Motif ID: EBF1.p2

Z-value: 1.232


Transcription factors associated with EBF1.p2:

Gene SymbolEntrez IDGene Name
EBF1 1879 early B-cell factor 1



Activity profile for motif EBF1.p2.

activity profile for motif EBF1.p2


Sorted Z-values histogram for motif EBF1.p2

Sorted Z-values for motif EBF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EBF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_23229959 3.103 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr15_-_79237320 1.763 CTSH
cathepsin H
chr6_-_32551993 1.710 HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr1_+_2005424 1.682 NM_001242874
PRKCZ
protein kinase C, zeta
chr15_-_79237353 1.654 NM_004390
CTSH
cathepsin H
chr22_-_37545944 1.580 NM_000878
IL2RB
interleukin 2 receptor, beta
chr7_+_26331493 1.565 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr17_-_38721701 1.509 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr7_+_26331611 1.193 SNX10
sorting nexin 10
chr16_+_22825481 1.113 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr5_-_149792276 1.112 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr14_+_61788398 1.056 NM_006255
PRKCH
protein kinase C, eta
chr5_-_149792370 1.022 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr7_-_150329735 1.000 NM_001244071
NM_001244072
NM_024711
GIMAP6


GTPase, IMAP family member 6


chr6_-_32634287 0.981 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chr14_-_94844881 0.967 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr19_+_4229494 0.930 NM_005755
EBI3
Epstein-Barr virus induced 3
chr7_-_150329285 0.927 GIMAP6
GTPase, IMAP family member 6
chr18_-_28681885 0.898 NM_004949
NM_024422
DSC2

desmocollin 2

chr1_+_2005083 0.881 NM_001033581
PRKCZ
protein kinase C, zeta
chr18_+_55711890 0.857 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr19_-_2042022 0.848 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr5_-_77656169 0.839


chr1_-_147142341 0.835 NM_016361
ACP6
acid phosphatase 6, lysophosphatidic
chr5_-_77656195 0.822 LOC728769
uncharacterized LOC728769
chr4_+_4387982 0.807 NM_001040101
NM_014392
D4S234E

DNA segment on chromosome 4 (unique) 234 expressed sequence

chr17_+_76164624 0.807 NM_004710
SYNGR2
synaptogyrin 2
chr21_-_43816123 0.793 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr1_-_108507474 0.782 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chrX_-_131623994 0.770 NM_001170704
MBNL3
muscleblind-like 3 (Drosophila)
chr1_+_207627614 0.768 NM_001006658
NM_001877
CR2

complement component (3d/Epstein Barr virus) receptor 2

chr19_+_42381189 0.762 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr7_-_994259 0.722 NM_006869
ADAP1
ArfGAP with dual PH domains 1
chr19_-_12512022 0.707 NM_001080821
ZNF799
zinc finger protein 799
chr10_+_114135013 0.691 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr10_+_114133775 0.688 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_+_110371887 0.685 NM_023016
ANKRD57
ankyrin repeat domain 57
chr9_-_136344182 0.681 NM_001145099
NM_017585
SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

chr10_+_114133838 0.679 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr11_+_69924407 0.678 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr2_-_220118610 0.670 NM_006000
TUBA4A
tubulin, alpha 4a
chr1_+_13521962 0.664 NM_001100114
PRAMEF21
PRAME family member 21
chr16_+_22825806 0.659 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr19_+_7702020 0.646 STXBP2
syntaxin binding protein 2
chr17_-_67323185 0.642 NM_172232
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr15_+_75074714 0.641 CSK
c-src tyrosine kinase
chr19_-_2041862 0.637 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr19_-_9731883 0.632 NM_152289
ZNF561
zinc finger protein 561
chr17_+_70117168 0.626 SOX9
SRY (sex determining region Y)-box 9
chr2_+_102608305 0.617 NM_004633
IL1R2
interleukin 1 receptor, type II
chr18_+_55711388 0.614 NM_001144967
NM_001243960
NM_015277
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like


chr16_-_4588738 0.607 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr12_+_7055736 0.606 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr17_-_53499055 0.603 NM_012329
MMD
monocyte to macrophage differentiation-associated
chr1_+_32716839 0.594 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr13_-_46679143 0.591 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr11_-_107729523 0.590 SLC35F2
solute carrier family 35, member F2
chr3_-_197282805 0.590 NM_004051
NM_203314
BDH1

3-hydroxybutyrate dehydrogenase, type 1

chr11_+_121461070 0.589 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr4_+_4388717 0.588 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr15_+_41136178 0.588 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr11_-_107729492 0.586 SLC35F2
solute carrier family 35, member F2
chr18_+_55711746 0.582 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr22_+_37309618 0.579 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr6_-_170102098 0.579 NM_001202550
NM_182552
WDR27

WD repeat domain 27

chr7_-_24797052 0.572 NM_001127453
DFNA5
deafness, autosomal dominant 5
chr19_-_12551762 0.571 ZNF443
zinc finger protein 443
chr19_-_51456159 0.571 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr22_+_37257004 0.569 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr12_-_26985922 0.565 NM_002223
ITPR2
inositol 1,4,5-trisphosphate receptor, type 2
chr4_+_4388804 0.563 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr4_+_37892698 0.553 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr3_+_48507209 0.553 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr14_-_94849552 0.551 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr2_-_44065888 0.528 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr4_-_90758126 0.525 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr21_-_43187197 0.520 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr16_-_4588379 0.513 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr14_+_59655351 0.510 NM_014992
DAAM1
dishevelled associated activator of morphogenesis 1
chr19_-_12551807 0.500 NM_005815
ZNF443
zinc finger protein 443
chr12_+_7055753 0.496 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr3_-_61237036 0.492 NM_001166243
NM_002012
FHIT

fragile histidine triad gene

chr7_+_128578246 0.492 NM_032643
IRF5
interferon regulatory factor 5
chr19_-_6591012 0.491 CD70
CD70 molecule
chr10_+_7745284 0.491 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr14_-_106691698 0.489


chr14_-_95786095 0.486 NM_024734
CLMN
calmin (calponin-like, transmembrane)
chr11_-_67205151 0.483 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr19_-_39264144 0.480 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr11_+_60223281 0.480 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr2_-_110874142 0.471 NM_005434
MALL
mal, T-cell differentiation protein-like
chr3_-_57113292 0.469 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr16_+_68679198 0.465 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr16_+_57406398 0.462 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr1_+_1981902 0.462 NM_002744
PRKCZ
protein kinase C, zeta
chr1_-_236445084 0.460 ERO1LB
ERO1-like beta (S. cerevisiae)
chr19_+_10381763 0.458 ICAM1
intercellular adhesion molecule 1
chr2_+_33738941 0.457 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr7_+_128577990 0.455 NM_001098629
NM_001098630
NM_001242452
IRF5


interferon regulatory factor 5


chr14_+_24563369 0.455 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr1_-_154842725 0.452 NM_001204087
NM_002249
KCNN3

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

chr17_-_46507481 0.451 NM_001075099
NM_003726
SKAP1

src kinase associated phosphoprotein 1

chr14_-_106926393 0.450 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr11_-_87908551 0.448 NM_022337
RAB38
RAB38, member RAS oncogene family
chr1_+_6094342 0.446 NM_001199860
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr2_+_228678556 0.442 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr11_+_46740769 0.441 F2
coagulation factor II (thrombin)
chr11_+_46740736 0.439 NM_000506
F2
coagulation factor II (thrombin)
chr5_+_153825497 0.439 NM_001131062
NM_001131063
NM_024632
SAP30L


SAP30-like


chr17_-_10101854 0.437 NM_201433
GAS7
growth arrest-specific 7
chr10_+_7745325 0.437 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745229 0.437 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_102107256 0.434


chr17_+_19551835 0.433 NM_000382
NM_001031806
ALDH3A2

aldehyde dehydrogenase 3 family, member A2

chr6_-_10419786 0.432 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr12_-_6484904 0.431 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr6_+_33043702 0.431 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr2_-_110873638 0.430 MALL
mal, T-cell differentiation protein-like
chr16_+_68679229 0.428 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr19_-_45909566 0.427 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr8_+_82192717 0.427 NM_001444
FABP5
fatty acid binding protein 5 (psoriasis-associated)
chr15_-_38856830 0.424 NM_001128602
NM_005739
RASGRP1

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

chr15_+_41625152 0.423 NUSAP1
nucleolar and spindle associated protein 1
chr8_+_54793516 0.423 RGS20
regulator of G-protein signaling 20
chr8_+_54793409 0.423 NM_003702
RGS20
regulator of G-protein signaling 20
chr1_+_13742801 0.423 NM_001100114
PRAMEF21
PRAME family member 21
chr11_+_706103 0.422 NM_022772
EPS8L2
EPS8-like 2
chr11_+_722282 0.420 EPS8L2
EPS8-like 2
chr15_+_41624891 0.418 NM_001243142
NM_001243143
NM_001243144
NM_016359
NM_018454
NUSAP1




nucleolar and spindle associated protein 1




chrX_+_128913881 0.417 NM_018990
SASH3
SAM and SH3 domain containing 3
chr1_-_236445294 0.415 NM_019891
ERO1LB
ERO1-like beta (S. cerevisiae)
chr19_+_10381516 0.415 NM_000201
ICAM1
intercellular adhesion molecule 1
chr7_+_89840999 0.415 NM_001244944
NM_001244945
NM_152999
NM_001040665
NM_001244946
STEAP2




STEAP family member 2, metalloreductase




chr5_-_150466696 0.414 NM_001252391
NM_001252392
TNIP1

TNFAIP3 interacting protein 1

chr11_+_73359734 0.412 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr14_-_67878859 0.407 PLEK2
pleckstrin 2
chr19_-_51327003 0.407 NM_002257
KLK1
kallikrein 1
chr14_-_67878770 0.406 NM_016445
PLEK2
pleckstrin 2
chr20_+_61448391 0.404 NM_001853
COL9A3
collagen, type IX, alpha 3
chr10_+_7745354 0.402 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr8_-_70745624 0.399 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr9_-_130742803 0.398 NM_001035254
FAM102A
family with sequence similarity 102, member A
chr9_-_116840604 0.397 AMBP
alpha-1-microglobulin/bikunin precursor
chr2_+_118846029 0.397 NM_016133
INSIG2
insulin induced gene 2
chr12_-_51717835 0.394 BIN2
bridging integrator 2
chr7_-_994008 0.394 ADAP1
ArfGAP with dual PH domains 1
chr22_+_24823529 0.394 NM_000675
ADORA2A
adenosine A2a receptor
chr1_+_111682248 0.393 NM_001007794
CEPT1
choline/ethanolamine phosphotransferase 1
chr15_+_41625052 0.392 NUSAP1
nucleolar and spindle associated protein 1
chrX_-_74376075 0.392 NM_004299
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr10_+_7745341 0.392 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr5_-_150467220 0.387 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr3_-_58200397 0.384 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr22_+_22723972 0.382


chr22_+_22550159 0.377 IGLV6-57
immunoglobulin lambda variable 6-57
chr5_+_133450353 0.370 NM_003202
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr6_+_21593963 0.369 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chrX_+_128913897 0.369 SASH3
SAM and SH3 domain containing 3
chr15_-_45480160 0.368 SHF
Src homology 2 domain containing F
chr9_-_132805456 0.365 NM_015033
FNBP1
formin binding protein 1
chr14_-_106994001 0.356 IGHV3-48
IGH@
IGHA1
IGHM
immunoglobulin heavy variable 3-48
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr20_+_42295747 0.356 MYBL2
v-myb myeloblastosis viral oncogene homolog (avian)-like 2
chr9_-_116840460 0.353 AMBP
alpha-1-microglobulin/bikunin precursor
chrX_+_105969875 0.353 NM_194463
RNF128
ring finger protein 128
chr16_+_3115641 0.351 NM_001012632
NM_001012636
IL32

interleukin 32

chr19_-_51487070 0.351 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chr19_+_49838673 0.350 NM_001040031
NM_001774
CD37

CD37 molecule

chr17_-_62009620 0.349 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr7_+_102074002 0.348 ORAI2
ORAI calcium release-activated calcium modulator 2
chr17_+_74380943 0.348 SPHK1
sphingosine kinase 1
chr9_-_92112887 0.347 SEMA4D
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr1_-_214724974 0.346 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr4_-_2965036 0.346 NOP14
NOP14 nucleolar protein homolog (yeast)
chr19_-_51522953 0.343 NM_145888
KLK10
kallikrein-related peptidase 10
chr14_-_23426356 0.342 HAUS4
HAUS augmin-like complex, subunit 4
chr12_-_6486522 0.341 NM_001159575
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr19_+_47813074 0.339 NM_001736
C5AR1
complement component 5a receptor 1
chr11_-_57282315 0.337 NM_001198810
SLC43A1
solute carrier family 43, member 1
chr3_-_11761946 0.337 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr18_-_46475702 0.336 NM_001190822
SMAD7
SMAD family member 7
chr2_+_237478379 0.336 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr14_-_107048697 0.336 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_55369163 0.336 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr17_-_39942937 0.335 NM_002230
NM_021991
JUP

junction plakoglobin

chr2_+_42396392 0.335 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr20_-_45976626 0.335 ZMYND8
zinc finger, MYND-type containing 8
chr18_+_60190657 0.333 NM_017742
ZCCHC2
zinc finger, CCHC domain containing 2
chr8_-_101322180 0.326 RNF19A
ring finger protein 19A
chr14_+_92790151 0.324 NM_153646
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr2_+_97426571 0.324 NM_020184
CNNM4
cyclin M4
chr8_-_70745403 0.323 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr7_-_1595746 0.323 NM_001097620
TMEM184A
transmembrane protein 184A
chr19_+_8274179 0.321 NM_024552
CERS4
ceramide synthase 4
chrX_+_152110214 0.318 NM_001178115
ZNF185
zinc finger protein 185 (LIM domain)
chr14_+_24701624 0.318 NM_001002000
NM_001002001
GMPR2

guanosine monophosphate reductase 2

chr19_+_49838646 0.317 CD37
CD37 molecule
chr12_+_100867550 0.317 NM_001206977
NM_001206978
NM_001206979
NM_005123
NR1H4



nuclear receptor subfamily 1, group H, member 4



chr1_-_234614848 0.317 NM_005646
TARBP1
TAR (HIV-1) RNA binding protein 1
chr8_+_142138684 0.316 NM_014957
DENND3
DENN/MADD domain containing 3
chr22_+_45705965 0.314 FAM118A
family with sequence similarity 118, member A

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
169.46 5.74e-05 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
52.19 2.22e-03 GO:0019882 antigen processing and presentation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
193.66 1.44e-05 GO:0042613 MHC class II protein complex
90.41 1.60e-04 GO:0042611 MHC protein complex
12.18 1.10e-03 GO:0005768 endosome
16.35 2.76e-03 GO:0000323 lytic vacuole
16.35 2.76e-03 GO:0005764 lysosome
28.60 5.23e-03 GO:0005770 late endosome
13.76 5.42e-03 GO:0005773 vacuole
38.52 4.80e-02 GO:0031902 late endosome membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
129.13 2.51e-03 GO:0004697 protein kinase C activity
26.38 4.05e-03 GO:0019955 cytokine binding