272256 1.705 NM_030962
SBF2
SET binding factor 2
chr14_+_85066207 1.704 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr11_+_19691397 1.688 NM_145117
NM_182964
NAV2

neuron navigator 2

chr14_-_26136799 1.687 NM_002515
NM_006489
NM_006491
NOVA1


neuro-oncological ventral antigen 1


chr17_+_1905104 1.685 NM_006497
HIC1
hypermethylated in cancer 1
chr14_+_32478209 1.684 NM_001164749
NM_001165893
NM_022123
NM_173159
NPAS3



neuronal PAS domain protein 3



chr11_+_94141151 1.678 NM_130847
AMOTL1
angiomotin like 1
chr16_+_1524162 1.661 NM_024600
TMEM204
transmembrane protein 204
chr1_-_158091296 1.656 C1orf204
chromosome 1 open reading frame 204
chr3_-_16530132 1.646 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr12_-_74711474 1.645 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr4_-_122063118 1.641 NM_018699
PRDM5
PR domain containing 5
chr6_-_78229838 1.635 NM_000863
HTR1B
5-hydroxytryptamine (serotonin) receptor 1B
chr6_-_91063301 1.602 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr13_+_100902942 1.600 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr9_-_109291130 1.592 KLF4
Kruppel-like factor 4 (gut)
chr8_-_13178327 1.589


chr10_-_60792666 1.584 NM_001143773
FAM13C
family with sequence similarity 13, member C
chr2_-_156897286 1.579 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr3_-_189354510 1.577 LOC339929
hypothetical LOC339929
chr17_+_56832492 1.573 TBX2
T-box 2
chr5_-_146869811 1.568 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr7_-_78920806 1.564 NM_012301
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr9_-_79835970 1.561 NM_002072
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
chr19_-_1518875 1.555 NM_001174118
NM_203304
MEX3D

mex-3 homolog D (C. elegans)

chr19_-_19793512 1.548 NM_001099269
NM_001145404
ZNF506

zinc finger protein 506

chrX_+_66683075 1.542 AR
androgen receptor
chr10_-_60792225 1.528 NM_001001971
NM_001166698
NM_198215
FAM13C


family with sequence similarity 13, member C


chr17_+_56832255 1.526 TBX2
T-box 2
chr12_+_26239535 1.526 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr2_+_238200922 1.525 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr2_+_23461802 1.523 NM_052920
KLHL29
kelch-like 29 (Drosophila)
chrX_+_51503219 1.516 NM_018094
GSPT2
G1 to S phase transition 2
chr5_-_146869613 1.511 DPYSL3
dihydropyrimidinase-like 3
chr10_+_72102563 1.510 NM_080722
NM_139155
ADAMTS14

ADAM metallopeptidase with thrombospondin type 1 motif, 14

chr10_+_111755715 1.503 NM_019903
ADD3
adducin 3 (gamma)
chr11_+_110916629 1.495 LAYN
layilin
chr4_+_108965167 1.490 NM_001136258
SGMS2
sphingomyelin synthase 2
chr1_-_72520735 1.490 NM_173808
NEGR1
neuronal growth regulator 1
chr2_-_160972606 1.481 RBMS1
RNA binding motif, single stranded interacting protein 1
chr5_-_58370693 1.480 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr11_+_101290930 1.468 NM_020802
KIAA1377
KIAA1377
chr5_+_40715799 1.467 PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr2_-_236741352 1.465 NM_001485
GBX2
gastrulation brain homeobox 2
chr8_-_89408832 1.460 NM_005941
MMP16
matrix metallopeptidase 16 (membrane-inserted)
chr12_+_56406296 1.458 LOC100130776
hypothetical LOC100130776
chr3_+_112273464 1.456 NM_015480
PVRL3
poliovirus receptor-related 3
chr3_-_185025989 1.451 NM_024871
MAP6D1
MAP6 domain containing 1
chr5_+_40715778 1.448 NM_000958
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr7_-_41709191 1.417 NM_002192
INHBA
inhibin, beta A
chr15_-_50608296 1.406 NM_000259
NM_001142495
MYO5A

myosin VA (heavy chain 12, myoxin)

chr7_+_115926679 1.396 NM_001233
NM_198212
CAV2

caveolin 2

chr7_+_116099648 1.395 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr9_-_83493415 1.387 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr17_+_56831951 1.387 NM_005994
TBX2
T-box 2
chr9_-_112381593 1.380 NM_153366
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr3_-_114947681 1.379 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr11_+_131285747 1.368 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr1_-_203447314 1.364 NM_015375
NM_199462
DSTYK

dual serine/threonine and tyrosine protein kinase

chr12_-_29827952 1.353 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr2_+_85213884 1.350 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr7_-_19123765 1.344 TWIST1
twist homolog 1 (Drosophila)
chrX_+_149282097 1.338 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr15_-_23659329 1.338 NM_024490
ATP10A
ATPase, class V, type 10A
chr1_-_143643324 1.332 NM_001002811
PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_85816520 1.323 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr3_+_49002285 1.319 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr7_-_19123787 1.313 NM_000474
TWIST1
twist homolog 1 (Drosophila)
chr12_+_95112385 1.310 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr19_+_43572679 1.307 NM_001039616
NM_001042522
SPRED3

sprouty-related, EVH1 domain containing 3

chr3_+_49002774 1.305 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr12_-_106011715 1.301 NM_004075
CRY1
cryptochrome 1 (photolyase-like)
chr12_+_52665196 1.297 NM_017409
HOXC10
homeobox C10
chr20_+_52525538 1.288 NM_018431
DOK5
docking protein 5
chr3_+_189354167 1.279 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr5_-_107034484 1.279 NM_001962
EFNA5
ephrin-A5
chrX_-_83329562 1.278 NM_014496
RPS6KA6
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr11_-_85108030 1.278 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr2_+_56265260 1.278


chr20_+_6696744 1.277 NM_001200
BMP2
bone morphogenetic protein 2
chr9_-_109290107 1.259 KLF4
Kruppel-like factor 4 (gut)
chr20_-_55718351 1.259 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr13_-_107317460 1.255 NM_001080396
FAM155A
family with sequence similarity 155, member A
chr2_-_210744158 1.252 NM_152519
C2orf67
chromosome 2 open reading frame 67
chr18_+_54681657 1.247 ZNF532
zinc finger protein 532
chr11_-_129803515 1.247 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr15_-_81037554 1.244 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr14_-_102593384 1.243 NM_006035
CDC42BPB
CDC42 binding protein kinase beta (DMPK-like)
chr14_+_37748345 1.233 SSTR1
somatostatin receptor 1
chr5_-_112658200 1.232 MCC
mutated in colorectal cancers
chr13_-_43259032 1.229 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr9_+_129893948 1.227 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr17_+_56888588 1.221 NM_018488
TBX4
T-box 4
chr8_-_13178399 1.217 DLC1
deleted in liver cancer 1
chr8_+_104222052 1.217 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr15_+_97009194 1.204 IGF1R
insulin-like growth factor 1 receptor
chr4_-_138673014 1.204 PCDH18
protocadherin 18
chr7_+_28415495 1.188 LOC401317
hypothetical LOC401317
chr15_-_80125514 1.188 MEX3B
mex-3 homolog B (C. elegans)
chr19_-_36531958 1.184 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr2_+_12774264 1.181 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr8_-_11096257 1.178 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr5_+_17270474 1.177 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr19_-_50977592 1.175 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr5_-_37875538 1.174 NM_000514
GDNF
glial cell derived neurotrophic factor
chr12_-_93568336 1.168 NM_020698
TMCC3
transmembrane and coiled-coil domain family 3
chr2_-_183610992 1.166 NCKAP1
NCK-associated protein 1
chr16_-_62573 1.165 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr15_-_32875040 1.164 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr10_-_105604942 1.164 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr1_+_64709063 1.162 NM_020925
CACHD1
cache domain containing 1
chr6_+_71434192 1.162 NM_001044305
NM_021940
SMAP1

small ArfGAP 1

chr22_-_34754343 1.160 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr7_+_78920846 1.153 LOC100505881
hypothetical LOC100505881
chr12_-_94708477 1.141 NTN4
netrin 4
chr15_+_45796802 1.141 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr17_+_52026058 1.140 NM_005450
NOG
noggin
chr6_+_1556543 1.136 FOXC1
forkhead box C1
chr13_+_113546841 1.134 NM_000820
GAS6
growth arrest-specific 6
chr1_-_33669190 1.133 PHC2
polyhomeotic homolog 2 (Drosophila)
chr5_+_17270781 1.131 BASP1
brain abundant, membrane attached signal protein 1
chr2_+_36436316 1.129 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr10_-_106088151 1.129 ITPRIP
inositol 1,4,5-triphosphate receptor interacting protein

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.19 5.96e-19 GO:0050794 regulation of cellular process
1.17 8.51e-17 GO:0050789 regulation of biological process
1.38 1.60e-15 GO:0048523 negative regulation of cellular process
1.15 4.40e-15 GO:0065007 biological regulation
1.26 2.49e-14 GO:0032502 developmental process
1.43 3.25e-13 GO:0009653 anatomical structure morphogenesis
1.67 7.90e-13 GO:0007167 enzyme linked receptor protein signaling pathway
1.25 8.62e-13 GO:0023052 signaling
1.33 8.65e-13 GO:0048519 negative regulation of biological process
1.26 1.03e-12 GO:0007275 multicellular organismal development
1.09 1.35e-12 GO:0009987 cellular process
1.27 3.32e-12 GO:0048856 anatomical structure development
1.31 4.31e-12 GO:0048522 positive regulation of cellular process
1.28 8.97e-12 GO:0048731 system development
1.72 1.94e-11 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.25 2.16e-11 GO:0007165 signal transduction
1.75 2.65e-11 GO:0072358 cardiovascular system development
1.75 2.65e-11 GO:0072359 circulatory system development
1.96 2.94e-11 GO:0001944 vasculature development
1.33 4.89e-11 GO:0048869 cellular developmental process
1.33 7.28e-11 GO:0030154 cell differentiation
1.28 1.25e-10 GO:0048518 positive regulation of biological process
1.49 1.20e-09 GO:0022008 neurogenesis
1.39 5.39e-09 GO:0051239 regulation of multicellular organismal process
1.36 1.12e-08 GO:0007399 nervous system development
1.48 1.47e-08 GO:0048699 generation of neurons
1.32 1.95e-08 GO:0007166 cell surface receptor linked signaling pathway
1.45 4.44e-08 GO:0048468 cell development
1.86 7.07e-08 GO:0001568 blood vessel development
1.19 1.02e-07 GO:0051716 cellular response to stimulus
1.32 1.26e-07 GO:0023051 regulation of signaling
1.21 1.38e-07 GO:0080090 regulation of primary metabolic process
1.21 2.12e-07 GO:0060255 regulation of macromolecule metabolic process
1.41 2.64e-07 GO:0042981 regulation of apoptosis
1.40 2.76e-07 GO:0043067 regulation of programmed cell death
1.20 5.28e-07 GO:0031323 regulation of cellular metabolic process
1.39 7.01e-07 GO:0010941 regulation of cell death
1.58 1.10e-06 GO:0000904 cell morphogenesis involved in differentiation
1.49 1.15e-06 GO:0030182 neuron differentiation
1.15 1.16e-06 GO:0032501 multicellular organismal process
1.89 1.23e-06 GO:0048514 blood vessel morphogenesis
1.49 1.30e-06 GO:0045595 regulation of cell differentiation
1.28 1.80e-06 GO:0006464 protein modification process
1.62 1.92e-06 GO:0007409 axonogenesis
1.17 2.95e-06 GO:0044260 cellular macromolecule metabolic process
1.32 3.52e-06 GO:0009966 regulation of signal transduction
1.72 4.35e-06 GO:0022603 regulation of anatomical structure morphogenesis
1.41 4.43e-06 GO:0050793 regulation of developmental process
1.52 4.62e-06 GO:0048666 neuron development
1.49 4.78e-06 GO:0030030 cell projection organization
1.18 4.97e-06 GO:0019222 regulation of metabolic process
1.56 6.02e-06 GO:0031175 neuron projection development
1.59 7.21e-06 GO:0048812 neuron projection morphogenesis
1.37 7.30e-06 GO:0010646 regulation of cell communication
1.59 7.37e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.49 7.72e-06 GO:0032989 cellular component morphogenesis
1.38 8.58e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.49 1.28e-05 GO:0000902 cell morphogenesis
1.53 2.85e-05 GO:0048858 cell projection morphogenesis
1.35 2.95e-05 GO:0051246 regulation of protein metabolic process
1.22 2.95e-05 GO:0044267 cellular protein metabolic process
1.42 3.56e-05 GO:2000026 regulation of multicellular organismal development
1.56 4.25e-05 GO:0010648 negative regulation of cell communication
1.33 5.17e-05 GO:0010604 positive regulation of macromolecule metabolic process
1.51 5.53e-05 GO:0032990 cell part morphogenesis
1.25 5.98e-05 GO:0043412 macromolecule modification
1.31 1.06e-04 GO:0009893 positive regulation of metabolic process
1.62 1.13e-04 GO:0007411 axon guidance
1.35 1.16e-04 GO:0032268 regulation of cellular protein metabolic process
1.56 1.23e-04 GO:0009968 negative regulation of signal transduction
1.54 1.26e-04 GO:0023057 negative regulation of signaling
1.39 1.38e-04 GO:0051128 regulation of cellular component organization
1.43 1.68e-04 GO:0042325 regulation of phosphorylation
1.29 1.92e-04 GO:0035556 intracellular signal transduction
1.88 1.98e-04 GO:0001525 angiogenesis
1.42 2.14e-04 GO:0009790 embryo development
1.40 2.22e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.51 2.23e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.63 2.31e-04 GO:0032870 cellular response to hormone stimulus
1.41 2.44e-04 GO:0019220 regulation of phosphate metabolic process
1.41 2.44e-04 GO:0051174 regulation of phosphorus metabolic process
1.74 2.69e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.62 2.82e-04 GO:0060284 regulation of cell development
1.37 2.85e-04 GO:0040011 locomotion
1.21 2.89e-04 GO:0010556 regulation of macromolecule biosynthetic process
1.31 3.63e-04 GO:0031325 positive regulation of cellular metabolic process
1.19 4.85e-04 GO:0009889 regulation of biosynthetic process
1.33 5.53e-04 GO:0006793 phosphorus metabolic process
1.33 5.53e-04 GO:0006796 phosphate metabolic process
1.20 6.98e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.40 7.49e-04 GO:0010628 positive regulation of gene expression
1.47 7.83e-04 GO:0043068 positive regulation of programmed cell death
1.19 8.20e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.46 8.48e-04 GO:0010942 positive regulation of cell death
1.47 8.71e-04 GO:0043065 positive regulation of apoptosis
1.58 8.75e-04 GO:0071495 cellular response to endogenous stimulus
1.43 9.65e-04 GO:0042060 wound healing
1.19 9.72e-04 GO:0031326 regulation of cellular biosynthetic process
1.42 1.03e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.90 1.21e-03 GO:0008286 insulin receptor signaling pathway
1.41 1.24e-03 GO:0001932 regulation of protein phosphorylation
1.32 1.25e-03 GO:0007154 cell communication
1.19 1.27e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.58 1.33e-03 GO:0001501 skeletal system development
1.13 1.37e-03 GO:0043170 macromolecule metabolic process
1.37 1.53e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.32 1.80e-03 GO:0032879 regulation of localization
1.32 1.95e-03 GO:0042127 regulation of cell proliferation
1.50 2.11e-03 GO:0016477 cell migration
1.39 2.40e-03 GO:0051254 positive regulation of RNA metabolic process
1.35 2.86e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.37 2.92e-03 GO:0006915 apoptosis
1.34 2.95e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.35 3.31e-03 GO:0031399 regulation of protein modification process
1.34 3.37e-03 GO:0009891 positive regulation of biosynthetic process
1.48 3.54e-03 GO:0008285 negative regulation of cell proliferation
1.36 3.79e-03 GO:0012501 programmed cell death
1.44 4.64e-03 GO:0048585 negative regulation of response to stimulus
1.65 5.92e-03 GO:0071375 cellular response to peptide hormone stimulus
1.62 5.97e-03 GO:0000165 MAPKKK cascade
1.73 6.12e-03 GO:0032869 cellular response to insulin stimulus
1.32 6.40e-03 GO:0008219 cell death
1.32 6.44e-03 GO:0016265 death
1.21 7.69e-03 GO:0048583 regulation of response to stimulus
1.18 7.82e-03 GO:0010468 regulation of gene expression
1.57 7.95e-03 GO:0051270 regulation of cellular component movement
1.35 8.35e-03 GO:0006468 protein phosphorylation
1.49 8.82e-03 GO:0007264 small GTPase mediated signal transduction
1.16 1.02e-02 GO:0019538 protein metabolic process
1.62 1.10e-02 GO:0030168 platelet activation
1.34 1.22e-02 GO:0007267 cell-cell signaling
1.56 1.27e-02 GO:0040012 regulation of locomotion
1.44 1.43e-02 GO:0048870 cell motility
1.44 1.43e-02 GO:0051674 localization of cell
1.43 1.57e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.56 1.74e-02 GO:0061061 muscle structure development
1.15 1.84e-02 GO:0016043 cellular component organization
1.57 2.05e-02 GO:0030334 regulation of cell migration
1.49 2.20e-02 GO:0006917 induction of apoptosis
1.18 2.31e-02 GO:0051252 regulation of RNA metabolic process
1.82 2.39e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.87 2.41e-02 GO:0035023 regulation of Rho protein signal transduction
1.48 2.56e-02 GO:0012502 induction of programmed cell death
2.85 2.57e-02 GO:0030199 collagen fibril organization
1.30 2.57e-02 GO:0031324 negative regulation of cellular metabolic process
1.38 2.75e-02 GO:0006928 cellular component movement
1.39 2.99e-02 GO:0070727 cellular macromolecule localization
1.34 3.00e-02 GO:0009890 negative regulation of biosynthetic process
1.20 3.04e-02 GO:0048513 organ development
1.29 3.11e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.16 3.12e-02 GO:0071842 cellular component organization at cellular level
1.81 3.12e-02 GO:0022604 regulation of cell morphogenesis
1.39 3.32e-02 GO:0034613 cellular protein localization
1.55 3.53e-02 GO:2000145 regulation of cell motility
1.40 3.64e-02 GO:0043549 regulation of kinase activity
1.34 3.98e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.28 4.06e-02 GO:0009892 negative regulation of metabolic process
1.18 4.82e-02 GO:0006355 regulation of transcription, DNA-dependent
1.29 4.88e-02 GO:0009888 tissue development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.07 7.96e-08 GO:0005622 intracellular
1.07 2.70e-07 GO:0044424 intracellular part
1.43 7.33e-05 GO:0030054 cell junction
1.52 8.41e-05 GO:0043005 neuron projection
1.08 1.23e-04 GO:0005737 cytoplasm
1.50 2.48e-04 GO:0045202 synapse
1.16 5.80e-04 GO:0043234 protein complex
1.76 5.97e-04 GO:0070161 anchoring junction
1.79 7.06e-04 GO:0005912 adherens junction
1.19 7.34e-04 GO:0044459 plasma membrane part
1.61 1.21e-02 GO:0030425 dendrite
2.06 1.38e-02 GO:0030427 site of polarized growth
1.28 1.46e-02 GO:0042995 cell projection
2.05 2.02e-02 GO:0030426 growth cone
1.60 2.71e-02 GO:0031252 cell leading edge
1.19 3.01e-02 GO:0005856 cytoskeleton
1.38 3.80e-02 GO:0044463 cell projection part
1.09 3.90e-02 GO:0005634 nucleus
1.16 4.91e-02 GO:0005829 cytosol

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 6.91e-21 GO:0005515 protein binding
1.09 3.60e-14 GO:0005488 binding
1.49 1.22e-07 GO:0043565 sequence-specific DNA binding
1.38 1.41e-06 GO:0001071 nucleic acid binding transcription factor activity
1.38 1.41e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.36 4.70e-06 GO:0030528 transcription regulator activity
1.36 4.42e-04 GO:0019899 enzyme binding
1.93 8.27e-04 GO:0051020 GTPase binding
1.77 1.30e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.58 1.80e-03 GO:0032403 protein complex binding
2.07 2.51e-03 GO:0019199 transmembrane receptor protein kinase activity
1.99 3.29e-03 GO:0017016 Ras GTPase binding
1.18 3.93e-03 GO:0000166 nucleotide binding
1.93 3.96e-03 GO:0031267 small GTPase binding
1.38 7.71e-03 GO:0008092 cytoskeletal protein binding
1.94 9.16e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
2.05 1.15e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.40 1.21e-02 GO:0030695 GTPase regulator activity
1.38 2.07e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.39 2.49e-02 GO:0019904 protein domain specific binding