ISMARA results for ENCODE cell lines, CTCF, averaged replicates (Ernst 2011)

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

Averaging sample configuration

Sample Condition
Rep1_GM12878 GM12878
Rep1_HepG2 HepG2
Rep1_HMEC HMEC
Rep1_HSMM HSMM
Rep1_Huvec Huvec
Rep1_K562 K562
Rep1_NHEK NHEK
Rep1_NHLF NHLF
Rep2_GM12878 GM12878
Rep2_HepG2 HepG2
Rep2_HMEC HMEC
Rep2_HSMM HSMM
Rep2_Huvec Huvec
Rep2_K562 K562
Rep2_NHEK NHEK
Rep2_NHLF NHLF

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
SNAI1..3.p2 5.876 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
HNF4A_NR2F1,2.p2 5.615 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
PITX1..3.p2 4.848 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
NRF1.p2 4.424 NRF1 (EWG, ALPHA-PAL)
HNF1A.p2 4.014 HNF1A (HNF1, LFB1)
HIC1.p2 3.669 HIC1 (ZBTB29)
POU2F1..3.p2 3.628 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
TEAD1.p2 3.628 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
ZNF143.p2 3.583 ZNF143 (SBF, pHZ-1, STAF)
ELK1,4_GABP{A,B1}.p3 3.504 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
CTCF.p2 3.164 CTCF
PRRX1,2.p2 3.145 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
FOS_FOS{B,L1}_JUN{B,D}.p2 3.127 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
KLF4.p3 3.064 KLF4 (EZF, GKLF)
MAFB.p2 2.906 MAFB
NFY{A,B,C}.p2 2.893 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
PATZ1.p2 2.873 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
YY1.p2 2.790 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
IRF1,2,7.p3 2.724 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
MZF1.p2 2.669 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
HOX{A6,A7,B6,B7}.p2 2.588 HOXB6
HOXA7
HOXB7
HOXA6
TLX1..3_NFIC{dimer}.p2 2.524 TLX1
TLX3 (RNX)
HMGA1,2.p2 2.518 HMGA1
HMGA2 (BABL, LIPO)
RUNX1..3.p2 2.510 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
MYOD1.p2 2.500 MYOD1 (PUM, MYOD, bHLHc1)
EBF1.p2 2.496 EBF1 (OLF1)
TFDP1.p2 2.477 TFDP1 (Dp-1, DRTF1, DP1)
AHR_ARNT_ARNT2.p2 2.476 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
NFE2L1.p2 2.425 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
NFE2L2.p2 2.356 NFE2L2 (NRF2)
ZEB1.p2 2.353 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
GATA6.p2 2.280 GATA6
MTF1.p2 2.158 MTF1
HBP1_HMGB_SSRP1_UBTF.p2 2.124 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
SPIB.p2 2.121 SPIB (SPI-B)
NKX3-2.p2 2.104 NKX3-2 (NKX3B, NKX3.2)
AR.p2 2.096 AR (AIS, NR3C4, SMAX1, HUMARA)
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 2.071 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
ESRRA.p2 2.015 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
SOX{8,9,10}.p2 2.015 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
RFX1..5_RFXANK_RFXAP.p2 2.012 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
NHLH1,2.p2 1.980 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
HES1.p2 1.957 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
FOXA2.p3 1.956 FOXA2
TGIF1.p2 1.905 TGIF1
ELF1,2,4.p2 1.891 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
GTF2A1,2.p2 1.878 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
EN1,2.p2 1.864 EN1
EN2
STAT2,4,6.p2 1.852 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
NR5A1,2.p2 1.847 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
GFI1B.p2 1.845 GFI1B
TBP.p2 1.827 TBP (TFIID)
BPTF.p2 1.827 BPTF (FAC1, NURF301)
GLI1..3.p2 1.793 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
NFKB1_REL_RELA.p2 1.784 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
ATF5_CREB3.p2 1.783 ATF5
CREB3 (LZIP, Luman)
HIF1A.p2 1.776 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
NKX3-1.p2 1.754 NKX3-1 (NKX3.1, BAPX2)
JUN.p2 1.747 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
SMAD1..7,9.p2 1.745 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
SOX17.p2 1.743 SOX17
E2F1..5.p2 1.718 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
NR1H4.p2 1.692 NR1H4 (FXR, RIP14, HRR1, HRR-1)
CREB1.p2 1.682 CREB1
GTF2I.p2 1.676 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
KLF12.p2 1.643 KLF12 (AP-2rep, HSPC122, AP2REP)
POU5F1_SOX2{dimer}.p2 1.625 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
HAND1,2.p2 1.610 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
PRDM1.p3 1.569 PRDM1 (PRDI-BF1)
POU5F1.p2 1.556 POU5F1 (OCT3, Oct4, MGC22487)
PAX2.p2 1.550 PAX2
RREB1.p2 1.540 RREB1 (HNT)
PAX5.p2 1.537 PAX5 (BSAP)
GFI1.p2 1.536 GFI1
IKZF1.p2 1.534 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
ZIC1..3.p2 1.534 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
TCF4_dimer.p2 1.532 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
ZBTB16.p2 1.505 ZBTB16 (PLZF)
RBPJ.p2 1.505 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
ZNF148.p2 1.503 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
ZFP161.p2 1.496 ZFP161 (ZNF478, ZBTB14)
ZNF423.p2 1.488 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
BACH2.p2 1.487 BACH2
HOX{A5,B5}.p2 1.484 HOXB5
HOXA5
EHF.p2 1.473 EHF
HMX1.p2 1.465 HMX1 (H6, NKX5-3)
DBP.p2 1.463 DBP (DABP)
ZBTB6.p2 1.463 ZBTB6 (ZID)
ONECUT1,2.p2 1.461 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
FOXQ1.p2 1.460 FOXQ1 (HFH1)
ATF6.p2 1.436 ATF6 (ATF6A)
SPI1.p2 1.422 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
FOXD3.p2 1.417 FOXD3 (Genesis, HFH2)
FOXO1,3,4.p2 1.411 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
EGR1..3.p2 1.391 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
NFE2.p2 1.389 NFE2 (NF-E2)
MYFfamily.p2 1.385 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
bHLH_family.p2 1.374 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
RXR{A,B,G}.p2 1.372 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
POU1F1.p2 1.363 POU1F1 (GHF-1)
HSF1,2.p2 1.357 HSF1 (HSTF1)
HSF2
NANOG{mouse}.p2 1.356 NANOG (FLJ12581, FLJ40451)
TFEB.p2 1.345 TFEB
TFAP4.p2 1.342 TFAP4 (AP-4)
NFIX.p2 1.342 NFIX (NF1A)
SREBF1,2.p2 1.333 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
ZNF238.p2 1.333 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
STAT5{A,B}.p2 1.296 STAT5B
STAT5A (MGF)
ARID5B.p2 1.291 ARID5B (FLJ21150, MRF2)
XBP1.p3 1.289 XBP1
ATF4.p2 1.283 ATF4 (TAXREB67, CREB-2)
FOX{I1,J2}.p2 1.255 FOXI1 (FREAC6)
FOXJ2 (FHX)
ZNF384.p2 1.255 ZNF384 (CAGH1A, CIZ, NMP4, NP)
CDC5L.p2 1.253 CDC5L (PCDC5RP, hCDC5, CEF1)
NFATC1..3.p2 1.250 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
TFCP2.p2 1.248 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
LEF1_TCF7_TCF7L1,2.p2 1.225 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
IKZF2.p2 1.221 IKZF2 (Helios)
SRY.p2 1.214 SRY (TDF)
REST.p3 1.213 REST (NRSF, XBR)
ETS1,2.p2 1.209 ETS2
ETS1 (FLJ10768, ETS-1)
FEV.p2 1.209 FEV (PET-1, HSRNAFEV)
NKX2-1,4.p2 1.182 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
TFAP2{A,C}.p2 1.179 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
SPZ1.p2 1.170 SPZ1 (NYD-TSP1, FLJ25709)
MYB.p2 1.168 MYB (c-myb)
SRF.p3 1.162 SRF (MCM1)
EP300.p2 1.156 EP300 (p300, KAT3B)
NKX2-2,8.p2 1.151 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
TAL1_TCF{3,4,12}.p2 1.131 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
POU3F1..4.p2 1.129 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
PPARG.p2 1.123 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
NKX6-1,2.p2 1.117 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
LMO2.p2 1.116 LMO2 (TTG2, RHOM2, RBTN2)
FOSL2.p2 1.108 FOSL2 (FRA2, FLJ23306)
TLX2.p2 1.089 TLX2 (Enx, Tlx2, NCX)
SOX2.p2 1.084 SOX2
FOXN1.p2 1.077 FOXN1 (FKHL20)
DMAP1_NCOR{1,2}_SMARC.p2 1.065 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
MEF2{A,B,C,D}.p2 1.056 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
HLF.p2 1.046 HLF (MGC33822)
FOXL1.p2 1.044 FOXL1 (FREAC7, FKH6)
FOX{F1,F2,J1}.p2 1.040 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
POU6F1.p2 1.040 POU6F1 (BRN5, MPOU, TCFB1)
FOXP3.p2 1.039 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
MAZ.p2 1.033 MAZ (ZF87, Pur-1, Zif87, ZNF801)
CEBPA,B_DDIT3.p2 1.029 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
TFAP2B.p2 1.021 TFAP2B (AP2-B)
MYBL2.p2 1.011 MYBL2 (BMYB, B-MYB)
ESR1.p2 0.991 ESR1 (NR3A1, Era)
PBX1.p2 0.961 PBX1
NR3C1.p2 0.960 NR3C1 (GR)
FOX{D1,D2}.p2 0.949 FOXD2 (FREAC9)
FOXD1 (FREAC4)
CRX.p2 0.944 CRX (CRD, LCA7, OTX3)
SP1.p2 0.917 SP1
EVI1.p2 0.890 EVI1 (MDS1-EVI1, PRDM3)
TP53.p2 0.890 TP53 (p53, LFS1)
ADNP_IRX_SIX_ZHX.p2 0.878 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
CDX1,2,4.p2 0.876 CDX1
CDX2
CDX4
NANOG.p2 0.861 NANOG (FLJ12581, FLJ40451)
SOX5.p2 0.853 SOX5 (L-SOX5, MGC35153)
CUX2.p2 0.830 CUX2 (KIAA0293, CDP2)
ATF2.p2 0.827 ATF2 (TREB7, CRE-BP1, HB16)
HOXA9_MEIS1.p2 0.823 MEIS1
HOXA9
ALX1.p2 0.823 ALX1
GATA1..3.p2 0.808 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
NKX2-3_NKX2-5.p2 0.783 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
HOX{A4,D4}.p2 0.765 HOXA4
HOXD4
NR6A1.p2 0.765 NR6A1 (GCNF1, RTR)
TBX4,5.p2 0.758 TBX5
TBX4
EOMES.p2 0.747 EOMES (TBR2)
FOX{C1,C2}.p2 0.743 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
PAX4.p2 0.706 PAX4
AIRE.p2 0.665 AIRE (PGA1, APS1)
RORA.p2 0.648 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
LHX3,4.p2 0.626 LHX3
LHX4 (Gsh4)
STAT1,3.p3 0.619 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
RXRA_VDR{dimer}.p2 0.614 VDR (NR1I1)
EWSR1-FLI1.p2 0.595 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
GZF1.p2 0.592 GZF1 (dJ322G13.2, ZBTB23)
T.p2 0.560 T
MSX1,2.p2 0.550 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
PAX6.p2 0.511 PAX6 (D11S812E, AN, WAGR)
RXRG_dimer.p3 0.508 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
NFIL3.p2 0.501 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
PDX1.p2 0.417 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
VSX1,2.p2 0.343 VSX2 (RET1)
VSX1 (PPD)
PAX8.p2 0.113 PAX8
PAX3,7.p2 0.087 PAX7 (Hup1)
PAX3 (HUP2)

All samples sorted alphabetically


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Sample name Condition Replicate/Batch
GM12878
HepG2
HMEC
HSMM
Huvec
K562
NHEK
NHLF