Motif ID: SOX2.p2

Z-value: 1.190


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_1829124050.543.2e-02Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_188021117 2.272 NM_005795
CALCRL
calcitonin receptor-like
chrX_+_86659370 2.127 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr3_-_150533948 2.066 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr9_+_18464090 2.040 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr1_-_197173159 1.899 LOC100131234
familial acute myelogenous leukemia related factor
chr6_+_12398514 1.853 NM_001168319
NM_001955
EDN1

endothelin 1

chr7_-_27186400 1.844 NM_153715
HOXA10
homeobox A10
chr10_-_13789628 1.817 FRMD4A
FERM domain containing 4A
chr9_+_18464138 1.767 ADAMTSL1
ADAMTS-like 1
chr12_-_6103945 1.674 NM_000552
VWF
von Willebrand factor
chr8_+_32623792 1.620 NM_013959
NRG1
neuregulin 1
chr8_-_124622434 1.541 NM_058229
FBXO32
F-box protein 32
chr4_-_101658094 1.515 NM_001159694
NM_016242
EMCN

endomucin

chr13_-_98428244 1.499 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr10_+_11246934 1.453 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chrX_+_77889861 1.449 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr2_-_37752272 1.443 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr10_+_11087280 1.424 CELF2
CUGBP, Elav-like family member 2
chr1_+_66570363 1.303 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr5_+_15553288 1.303 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr5_-_88235624 1.291 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr10_+_70517823 1.276 NM_002727
SRGN
serglycin
chr10_+_11087259 1.265 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr17_-_44006808 1.258 NM_002146
HOXB3
homeobox B3
chrX_-_139694248 1.238 NM_004065
CDR1
cerebellar degeneration-related protein 1, 34kDa
chr3_-_158704056 1.196 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr4_+_86918882 1.159 ARHGAP24
Rho GTPase activating protein 24
chr11_+_36274300 1.146 NM_001160167
PRR5L
proline rich 5 like
chr7_+_20337249 1.120 NM_002214
ITGB8
integrin, beta 8
chr6_+_114285209 1.116 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr3_+_174598937 1.090 NM_014932
NLGN1
neuroligin 1
chr7_-_27190882 1.087 HOXA11
homeobox A11
chr14_+_85066207 1.081 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr10_+_11247059 1.081 CELF2
CUGBP, Elav-like family member 2
chr1_-_68470585 1.067 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr7_-_27171673 1.061 NM_152739
HOXA9
homeobox A9
chr6_-_74284522 1.057 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr1_+_66230977 1.043 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr6_+_153060722 1.028 NM_025107
MYCT1
myc target 1
chr8_-_29262240 1.022 NM_057158
DUSP4
dual specificity phosphatase 4
chr3_-_170347019 1.020 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr4_+_110968594 1.019 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr6_+_130381408 0.994 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr9_+_115678365 0.993 NM_133374
ZNF618
zinc finger protein 618
chr6_-_139654807 0.992 NM_153235
TXLNB
taxilin beta
chr9_+_27099138 0.986 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr3_+_148593911 0.974


chr13_-_109757442 0.955 NM_001845
COL4A1
collagen, type IV, alpha 1
chr4_+_40953698 0.946 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr11_-_85107569 0.939 NM_206929
SYTL2
synaptotagmin-like 2
chr14_+_85066265 0.923 FLRT2
fibronectin leucine rich transmembrane protein 2
chr10_+_70517863 0.913 SRGN
serglycin
chr15_+_47502666 0.895 NM_002009
FGF7
fibroblast growth factor 7
chr21_-_38792173 0.879 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr7_+_28418668 0.876 NM_182898
CREB5
cAMP responsive element binding protein 5
chr10_-_88707299 0.871 NM_024756
MMRN2
multimerin 2
chr7_+_102340579 0.862 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr6_+_121798443 0.862 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_-_171441234 0.851 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr4_+_87070449 0.839 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr13_-_73606362 0.838 KLF12
Kruppel-like factor 12
chr12_+_50342814 0.834 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr2_-_151052391 0.830 NM_005168
RND3
Rho family GTPase 3
chr9_-_21472311 0.823 NM_176891
IFNE
interferon, epsilon
chr13_-_73605914 0.822 NM_007249
KLF12
Kruppel-like factor 12
chr7_-_41709191 0.821 NM_002192
INHBA
inhibin, beta A
chr1_+_161305558 0.818 NM_001113381
RGS4
regulator of G-protein signaling 4
chrX_+_15428820 0.792 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr17_-_30783631 0.791 NM_018042
SLFN12
schlafen family member 12
chr6_+_21701942 0.786 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr5_-_16989290 0.786 MYO10
myosin X
chr5_-_39400319 0.783 NM_001737
C9
complement component 9
chr2_-_160765008 0.779 ITGB6
integrin, beta 6
chr7_-_27108826 0.775 NM_006735
HOXA2
homeobox A2
chr3_-_194118627 0.772 NM_178496
MB21D2
Mab-21 domain containing 2
chrX_-_10605726 0.764 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr2_-_37752731 0.764 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr1_-_102234959 0.764 OLFM3
olfactomedin 3
chrX_-_128616594 0.763 NM_017413
APLN
apelin
chr1_+_85819004 0.763 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr15_-_80125403 0.759 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr11_+_10786137 0.758 LOC144017
hypothetical protein LOC144017
chr12_+_79362256 0.753 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr15_-_76890626 0.751 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr14_+_62740878 0.750 NM_020663
RHOJ
ras homolog gene family, member J
chr7_+_20336849 0.748 ITGB8
integrin, beta 8
chr3_-_194118321 0.745 MB21D2
Mab-21 domain containing 2
chr12_-_16649211 0.744 LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_+_44665220 0.743 NM_003420
ZNF35
zinc finger protein 35
chr17_-_59817456 0.738 PECAM1
platelet/endothelial cell adhesion molecule
chr3_-_158703821 0.738 NM_001167911
NM_001167912
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr8_-_93176618 0.734 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr10_-_62002672 0.733 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_-_140696740 0.731 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr5_+_140181405 0.722 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr5_-_83715947 0.717 EDIL3
EGF-like repeats and discoidin I-like domains 3
chr10_+_17311282 0.717 VIM
vimentin
chr9_-_14388981 0.714 NM_001190738
NFIB
nuclear factor I/B
chr3_-_58538110 0.713 FAM107A
family with sequence similarity 107, member A
chr3_-_121652183 0.708 NM_007085
FSTL1
follistatin-like 1
chr15_-_39973566 0.706 NM_016642
SPTBN5
spectrin, beta, non-erythrocytic 5
chr7_+_93388951 0.703 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr18_-_21186107 0.703 NM_015461
ZNF521
zinc finger protein 521
chr15_-_80125514 0.700 MEX3B
mex-3 homolog B (C. elegans)
chr1_+_194887630 0.697 NM_000186
NM_001014975
CFH

complement factor H

chr9_+_112470871 0.686 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr14_-_104515738 0.685 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr1_+_161305188 0.681 NM_005613
RGS4
regulator of G-protein signaling 4
chrX_-_142551587 0.678 NM_001184749
SLITRK4
SLIT and NTRK-like family, member 4
chr5_+_15553736 0.677 FBXL7
F-box and leucine-rich repeat protein 7
chr7_-_27180398 0.670 NM_018951
HOXA10
homeobox A10
chr12_-_41164010 0.666 PRICKLE1
prickle homolog 1 (Drosophila)
chr4_+_146623405 0.666 NM_001003688
SMAD1
SMAD family member 1
chr12_-_41164052 0.663 NM_001144882
NM_001144883
PRICKLE1

prickle homolog 1 (Drosophila)

chr12_-_69289889 0.661 NM_002837
PTPRB
protein tyrosine phosphatase, receptor type, B
chr1_+_43539239 0.657 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr9_-_14303509 0.653 NFIB
nuclear factor I/B
chrX_-_50573759 0.649 NM_020717
SHROOM4
shroom family member 4
chr6_-_75972473 0.648 COL12A1
collagen, type XII, alpha 1
chr5_+_15553539 0.647 FBXL7
F-box and leucine-rich repeat protein 7
chr10_+_53744043 0.646 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr12_-_16650697 0.641 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr15_-_81667773 0.640 HDGFRP3
hepatoma-derived growth factor, related protein 3
chr11_+_13646727 0.636 NM_032228
FAR1
fatty acyl CoA reductase 1
chr14_+_59934178 0.634


chr1_-_230717850 0.632 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr2_+_33213111 0.624 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr5_+_149960820 0.623 NM_001166208
SYNPO
synaptopodin
chr15_-_80123935 0.621 MEX3B
mex-3 homolog B (C. elegans)
chr1_+_176577228 0.619 NM_004841
RASAL2
RAS protein activator like 2
chr2_-_56266408 0.619 LOC100129434
hypothetical LOC100129434
chr17_+_8154280 0.619 NM_173728
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr3_-_150993299 0.614 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr2_-_189752575 0.613 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_+_89871231 0.611 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr17_-_16413188 0.609 NM_020653
ZNF287
zinc finger protein 287
chr3_+_153469421 0.608 MBNL1
muscleblind-like (Drosophila)
chr12_+_14429499 0.604 ATF7IP
activating transcription factor 7 interacting protein
chr15_+_37330176 0.603 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr1_+_216585298 0.600 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr2_+_206255376 0.598 NM_003872
NM_018534
NM_201264
NM_201266
NM_201267
NM_201279
NRP2





neuropilin 2





chr15_-_81667169 0.595 NM_016073
HDGFRP3
hepatoma-derived growth factor, related protein 3
chr17_-_35017691 0.590 NM_006160
NEUROD2
neurogenic differentiation 2
chr6_+_116939500 0.589 NM_153711
FAM26E
family with sequence similarity 26, member E
chr6_-_64087806 0.584 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr19_+_13767207 0.581 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr5_-_71838875 0.580 NM_152625
ZNF366
zinc finger protein 366
chr2_-_136590210 0.579 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr11_+_13646806 0.578 FAR1
fatty acyl CoA reductase 1
chr18_+_54681657 0.578 ZNF532
zinc finger protein 532
chr17_-_59817722 0.578 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr5_-_156935283 0.577


chr15_+_45797977 0.575 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr7_-_13997574 0.575 NM_001163148
ETV1
ets variant 1
chr9_+_90193058 0.574 NM_006717
SPIN1
spindlin 1
chrX_-_47815944 0.571 NM_001190255
ZNF630
zinc finger protein 630
chr9_+_36026900 0.570 NM_021111
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chr2_-_1727220 0.570 PXDN
peroxidasin homolog (Drosophila)
chr12_-_69434598 0.568 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr5_-_88155360 0.568 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr8_-_60194099 0.568 NM_014729
TOX
thymocyte selection-associated high mobility group box
chr6_+_100161370 0.566 NM_021620
PRDM13
PR domain containing 13
chr3_+_29297806 0.566 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr4_+_86918870 0.565 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr10_+_11247449 0.561 CELF2
CUGBP, Elav-like family member 2
chr11_+_5667494 0.561 NM_006074
TRIM22
tripartite motif containing 22
chr3_-_69254226 0.559 NM_198271
LMOD3
leiomodin 3 (fetal)
chr17_+_51585834 0.551 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr11_+_55319607 0.546 NM_001004735
OR5D14
olfactory receptor, family 5, subfamily D, member 14
chr1_-_95165089 0.544 NM_001839
CNN3
calponin 3, acidic
chr7_+_22733290 0.543 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr3_-_69212192 0.540 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr5_+_176494690 0.539 NSD1
nuclear receptor binding SET domain protein 1
chr16_+_64958025 0.535 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr11_-_14342627 0.535 NM_001177314
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr11_-_6633427 0.535 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr2_+_210152609 0.534 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr3_-_58538530 0.532 NM_001076778
NM_007177
FAM107A

family with sequence similarity 107, member A

chr18_-_51406841 0.530 NM_001083962
NM_003199
TCF4

transcription factor 4

chr8_-_108579270 0.529 NM_001146
ANGPT1
angiopoietin 1
chr12_-_8706746 0.525 MFAP5
microfibrillar associated protein 5
chrX_-_99778340 0.524 NM_003270
TSPAN6
tetraspanin 6
chr18_+_3439972 0.520 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr9_-_23816062 0.520 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr4_+_91035025 0.517 NM_007351
MMRN1
multimerin 1
chr1_-_79244948 0.516 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr10_-_115924353 0.513 NM_018017
C10orf118
chromosome 10 open reading frame 118
chr11_+_36354110 0.513 NM_001160168
NM_024841
PRR5L

proline rich 5 like

chrX_+_100692071 0.511 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr20_+_6696744 0.510 NM_001200
BMP2
bone morphogenetic protein 2
chr17_-_39265965 0.510 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr17_+_30594192 0.505 NM_144975
SLFN5
schlafen family member 5
chr12_+_58369392 0.502 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chrX_+_12903145 0.500 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr9_+_108665168 0.499 NM_021224
ZNF462
zinc finger protein 462
chr5_-_150306298 0.499 ZNF300P1
zinc finger protein 300 pseudogene 1
chr7_-_27171648 0.497 HOXA9
homeobox A9
chr9_-_3213007 0.496


chr11_-_55942283 0.492 NM_001004744
OR5R1
olfactory receptor, family 5, subfamily R, member 1
chr1_-_95165037 0.490 CNN3
calponin 3, acidic

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.13 2.43e-04 GO:0050794 regulation of cellular process
1.21 4.98e-04 GO:0007275 multicellular organismal development
1.24 7.75e-04 GO:0048731 system development
1.34 1.12e-03 GO:0007399 nervous system development
1.15 3.03e-03 GO:0032501 multicellular organismal process
1.18 3.97e-03 GO:0032502 developmental process
1.11 4.09e-03 GO:0065007 biological regulation
1.11 6.10e-03 GO:0050789 regulation of biological process
1.45 8.77e-03 GO:2000026 regulation of multicellular organismal development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.74 3.47e-04 GO:0005578 proteinaceous extracellular matrix
3.43 1.24e-03 GO:0042641 actomyosin
1.63 1.68e-03 GO:0031012 extracellular matrix
3.54 3.35e-03 GO:0001725 stress fiber
2.16 4.28e-03 GO:0030055 cell-substrate junction
3.30 9.19e-03 GO:0032432 actin filament bundle
2.07 1.22e-02 GO:0044420 extracellular matrix part
2.07 3.45e-02 GO:0005925 focal adhesion
1.85 3.63e-02 GO:0005912 adherens junction
1.58 4.93e-02 GO:0015629 actin cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.42 1.04e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity
2.12 1.18e-02 GO:0017124 SH3 domain binding
2.12 1.70e-02 GO:0019838 growth factor binding
1.61 1.81e-02 GO:0003779 actin binding
2.18 3.11e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity