Motif ID: SOX2.p2

Z-value: 1.069


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_182912405-0.342.1e-01Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_39484073 1.714 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr11_-_16380967 1.703 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr1_-_51660328 1.633 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr2_+_169631777 1.526 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_-_7923464 1.331 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr7_+_128802719 1.327 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr1_+_181028016 1.195 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr8_-_38324809 1.160 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr7_+_106292932 1.157 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr22_-_25344037 1.155 CRYBB1
crystallin, beta B1
chr3_-_3127057 1.143 NM_000564
NM_175724
NM_175725
NM_175726
NM_175727
NM_175728
IL5RA





interleukin 5 receptor, alpha





chr15_-_48198697 1.095 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr1_-_41398126 1.066 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr7_+_106292975 1.057 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr4_+_71806538 1.027 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr21_+_34112456 1.017 ITSN1
intersectin 1 (SH3 domain protein)
chr7_-_112515068 1.006 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr10_-_61570665 0.992 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr22_-_25343959 0.990 NM_001887
CRYBB1
crystallin, beta B1
chr7_-_112515035 0.989 GPR85
G protein-coupled receptor 85
chr7_-_111633428 0.978 DOCK4
dedicator of cytokinesis 4
chr7_-_112514990 0.955 GPR85
G protein-coupled receptor 85
chr19_+_39402167 0.914 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr17_+_63252704 0.907 BPTF
bromodomain PHD finger transcription factor
chr1_-_151296611 0.902 NM_005988
SPRR2A
small proline-rich protein 2A
chr3_+_142587973 0.890


chr2_+_101874809 0.875 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr9_+_100745531 0.843 NM_001855
COL15A1
collagen, type XV, alpha 1
chrX_-_11194015 0.839 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr8_+_124263932 0.823 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr17_-_30909219 0.822 NM_001129820
SLFN14
schlafen family member 14
chr14_-_72563497 0.812 NM_021260
ZFYVE1
zinc finger, FYVE domain containing 1
chr17_+_19930926 0.812 NM_001033553
NM_152904
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr7_-_92693716 0.808 NM_001039372
HEPACAM2
HEPACAM family member 2
chr6_+_114285209 0.802 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr7_+_116447499 0.802 ST7
suppression of tumorigenicity 7
chr5_-_88235624 0.783 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr9_+_102275310 0.780 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr17_+_63252668 0.774 BPTF
bromodomain PHD finger transcription factor
chr19_+_40824486 0.770 NM_014209
ETV2
ets variant 2
chr3_-_197726587 0.769 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr5_+_121493113 0.767 NM_207317
ZNF474
zinc finger protein 474
chr11_-_5130174 0.767 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr15_+_65145248 0.765 NM_005902
SMAD3
SMAD family member 3
chr10_-_76538859 0.764 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chrX_+_86659370 0.764 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr5_-_39238818 0.742 FYB
FYN binding protein
chr1_-_165754325 0.739 NM_000734
NM_198053
CD247

CD247 molecule

chr1_-_31117948 0.738 SDC3
syndecan 3
chr1_+_87569889 0.736


chr11_-_83071084 0.722 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr2_+_27518736 0.719 NM_001168364
NM_173853
KRTCAP3

keratinocyte associated protein 3

chr1_-_611896 0.716 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr2_+_101680594 0.708 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr6_-_130578110 0.703 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr1_-_151780720 0.691 NM_002962
S100A5
S100 calcium binding protein A5
chr17_+_55269974 0.691


chr7_-_111633620 0.684 NM_014705
DOCK4
dedicator of cytokinesis 4
chr14_+_19761708 0.675 NM_001004480
OR11H6
olfactory receptor, family 11, subfamily H, member 6
chr1_+_87569959 0.663 LMO4
LIM domain only 4
chr10_+_63331018 0.654 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr17_-_36915329 0.653 NM_002274
NM_153490
KRT13

keratin 13

chr2_-_174475528 0.653


chr22_-_20314366 0.652 YDJC
YdjC homolog (bacterial)
chr1_-_180624380 0.649 GLUL
glutamate-ammonia ligase
chr6_-_31789824 0.648


chr1_-_41399632 0.647 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr11_+_60858611 0.646 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr1_-_151280201 0.643 NM_006945
SPRR2D
small proline-rich protein 2D
chr1_-_151310707 0.640 NM_001017418
SPRR2B
small proline-rich protein 2B
chr1_-_229058404 0.635 NM_001136495
C1orf198
chromosome 1 open reading frame 198
chr3_-_13032130 0.633


chr1_-_151352587 0.625 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr22_-_20314274 0.621 NM_001017964
YDJC
YdjC homolog (bacterial)
chr18_+_3441589 0.621 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr13_-_38462857 0.616 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr1_+_116727514 0.615 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr22_+_21852743 0.612 BCR
breakpoint cluster region
chr17_-_53761119 0.611 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr15_-_56093477 0.607 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr18_-_27594696 0.596 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr7_+_123036312 0.596 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr6_-_136829705 0.593 NM_001198615
MAP7
microtubule-associated protein 7
chr19_+_17923110 0.589 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr9_+_126460511 0.588


chr1_+_85819004 0.587 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr1_+_205068844 0.587 NM_013371
IL19
interleukin 19
chr5_+_149845503 0.583 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr10_+_74323344 0.581 NM_152635
OIT3
oncoprotein induced transcript 3
chr12_-_101396459 0.581 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_+_165564904 0.581 NM_001198783
POU2F1
POU class 2 homeobox 1
chr22_+_21852911 0.579 BCR
breakpoint cluster region
chr1_-_160648429 0.579 NM_053282
SH2D1B
SH2 domain containing 1B
chr1_+_165565006 0.578 POU2F1
POU class 2 homeobox 1
chr1_+_160618143 0.577 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr21_+_29593607 0.577 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr1_-_149955870 0.575 NM_007185
CELF3
CUGBP, Elav-like family member 3
chr5_-_71838875 0.575 NM_152625
ZNF366
zinc finger protein 366
chr1_+_46910086 0.574 NM_001145474
C1orf223
chromosome 1 open reading frame 223
chr22_+_21852699 0.572 BCR
breakpoint cluster region
chr12_-_53065758 0.571 ZNF385A
zinc finger protein 385A
chr17_+_53761293 0.562 LOC100506779
hypothetical LOC100506779
chr1_+_32251988 0.562 NM_006559
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr10_+_11246934 0.559 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr3_-_192531018 0.556 NM_198152
UTS2D
urotensin 2 domain containing
chr3_+_112743729 0.554 CD96
CD96 molecule
chr8_+_21833162 0.553 XPO7
exportin 7
chr6_-_11887265 0.553 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr1_-_114215768 0.552 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr12_-_107551783 0.551 NM_003006
SELPLG
selectin P ligand
chr7_+_156128431 0.550 NM_001184997
RNF32
ring finger protein 32
chr1_+_61320213 0.548 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr22_+_38652555 0.546 GRAP2
GRB2-related adaptor protein 2
chr12_-_107551744 0.545 SELPLG
selectin P ligand
chr1_-_155095289 0.545 NM_014215
INSRR
insulin receptor-related receptor
chr7_-_104696678 0.540 NM_182691
SRPK2
SRSF protein kinase 2
chr1_-_154665807 0.533 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr7_+_111633972 0.533 ZNF277
zinc finger protein 277
chr7_-_5429702 0.531 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr1_+_1062137 0.530 LOC254099
hypothetical protein LOC254099
chr1_-_21375891 0.529 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_-_32574185 0.529 NM_023009
MARCKSL1
MARCKS-like 1
chr5_+_140215778 0.526 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr15_-_43280664 0.526 NM_138356
SHF
Src homology 2 domain containing F
chr17_-_36232366 0.521 NM_000421
KRT10
keratin 10
chr1_-_180624494 0.521 GLUL
glutamate-ammonia ligase
chr3_-_143230124 0.518 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr7_-_158304062 0.516 ESYT2
extended synaptotagmin-like protein 2
chr1_+_154120170 0.512 SYT11
synaptotagmin XI
chr2_+_33213111 0.512 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chrX_+_70419766 0.512 NM_001145408
NM_001145409
NM_001145410
NM_007363
NONO



non-POU domain containing, octamer-binding



chr22_-_20419975 0.511 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr16_-_20610078 0.509 NM_052956
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr1_-_21375939 0.509 NM_001198801
NM_001198802
EIF4G3

eukaryotic translation initiation factor 4 gamma, 3

chr1_-_26105954 0.505 NM_203399
STMN1
stathmin 1
chr4_-_76817635 0.503 NM_203504
NM_203505
G3BP2

GTPase activating protein (SH3 domain) binding protein 2

chr6_-_76022565 0.498 TMEM30A
transmembrane protein 30A
chr2_+_220017617 0.497 SPEG
SPEG complex locus
chr2_+_101874765 0.496 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr11_-_4555625 0.495 NM_144663
C11orf40
chromosome 11 open reading frame 40
chr7_+_106293112 0.492 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr7_-_142293382 0.491 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr14_+_59934178 0.491


chr1_-_24112345 0.490 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr2_-_38683119 0.489 HNRPLL
heterogeneous nuclear ribonucleoprotein L-like
chr1_+_198975227 0.487 NM_203459
CAMSAP1L1
calmodulin regulated spectrin-associated protein 1-like 1
chr17_-_44006808 0.487 NM_002146
HOXB3
homeobox B3
chr1_+_39647762 0.487 NM_015038
KIAA0754
KIAA0754
chr12_-_107551694 0.486 SELPLG
selectin P ligand
chr13_+_92677012 0.486 NM_005708
GPC6
glypican 6
chr8_+_124264054 0.485 FAM83A
family with sequence similarity 83, member A
chrX_-_151370325 0.485 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr14_-_80475636 0.483 NM_152446
C14orf145
chromosome 14 open reading frame 145
chr5_+_140871107 0.483


chr3_-_158704056 0.482 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr10_+_70517823 0.480 NM_002727
SRGN
serglycin
chr4_-_40211324 0.479 RBM47
RNA binding motif protein 47
chr4_-_68793928 0.478 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr1_+_36121382 0.466 NM_012199
EIF2C1
eukaryotic translation initiation factor 2C, 1
chr2_-_30883775 0.464 NM_144575
CAPN13
calpain 13
chr10_+_70517863 0.460 SRGN
serglycin
chr19_+_12810258 0.459 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr11_-_117600918 0.459 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr12_+_14429499 0.456 ATF7IP
activating transcription factor 7 interacting protein
chr17_-_1195096 0.455 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr5_-_178977441 0.454 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr5_+_180726874 0.448 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr7_+_115637795 0.448 NM_015641
TES
testis derived transcript (3 LIM domains)
chr10_-_74863303 0.448 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr8_-_107023 0.448 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr1_-_223907283 0.447 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr1_-_152431175 0.447 NM_152263
TPM3
tropomyosin 3
chr1_+_242283906 0.447


chr1_+_36121400 0.446 EIF2C1
eukaryotic translation initiation factor 2C, 1
chr7_+_142670624 0.446 NM_001143679
NM_001143680
NM_001143681
NM_015917
GSTK1



glutathione S-transferase kappa 1



chr7_-_106088565 0.446 NM_175884
FLJ36031
hypothetical protein FLJ36031
chr1_+_22107137 0.443 RPL21
ribosomal protein L21
chr11_-_5523328 0.440 NM_001005289
OR52H1
olfactory receptor, family 52, subfamily H, member 1
chr1_+_86785346 0.439 NM_012128
CLCA4
chloride channel accessory 4
chr1_+_207668787 0.437 NM_001104548
LOC642587
NPC-A-5
chr1_+_242283129 0.435 NM_006352
ZNF238
zinc finger protein 238
chr11_+_5667494 0.435 NM_006074
TRIM22
tripartite motif containing 22
chr3_+_112743615 0.434 NM_005816
NM_198196
CD96

CD96 molecule

chr3_+_49543374 0.433


chr4_+_48180033 0.432 NM_152679
SLC10A4
solute carrier family 10 (sodium/bile acid cotransporter family), member 4
chrX_+_106336517 0.432 NM_001169154
NM_173494
CXorf41

chromosome X open reading frame 41

chr5_+_137701122 0.432 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr22_+_38213174 0.431 NM_001098270
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr22_+_18091065 0.429 NM_000407
GP1BB
glycoprotein Ib (platelet), beta polypeptide
chr14_+_31868229 0.429 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr2_+_62787534 0.428 NM_001142614
EHBP1
EH domain binding protein 1
chr22_+_25347927 0.425 NM_001886
CRYBA4
crystallin, beta A4
chr7_+_111633878 0.421 NM_021994
ZNF277
zinc finger protein 277
chr19_+_11510578 0.420 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr3_-_15348811 0.419 SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr17_-_72151314 0.417 NM_018414
ST6GALNAC1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
chr13_-_98757634 0.416 NM_004951
GPR183
G protein-coupled receptor 183
chr11_-_64403712 0.416 EHD1
EH-domain containing 1
chr1_-_117011824 0.415 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr1_-_115039614 0.414 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 8.12e-04 GO:0032501 multicellular organismal process
2.20 7.91e-03 GO:0010638 positive regulation of organelle organization
1.69 1.31e-02 GO:0033043 regulation of organelle organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.07 1.11e-04 GO:0035770 RNA granule
1.14 2.19e-04 GO:0005634 nucleus
1.31 4.95e-04 GO:0005856 cytoskeleton
1.22 6.67e-04 GO:0043228 non-membrane-bounded organelle
1.22 6.67e-04 GO:0043232 intracellular non-membrane-bounded organelle
3.43 2.77e-03 GO:0000932 cytoplasmic mRNA processing body
1.03 1.13e-02 GO:0044464 cell part
1.03 1.17e-02 GO:0005623 cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.43 3.93e-03 GO:0019899 enzyme binding
1.59 9.63e-03 GO:0003712 transcription cofactor activity
1.58 1.07e-02 GO:0000988 protein binding transcription factor activity
1.58 1.07e-02 GO:0000989 transcription factor binding transcription factor activity
2.33 1.58e-02 GO:0031625 ubiquitin protein ligase binding
1.17 2.43e-02 GO:0003676 nucleic acid binding
1.09 4.11e-02 GO:0005515 protein binding