Motif ID: PDX1.p2

Z-value: 0.702


Transcription factors associated with PDX1.p2:

Gene SymbolEntrez IDGene Name
PDX1 3651 pancreatic and duodenal homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PDX1chr13_+_273921360.097.5e-01Click!


Activity profile for motif PDX1.p2.

activity profile for motif PDX1.p2


Sorted Z-values histogram for motif PDX1.p2

Sorted Z-values for motif PDX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PDX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_113452066 1.668 NM_019618
IL1F9
interleukin 1 family, member 9
chr3_+_101720753 1.407 TMEM45A
transmembrane protein 45A
chr6_-_52060327 1.383 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr1_-_31251315 1.322 PUM1
pumilio homolog 1 (Drosophila)
chr12_+_45896511 1.198 FAM113B
family with sequence similarity 113, member B
chr12_+_45896318 1.147 NM_138371
FAM113B
family with sequence similarity 113, member B
chr15_-_38185578 0.983 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr14_+_20580224 0.901 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr3_-_139315011 0.772 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr1_+_36409277 0.744 MAP7D1
MAP7 domain containing 1
chr1_-_20122638 0.694 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr10_+_118177371 0.669 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr3_-_110155237 0.584 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr3_+_176059763 0.526 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr7_-_128330615 0.398 KCP
kielin/chordin-like protein
chr4_+_109033868 0.368 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr15_-_38185865 0.353 NM_033503
BMF
Bcl2 modifying factor
chr10_-_62002672 0.346 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_+_17861266 0.345 NM_001105569
MSGN1
mesogenin 1
chr19_-_57100052 0.324 NM_023074
ZNF649
zinc finger protein 649
chr1_+_151456683 0.300 NM_001195571
PRR9
proline rich 9
chr21_+_44844924 0.296 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr8_-_17624304 0.286 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr3_+_199363633 0.250 NM_001145248
FAM157A
family with sequence similarity 157, member A
chr7_+_147918589 0.248 NM_145304
C7orf33
chromosome 7 open reading frame 33
chr17_+_35372751 0.245 NM_178171
GSDMA
gasdermin A
chr9_+_140226457 0.237 NM_001145249
FAM157B
family with sequence similarity 157, member B
chr21_-_30460841 0.234 NM_012131
CLDN17
claudin 17
chr12_+_31691360 0.223 NM_001135864
METTL20
methyltransferase like 20
chr6_-_133076873 0.216 NM_004666
VNN1
vanin 1
chr8_-_17624009 0.214 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr18_-_49944986 0.209 MBD2
methyl-CpG binding domain protein 2
chr19_-_56229808 0.208 NM_019598
NM_145894
NM_145895
KLK12


kallikrein-related peptidase 12


chr8_+_11877238 0.208 NM_001033017
DEFB135
defensin, beta 135
chr16_-_66075216 0.208 NM_001138
AGRP
agouti related protein homolog (mouse)
chr21_-_45173061 0.204 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr18_-_45630154 0.200 MYO5B
myosin VB
chr4_+_86615275 0.196 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr18_+_27152049 0.180 NM_001942
DSG1
desmoglein 1
chr14_-_80934523 0.177 NM_033104
STON2
stonin 2
chr17_-_36725470 0.177 NM_031964
KRTAP17-1
keratin associated protein 17-1
chrX_-_131375217 0.175 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr2_-_121964373 0.172 CLASP1
cytoplasmic linker associated protein 1
chr4_-_176970372 0.169 GPM6A
glycoprotein M6A
chr6_+_167624792 0.168 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr8_-_27906287 0.168 NM_173833
SCARA5
scavenger receptor class A, member 5 (putative)
chr10_+_63478974 0.165 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr11_-_116168316 0.154 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr17_-_36418869 0.150 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr3_-_124822113 0.148 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr2_+_227900471 0.146 NM_020194
MFF
mitochondrial fission factor
chr20_+_43423990 0.145 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr4_+_77575276 0.143 NM_020859
SHROOM3
shroom family member 3
chr17_-_36409632 0.141 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr8_-_81155564 0.132 NM_001025252
TPD52
tumor protein D52
chr4_-_69116839 0.129 NM_001077
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr1_-_150328153 0.126 NM_001008536
TCHHL1
trichohyalin-like 1
chr21_-_30631882 0.124 NM_001077711
KRTAP27-1
keratin associated protein 27-1
chr1_+_62835759 0.123 NM_014495
ANGPTL3
angiopoietin-like 3
chr2_+_169465995 0.118 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr3_+_52786642 0.117 NM_002215
ITIH1
inter-alpha (globulin) inhibitor H1
chr16_+_18986721 0.113 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chrX_-_48655978 0.112 PIM2
pim-2 oncogene
chr5_+_147628567 0.112 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr7_-_44195405 0.111 NM_000162
GCK
glucokinase (hexokinase 4)
chr4_-_176970407 0.109 GPM6A
glycoprotein M6A
chr8_+_32698892 0.108 NM_001159996
NRG1
neuregulin 1
chr16_+_18986417 0.107 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr17_-_36113502 0.106 NM_019016
KRT24
keratin 24
chr22_-_23665312 0.106 NM_001001663
TMEM211
transmembrane protein 211
chr17_-_1359745 0.105 INPP5K
inositol polyphosphate-5-phosphatase K
chr2_-_165768798 0.105 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr1_+_43508251 0.102 NM_144626
TMEM125
transmembrane protein 125
chr19_-_7672978 0.101 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr3_+_46594079 0.098 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr5_-_180099663 0.096 NM_001001657
OR2Y1
olfactory receptor, family 2, subfamily Y, member 1
chr12_-_101835510 0.091 NM_000277
PAH
phenylalanine hydroxylase
chr19_-_40711034 0.090 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr1_+_40635058 0.082 NM_001198980
SMAP2
small ArfGAP2
chr17_-_9635325 0.081 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chrX_+_77041612 0.081 NM_001866
COX7B
cytochrome c oxidase subunit VIIb
chr6_-_41362370 0.079 NM_018643
TREM1
triggering receptor expressed on myeloid cells 1
chrX_+_123307812 0.079 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr15_-_42756377 0.078 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr4_-_176970895 0.077 GPM6A
glycoprotein M6A
chr11_-_62213946 0.075 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr1_-_156657279 0.075 NM_001004476
OR10K2
olfactory receptor, family 10, subfamily K, member 2
chr1_+_57093030 0.073 NM_000562
C8A
complement component 8, alpha polypeptide
chr4_+_89115825 0.073 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr9_+_33614214 0.072 ANXA2P2
annexin A2 pseudogene 2
chr4_+_88939725 0.071 NM_004967
IBSP
integrin-binding sialoprotein
chr11_+_111294810 0.070 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr12_-_52306348 0.069 NM_001130060
NM_006856
ATF7

activating transcription factor 7

chr19_-_55539769 0.069 NAPSB
napsin B aspartic peptidase pseudogene
chr12_-_4358968 0.069 NM_020638
FGF23
fibroblast growth factor 23
chr17_+_7900926 0.068


chr16_+_18986459 0.067 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr5_-_172016174 0.065


chr11_+_22652894 0.065 NM_005256
GAS2
growth arrest-specific 2
chr12_-_14740694 0.062 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr18_+_19286784 0.059 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr16_+_56286212 0.058 NM_032269
CCDC135
coiled-coil domain containing 135
chr2_+_169634330 0.056 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr12_+_4569504 0.056 NM_003845
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr11_-_70971556 0.056 NM_001005405
KRTAP5-11
keratin associated protein 5-11
chr5_+_140207540 0.055 NM_014005
NM_031857
PCDHA9

protocadherin alpha 9

chr11_-_55661769 0.055 NM_001004064
OR8J3
olfactory receptor, family 8, subfamily J, member 3
chr4_-_140280031 0.054 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr7_+_156128431 0.054 NM_001184997
RNF32
ring finger protein 32
chr2_+_185171537 0.052 ZNF804A
zinc finger protein 804A
chr3_+_49522871 0.052 DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr4_-_155753249 0.052 FGG
fibrinogen gamma chain
chr6_-_55848346 0.052 BMP5
bone morphogenetic protein 5
chrX_+_110252960 0.050 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr17_-_36559579 0.049 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr5_-_142795269 0.045 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr3_+_185253528 0.045 NM_130770
HTR3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
chr3_+_116824840 0.044 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr16_+_29582480 0.044 SPN
sialophorin
chr1_-_150463292 0.043 NM_001009931
HRNR
hornerin
chr3_-_51884639 0.043 NM_001145059
IQCF5
IQ motif containing F5
chr14_-_46882144 0.042 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr2_+_185171480 0.042 ZNF804A
zinc finger protein 804A
chr2_+_105799354 0.041 NCK2
NCK adaptor protein 2
chr2_+_24660849 0.041 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr14_+_38653177 0.041 NM_001009182
NM_001009183
NM_003616
SIP1


survival of motor neuron protein interacting protein 1


chrX_-_131923092 0.039 NM_001077188
NM_147175
HS6ST2

heparan sulfate 6-O-sulfotransferase 2

chr6_+_158653679 0.038 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr1_+_84382575 0.038 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_+_22652957 0.038 GAS2
growth arrest-specific 2
chr19_+_41872141 0.037 NM_152603
ZNF567
zinc finger protein 567
chr11_+_61732715 0.034 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chr21_-_44824907 0.031 NM_198694
KRTAP10-5
keratin associated protein 10-5
chr9_+_96561750 0.030 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr17_-_36444626 0.030 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr17_-_39500512 0.030 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr11_-_66201894 0.026 RBM4B
RNA binding motif protein 4B
chr3_+_99350859 0.026 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr2_-_46988449 0.025 MCFD2
multiple coagulation factor deficiency 2
chr1_+_157676135 0.024 NM_012351
OR10J1
olfactory receptor, family 10, subfamily J, member 1
chr10_+_70650064 0.024 NM_025130
HKDC1
hexokinase domain containing 1
chr12_-_54150188 0.023 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr17_-_36890877 0.022 NM_002280
KRT35
keratin 35
chrX_+_118592568 0.021 UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr1_-_153915867 0.019


chr10_+_86174665 0.019 FAM190B
family with sequence similarity 190, member B
chrX_+_118592879 0.019 UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr7_+_128099581 0.019 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr2_+_203763649 0.018 RPL12
ribosomal protein L12
chr17_+_18566060 0.017 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr2_-_188127294 0.017 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chrX_+_37524250 0.014 CYBB
cytochrome b-245, beta polypeptide
chr10_+_80942362 0.012 NM_001099692
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chr7_+_150376537 0.012 NM_004769
NM_020321
NM_020322
ACCN3


amiloride-sensitive cation channel 3


chr9_+_81377419 0.012 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_-_246869181 0.010 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr10_-_108448990 0.008 SORCS1
sortilin-related VPS10 domain containing receptor 1
chrX_+_99786044 0.008 SRPX2
sushi-repeat containing protein, X-linked 2
chrX_+_48572226 0.008 NM_181532
ERAS
ES cell expressed Ras
chr5_+_179934143 0.007 CNOT6
CCR4-NOT transcription complex, subunit 6
chr1_-_159786441 0.007 NM_000569
NM_001127592
FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

chr5_-_134290789 0.007


chr8_-_20084892 0.006 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr6_-_138581319 0.006 NM_021635
PBOV1
prostate and breast cancer overexpressed 1
chr6_-_29563657 0.006 NM_052967
MAS1L
MAS1 oncogene-like
chr18_+_59374372 0.006 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr11_-_57883117 0.004 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr4_+_123380569 0.003 KIAA1109
KIAA1109
chr11_+_88550687 0.003 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr19_-_14646626 0.002 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr3_-_152517204 0.001 NM_023915
GPR87
G protein-coupled receptor 87

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
7.19 1.67e-04 GO:0005882 intermediate filament
6.22 6.14e-04 GO:0045111 intermediate filament cytoskeleton
2.06 5.08e-03 GO:0005576 extracellular region
9.00 6.68e-03 GO:0045095 keratin filament

Nothing significant found in function category.