Motif ID: NFE2.p2

Z-value: 0.934


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2chr12_-_52980984-0.341.9e-01Click!


Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_141041982 1.337 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr12_+_76749199 1.317 NM_014903
NAV3
neuron navigator 3
chr5_+_150000394 1.218 NM_001109974
NM_007286
SYNPO

synaptopodin

chr5_-_141041933 1.107 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr11_-_6298284 0.937 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr5_+_35892747 0.883 NM_002185
IL7R
interleukin 7 receptor
chr14_+_62740878 0.841 NM_020663
RHOJ
ras homolog gene family, member J
chrX_+_99786044 0.809 SRPX2
sushi-repeat containing protein, X-linked 2
chr2_-_85494639 0.778 CAPG
capping protein (actin filament), gelsolin-like
chr11_-_102174102 0.775 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr9_-_116920232 0.775 NM_002160
TNC
tenascin C
chr18_+_59405513 0.754 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr10_-_102780840 0.752 PDZD7
PDZ domain containing 7
chr11_-_102174032 0.726 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr7_-_42243142 0.716 NM_000168
GLI3
GLI family zinc finger 3
chr10_-_30064600 0.708 NM_003174
SVIL
supervillin
chrX_-_15593074 0.706 NM_020665
TMEM27
transmembrane protein 27
chr7_-_42243318 0.696 GLI3
GLI family zinc finger 3
chrX_+_12903145 0.693 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr11_-_65860450 0.693 NM_004292
RIN1
Ras and Rab interactor 1
chr11_-_66898223 0.674 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr10_-_88720908 0.665 LOC100133190
hypothetical LOC100133190
chrX_-_10761729 0.662 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr19_+_43502380 0.659 KCNK6
potassium channel, subfamily K, member 6
chr19_+_43572679 0.656 NM_001039616
NM_001042522
SPRED3

sprouty-related, EVH1 domain containing 3

chr11_-_6633427 0.644 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr3_-_48607596 0.629 NM_000094
COL7A1
collagen, type VII, alpha 1
chr16_+_2023279 0.618 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr2_-_85494664 0.604 CAPG
capping protein (actin filament), gelsolin-like
chr1_-_45045543 0.601 NM_001013632
TCTEX1D4
Tctex1 domain containing 4
chrX_+_99785818 0.599 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr18_+_19706979 0.598 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr18_+_59788242 0.596 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr1_+_17507276 0.593 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr14_-_95011790 0.587 NM_152592
C14orf49
chromosome 14 open reading frame 49
chr11_+_67107641 0.586 NM_000852
GSTP1
glutathione S-transferase pi 1
chr15_-_38417564 0.574 C15orf52
chromosome 15 open reading frame 52
chr16_-_3025542 0.555 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr20_-_1257782 0.549 SDCBP2
syndecan binding protein (syntenin) 2
chr1_-_89261021 0.547 NM_018284
GBP3
guanylate binding protein 3
chr17_+_21131940 0.534 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chrX_+_149282097 0.530 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr9_-_129381086 0.528 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr2_+_132890616 0.526 NM_001508
GPR39
G protein-coupled receptor 39
chr7_+_22733290 0.521 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr5_-_149515613 0.519 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr5_+_148501178 0.517 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr16_+_82544327 0.516 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr10_+_134751398 0.512 NM_001083909
GPR123
G protein-coupled receptor 123
chr9_-_139042526 0.511 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr5_-_149515502 0.501 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr12_-_54646061 0.500 NM_006928
PMEL
premelanosome protein
chr1_-_6474346 0.493 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr19_-_53935648 0.485 NM_017805
RASIP1
Ras interacting protein 1
chr18_+_59593591 0.475 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr15_+_84021271 0.472 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr2_+_28469275 0.472 NM_005253
FOSL2
FOS-like antigen 2
chr5_+_176807931 0.471 NM_001174102
PRR7
proline rich 7 (synaptic)
chr11_+_67107852 0.463 GSTP1
glutathione S-transferase pi 1
chr1_-_115682374 0.463 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr12_-_51153788 0.463 NM_173086
KRT6C
keratin 6C
chr11_-_128399218 0.460 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr8_-_145097031 0.455 NM_201380
PLEC
plectin
chr1_+_152644471 0.448 IL6R
interleukin 6 receptor
chr19_-_40939756 0.442 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr3_+_106568334 0.442 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr1_+_81544432 0.442 LPHN2
latrophilin 2
chr1_+_151147646 0.441 NM_005547
IVL
involucrin
chr3_+_30622905 0.441 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr5_-_149515331 0.441 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr12_-_15005761 0.436 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr3_+_120799411 0.435 NM_015900
PLA1A
phospholipase A1 member A
chr17_-_36928604 0.434 NM_002275
KRT15
keratin 15
chr1_+_148747208 0.432 ECM1
extracellular matrix protein 1
chr19_+_43486640 0.431 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr7_-_128330615 0.430 KCP
kielin/chordin-like protein
chrX_-_53327473 0.428 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr1_-_84237316 0.428 NM_024686
TTLL7
tubulin tyrosine ligase-like family, member 7
chr8_-_145088679 0.426 NM_201383
PLEC
plectin
chr22_-_43040063 0.425 NM_001099294
KIAA1644
KIAA1644
chr12_-_49897743 0.424 POU6F1
POU class 6 homeobox 1
chr4_-_87500398 0.423 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr19_+_41322841 0.422 CAPNS1
calpain, small subunit 1
chr6_+_1556543 0.421 FOXC1
forkhead box C1
chr16_+_55199978 0.416 NM_005953
MT2A
metallothionein 2A
chr6_+_74462630 0.416 CD109
CD109 molecule
chr11_+_35117226 0.416 CD44
CD44 molecule (Indian blood group)
chr15_+_78520634 0.413 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr11_-_65424434 0.412 FOSL1
FOS-like antigen 1
chr10_-_6059460 0.410 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr8_-_122722674 0.405 NM_005328
HAS2
hyaluronan synthase 2
chr4_+_40953698 0.404 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr11_+_47386621 0.403 NM_001128225
NM_152264
SLC39A13

solute carrier family 39 (zinc transporter), member 13

chr9_+_35528890 0.401 RUSC2
RUN and SH3 domain containing 2
chr17_-_18848713 0.400 NM_001039999
FAM83G
family with sequence similarity 83, member G
chr2_+_28469172 0.399 FOSL2
FOS-like antigen 2
chr12_-_54522881 0.397 NM_002429
MMP19
matrix metallopeptidase 19
chr3_+_11153778 0.395 NM_001098213
HRH1
histamine receptor H1
chr12_-_90097384 0.394 NM_133503
DCN
decorin
chr16_+_56219802 0.391 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr9_-_139042416 0.391 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr3_+_49002285 0.389 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr19_+_41119861 0.389 NM_024509
LRFN3
leucine rich repeat and fibronectin type III domain containing 3
chr11_+_128068982 0.388 NM_002017
FLI1
Friend leukemia virus integration 1
chr11_-_65424436 0.388 NM_005438
FOSL1
FOS-like antigen 1
chr1_-_151788341 0.387 NM_002960
S100A3
S100 calcium binding protein A3
chr8_-_26780665 0.387 ADRA1A
adrenergic, alpha-1A-, receptor
chr11_+_48303047 0.387 NM_001004702
OR4C3
olfactory receptor, family 4, subfamily C, member 3
chr16_+_88515917 0.386 NM_001197181
TUBB3
tubulin, beta 3
chr7_+_100557098 0.386 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr1_+_148747110 0.385 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr3_-_58175437 0.383 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr11_-_65424385 0.383 FOSL1
FOS-like antigen 1
chr21_-_35181956 0.382 RUNX1
runt-related transcription factor 1
chr6_+_106653429 0.381 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr17_+_58058479 0.379 NM_006039
MRC2
mannose receptor, C type 2
chr15_+_72315719 0.379 NM_025055
CCDC33
coiled-coil domain containing 33
chr7_+_1543644 0.379 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr15_+_99276982 0.378 NM_024652
LRRK1
leucine-rich repeat kinase 1
chr22_-_43986896 0.377 KIAA0930
KIAA0930
chr21_-_35343331 0.376 RUNX1
runt-related transcription factor 1
chr16_-_73830480 0.375 NM_001170721
BCAR1
breast cancer anti-estrogen resistance 1
chr6_+_74462654 0.370 CD109
CD109 molecule
chr15_-_68971665 0.369 NM_020147
THAP10
THAP domain containing 10
chr6_+_41712907 0.366 MDFI
MyoD family inhibitor
chr17_-_7064092 0.365 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr12_-_46439127 0.364 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr17_-_7063625 0.363 DLG4
discs, large homolog 4 (Drosophila)
chr7_+_90177082 0.362 CDK14
cyclin-dependent kinase 14
chr6_+_74462226 0.361 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr1_-_161105174 0.359 NM_178550
C1orf110
chromosome 1 open reading frame 110
chr11_+_62136788 0.358 NM_000327
ROM1
retinal outer segment membrane protein 1
chr3_-_48576204 0.357 NM_033199
UCN2
urocortin 2
chr9_+_35528628 0.356 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr7_+_1536847 0.353 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr11_+_101488380 0.352 NM_001195045
YAP1
Yes-associated protein 1
chr11_+_19328846 0.352 NM_001111018
NAV2
neuron navigator 2
chr16_+_4370879 0.352 VASN
vasorin
chr2_-_219566364 0.352 NM_005209
NM_057093
NM_057094
CRYBA2


crystallin, beta A2


chr1_-_17180659 0.351 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr16_+_15503623 0.351 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr11_+_128069203 0.351 FLI1
Friend leukemia virus integration 1
chr2_+_28469199 0.350 FOSL2
FOS-like antigen 2
chr16_+_55684031 0.346 CPNE2
copine II
chr20_-_1257809 0.346 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr9_+_130942029 0.345 PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr22_-_28972683 0.345 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr11_-_89248832 0.338 NM_001164397
TRIM64B
tripartite motif containing 64B
chr16_+_31274030 0.337 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chrX_-_19727828 0.337 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr9_-_101621964 0.337


chr19_-_3920736 0.336 NM_001348
DAPK3
death-associated protein kinase 3
chr14_-_104507862 0.335 AHNAK2
AHNAK nucleoprotein 2
chr3_-_115826481 0.335 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr17_+_77261401 0.333 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr19_+_12996368 0.330 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_-_176205672 0.329 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr1_+_152644292 0.328 NM_000565
NM_181359
IL6R

interleukin 6 receptor

chr18_+_41560915 0.327 NM_001146037
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr1_+_36394338 0.324 NM_018067
MAP7D1
MAP7 domain containing 1
chr18_+_59705918 0.323 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr3_+_106568243 0.323 ALCAM
activated leukocyte cell adhesion molecule
chr16_-_2848106 0.322 NM_022119
PRSS22
protease, serine, 22
chr17_-_35975227 0.321 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr11_+_47386707 0.320 SLC39A13
solute carrier family 39 (zinc transporter), member 13
chr21_-_35343448 0.320 RUNX1
runt-related transcription factor 1
chr9_-_34652629 0.319 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr14_+_22422270 0.318 NM_173527
REM2
RAS (RAD and GEM)-like GTP binding 2
chr13_+_52500830 0.317 NM_006418
OLFM4
olfactomedin 4
chr4_-_68678181 0.317 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr9_-_35101534 0.316 KIAA1539
KIAA1539
chr10_+_115302767 0.315 NM_004132
HABP2
hyaluronan binding protein 2
chr10_-_99521701 0.314 NM_003015
SFRP5
secreted frizzled-related protein 5
chr17_-_35911340 0.311 NM_032865
TNS4
tensin 4
chrX_-_110400406 0.311 NM_014289
CAPN6
calpain 6
chr19_+_12996830 0.310 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr6_+_74462577 0.309 CD109
CD109 molecule
chr14_+_78815406 0.309 NM_001105250
NM_138970
NRXN3

neurexin 3

chr17_-_36877002 0.308 NM_002278
KRT32
keratin 32
chr1_+_27541086 0.308 SYTL1
synaptotagmin-like 1
chr17_+_18566060 0.307 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr2_-_73170290 0.306 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr10_-_29963906 0.306 NM_021738
SVIL
supervillin
chr3_-_115825742 0.304 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_168381811 0.303 NM_001136107
METTL11B
methyltransferase like 11B
chr12_+_54611212 0.301 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chr1_+_152644668 0.298 IL6R
interleukin 6 receptor
chr1_+_109827975 0.297 NM_153340
ATXN7L2
ataxin 7-like 2
chrX_+_47326594 0.295 NM_003254
TIMP1
TIMP metallopeptidase inhibitor 1
chr11_+_35154775 0.293 CD44
CD44 molecule (Indian blood group)
chr7_-_1465487 0.291 MICALL2
MICAL-like 2
chr17_+_58058774 0.291 MRC2
mannose receptor, C type 2
chr16_+_66128843 0.290 NM_001193524
FAM65A
family with sequence similarity 65, member A
chr17_-_31231421 0.290 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr11_+_5916033 0.288


chr21_-_35343065 0.287 RUNX1
runt-related transcription factor 1
chr7_-_98305599 0.284 NM_001134450
NM_001134451
NM_152913
TMEM130


transmembrane protein 130


chr21_+_46367216 0.284 COL6A2
collagen, type VI, alpha 2
chr12_-_53099269 0.283 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr3_-_187744808 0.282 NM_017541
CRYGS
crystallin, gamma S

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.76 2.19e-04 GO:0051246 regulation of protein metabolic process
1.46 5.20e-04 GO:0048522 positive regulation of cellular process
1.42 1.22e-03 GO:0048518 positive regulation of biological process
1.54 3.17e-03 GO:0023051 regulation of signaling
1.49 3.92e-03 GO:0048583 regulation of response to stimulus
1.58 4.42e-03 GO:0009966 regulation of signal transduction
1.34 6.45e-03 GO:0007165 signal transduction
1.22 8.68e-03 GO:0050896 response to stimulus
3.44 9.50e-03 GO:0009612 response to mechanical stimulus
1.72 9.88e-03 GO:0009611 response to wounding
1.60 1.63e-02 GO:0050790 regulation of catalytic activity
1.85 1.69e-02 GO:0001932 regulation of protein phosphorylation
3.05 1.90e-02 GO:0031960 response to corticosteroid stimulus
2.05 2.07e-02 GO:0043086 negative regulation of catalytic activity
1.74 2.24e-02 GO:0031399 regulation of protein modification process
1.71 2.26e-02 GO:0009888 tissue development
1.80 2.80e-02 GO:0042325 regulation of phosphorylation
1.63 3.34e-02 GO:0032268 regulation of cellular protein metabolic process
1.62 3.35e-02 GO:0042981 regulation of apoptosis
1.78 3.37e-02 GO:0019220 regulation of phosphate metabolic process
1.78 3.37e-02 GO:0051174 regulation of phosphorus metabolic process
1.99 3.57e-02 GO:0051094 positive regulation of developmental process
1.29 3.59e-02 GO:0023052 signaling
1.73 4.03e-02 GO:0006955 immune response
1.92 4.43e-02 GO:0007599 hemostasis
1.61 4.54e-02 GO:0043067 regulation of programmed cell death
1.73 4.69e-02 GO:2000026 regulation of multicellular organismal development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.54 1.39e-05 GO:0005578 proteinaceous extracellular matrix
1.75 5.94e-05 GO:0044421 extracellular region part
2.25 2.05e-04 GO:0031012 extracellular matrix
1.45 2.63e-04 GO:0044459 plasma membrane part
1.30 4.30e-04 GO:0071944 cell periphery
1.29 5.71e-04 GO:0005886 plasma membrane
3.35 6.37e-04 GO:0044420 extracellular matrix part
1.86 2.11e-03 GO:0030054 cell junction
1.49 3.97e-03 GO:0005856 cytoskeleton
1.63 2.03e-02 GO:0005626 insoluble fraction
3.51 2.36e-02 GO:0005604 basement membrane
2.68 2.90e-02 GO:0043235 receptor complex
1.36 3.33e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.97 7.47e-05 GO:0005126 cytokine receptor binding