Motif ID: TFAP2B.p2

Z-value: 3.823


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_50894397-0.351.8e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_5533967 6.173 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr19_+_39664706 4.813 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr2_-_127580975 4.465 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr7_-_139987044 4.424 DENND2A
DENN/MADD domain containing 2A
chr20_+_56701224 4.122 NM_024663
NPEPL1
aminopeptidase-like 1
chr5_+_10617431 3.846 NM_001164440
ANKRD33B
ankyrin repeat domain 33B
chr11_+_93917214 3.474 FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chrX_+_9943793 3.458 NM_015691
WWC3
WWC family member 3
chr2_-_160972606 3.419 RBMS1
RNA binding motif, single stranded interacting protein 1
chr3_-_130807865 3.396 NM_015103
PLXND1
plexin D1
chr16_-_79395379 3.382 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr19_-_1518875 3.288 NM_001174118
NM_203304
MEX3D

mex-3 homolog D (C. elegans)

chr7_+_1536847 3.264 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr9_-_38059082 3.067 SHB
Src homology 2 domain containing adaptor protein B
chr17_+_78630793 3.039 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr22_-_48607449 2.991 BRD1
bromodomain containing 1
chr14_+_105012106 2.905 NM_001312
CRIP2
cysteine-rich protein 2
chr17_-_74432800 2.799 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_+_148388870 2.767 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr19_+_16296632 2.702 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr13_+_110565587 2.661 NM_001113511
NM_001113512
NM_145735
ARHGEF7


Rho guanine nucleotide exchange factor (GEF) 7


chr1_+_148389039 2.643 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr1_-_95165089 2.600 NM_001839
CNN3
calponin 3, acidic
chr11_+_1367665 2.589 NM_003957
BRSK2
BR serine/threonine kinase 2
chr4_+_89147821 2.588 NM_000297
PKD2
polycystic kidney disease 2 (autosomal dominant)
chr2_+_241586927 2.584 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr17_-_53387493 2.566 CUEDC1
CUE domain containing 1
chr20_+_8060762 2.565 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr9_+_127549437 2.549 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr14_-_29466562 2.544 NM_002742
PRKD1
protein kinase D1
chr13_-_27967215 2.515 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr16_+_88169612 2.469 NM_014427
NM_153636
CPNE7

copine VII

chr20_-_4177519 2.463 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr12_+_26003218 2.444 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr19_+_18391423 2.440


chr17_-_74433048 2.409 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr4_+_14614462 2.400 CPEB2
cytoplasmic polyadenylation element binding protein 2
chr4_-_7991992 2.395 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr1_+_148388719 2.385 NM_016274
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr17_+_56831951 2.360 NM_005994
TBX2
T-box 2
chr19_+_16296734 2.352 KLF2
Kruppel-like factor 2 (lung)
chr11_-_110087982 2.326 ARHGAP20
Rho GTPase activating protein 20
chr22_-_27405708 2.319 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chr6_+_1335067 2.307 NM_001452
FOXF2
forkhead box F2
chr22_-_41446740 2.303 NM_017436
A4GALT
alpha 1,4-galactosyltransferase
chr15_-_53667800 2.303 PYGO1
pygopus homolog 1 (Drosophila)
chr1_+_199884152 2.272 NAV1
neuron navigator 1
chr19_+_1358664 2.266 DAZAP1
DAZ associated protein 1
chr1_+_9275542 2.241 SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr1_-_1465602 2.224 NM_001114748
C1orf70
chromosome 1 open reading frame 70
chr10_-_725522 2.203 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr1_-_29321599 2.180 NM_001171868
TMEM200B
transmembrane protein 200B
chr17_-_74432671 2.175 TIMP2
TIMP metallopeptidase inhibitor 2
chr14_+_99329198 2.174 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr12_-_105165805 2.159 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr8_+_17058170 2.128 NM_016353
ZDHHC2
zinc finger, DHHC-type containing 2
chr12_+_63958949 2.123 NM_001193461
MSRB3
methionine sulfoxide reductase B3
chr7_+_55922623 2.119 ZNF713
zinc finger protein 713
chr4_+_151218862 2.116 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr4_+_6835363 2.099 KIAA0232
KIAA0232
chr10_+_123913094 2.097 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr5_+_14196287 2.094 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chr1_+_179148935 2.094 NM_020950
KIAA1614
KIAA1614
chr11_-_110088330 2.094 NM_020809
ARHGAP20
Rho GTPase activating protein 20
chr2_+_109112428 2.093 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr5_+_98132898 2.087 NM_001012761
RGMB
RGM domain family, member B
chr2_-_239987629 2.078 HDAC4
histone deacetylase 4
chr17_-_19711580 2.042 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr18_-_24011349 2.037 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr9_-_38059207 2.035 NM_003028
SHB
Src homology 2 domain containing adaptor protein B
chr7_-_50828608 2.033 NM_001001555
GRB10
growth factor receptor-bound protein 10
chr2_-_133144094 1.999 LYPD1
LY6/PLAUR domain containing 1
chr4_-_177950658 1.979 NM_005429
VEGFC
vascular endothelial growth factor C
chr1_+_22909916 1.969 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr16_+_88517187 1.967 NM_006086
TUBB3
tubulin, beta 3
chr10_+_123912930 1.962 TACC2
transforming, acidic coiled-coil containing protein 2
chr5_+_34692239 1.961 RAI14
retinoic acid induced 14
chr13_+_97593411 1.961 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr1_-_95165037 1.956 CNN3
calponin 3, acidic
chr15_-_62854749 1.947 NM_194272
RBPMS2
RNA binding protein with multiple splicing 2
chr10_+_11100111 1.938 CELF2
CUGBP, Elav-like family member 2
chr4_-_2233504 1.938 NM_006454
MXD4
MAX dimerization protein 4
chr1_+_199884072 1.935 NM_020443
NAV1
neuron navigator 1
chr14_+_23908141 1.935 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr17_+_56832492 1.933 TBX2
T-box 2
chr6_-_117193505 1.909 NM_001085480
FAM162B
family with sequence similarity 162, member B
chr12_+_50271283 1.907 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr14_+_23907065 1.862 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr17_+_17525571 1.858


chr7_-_150576634 1.851 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr7_-_150576660 1.851 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr21_+_45649429 1.835 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr6_+_72055229 1.820 OGFRL1
opioid growth factor receptor-like 1
chr13_+_30378311 1.819 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr19_+_18391211 1.807 NM_001009998
NM_032627
SSBP4

single stranded DNA binding protein 4

chr4_-_1232882 1.778 NM_001012614
NM_001328
CTBP1

C-terminal binding protein 1

chr21_+_45649719 1.775


chr7_+_90063543 1.771 CDK14
cyclin-dependent kinase 14
chr12_+_47498778 1.762 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr10_+_11100075 1.750 CELF2
CUGBP, Elav-like family member 2
chr9_+_138680064 1.730 EGFL7
EGF-like-domain, multiple 7
chr17_+_72880967 1.727 SEPT9
septin 9
chr2_-_239987557 1.717 NM_006037
HDAC4
histone deacetylase 4
chr17_+_1906262 1.716 NM_001098202
HIC1
hypermethylated in cancer 1
chr1_-_85703321 1.712 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr19_-_1188840 1.708 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr7_+_18093068 1.707 HDAC9
histone deacetylase 9
chr3_-_126257425 1.707 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr19_+_1358531 1.702 NM_018959
NM_170711
DAZAP1

DAZ associated protein 1

chr17_-_8006979 1.702 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr6_-_112682038 1.701 LAMA4
laminin, alpha 4
chr4_+_72271218 1.697 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr22_-_45512708 1.692 CERK
ceramide kinase
chr11_+_12355600 1.692 NM_018222
PARVA
parvin, alpha
chr4_+_1842947 1.690 WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr11_-_77806500 1.680 NM_080491
GAB2
GRB2-associated binding protein 2
chr19_-_8581559 1.679 NM_030957
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr5_+_34692352 1.677 NM_001145520
RAI14
retinoic acid induced 14
chr6_+_3696224 1.676


chr11_-_77806413 1.673 GAB2
GRB2-associated binding protein 2
chr14_+_58174489 1.672 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr8_-_93184629 1.671 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr6_-_169865990 1.664 PHF10
PHD finger protein 10
chr14_+_54102518 1.650 LOC644925
hypothetical LOC644925
chr2_-_110769670 1.650 NM_001164463
NM_005054
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr6_-_3697244 1.646 NM_183373
C6orf145
chromosome 6 open reading frame 145
chr2_-_197883739 1.637 NM_001195144
NM_153697
ANKRD44

ankyrin repeat domain 44

chr22_-_49041786 1.635 MAPK12
mitogen-activated protein kinase 12
chr16_+_11669736 1.635 NM_003498
SNN
stannin
chr13_+_109757593 1.634 NM_001846
COL4A2
collagen, type IV, alpha 2
chr4_-_2233606 1.634 MXD4
MAX dimerization protein 4
chr6_+_72055197 1.631 NM_024576
OGFRL1
opioid growth factor receptor-like 1
chr12_+_120132319 1.621 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr10_-_30388439 1.601 NM_020848
KIAA1462
KIAA1462
chr15_-_53822468 1.598 NM_173814
PRTG
protogenin
chr3_+_160964574 1.594 SCHIP1
schwannomin interacting protein 1
chr15_-_23659329 1.593 NM_024490
ATP10A
ATPase, class V, type 10A
chr8_+_107351519 1.587 NM_001198533
NM_018002
LOC346887
OXR1

similar to solute carrier family 16 (monocarboxylic acid transporters), member 14
oxidation resistance 1

chr4_-_1232742 1.579 CTBP1
C-terminal binding protein 1
chr15_+_29406335 1.576 NM_015995
KLF13
Kruppel-like factor 13
chr22_-_48607199 1.575 BRD1
bromodomain containing 1
chr17_+_75808685 1.563 NM_001166347
NM_001166348
NM_001166349
NM_173626
SLC26A11



solute carrier family 26, member 11



chr18_+_12648191 1.561


chr1_-_85703198 1.560 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr6_-_132764257 1.551 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr10_+_122206455 1.550 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr3_+_61522922 1.548 PTPRG
protein tyrosine phosphatase, receptor type, G
chr4_+_3264509 1.547 RGS12
regulator of G-protein signaling 12
chr5_-_176833197 1.543 DBN1
drebrin 1
chr20_-_38751289 1.540 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr4_+_6835388 1.536 KIAA0232
KIAA0232
chr5_-_178704934 1.536 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr13_+_97593469 1.530 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr14_+_104785898 1.529 NM_033271
BTBD6
BTB (POZ) domain containing 6
chr21_-_43671355 1.525 NM_173354
SIK1
salt-inducible kinase 1
chr15_+_45797977 1.523 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr2_+_176702667 1.518 NM_019558
HOXD8
homeobox D8
chr18_+_18969724 1.516 NM_001100619
CABLES1
Cdk5 and Abl enzyme substrate 1
chr9_-_129701644 1.504 NM_013443
ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr9_+_136673534 1.499 COL5A1
collagen, type V, alpha 1
chr9_-_25668230 1.492 TUSC1
tumor suppressor candidate 1
chr14_+_76297885 1.490 NM_014909
VASH1
vasohibin 1
chr11_+_93916653 1.488 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr12_+_63958689 1.482 NM_001031679
NM_001193460
NM_198080
MSRB3


methionine sulfoxide reductase B3


chr11_+_7997366 1.473 TUB
tubby homolog (mouse)
chr8_+_30361485 1.467 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr2_+_42128521 1.464 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr10_+_104394185 1.463 NM_030912
TRIM8
tripartite motif containing 8
chr6_-_169866011 1.463 NM_018288
NM_133325
PHF10

PHD finger protein 10

chr1_+_181259317 1.461


chr22_-_41447214 1.461 A4GALT
alpha 1,4-galactosyltransferase
chr1_-_40009513 1.459 NM_022120
OXCT2
3-oxoacid CoA transferase 2
chr13_-_112392051 1.452 LOC440149
hypothetical LOC440149
chr20_-_3944035 1.451 NM_007219
NM_001134337
NM_001134338
RNF24


ring finger protein 24


chr5_-_158459006 1.450 EBF1
early B-cell factor 1
chr19_+_1358750 1.449 DAZAP1
DAZ associated protein 1
chr17_-_40263124 1.449 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr2_+_205118801 1.447 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr20_-_46877811 1.445 NM_020820
PREX1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr11_-_110088097 1.445 ARHGAP20
Rho GTPase activating protein 20
chr4_-_141896920 1.445 NM_015130
TBC1D9
TBC1 domain family, member 9 (with GRAM domain)
chr19_+_50196526 1.444 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr8_+_38763911 1.440 TACC1
transforming, acidic coiled-coil containing protein 1
chr16_-_1404635 1.437 NM_001037125
NM_001193388
UNKL

unkempt homolog (Drosophila)-like

chr11_+_2355119 1.434 NM_004356
CD81
CD81 molecule
chr19_-_4016467 1.434 ZBTB7A
zinc finger and BTB domain containing 7A
chr17_-_1029758 1.423 NM_021962
ABR
active BCR-related gene
chr15_-_68933481 1.420 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr19_+_1358604 1.419 DAZAP1
DAZ associated protein 1
chr22_+_38075703 1.416 NM_004711
NM_145731
SYNGR1

synaptogyrin 1

chr16_+_68233 1.416 MPG
N-methylpurine-DNA glycosylase
chr13_+_97593711 1.413 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr1_-_54644269 1.410 SSBP3
single stranded DNA binding protein 3
chr2_+_149895274 1.398 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr22_+_36286350 1.391 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr14_+_76297536 1.386


chr10_+_128583984 1.384 NM_001380
DOCK1
dedicator of cytokinesis 1
chr10_+_11099860 1.381 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr4_-_140696740 1.380 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr2_-_144991386 1.375 ZEB2
zinc finger E-box binding homeobox 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 2.31e-22 GO:0009987 cellular process
1.16 2.16e-21 GO:0044237 cellular metabolic process
1.20 1.18e-20 GO:0044260 cellular macromolecule metabolic process
1.13 4.99e-17 GO:0008152 metabolic process
1.17 6.42e-17 GO:0043170 macromolecule metabolic process
1.14 4.98e-16 GO:0044238 primary metabolic process
1.28 6.81e-16 GO:0048523 negative regulation of cellular process
1.21 6.88e-16 GO:0071840 cellular component organization or biogenesis
1.21 1.35e-15 GO:0016043 cellular component organization
1.24 5.46e-15 GO:0071841 cellular component organization or biogenesis at cellular level
1.24 8.16e-15 GO:0071842 cellular component organization at cellular level
1.25 1.18e-13 GO:0048519 negative regulation of biological process
1.11 2.33e-11 GO:0050794 regulation of cellular process
1.11 9.08e-11 GO:0050789 regulation of biological process
1.10 1.33e-10 GO:0065007 biological regulation
1.27 6.39e-10 GO:0006996 organelle organization
1.21 3.52e-09 GO:0048522 positive regulation of cellular process
1.19 2.65e-08 GO:0044267 cellular protein metabolic process
1.25 4.61e-08 GO:0023051 regulation of signaling
1.42 4.90e-08 GO:0000902 cell morphogenesis
1.16 5.44e-08 GO:0006807 nitrogen compound metabolic process
1.17 6.65e-08 GO:0034641 cellular nitrogen compound metabolic process
1.18 6.94e-08 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.45 8.58e-08 GO:0000904 cell morphogenesis involved in differentiation
1.40 8.81e-08 GO:0032989 cellular component morphogenesis
1.39 1.36e-07 GO:0007167 enzyme linked receptor protein signaling pathway
1.26 1.63e-07 GO:0009966 regulation of signal transduction
1.18 2.14e-07 GO:0048518 positive regulation of biological process
1.43 2.51e-07 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.15 8.24e-07 GO:0031323 regulation of cellular metabolic process
1.19 9.33e-07 GO:0090304 nucleic acid metabolic process
1.24 1.00e-06 GO:0009653 anatomical structure morphogenesis
1.30 1.09e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.21 1.40e-06 GO:0006464 protein modification process
1.14 1.88e-06 GO:0032502 developmental process
1.19 2.34e-06 GO:0048869 cellular developmental process
1.31 2.84e-06 GO:0048699 generation of neurons
1.20 3.23e-06 GO:0043412 macromolecule modification
1.15 5.29e-06 GO:0019538 protein metabolic process
1.17 6.56e-06 GO:0044249 cellular biosynthetic process
1.21 6.78e-06 GO:0016070 RNA metabolic process
1.30 7.01e-06 GO:0022008 neurogenesis
1.19 8.59e-06 GO:0030154 cell differentiation
1.28 9.00e-06 GO:0007049 cell cycle
1.39 1.33e-05 GO:0032990 cell part morphogenesis
1.39 1.69e-05 GO:0048858 cell projection morphogenesis
1.14 1.70e-05 GO:0007275 multicellular organismal development
1.20 1.79e-05 GO:0010467 gene expression
1.43 1.89e-05 GO:0007409 axonogenesis
1.14 1.94e-05 GO:0080090 regulation of primary metabolic process
1.29 2.03e-05 GO:0048468 cell development
1.25 2.04e-05 GO:0031325 positive regulation of cellular metabolic process
1.25 2.41e-05 GO:0010604 positive regulation of macromolecule metabolic process
1.14 2.45e-05 GO:0048856 anatomical structure development
1.41 2.48e-05 GO:0048812 neuron projection morphogenesis
1.13 2.69e-05 GO:0019222 regulation of metabolic process
1.42 2.78e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.39 3.82e-05 GO:0031175 neuron projection development
1.30 3.98e-05 GO:0051128 regulation of cellular component organization
1.57 4.10e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.22 4.30e-05 GO:0007399 nervous system development
1.16 4.42e-05 GO:0009058 biosynthetic process
1.33 1.02e-04 GO:0030030 cell projection organization
1.23 1.05e-04 GO:0009893 positive regulation of metabolic process
1.43 1.27e-04 GO:0051056 regulation of small GTPase mediated signal transduction
1.13 1.30e-04 GO:0060255 regulation of macromolecule metabolic process
1.46 1.35e-04 GO:0060284 regulation of cell development
1.28 1.60e-04 GO:0006351 transcription, DNA-dependent
1.14 2.08e-04 GO:0048731 system development
1.21 2.70e-04 GO:0035556 intracellular signal transduction
1.27 3.01e-04 GO:0031324 negative regulation of cellular metabolic process
1.44 3.15e-04 GO:0007411 axon guidance
1.51 3.23e-04 GO:0030036 actin cytoskeleton organization
1.19 3.51e-04 GO:0034645 cellular macromolecule biosynthetic process
1.19 4.13e-04 GO:0009059 macromolecule biosynthetic process
1.25 4.26e-04 GO:0009892 negative regulation of metabolic process
1.40 6.10e-04 GO:0007264 small GTPase mediated signal transduction
1.35 7.78e-04 GO:0007010 cytoskeleton organization
1.25 8.14e-04 GO:0050793 regulation of developmental process
1.27 9.19e-04 GO:0022402 cell cycle process
1.25 1.32e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.21 1.65e-03 GO:0051641 cellular localization
1.27 1.69e-03 GO:2000026 regulation of multicellular organismal development
1.31 2.02e-03 GO:0048666 neuron development
1.28 2.22e-03 GO:0006915 apoptosis
1.29 2.32e-03 GO:0045595 regulation of cell differentiation
1.68 2.95e-03 GO:0007265 Ras protein signal transduction
1.30 3.55e-03 GO:0000278 mitotic cell cycle
1.23 3.80e-03 GO:0032774 RNA biosynthetic process
1.27 3.98e-03 GO:0006468 protein phosphorylation
1.27 4.61e-03 GO:0012501 programmed cell death
1.21 5.30e-03 GO:0044248 cellular catabolic process
1.27 9.13e-03 GO:0030182 neuron differentiation
1.22 9.32e-03 GO:0006793 phosphorus metabolic process
1.22 9.32e-03 GO:0006796 phosphate metabolic process
1.41 9.39e-03 GO:0030029 actin filament-based process
1.35 9.86e-03 GO:0009968 negative regulation of signal transduction
1.29 9.96e-03 GO:0010629 negative regulation of gene expression
1.28 1.04e-02 GO:0051726 regulation of cell cycle
1.13 1.05e-02 GO:0010468 regulation of gene expression
1.26 1.17e-02 GO:0009790 embryo development
1.37 1.17e-02 GO:0044419 interspecies interaction between organisms
1.44 1.26e-02 GO:0050767 regulation of neurogenesis
1.24 1.37e-02 GO:0033554 cellular response to stress
1.33 1.37e-02 GO:0010648 negative regulation of cell communication
1.47 1.45e-02 GO:0045786 negative regulation of cell cycle
1.24 1.48e-02 GO:0046907 intracellular transport
1.15 1.48e-02 GO:0048583 regulation of response to stimulus
1.23 1.51e-02 GO:0008219 cell death
1.32 1.85e-02 GO:0023057 negative regulation of signaling
1.26 1.92e-02 GO:0022403 cell cycle phase
1.18 1.94e-02 GO:0009056 catabolic process
1.35 1.95e-02 GO:0016568 chromatin modification
1.26 2.00e-02 GO:0051254 positive regulation of RNA metabolic process
1.13 2.27e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.23 2.54e-02 GO:0016265 death
1.12 2.67e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.36 3.41e-02 GO:0071495 cellular response to endogenous stimulus
1.54 3.67e-02 GO:0031344 regulation of cell projection organization
1.18 3.79e-02 GO:0033036 macromolecule localization
1.76 3.91e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.37 4.10e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.25 4.81e-02 GO:0010628 positive regulation of gene expression

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 8.11e-53 GO:0005622 intracellular
1.13 1.04e-51 GO:0044424 intracellular part
1.14 3.86e-41 GO:0043226 organelle
1.14 8.55e-41 GO:0043229 intracellular organelle
1.15 2.60e-39 GO:0043227 membrane-bounded organelle
1.15 9.77e-39 GO:0043231 intracellular membrane-bounded organelle
1.16 8.44e-37 GO:0005737 cytoplasm
1.19 5.87e-26 GO:0005634 nucleus
1.16 1.26e-21 GO:0044444 cytoplasmic part
1.16 5.58e-20 GO:0044446 intracellular organelle part
1.16 6.05e-20 GO:0044422 organelle part
1.29 2.73e-18 GO:0044428 nuclear part
1.28 5.64e-14 GO:0031981 nuclear lumen
1.23 1.54e-12 GO:0070013 intracellular organelle lumen
1.23 1.73e-12 GO:0031974 membrane-enclosed lumen
1.23 1.82e-12 GO:0043233 organelle lumen
1.24 2.02e-12 GO:0005829 cytosol
1.04 2.80e-12 GO:0044464 cell part
1.04 3.15e-12 GO:0005623 cell
1.30 1.15e-11 GO:0005654 nucleoplasm
1.33 4.21e-07 GO:0044451 nucleoplasm part
1.71 2.43e-06 GO:0005912 adherens junction
1.64 3.16e-06 GO:0031252 cell leading edge
1.13 1.58e-05 GO:0032991 macromolecular complex
1.20 1.60e-05 GO:0012505 endomembrane system
1.14 2.11e-05 GO:0043234 protein complex
1.17 2.30e-05 GO:0031090 organelle membrane
2.01 3.02e-05 GO:0031256 leading edge membrane
1.14 3.62e-05 GO:0043228 non-membrane-bounded organelle
1.14 3.62e-05 GO:0043232 intracellular non-membrane-bounded organelle
1.61 4.09e-05 GO:0070161 anchoring junction
1.66 1.62e-03 GO:0030055 cell-substrate junction
2.04 2.18e-03 GO:0017053 transcriptional repressor complex
1.39 2.58e-03 GO:0015629 actin cytoskeleton
2.07 4.39e-03 GO:0000118 histone deacetylase complex
1.16 5.04e-03 GO:0005856 cytoskeleton
1.64 5.09e-03 GO:0005924 cell-substrate adherens junction
1.24 6.05e-03 GO:0015630 microtubule cytoskeleton
1.63 1.06e-02 GO:0005925 focal adhesion
1.25 1.39e-02 GO:0030054 cell junction
1.30 2.12e-02 GO:0043005 neuron projection
1.34 2.21e-02 GO:0005773 vacuole
1.19 2.97e-02 GO:0005794 Golgi apparatus
1.19 4.00e-02 GO:0042995 cell projection
1.72 4.07e-02 GO:0030427 site of polarized growth
1.73 4.50e-02 GO:0030426 growth cone
1.36 4.65e-02 GO:0005635 nuclear envelope

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 1.31e-31 GO:0005515 protein binding
1.07 6.22e-19 GO:0005488 binding
1.49 9.35e-06 GO:0008134 transcription factor binding
1.42 2.90e-05 GO:0000988 protein binding transcription factor activity
1.42 2.90e-05 GO:0000989 transcription factor binding transcription factor activity
1.41 4.16e-05 GO:0003712 transcription cofactor activity
1.25 7.17e-05 GO:0030528 transcription regulator activity
1.24 1.69e-04 GO:0001071 nucleic acid binding transcription factor activity
1.24 1.69e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.25 2.16e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.18 2.27e-04 GO:0016740 transferase activity
1.32 2.47e-04 GO:0008092 cytoskeletal protein binding
1.42 3.51e-04 GO:0016563 transcription activator activity
1.26 6.41e-04 GO:0016301 kinase activity
1.14 7.32e-04 GO:0000166 nucleotide binding
1.11 1.08e-03 GO:0003676 nucleic acid binding
1.26 1.14e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.25 2.06e-03 GO:0019899 enzyme binding
1.40 2.07e-03 GO:0016564 transcription repressor activity
1.08 2.39e-03 GO:0003824 catalytic activity
1.32 2.48e-03 GO:0030695 GTPase regulator activity
1.56 4.20e-03 GO:0003714 transcription corepressor activity
1.15 5.44e-03 GO:0017076 purine nucleotide binding
1.31 6.09e-03 GO:0019904 protein domain specific binding
1.16 6.73e-03 GO:0030554 adenyl nucleotide binding
1.14 7.70e-03 GO:0032553 ribonucleotide binding
1.14 7.70e-03 GO:0032555 purine ribonucleotide binding
1.30 8.23e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.16 9.04e-03 GO:0032559 adenyl ribonucleotide binding
1.15 9.05e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.31 1.12e-02 GO:0004674 protein serine/threonine kinase activity
1.26 1.17e-02 GO:0004672 protein kinase activity
1.16 1.20e-02 GO:0005524 ATP binding
1.35 1.27e-02 GO:0003779 actin binding