Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 0.836


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZHX2chr8_+_123793988,
chr8_+_123794043
-0.552.8e-02Click!
ZHX3chr20_-_39946119-0.514.1e-02Click!
ADNPchr20_-_495474510.381.4e-01Click!
IRX4chr5_-_1882764-0.312.4e-01Click!
SIX5chr19_-_46272496-0.185.0e-01Click!
SIX2chr2_-_452365210.165.5e-01Click!
IRX5chr16_+_549651100.039.2e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_137821514 3.053 NM_033642
FGF13
fibroblast growth factor 13
chr21_-_15918635 2.442 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr6_+_12717036 1.734 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr5_-_88199868 1.707 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr18_-_53089722 1.619 NM_001243233
TCF4
transcription factor 4
chr5_+_102465256 1.368 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr10_+_70847857 1.350 SRGN
serglycin
chr14_-_55650348 1.335 DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr3_-_141747434 1.285 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr10_+_70847817 1.275 NM_002727
SRGN
serglycin
chr11_-_33913835 1.237 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr2_-_192711923 1.168 NM_004657
SDPR
serum deprivation response
chr5_+_141346401 1.114 NM_001201365
NM_183399
RNF14

ring finger protein 14

chr17_-_46622274 1.022 NM_002145
HOXB2
homeobox B2
chr8_-_86290333 1.015 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr12_-_71148063 0.938 PTPRR
protein tyrosine phosphatase, receptor type, R
chr2_+_33738941 0.914 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_198608136 0.876 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_+_78470593 0.872 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr4_+_169013687 0.860 NM_007193
ANXA10
annexin A10
chr2_-_192711651 0.788 SDPR
serum deprivation response
chr3_-_33700480 0.788 CLASP2
cytoplasmic linker associated protein 2
chr1_+_198608216 0.745 PTPRC
protein tyrosine phosphatase, receptor type, C
chr18_-_53177999 0.731 NM_001243231
TCF4
transcription factor 4
chr6_-_119252887 0.729 NM_017696
MCM9
minichromosome maintenance complex component 9
chr18_-_53303129 0.715 NM_001243226
TCF4
transcription factor 4
chr12_-_102874373 0.709 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr17_-_10325266 0.699 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr3_-_57234279 0.698 NM_003865
HESX1
HESX homeobox 1
chr1_+_198608244 0.686 PTPRC
protein tyrosine phosphatase, receptor type, C
chr8_+_77593506 0.685 NM_024721
ZFHX4
zinc finger homeobox 4
chr9_+_2015218 0.659 NM_003070
NM_139045
SMARCA2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr8_-_82395401 0.642 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr13_+_53035227 0.642 CKAP2
cytoskeleton associated protein 2
chr3_-_167191808 0.642 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr7_-_14025826 0.642 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr8_-_102803438 0.638 NM_032041
NCALD
neurocalcin delta
chr12_-_102874321 0.631 IGF1
insulin-like growth factor 1 (somatomedin C)
chr11_+_114167197 0.617 NNMT
nicotinamide N-methyltransferase
chr11_+_114167168 0.611 NNMT
nicotinamide N-methyltransferase
chr7_-_26232148 0.607 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr4_+_146031528 0.605 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr11_-_57195052 0.597 NM_017611
SLC43A3
solute carrier family 43, member 3
chr4_-_153273683 0.597 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr4_+_41700736 0.594 LIMCH1
LIM and calponin homology domains 1
chr1_+_167298280 0.594 NM_001198783
POU2F1
POU class 2 homeobox 1
chr2_-_200329810 0.589 NM_001172517
SATB2
SATB homeobox 2
chr8_-_108510094 0.589 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr14_+_58906398 0.587 NM_001244193
KIAA0586
KIAA0586
chr3_-_33700932 0.570 NM_001207044
CLASP2
cytoplasmic linker associated protein 2
chr14_-_106610338 0.566 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_-_72649734 0.564 NM_000583
GC
group-specific component (vitamin D binding protein)
chr12_-_15114495 0.564 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr1_-_103496768 0.556 COL11A1
collagen, type XI, alpha 1
chr8_-_102803196 0.556 NCALD
neurocalcin delta
chr12_+_54410893 0.553 HOXC5
HOXC6
homeobox C5
homeobox C6
chr8_-_102803178 0.551 NCALD
neurocalcin delta
chr12_-_102512277 0.547 NM_024057
NUP37
nucleoporin 37kDa
chr2_-_200325200 0.546 SATB2
SATB homeobox 2
chr1_+_35851101 0.542 ZMYM4
zinc finger, MYM-type 4
chr12_+_50869531 0.541 LARP4
La ribonucleoprotein domain family, member 4
chr12_+_29376596 0.541 NM_018099
FAR2
fatty acyl CoA reductase 2
chr4_+_41614911 0.541 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr3_+_69812961 0.539 NM_006722
MITF
microphthalmia-associated transcription factor
chr3_-_25683825 0.532 TOP2B
topoisomerase (DNA) II beta 180kDa
chr9_-_124989755 0.525 NM_001242334
LHX6
LIM homeobox 6
chr17_-_10452939 0.524 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr4_-_111563278 0.523 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr22_+_22735134 0.514 CYAT1
immunoglobulin lambda light chain-like
chrX_-_135863104 0.512 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_-_158656487 0.509 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr12_+_20963637 0.503 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr12_-_71148383 0.498 NM_130846
NM_001207016
PTPRR

protein tyrosine phosphatase, receptor type, R

chr16_+_7382750 0.497 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr11_+_10476665 0.492 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr2_-_61764661 0.490 XPO1
exportin 1 (CRM1 homolog, yeast)
chr3_+_121774208 0.488 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr12_-_102874299 0.486 IGF1
insulin-like growth factor 1 (somatomedin C)
chr11_-_118900078 0.482 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr10_+_71075609 0.480 NM_033496
HK1
hexokinase 1
chr1_+_168250277 0.474 NM_005149
TBX19
T-box 19
chr11_+_114166534 0.471 NM_006169
NNMT
nicotinamide N-methyltransferase
chr10_-_69752385 0.468 HERC4
hect domain and RLD 4
chr2_-_133429069 0.467 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr1_+_101185195 0.467 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chrX_-_135863033 0.467 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr20_-_7921068 0.463 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr21_-_40033617 0.453 NM_001243432
NM_001136154
NM_004449
ERG


v-ets erythroblastosis virus E26 oncogene homolog (avian)


chr12_-_71148331 0.453 PTPRR
protein tyrosine phosphatase, receptor type, R
chr15_-_25650647 0.446 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr6_-_26235160 0.435 NM_005320
HIST1H1D
histone cluster 1, H1d
chr12_-_102874340 0.431 IGF1
insulin-like growth factor 1 (somatomedin C)
chr17_-_10421858 0.428 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr17_-_39191100 0.427 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr16_+_56817367 0.426 NM_001242796
NUP93
nucleoporin 93kDa
chr8_-_6420454 0.424 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr1_+_199996729 0.409 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr14_+_67831484 0.408 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chrX_-_152736602 0.404 NM_017518
HAUS7
HAUS augmin-like complex, subunit 7
chr8_+_77593522 0.403 ZFHX4
zinc finger homeobox 4
chr13_-_99959649 0.400 NM_004951
GPR183
G protein-coupled receptor 183
chr7_-_16505292 0.400 NM_015464
SOSTDC1
sclerostin domain containing 1
chr1_+_212475147 0.399 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chrX_-_55057408 0.398 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr18_+_33234532 0.398 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr8_-_86253863 0.398 NM_001164830
CA1
carbonic anhydrase I
chrX_+_65382627 0.397 HEPH
hephaestin
chr2_+_33661392 0.394 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_-_42965948 0.394 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr12_-_102874158 0.393 IGF1
insulin-like growth factor 1 (somatomedin C)
chr7_-_87856282 0.392 NM_198901
SRI
sorcin
chr1_-_159684274 0.388 NM_000567
CRP
C-reactive protein, pentraxin-related
chr2_-_200322699 0.381 NM_001172509
SATB2
SATB homeobox 2
chr13_-_46756295 0.378 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_-_71532206 0.378 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr5_+_44808967 0.377 NM_016640
MRPS30
mitochondrial ribosomal protein S30
chr11_+_113775517 0.376 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr3_+_173116243 0.375 NM_014932
NLGN1
neuroligin 1
chr15_-_56209305 0.372 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr7_-_37025696 0.372 ELMO1
engulfment and cell motility 1
chr2_+_237478379 0.370 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr6_-_32908583 0.367 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr9_+_135854097 0.367 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr1_+_147425566 0.366 NM_001097616
GPR89C
G protein-coupled receptor 89C
chr11_+_99426872 0.362 NM_175566
CNTN5
contactin 5
chr1_+_151032683 0.362 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr7_+_55433140 0.359 NM_018697
LANCL2
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr8_+_18079176 0.355 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr10_+_124320180 0.355 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr8_-_74659942 0.353 NM_001164384
STAU2
staufen, RNA binding protein, homolog 2 (Drosophila)
chr9_-_75567915 0.348 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr22_+_22735207 0.348 IGLJ3
immunoglobulin lambda joining 3
chr7_-_104909442 0.345 NM_182691
SRPK2
SRSF protein kinase 2
chr17_-_40428391 0.344 NM_012448
STAT5B
signal transducer and activator of transcription 5B
chr7_-_107880492 0.343 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr6_-_33041266 0.341 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr3_-_164796275 0.341 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr1_+_151032866 0.341 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr12_+_14538232 0.340 ATF7IP
activating transcription factor 7 interacting protein
chr16_+_20775311 0.340 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr5_-_88119604 0.339 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr7_-_50772997 0.338 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr2_+_169757749 0.336 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr10_+_11047253 0.335 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr19_-_48752921 0.335 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr22_+_44422183 0.334 NM_001243386
PARVB
parvin, beta
chr21_-_39870303 0.334 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr11_+_71900958 0.334 NM_000802
FOLR1
folate receptor 1 (adult)
chr10_+_11047274 0.327 CELF2
CUGBP, Elav-like family member 2
chr4_-_74088773 0.326 ANKRD17
ankyrin repeat domain 17
chr17_-_67240955 0.325 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr1_-_51887740 0.319 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr9_+_93589704 0.318 NM_001174167
SYK
spleen tyrosine kinase
chr1_+_174843523 0.317 NM_001243763
RABGAP1L
RAB GTPase activating protein 1-like
chr3_+_151985828 0.316 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr2_-_170430312 0.316 NM_024622
FASTKD1
FAST kinase domains 1
chr2_+_103035148 0.313 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr10_-_94257470 0.313 NM_001165946
IDE
insulin-degrading enzyme
chr7_-_25268057 0.312 NM_022150
NPVF
neuropeptide VF precursor
chr3_+_69812620 0.312 NM_001184967
MITF
microphthalmia-associated transcription factor
chr5_+_65372744 0.307 ERBB2IP
erbb2 interacting protein
chr7_+_102987970 0.306 NM_001204453
NM_002803
PSMC2

proteasome (prosome, macropain) 26S subunit, ATPase, 2

chr12_-_8765438 0.305 NM_020661
AICDA
activation-induced cytidine deaminase
chr5_-_98262217 0.304 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr2_+_172821874 0.304 HAT1
histone acetyltransferase 1
chr4_+_170581212 0.300 NM_001243374
CLCN3
chloride channel 3
chr6_-_31845446 0.297 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr2_-_87248942 0.290 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr15_-_50647275 0.290 GABPB1
GA binding protein transcription factor, beta subunit 1
chr1_+_52082545 0.289 NM_024586
NM_148906
NM_148908
NM_148909
OSBPL9



oxysterol binding protein-like 9



chr1_+_115572414 0.289 NM_000549
TSHB
thyroid stimulating hormone, beta
chr2_-_55845985 0.289 SMEK2
SMEK homolog 2, suppressor of mek1 (Dictyostelium)
chr10_+_11207053 0.287 CELF2
CUGBP, Elav-like family member 2
chrX_+_100354797 0.286 NM_006733
CENPI
centromere protein I
chr12_+_48516428 0.285 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr1_-_163113938 0.283 RGS5
regulator of G-protein signaling 5
chrX_-_49460568 0.283 NM_003785
PAGE1
P antigen family, member 1 (prostate associated)
chr3_+_35721115 0.282 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr1_-_241799101 0.280 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr10_-_17171789 0.279 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr7_-_27166638 0.278 NM_153631
HOXA3
homeobox A3
chr5_+_115898218 0.275


chr5_-_179044835 0.275 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr18_-_52988916 0.274 NM_001243234
NM_001243235
TCF4

transcription factor 4

chr1_+_158801105 0.274 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr10_+_11206928 0.273 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr12_-_16760935 0.271 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr10_-_98031154 0.269 NM_001114094
NM_013314
BLNK

B-cell linker

chr22_+_23229959 0.269 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr4_-_123542165 0.267 NM_001207006
NM_021803
IL21

interleukin 21

chr1_-_197036350 0.267 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr14_+_102276279 0.267 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chrX_-_13835012 0.262 GPM6B
glycoprotein M6B
chr11_+_71900601 0.262 NM_016724
NM_016725
FOLR1

folate receptor 1 (adult)

chr21_+_38791206 0.262 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr2_-_136634002 0.261 NM_005915
MCM6
minichromosome maintenance complex component 6
chr2_-_211179765 0.261 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr2_-_211168315 0.261 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr14_+_100563817 0.260 EVL
Enah/Vasp-like
chr1_-_203055376 0.259 NM_002479
MYOG
myogenin (myogenic factor 4)

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.