Motif ID: CRX.p2

Z-value: 1.183


Transcription factors associated with CRX.p2:

Gene SymbolEntrez IDGene Name
CRX 1406 cone-rod homeobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CRXchr19_+_483250980.401.3e-01Click!


Activity profile for motif CRX.p2.

activity profile for motif CRX.p2


Sorted Z-values histogram for motif CRX.p2

Sorted Z-values for motif CRX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CRX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_122044010 2.915 NM_005213
CSTA
cystatin A (stefin A)
chr10_-_118680978 2.431 KIAA1598
KIAA1598
chr12_-_89746244 2.430 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr12_-_89746238 2.380 DUSP6
dual specificity phosphatase 6
chr4_+_88896868 2.157 SPP1
secreted phosphoprotein 1
chr4_+_88896899 2.096 SPP1
secreted phosphoprotein 1
chr4_+_88896838 2.071 SPP1
secreted phosphoprotein 1
chrX_-_131573638 1.988 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr8_-_80993009 1.943 NM_001025252
TPD52
tumor protein D52
chr21_-_43187265 1.911 RIPK4
receptor-interacting serine-threonine kinase 4
chr4_+_74281884 1.876 ALB
albumin
chr18_+_55714457 1.838 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_207277577 1.677 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr2_+_234590583 1.508 NM_019077
UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7
chr12_-_53012332 1.488 NM_175068
KRT73
keratin 73
chr12_-_89745997 1.466 DUSP6
dual specificity phosphatase 6
chr4_+_74269971 1.462 NM_000477
ALB
albumin
chr4_-_69886112 1.437 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr11_+_101983170 1.375 NM_001195045
YAP1
Yes-associated protein 1
chr4_-_155533800 1.343 FGG
fibrinogen gamma chain
chr3_+_50306578 1.302 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr17_-_39092714 1.290 KRT23
keratin 23 (histone deacetylase inducible)
chr4_-_155533757 1.287 FGG
fibrinogen gamma chain
chr13_-_49018802 1.241 NM_005767
LPAR6
lysophosphatidic acid receptor 6
chr18_+_29027731 1.195 NM_001944
DSG3
desmoglein 3
chr2_-_88427535 1.176 NM_001443
FABP1
fatty acid binding protein 1, liver
chr2_+_102608305 1.127 NM_004633
IL1R2
interleukin 1 receptor, type II
chr3_+_50306305 1.119 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr10_-_116418056 1.119 NM_002313
ABLIM1
actin binding LIM protein 1
chr20_+_43803539 1.099 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr1_-_169555710 1.009 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr4_-_155533882 1.003 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr10_+_7745354 1.003 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_123754141 0.995 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_-_169555624 0.990 F5
coagulation factor V (proaccelerin, labile factor)
chr16_-_10674443 0.967 NM_001424
EMP2
epithelial membrane protein 2
chr2_+_228678556 0.959 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr4_-_155533850 0.934 FGG
fibrinogen gamma chain
chr14_-_61748510 0.919 NM_001017970
TMEM30B
transmembrane protein 30B
chr2_+_113885137 0.915 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr3_-_194072004 0.911 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr7_+_26400503 0.898 NM_001199837
SNX10
sorting nexin 10
chr1_+_86889768 0.891 NM_006536
CLCA2
chloride channel accessory 2
chr9_-_112191105 0.889 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr2_-_216259197 0.868 FN1
fibronectin 1
chr10_+_5005685 0.853 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr18_+_3453771 0.817 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr14_-_24777153 0.784 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_61747956 0.768 TMEM30B
transmembrane protein 30B
chr2_+_234580504 0.767 NM_021027
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr4_+_88896801 0.762 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr2_-_26101329 0.730 ASXL2
additional sex combs like 2 (Drosophila)
chr14_-_24777160 0.706 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_24777184 0.705 CIDEB
cell death-inducing DFFA-like effector b
chr18_+_33234532 0.692 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr13_+_73633097 0.689 NM_001730
KLF5
Kruppel-like factor 5 (intestinal)
chr5_+_135364583 0.679 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr10_-_82049178 0.676 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr2_-_26101301 0.675 NM_018263
ASXL2
additional sex combs like 2 (Drosophila)
chr7_+_29519485 0.673 NM_001039936
CHN2
chimerin (chimaerin) 2
chr22_-_37975937 0.669 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr2_+_234545099 0.660 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr8_+_86376130 0.652 NM_000067
CA2
carbonic anhydrase II
chr19_-_51530781 0.651 NM_144947
KLK11
kallikrein-related peptidase 11
chr1_+_153330329 0.645 NM_002965
S100A9
S100 calcium binding protein A9
chr18_+_29171729 0.644 NM_000371
TTR
transthyretin
chrX_-_106362018 0.643 RBM41
RNA binding motif protein 41
chr9_-_99801924 0.635 NM_001201575
CTSL2
cathepsin L2
chr11_+_69467210 0.630 CCND1
cyclin D1
chr2_+_113885145 0.627 IL1RN
interleukin 1 receptor antagonist
chr1_+_207262583 0.622 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr12_-_31479084 0.612 FAM60A
family with sequence similarity 60, member A
chr13_-_45048436 0.612 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr8_-_17752847 0.610 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr1_-_168513201 0.608 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr3_-_69171536 0.585 NM_198271
LMOD3
leiomodin 3 (fetal)
chr19_-_43032525 0.583 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001205344
NM_001712
CEACAM1





carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)





chr17_+_41052813 0.580 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chrX_-_106362050 0.575 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41

chrX_-_107682600 0.571 NM_001847
COL4A6
collagen, type IV, alpha 6
chr17_-_64225496 0.558 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr1_-_27998700 0.557 IFI6
interferon, alpha-inducible protein 6
chr14_+_21156922 0.537 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr1_-_182354649 0.535 GLUL
glutamate-ammonia ligase
chr13_+_78109808 0.531 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr2_+_211342405 0.526 NM_001122633
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr4_-_186877413 0.521 SORBS2
sorbin and SH3 domain containing 2
chr1_-_6662681 0.517 KLHL21
kelch-like 21 (Drosophila)
chrX_-_102319080 0.516 BEX1
brain expressed, X-linked 1
chr16_+_22524843 0.509 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chr11_-_102651321 0.506 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr10_+_102121371 0.502 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr12_-_31479120 0.495 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr3_-_149086884 0.489 TM4SF1
transmembrane 4 L six family member 1
chr10_-_5045967 0.489 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr14_-_23540770 0.484 NM_001164816
NM_001164817
ACIN1

apoptotic chromatin condensation inducer 1

chr10_+_5005453 0.482 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chrX_-_2882288 0.478 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr17_-_26697293 0.476 VTN
vitronectin
chr14_-_24037266 0.476 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr10_-_35103894 0.473 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr4_+_71062241 0.467 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr4_+_70146216 0.464 NM_001207004
NM_053039
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chr21_-_45079327 0.463 NM_007031
HSF2BP
heat shock transcription factor 2 binding protein
chr4_-_186732047 0.462 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr8_+_32579350 0.450 NM_001159996
NRG1
neuregulin 1
chr1_+_168545710 0.448 NM_002995
XCL1
chemokine (C motif) ligand 1
chr11_+_73357222 0.446 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr1_+_32042085 0.445 NM_001204414
NM_022164
TINAGL1

tubulointerstitial nephritis antigen-like 1

chr6_-_134496833 0.444 SGK1
serum/glucocorticoid regulated kinase 1
chr12_-_31479038 0.443 FAM60A
family with sequence similarity 60, member A
chr4_+_166299942 0.438 NM_001873
CPE
carboxypeptidase E
chr20_-_34243118 0.436 RBM12
RNA binding motif protein 12
chr5_+_36608430 0.428 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_-_7682741 0.427 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr10_-_52645384 0.426 A1CF
APOBEC1 complementation factor
chr17_+_78518742 0.424 RPTOR
regulatory associated protein of MTOR, complex 1
chr4_-_186877869 0.423 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chrM_+_12283 0.421


chr11_+_43665772 0.421


chr14_-_23540732 0.420 ACIN1
apoptotic chromatin condensation inducer 1
chr10_+_5005601 0.416 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr3_+_50304989 0.412 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr2_+_211421322 0.408 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr20_+_34556528 0.408 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chr13_-_48987017 0.406 LPAR6
lysophosphatidic acid receptor 6
chr10_+_124151818 0.406 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr2_+_113875469 0.405 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr14_-_94789641 0.400 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr7_+_115863004 0.399 NM_152829
TES
testis derived transcript (3 LIM domains)
chr21_+_39628869 0.397 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr5_-_150467220 0.385 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr17_-_26697224 0.385 VTN
vitronectin
chrX_-_110655384 0.383 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr2_+_62934030 0.383 NM_001142614
EHBP1
EH domain binding protein 1
chr14_-_95608054 0.380 NM_030621
DICER1
dicer 1, ribonuclease type III
chr7_+_129932973 0.379 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr4_+_69962191 0.378 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr12_+_56324945 0.378 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chrX_-_24690740 0.374 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr2_-_161056762 0.370 ITGB6
integrin, beta 6
chr6_+_31913708 0.369 NM_001710
CFB
complement factor B
chr18_+_55862577 0.366 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr13_-_48987652 0.364 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chrY_+_16634487 0.364 NM_001206850
NLGN4Y
neuroligin 4, Y-linked
chr1_-_173886464 0.363 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr19_+_35607218 0.363 FXYD3
FXYD domain containing ion transport regulator 3
chr3_-_120401401 0.360 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr17_-_7082654 0.360 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr17_-_74483806 0.359 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr2_-_165424993 0.359 GRB14
growth factor receptor-bound protein 14
chr3_-_11685395 0.358 NM_001128219
VGLL4
vestigial like 4 (Drosophila)
chr4_-_186732208 0.354 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr20_-_49253425 0.352 NM_080829
FAM65C
family with sequence similarity 65, member C
chr4_+_187187342 0.352 F11
coagulation factor XI
chr10_+_102732285 0.352 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr14_+_85999464 0.349


chr8_-_8750739 0.349 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr4_-_16077740 0.346 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr13_-_48987247 0.344 LPAR6
lysophosphatidic acid receptor 6
chr7_+_94536926 0.344 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr21_+_39628663 0.343 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_-_108231122 0.342 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr1_-_153067000 0.341 NM_001024209
SPRR2E
small proline-rich protein 2E
chrX_+_105969875 0.340 NM_194463
RNF128
ring finger protein 128
chr7_+_57509882 0.339 NM_001159279
ZNF716
zinc finger protein 716
chr6_+_31913763 0.338 CFB
complement factor B
chrX_+_102631267 0.334 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr3_+_46619075 0.334 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr2_-_165478357 0.332 NM_004490
GRB14
growth factor receptor-bound protein 14
chr6_+_10585978 0.331 NM_145655
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr12_-_9268513 0.326 A2M
alpha-2-macroglobulin
chr3_-_42305438 0.323 NM_001174138
CCK
cholecystokinin
chr15_-_52483564 0.320 NM_016194
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr12_-_9268522 0.320 NM_000014
A2M
alpha-2-macroglobulin
chrM_+_4465 0.320


chr1_-_27998658 0.319 IFI6
interferon, alpha-inducible protein 6
chr1_-_27998719 0.318 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr1_-_60392461 0.318 CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr20_-_16553911 0.304 NM_001199865
NM_001199866
NM_024704
KIF16B


kinesin family member 16B


chr18_+_13611664 0.304 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr1_-_153044083 0.303 NM_001017418
SPRR2B
small proline-rich protein 2B
chr3_+_142342265 0.300 NM_002670
PLS1
plastin 1
chr4_-_70080448 0.300 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr14_+_74035762 0.299 NM_006821
ACOT2
acyl-CoA thioesterase 2
chr1_-_202927699 0.294 NM_001127687
ADIPOR1
adiponectin receptor 1
chr11_-_102962903 0.292 NM_032299
DCUN1D5
DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
chr12_+_56325788 0.289 NM_201444
NM_201445
NM_201554
DGKA


diacylglycerol kinase, alpha 80kDa


chr12_-_46633551 0.286 SLC38A1
solute carrier family 38, member 1
chr16_-_31483425 0.283


chr6_+_43543921 0.281 POLH
polymerase (DNA directed), eta
chr3_-_170744767 0.281 NM_000340
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr1_+_24834083 0.281 NM_001251978
RCAN3
RCAN family member 3
chr17_-_7082559 0.281 ASGR1
asialoglycoprotein receptor 1
chr2_-_161056573 0.280 NM_000888
ITGB6
integrin, beta 6
chr2_-_20251788 0.279 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr22_+_24999113 0.278 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr14_+_23938883 0.278 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr16_+_3070310 0.276 NM_016639
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr16_+_28722781 0.276 NM_001099661
NM_001037808
NM_003752
EIF3CL
EIF3C

eukaryotic translation initiation factor 3, subunit C-like
eukaryotic translation initiation factor 3, subunit C


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
8.17 8.80e-03 GO:0046903 secretion

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
31.09 6.73e-03 GO:0031093 platelet alpha granule lumen
30.44 7.17e-03 GO:0034774 secretory granule lumen
29.23 8.10e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
28.10 9.11e-03 GO:0031983 vesicle lumen
26.10 1.14e-02 GO:0031091 platelet alpha granule

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
29.23 5.53e-03 GO:0033293 monocarboxylic acid binding
20.31 1.64e-02 GO:0008144 drug binding
8.80 3.87e-02 GO:0004857 enzyme inhibitor activity
38.96 4.78e-02 GO:0015020 glucuronosyltransferase activity