Motif ID: ALX1.p2

Z-value: 0.964


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ALX1chr12_+_856738840.611.2e-02Click!


Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_48752921 2.370 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr7_-_150329285 1.867 GIMAP6
GTPase, IMAP family member 6
chr7_-_150329735 1.522 NM_001244071
NM_001244072
NM_024711
GIMAP6


GTPase, IMAP family member 6


chr3_+_158991035 1.496 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr4_-_159093523 1.225 FAM198B
family with sequence similarity 198, member B
chr19_-_48759141 1.219 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chrX_-_21776158 1.189 NM_014332
SMPX
small muscle protein, X-linked
chr1_-_89591685 1.180 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr1_+_78470593 1.158 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr2_-_99279935 1.118 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr2_+_102953716 1.013 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr14_-_23285011 0.986 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr11_+_5710926 0.934 TRIM22
tripartite motif containing 22
chr7_-_115670774 0.929 TFEC
transcription factor EC
chr4_-_159094163 0.918 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr12_-_10021932 0.844 CLEC2B
C-type lectin domain family 2, member B
chr1_-_163113938 0.835 RGS5
regulator of G-protein signaling 5
chr1_+_155853546 0.793 SYT11
synaptotagmin XI
chr13_-_49018802 0.754 NM_005767
LPAR6
lysophosphatidic acid receptor 6
chr1_-_163113129 0.754 RGS5
regulator of G-protein signaling 5
chr3_+_148583042 0.737 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr13_-_52980628 0.725 NM_018676
NM_199263
THSD1

thrombospondin, type I, domain containing 1

chr12_-_10022457 0.723 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr5_-_94417185 0.721 MCTP1
multiple C2 domains, transmembrane 1
chr4_-_186578122 0.702 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr5_-_94224601 0.679 MCTP1
multiple C2 domains, transmembrane 1
chrX_+_114827818 0.672 NM_001136025
NM_001172335
PLS3

plastin 3

chr1_-_163172863 0.671 NM_003617
RGS5
regulator of G-protein signaling 5
chr3_-_15382874 0.665 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr8_+_38585703 0.644 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr4_-_186577858 0.632 SORBS2
sorbin and SH3 domain containing 2
chr3_+_8775485 0.594 NM_001234
NM_033337
CAV3

caveolin 3

chr5_-_139726173 0.592 NM_001945
HBEGF
heparin-binding EGF-like growth factor
chr7_-_107880492 0.578 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr3_-_69037498 0.560 C3orf64
chromosome 3 open reading frame 64
chrX_+_66788682 0.554 NM_001011645
AR
androgen receptor
chr17_-_29641087 0.517 EVI2B
ecotropic viral integration site 2B
chr2_-_89165652 0.495


chr14_-_106926393 0.493 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_+_124320180 0.493 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr17_-_29641094 0.492 NM_006495
EVI2B
ecotropic viral integration site 2B
chr2_+_132480063 0.489 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr7_+_74188308 0.487 NM_000265
NCF1
NCF1B
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
chr18_+_33234532 0.473 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr4_-_70626429 0.458 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr9_-_4742042 0.452 NM_001199853
AK3
adenylate kinase 3
chr2_+_207406815 0.450 ADAM23
ADAM metallopeptidase domain 23
chr13_-_99959649 0.448 NM_004951
GPR183
G protein-coupled receptor 183
chr19_-_39826676 0.440 NM_004877
GMFG
glia maturation factor, gamma
chr1_+_84647342 0.440 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr21_-_39870303 0.428 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr7_-_115608366 0.426 NM_001244583
TFEC
transcription factor EC
chr6_-_31648140 0.413 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr1_-_244006471 0.402 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr15_+_100173182 0.402 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr17_-_29641068 0.401 EVI2B
ecotropic viral integration site 2B
chr18_+_47088400 0.391 NM_006033
LIPG
lipase, endothelial
chr2_-_188419185 0.387 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr6_+_153019029 0.386 NM_025107
MYCT1
myc target 1
chr16_+_55515468 0.383 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr8_-_82395401 0.365 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr14_-_106471439 0.351 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr9_-_117568292 0.350 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr2_+_33738941 0.346 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr7_-_115670828 0.345 NM_001018058
NM_012252
TFEC

transcription factor EC

chr6_-_133084585 0.345 NM_078488
VNN2
vanin 2
chrX_+_51546154 0.344 NM_001005332
MAGED1
melanoma antigen family D, 1
chr19_-_48614013 0.339 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr8_-_98290171 0.338 NM_033512
TSPYL5
TSPY-like 5
chr9_+_27109138 0.331 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr4_+_166131170 0.330 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr9_+_79968344 0.322 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr6_+_29913400 0.311


chr5_-_150467220 0.294 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr1_+_84630575 0.286 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr2_+_87144737 0.286 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr2_-_88285308 0.284 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr22_-_43485333 0.282 NM_012263
TTLL1
tubulin tyrosine ligase-like family, member 1
chrY_+_16634487 0.280 NM_001206850
NLGN4Y
neuroligin 4, Y-linked
chr13_-_24007822 0.278 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr11_+_7618416 0.275 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr3_+_119187782 0.269 NM_152305
POGLUT1
protein O-glucosyltransferase 1
chr12_+_29376596 0.265 NM_018099
FAR2
fatty acyl CoA reductase 2
chr18_-_53177999 0.265 NM_001243231
TCF4
transcription factor 4
chr8_+_98703361 0.264 MTDH
metadherin
chr11_-_59950498 0.255 NM_022349
NM_152851
MS4A6A

membrane-spanning 4-domains, subfamily A, member 6A

chr4_+_68424444 0.252 NM_012108
STAP1
signal transducing adaptor family member 1
chr22_-_23922376 0.248 NM_020070
NM_152855
IGLL1

immunoglobulin lambda-like polypeptide 1

chr14_-_106552313 0.233 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr19_+_7504573 0.230 NM_001130955
ARHGEF18
Rho/Rac guanine nucleotide exchange factor (GEF) 18
chr3_-_168864325 0.222 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr22_-_38881529 0.213 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr12_-_54653317 0.210 NM_001127322
CBX5
chromobox homolog 5
chr4_-_139163222 0.209 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr2_+_33661392 0.204 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr5_+_162930230 0.203 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr2_-_190927321 0.200 NM_005259
MSTN
myostatin
chr12_-_54653369 0.200 NM_001127321
CBX5
chromobox homolog 5
chr14_+_57046490 0.198 NM_017799
C14orf101
chromosome 14 open reading frame 101
chr2_-_188419049 0.194 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr19_-_23941571 0.192 NM_138286
ZNF681
zinc finger protein 681
chr12_+_4699243 0.191 NM_003845
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr1_+_151739130 0.190 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chr11_-_102668822 0.189 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr16_-_4896197 0.186 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr4_+_41258941 0.186 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr13_-_48987652 0.185 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr16_+_57392694 0.184 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr12_+_81110689 0.184 NM_005593
MYF5
myogenic factor 5
chr5_-_39394423 0.183 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr12_-_16759430 0.183 LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_-_18902077 0.183 NM_000095
COMP
cartilage oligomeric matrix protein
chr10_-_91102430 0.183 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr21_+_38455246 0.180 NM_003316
TTC3
tetratricopeptide repeat domain 3
chr5_+_134209909 0.176 TXNDC15
thioredoxin domain containing 15
chr7_+_22766765 0.170 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr12_+_20963637 0.169 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr4_+_120056938 0.166 NM_016599
MYOZ2
myozenin 2
chr5_+_134209426 0.165 NM_024715
TXNDC15
thioredoxin domain containing 15
chr3_-_27498244 0.163 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr12_-_46385849 0.163 SCAF11
SR-related CTD-associated factor 11
chr1_-_151414641 0.163 NM_207171
POGZ
pogo transposable element with ZNF domain
chr18_-_51690988 0.162 MBD2
methyl-CpG binding domain protein 2
chr3_-_52713728 0.161 NM_018165
NM_181042
PBRM1

polybromo 1

chr7_+_94297448 0.156 PEG10
paternally expressed 10
chr6_+_36644236 0.154 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr19_-_4559713 0.145 NM_032108
SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr3_+_98250742 0.143 NM_005290
GPR15
G protein-coupled receptor 15
chr4_-_69434215 0.143 NM_001077
UGT2B15
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B15
UDP glucuronosyltransferase 2 family, polypeptide B17
chr16_-_49860917 0.140 NM_015069
ZNF423
zinc finger protein 423
chr6_-_46825942 0.138 GPR116
G protein-coupled receptor 116
chr3_+_121774208 0.136 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr6_-_8064561 0.135 MUTED-TXNDC5
MUTED
MUTED-TXNDC5 readthrough (non-protein coding)
muted homolog (mouse)
chr9_-_132586398 0.134 TOR1A
torsin family 1, member A (torsin A)
chr16_+_15596122 0.132 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr4_-_72669757 0.131 NM_001204307
GC
group-specific component (vitamin D binding protein)
chr11_+_5646206 0.130 NM_021616
TRIM34
tripartite motif containing 34
chr1_-_173020011 0.130 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr14_-_75600111 0.130 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr5_-_93447237 0.128 NM_001163417
NM_001163418
NM_032042
FAM172A


family with sequence similarity 172, member A


chr10_+_35484054 0.127 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr12_-_16759733 0.124 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_-_154651214 0.122 NM_001130699
IPCEF1
interaction protein for cytohesin exchange factors 1
chr9_-_139292888 0.122 NM_003086
SNAPC4
small nuclear RNA activating complex, polypeptide 4, 190kDa
chr1_+_151735444 0.121 NM_001134939
OAZ3
ornithine decarboxylase antizyme 3
chr15_-_59981433 0.119 BNIP2
BCL2/adenovirus E1B 19kDa interacting protein 2
chr17_+_66031814 0.119 NM_002266
KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
chr10_+_94352960 0.119 KIF11
kinesin family member 11
chr10_-_22498911 0.117 NM_001199938
EBLN1
endogenous Bornavirus-like nucleoprotein 1
chr12_+_70759974 0.117 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr11_-_10590078 0.117 NM_006691
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr11_-_128737132 0.113 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr9_+_111624545 0.113 NM_006687
ACTL7A
actin-like 7A
chr6_-_47254143 0.111 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr2_-_89513056 0.109 IGKC
immunoglobulin kappa constant
chr20_-_33734894 0.109 EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr2_-_74382352 0.108


chr11_-_104827421 0.107 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr12_-_16759531 0.107 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_101295409 0.106 MEG3
maternally expressed 3 (non-protein coding)
chr9_-_132586440 0.106 NM_000113
TOR1A
torsin family 1, member A (torsin A)
chr17_-_34328530 0.106 CCL14-CCL15
CCL15
CCL14-CCL15 readthrough
chemokine (C-C motif) ligand 15
chr15_-_59981517 0.105 NM_004330
BNIP2
BCL2/adenovirus E1B 19kDa interacting protein 2
chr5_+_140729723 0.105 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr2_-_211168315 0.103 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr15_-_90222572 0.103 NM_001145311
NM_002666
PLIN1

perilipin 1

chr1_+_241695433 0.103 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr3_+_35722428 0.102 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr2_-_25466795 0.101 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr6_+_26251826 0.101 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr16_+_53479685 0.100 RBL2
retinoblastoma-like 2 (p130)
chr2_+_88047603 0.100 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr12_+_21168629 0.099 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr6_-_26189303 0.097 NM_003539
HIST1H4D
histone cluster 1, H4d
chr8_-_33457435 0.097 NM_024025
DUSP26
dual specificity phosphatase 26 (putative)
chr4_-_72649734 0.096 NM_000583
GC
group-specific component (vitamin D binding protein)
chrX_-_10535476 0.095 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr1_+_168250277 0.092 NM_005149
TBX19
T-box 19
chr19_+_48758931 0.091 LOC100505812
uncharacterized LOC100505812
chr11_-_2162340 0.091 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr6_-_75965845 0.090 TMEM30A
transmembrane protein 30A
chr16_+_29086269 0.090 RRN3P2
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2
chr8_-_110986923 0.090 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr10_+_123748688 0.089 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr1_-_182573393 0.089 NM_002928
RGS16
regulator of G-protein signaling 16
chr10_+_94352873 0.087 KIF11
kinesin family member 11
chr4_-_164534656 0.087 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr12_-_25150372 0.083 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr12_+_21284127 0.083 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr20_-_18477811 0.081 NM_006606
RBBP9
retinoblastoma binding protein 9
chrX_+_80457559 0.079 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr12_-_91398757 0.078 NM_004950
EPYC
epiphycan
chr7_-_87856282 0.077 NM_198901
SRI
sorcin
chr6_-_101329197 0.076 NM_006828
NM_022091
ASCC3

activating signal cointegrator 1 complex subunit 3

chr1_+_236958690 0.076 MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
chr1_-_62191094 0.076 NM_032027
TM2D1
TM2 domain containing 1
chr9_-_21305311 0.075 NM_002169
IFNA5
interferon, alpha 5
chr2_-_87248942 0.074 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr4_-_38858407 0.074 NM_006068
TLR6
toll-like receptor 6
chr22_+_25202135 0.072 NM_001039948
NM_001098497
NM_001098498
NM_133454
SGSM1



small G protein signaling modulator 1




Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
253.06 8.82e-04 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB cascade

Nothing significant found in compartment category.

Nothing significant found in function category.