Motif ID: NFE2.p2

Z-value: 1.200


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2chr12_-_529809840.467.1e-02Click!


Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_156923111 2.919 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chrX_-_100527799 2.725 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr5_-_141041982 2.628 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr11_+_118463906 2.433 NM_001024382
HMBS
hydroxymethylbilane synthase
chr22_+_21495273 2.418


chr3_-_197549640 2.404 NM_138461
TM4SF19
transmembrane 4 L six family member 19
chr10_-_6059460 2.306 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr3_-_197549588 2.296 TM4SF19
transmembrane 4 L six family member 19
chrX_-_154216929 2.233 NM_001289
CLIC2
chloride intracellular channel 2
chr5_-_141041933 2.190 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr7_-_86526880 2.153 NM_001142749
KIAA1324L
KIAA1324-like
chr12_-_15005761 2.126 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr1_+_12046020 2.035 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chrX_+_65299352 1.918 HEPH
hephaestin
chr11_+_384199 1.881 NM_007183
PKP3
plakophilin 3
chr6_+_106653429 1.814 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr11_+_20342262 1.786 NM_001098523
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr4_+_22608252 1.772


chr22_+_21370394 1.747 IGL@
immunoglobulin lambda locus
chr12_-_51629874 1.746 KRT8
keratin 8
chr1_-_93030538 1.731 NM_005665
EVI5
ecotropic viral integration site 5
chr1_+_173111306 1.713 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chrX_+_65299157 1.710 NM_138737
HEPH
hephaestin
chr18_+_54039818 1.670 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_-_84197573 1.650 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr4_-_38710376 1.647 NM_024943
TMEM156
transmembrane protein 156
chr22_-_25343959 1.621 NM_001887
CRYBB1
crystallin, beta B1
chr6_-_84197370 1.611 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr6_+_34314545 1.607 NM_145905
HMGA1
high mobility group AT-hook 1
chr6_-_84197463 1.601 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr6_-_84197477 1.593 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr10_+_70745615 1.587 NM_033496
HK1
hexokinase 1
chr3_+_154035425 1.584 NM_002563
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr18_+_54039779 1.563 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_-_21502993 1.558 NEBL
nebulette
chr11_+_20341900 1.552 NM_001098522
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr15_+_38849450 1.535 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr18_+_54039730 1.504 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_+_20341835 1.484 NM_001098520
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr22_-_25344037 1.479 CRYBB1
crystallin, beta B1
chr6_-_28429950 1.472 NM_145909
ZNF323
zinc finger protein 323
chr11_+_20341806 1.439 NM_006410
NM_001098521
HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

chr19_-_54350457 1.405 NM_002152
HRC
histidine rich calcium binding protein
chr11_+_384238 1.388 PKP3
plakophilin 3
chrX_+_9391314 1.384 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr3_+_70131572 1.369


chr19_-_53935648 1.342 NM_017805
RASIP1
Ras interacting protein 1
chr17_-_77474597 1.320 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr1_+_153232685 1.308 NM_018655
LENEP
lens epithelial protein
chr16_-_87570716 1.282 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr16_-_1369613 1.233 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr11_-_8982107 1.229 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr5_-_169657312 1.218 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr4_-_174687104 1.218 HAND2
heart and neural crest derivatives expressed 2
chr1_-_159257567 1.217 F11R
F11 receptor
chr2_-_85494639 1.200 CAPG
capping protein (actin filament), gelsolin-like
chr2_-_85494664 1.188 CAPG
capping protein (actin filament), gelsolin-like
chr13_-_98757634 1.183 NM_004951
GPR183
G protein-coupled receptor 183
chr12_-_68369322 1.181 NM_152439
BEST3
bestrophin 3
chr11_+_67107641 1.174 NM_000852
GSTP1
glutathione S-transferase pi 1
chr5_-_169657395 1.174 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_-_30792830 1.163 MDC1
mediator of DNA-damage checkpoint 1
chr10_-_76538859 1.162 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr11_+_10434056 1.158 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr11_+_67107852 1.146 GSTP1
glutathione S-transferase pi 1
chr2_+_169634330 1.141 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr4_-_977163 1.135 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr1_+_181421984 1.124 LAMC2
laminin, gamma 2
chr19_-_48976852 1.072 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_-_223683141 1.067 NM_194442
LBR
lamin B receptor
chr5_-_169657192 1.063 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr1_-_159257595 1.047 NM_016946
F11R
F11 receptor
chr4_+_74825138 1.039 NM_000584
IL8
interleukin 8
chr17_-_35975227 1.035 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr6_+_44302973 1.025 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr4_+_111053488 1.018 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chrX_+_12903145 1.003 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr5_-_169657360 0.984 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr10_-_21503025 0.969 NM_001173484
NM_213569
NEBL

nebulette

chr1_-_159257486 0.958 F11R
F11 receptor
chr6_-_31812049 0.954 CLIC1
chloride intracellular channel 1
chr6_-_31853027 0.943 NM_025258
C6orf27
chromosome 6 open reading frame 27
chrX_-_15421279 0.942 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr22_+_20715340 0.934


chr18_+_9875722 0.925 NM_001098529
NM_032243
TXNDC2

thioredoxin domain containing 2 (spermatozoa)

chrX_-_152863251 0.924 NM_002910
RENBP
renin binding protein
chr22_+_21393107 0.910 IGLJ3
immunoglobulin lambda joining 3
chrX_-_53327473 0.909 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr22_+_21042091 0.908 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr22_+_21053972 0.901


chr19_-_56260135 0.887 NM_015596
KLK13
kallikrein-related peptidase 13
chr16_+_88696172 0.885 FAM157C
family with sequence similarity 157, member C
chrX_-_39921525 0.881 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr4_-_145159889 0.878 NM_002100
GYPB
glycophorin B (MNS blood group)
chr19_+_45564549 0.870 PLD3
phospholipase D family, member 3
chr6_-_31812072 0.867 CLIC1
chloride intracellular channel 1
chr22_+_43451600 0.866 PRR5
proline rich 5 (renal)
chr7_-_150352484 0.864 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr20_+_33223434 0.864 NM_006404
PROCR
protein C receptor, endothelial
chr6_+_32229278 0.846 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chrX_-_10761729 0.843 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr1_+_89763030 0.843 LRRC8B
leucine rich repeat containing 8 family, member B
chr12_-_51585004 0.839 NM_002273
KRT8
keratin 8
chrX_-_152938528 0.837 NM_001025242
NM_001025243
NM_001569
IRAK1


interleukin-1 receptor-associated kinase 1


chrX_+_69314060 0.837 NM_198512
DGAT2L6
diacylglycerol O-acyltransferase 2-like 6
chr4_+_170817787 0.836 CLCN3
chloride channel 3
chr22_+_18388656 0.835 C22orf25
chromosome 22 open reading frame 25
chr17_+_72827185 0.833 NM_006640
SEPT9
septin 9
chr1_+_181421796 0.832 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr12_-_53099269 0.829 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr17_+_72827227 0.827 SEPT9
septin 9
chr19_-_48977247 0.823 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_+_17507276 0.816 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr19_-_4510713 0.803 SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr9_-_139042416 0.801 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr22_+_19699441 0.798 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr16_+_28413421 0.796 NM_018690
APOBR
apolipoprotein B receptor
chr6_-_30793436 0.796 NM_014641
MDC1
mediator of DNA-damage checkpoint 1
chr11_+_60039461 0.791 NM_001012417
NM_001100909
MS4A13

membrane-spanning 4-domains, subfamily A, member 13

chr9_+_130231027 0.785 CERCAM
cerebral endothelial cell adhesion molecule
chr6_-_31812251 0.785 CLIC1
chloride intracellular channel 1
chrX_-_152938441 0.783 IRAK1
interleukin-1 receptor-associated kinase 1
chr7_+_142205266 0.782


chr6_-_31812260 0.782 CLIC1
chloride intracellular channel 1
chr6_-_31812214 0.776 CLIC1
chloride intracellular channel 1
chr19_+_10388448 0.776 PDE4A
phosphodiesterase 4A, cAMP-specific
chr15_+_38318528 0.775 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr6_-_29563657 0.774 NM_052967
MAS1L
MAS1 oncogene-like
chr17_+_22823151 0.768 NM_014238
KSR1
kinase suppressor of ras 1
chr19_+_3317536 0.767 NM_005597
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr4_+_88076418 0.761


chr22_+_21116283 0.758


chr6_-_31812297 0.748 NM_001288
CLIC1
chloride intracellular channel 1
chr22_+_43451351 0.746 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr6_-_31812283 0.745 CLIC1
chloride intracellular channel 1
chr6_+_41712907 0.744 MDFI
MyoD family inhibitor
chr1_-_203916160 0.740 SLC45A3
solute carrier family 45, member 3
chr9_-_139042526 0.737 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr1_+_226399026 0.736 NM_001159391
GUK1
guanylate kinase 1
chr6_-_31812266 0.731 CLIC1
chloride intracellular channel 1
chr12_-_53099203 0.727 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr7_+_26298018 0.726 NM_013322
SNX10
sorting nexin 10
chr17_-_39700960 0.725 NM_000342
SLC4A1
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
chr15_-_58477407 0.719 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr19_+_3317575 0.716 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr1_-_205272619 0.715 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr9_-_130006309 0.703 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr17_+_53769659 0.696 LOC100506779
hypothetical LOC100506779
chr7_+_139175420 0.694 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr6_+_56927882 0.690 BEND6
BEN domain containing 6
chr15_-_74091817 0.688 NM_138573
NRG4
neuregulin 4
chr1_+_181422016 0.687 LAMC2
laminin, gamma 2
chr11_+_62405736 0.676 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr2_+_102401580 0.673 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chrX_-_152938456 0.665 IRAK1
interleukin-1 receptor-associated kinase 1
chr12_-_53099277 0.662 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr6_+_56927665 0.661 NM_152731
BEND6
BEN domain containing 6
chr19_+_3317589 0.660 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr7_-_128330615 0.660 KCP
kielin/chordin-like protein
chr22_+_21006814 0.652


chr9_+_131291224 0.652 LOC100506190
hypothetical LOC100506190
chr22_+_21340757 0.644


chr12_-_37585602 0.639 NM_153634
CPNE8
copine VIII
chr19_-_56653460 0.636 NM_014442
SIGLEC8
sialic acid binding Ig-like lectin 8
chr6_+_32229599 0.632 NM_005155
PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr17_-_31231421 0.629 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr19_+_43486640 0.628 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr6_-_50025115 0.626 NM_001166478
DEFB133
defensin, beta 133
chr12_-_8110268 0.626 C3AR1
complement component 3a receptor 1
chr11_+_62405801 0.622 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr22_+_20899155 0.620


chr22_+_21464980 0.619


chr7_-_102772304 0.617 NM_001129887
NM_014377
DNAJC2

DnaJ (Hsp40) homolog, subfamily C, member 2

chr1_-_157313179 0.616 NM_004833
AIM2
absent in melanoma 2
chr12_-_46439127 0.612 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr8_-_13018123 0.610 NM_001164271
DLC1
deleted in liver cancer 1
chr22_-_17846711 0.607 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr4_-_145046109 0.605 NM_002102
NM_198682
GYPE

glycophorin E (MNS blood group)

chr7_+_26298136 0.604 SNX10
sorting nexin 10
chr17_+_7279485 0.602 NM_178518
TMEM102
transmembrane protein 102
chr22_+_20316968 0.601 NM_152612
CCDC116
coiled-coil domain containing 116
chr12_+_54808220 0.601 NM_001184796
NM_015292
ESYT1

extended synaptotagmin-like protein 1

chr9_+_139292094 0.598 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr22_+_21011653 0.596


chr6_-_35996915 0.589 NM_003137
SRPK1
SRSF protein kinase 1
chr2_+_172658453 0.588 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr8_-_11242408 0.578 LOC100129129
hypothetical LOC100129129
chrX_+_133952633 0.577 NM_001163438
LOC644538
hypothetical protein LOC644538
chr1_+_221966849 0.569 CAPN2
calpain 2, (m/II) large subunit
chr1_-_199259133 0.566 KIF21B
kinesin family member 21B
chr1_+_221966835 0.565 CAPN2
calpain 2, (m/II) large subunit
chr12_-_55316350 0.563 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chrX_-_129072152 0.563 NM_001421
ELF4
E74-like factor 4 (ets domain transcription factor)
chr6_-_35996794 0.562 SRPK1
SRSF protein kinase 1
chr6_-_35996867 0.559 SRPK1
SRSF protein kinase 1
chr17_+_77910411 0.557 NM_207459
TEX19
testis expressed 19
chr4_-_139382672 0.549 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr12_+_54808310 0.546 ESYT1
extended synaptotagmin-like protein 1
chr12_+_54808344 0.546 ESYT1
extended synaptotagmin-like protein 1
chr9_+_131291144 0.545



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.76 2.97e-04 GO:0043067 regulation of programmed cell death
1.75 3.94e-04 GO:0042981 regulation of apoptosis
1.73 6.02e-04 GO:0010941 regulation of cell death
4.51 9.02e-03 GO:0006521 regulation of cellular amino acid metabolic process
4.02 1.64e-02 GO:0033238 regulation of cellular amine metabolic process
1.31 2.31e-02 GO:0007165 signal transduction
1.29 2.35e-02 GO:0023052 signaling
1.60 2.90e-02 GO:0051246 regulation of protein metabolic process
2.19 3.93e-02 GO:0031401 positive regulation of protein modification process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.38 3.63e-04 GO:0000502 proteasome complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.68 1.52e-03 GO:0005126 cytokine receptor binding