Motif ID: EN1,2.p2

Z-value: 0.865


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EN1chr2_-_119605758-0.552.8e-02Click!
EN2chr7_+_155250705-0.543.1e-02Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74281884 2.224 ALB
albumin
chr11_+_22696318 1.636 NM_005256
GAS2
growth arrest-specific 2
chr10_-_98031154 1.444 NM_001114094
NM_013314
BLNK

B-cell linker

chr12_+_53342842 1.433 NM_000224
KRT18
keratin 18
chr17_-_39675078 1.407 NM_002275
KRT15
keratin 15
chr12_+_53342899 1.184 KRT18
keratin 18
chr17_-_64225496 0.923 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr12_-_6486522 0.749 NM_001159575
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr6_+_30294224 0.739


chr11_+_60223281 0.736 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr12_-_53343607 0.733 KRT8
keratin 8
chr2_-_88427535 0.723 NM_001443
FABP1
fatty acid binding protein 1, liver
chr14_-_65409445 0.694 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr6_+_32407618 0.693 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr10_+_114133838 0.685 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr19_-_7764283 0.671 NM_001207019
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr10_+_114133775 0.584 ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_-_102591547 0.567 NM_002674
PMCH
pro-melanin-concentrating hormone
chr3_-_148939784 0.562 NM_000096
CP
ceruloplasmin (ferroxidase)
chr1_+_32043745 0.555 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr6_-_41703938 0.554 NM_001167827
TFEB
transcription factor EB
chr19_+_41281281 0.545 NM_006533
MIA
melanoma inhibitory activity
chr1_+_32050510 0.527 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr10_-_105845619 0.525 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr12_+_6554032 0.523 NM_001242
CD27
CD27 molecule
chr19_+_41281081 0.517 NM_001202553
MIA
melanoma inhibitory activity
chr2_+_11674241 0.517 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr17_-_34417386 0.516 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr15_-_80263460 0.508 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr4_+_74269971 0.508 NM_000477
ALB
albumin
chr4_+_40198526 0.498 NM_004310
RHOH
ras homolog gene family, member H
chr6_-_123957941 0.498 NM_001251987
NM_006073
TRDN

triadin

chr10_-_105845556 0.493 COL17A1
collagen, type XVII, alpha 1
chr2_-_158300517 0.482 NM_004288
CYTIP
cytohesin 1 interacting protein
chr7_+_26400503 0.474 NM_001199837
SNX10
sorting nexin 10
chr3_-_183273407 0.472 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr15_-_55563091 0.446 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr1_+_111415721 0.443 NM_000560
CD53
CD53 molecule
chr20_-_45976626 0.439 ZMYND8
zinc finger, MYND-type containing 8
chr5_+_68800003 0.438 NM_001205255
OCLN
occludin
chr1_+_6105980 0.419 NM_001199862
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr8_-_28347733 0.417 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr3_-_120401401 0.402 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr19_-_51472816 0.397 NM_002774
KLK6
kallikrein-related peptidase 6
chr8_+_11665394 0.390 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr6_+_14117857 0.383 NM_001040280
NM_004233
CD83

CD83 molecule

chr6_+_31583766 0.382 NM_032955
AIF1
allograft inflammatory factor 1
chr5_-_176836535 0.382 NM_000505
F12
coagulation factor XII (Hageman factor)
chr6_+_32605182 0.375 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr2_+_33738941 0.374 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_+_113344811 0.373 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr9_+_33026482 0.369 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr1_-_161193375 0.368 NM_001643
APOA2
apolipoprotein A-II
chr3_-_151034514 0.365 NM_023915
GPR87
G protein-coupled receptor 87
chr22_+_40297085 0.359 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr5_-_86703927 0.347 CCNH
cyclin H
chr4_+_155484131 0.345 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr9_-_123812535 0.341 NM_001735
C5
complement component 5
chr22_+_23054862 0.340 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr19_+_42381189 0.338 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr15_-_52587851 0.336 NM_018728
MYO5C
myosin VC
chr7_+_20686965 0.336 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr7_+_94292816 0.335 PEG10
paternally expressed 10
chr14_-_24037266 0.333 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr10_-_7682741 0.325 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr12_-_123201319 0.316 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr12_-_53298765 0.313 NM_002273
KRT8
keratin 8
chr14_+_88471467 0.311 NM_003608
GPR65
G protein-coupled receptor 65
chr19_+_35739778 0.307 LSR
lipolysis stimulated lipoprotein receptor
chr22_+_40297183 0.299 GRAP2
GRB2-related adaptor protein 2
chr20_+_62367945 0.298 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr11_+_22689653 0.297 NM_177553
GAS2
growth arrest-specific 2
chr20_-_23967431 0.295 NM_178312
GGTLC1
gamma-glutamyltransferase light chain 1
chr12_+_21168629 0.294 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr7_+_115863004 0.293 NM_152829
TES
testis derived transcript (3 LIM domains)
chr15_+_43885251 0.290 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr6_+_31913852 0.288 CFB
complement factor B
chr14_-_94855120 0.287 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr1_+_212209129 0.286 DTL
denticleless homolog (Drosophila)
chr1_-_24194760 0.285 NM_000147
FUCA1
fucosidase, alpha-L- 1, tissue
chr12_+_7055736 0.283 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr14_-_94854910 0.282 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_+_95078713 0.282 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr12_-_102872329 0.280 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr7_-_25268057 0.277 NM_022150
NPVF
neuropeptide VF precursor
chr9_-_104145800 0.271 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr4_+_71062241 0.269 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr6_-_33282006 0.263 NM_003190
NM_172208
NM_172209
TAPBP


TAP binding protein (tapasin)


chr12_-_63328857 0.262 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr2_-_142889269 0.261 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr19_+_34710327 0.260 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr6_+_106546736 0.256 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr14_+_95047730 0.256 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr1_-_108231122 0.255 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chrX_+_128913897 0.252 SASH3
SAM and SH3 domain containing 3
chr1_+_86889768 0.252 NM_006536
CLCA2
chloride channel accessory 2
chr19_-_39826625 0.252 GMFG
glia maturation factor, gamma
chr18_+_29171729 0.252 NM_000371
TTR
transthyretin
chr4_-_17806820 0.251 DCAF16
DDB1 and CUL4 associated factor 16
chr7_+_50348255 0.250 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr2_+_103035148 0.249 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr14_-_95608054 0.247 NM_030621
DICER1
dicer 1, ribonuclease type III
chr21_-_34883620 0.245 GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr1_+_212208918 0.243 NM_016448
DTL
denticleless homolog (Drosophila)
chr12_+_113344738 0.241 NM_001032409
NM_002534
NM_016816
OAS1


2'-5'-oligoadenylate synthetase 1, 40/46kDa


chr6_+_6588933 0.240 NM_004271
LY86
lymphocyte antigen 86
chr13_-_46679143 0.239 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr7_+_107110501 0.237 NM_005295
GPR22
G protein-coupled receptor 22
chr3_-_120400957 0.237 HGD
homogentisate 1,2-dioxygenase
chr12_-_102512277 0.237 NM_024057
NUP37
nucleoporin 37kDa
chr14_-_95599794 0.237 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr17_-_27467395 0.236 MYO18A
myosin XVIIIA
chr14_-_106641585 0.235 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_+_53497273 0.234 NM_003578
SOAT2
sterol O-acyltransferase 2
chr6_-_79675672 0.230 PHIP
pleckstrin homology domain interacting protein
chr13_-_76055872 0.229 NM_014832
TBC1D4
TBC1 domain family, member 4
chr2_+_69001932 0.226 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr12_+_53497287 0.225 SOAT2
sterol O-acyltransferase 2
chr17_-_56591900 0.224 MTMR4
myotubularin related protein 4
chr19_-_39826676 0.223 NM_004877
GMFG
glia maturation factor, gamma
chr5_+_68667280 0.221 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr17_-_39093671 0.219 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr5_-_169816637 0.219 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr22_-_37545944 0.216 NM_000878
IL2RB
interleukin 2 receptor, beta
chr16_+_29827707 0.213 C16orf53
chromosome 16 open reading frame 53
chr1_+_20915440 0.212 NM_001785
CDA
cytidine deaminase
chr1_+_111770280 0.211 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr7_+_128578246 0.209 NM_032643
IRF5
interferon regulatory factor 5
chr3_-_121379757 0.209 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chrX_+_128913881 0.208 NM_018990
SASH3
SAM and SH3 domain containing 3
chr7_+_45933096 0.207


chrX_-_70474402 0.206 NM_001171163
NM_005096
ZMYM3

zinc finger, MYM-type 3

chr18_-_58040000 0.205 NM_005912
MC4R
melanocortin 4 receptor
chr1_+_57320442 0.204 NM_000562
C8A
complement component 8, alpha polypeptide
chr18_-_59854288 0.204 NM_012327
NM_176787
PIGN

phosphatidylinositol glycan anchor biosynthesis, class N

chr10_-_116418056 0.202 NM_002313
ABLIM1
actin binding LIM protein 1
chr7_+_94292737 0.199 PEG10
paternally expressed 10
chr2_+_68592432 0.199 PLEK
pleckstrin
chr4_-_76928601 0.199 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr10_+_5005453 0.198 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr16_+_29827489 0.198 NM_024516
C16orf53
chromosome 16 open reading frame 53
chr16_+_57392694 0.196 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr14_+_95047792 0.196 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr2_-_167005641 0.195 NM_001202435
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr12_+_7055753 0.194 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr6_-_41715078 0.193 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr10_-_52645384 0.192 A1CF
APOBEC1 complementation factor
chr10_-_5045967 0.191 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr22_+_22712091 0.187 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr15_-_65412175 0.187 PDCD7
programmed cell death 7
chr6_-_133084585 0.186 NM_078488
VNN2
vanin 2
chr4_-_46996423 0.186 NM_000809
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr13_-_46756326 0.184 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_21225640 0.183 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_27732069 0.179 WASF2
WAS protein family, member 2
chr6_-_154651214 0.179 NM_001130699
IPCEF1
interaction protein for cytohesin exchange factors 1
chr8_+_40010986 0.178 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr3_-_121379701 0.178 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr18_-_59854179 0.177 PIGN
phosphatidylinositol glycan anchor biosynthesis, class N
chr1_-_153919140 0.176 NM_014856
DENND4B
DENN/MADD domain containing 4B
chr13_-_46756295 0.174 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_-_119470336 0.174 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr16_-_20364029 0.173 NM_001008389
NM_003361
UMOD

uromodulin

chr12_+_86268072 0.173 NM_006183
NTS
neurotensin
chr4_+_39063851 0.170 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr5_-_176836488 0.169 F12
coagulation factor XII (Hageman factor)
chr17_+_72462766 0.169 CD300A
CD300a molecule
chr13_+_53216564 0.168 HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr18_+_55888838 0.168 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_-_24036939 0.167 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr7_+_141463896 0.165 NM_016943
TAS2R3
taste receptor, type 2, member 3
chr7_+_94539209 0.165 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr5_-_150603615 0.165 CCDC69
coiled-coil domain containing 69
chr7_-_115670828 0.164 NM_001018058
NM_012252
TFEC

transcription factor EC

chr14_+_95027760 0.164 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr19_-_45908288 0.164 NM_006663
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr5_-_150603649 0.162 NM_015621
CCDC69
coiled-coil domain containing 69
chr16_-_89831445 0.162 FANCA
Fanconi anemia, complementation group A
chr2_-_192015706 0.162 STAT4
signal transducer and activator of transcription 4
chr2_-_74382352 0.161


chr16_+_50731049 0.161 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr1_-_12908141 0.161 NM_001146181
HNRNPCL1
LOC649330
heterogeneous nuclear ribonucleoprotein C-like 1
heterogeneous nuclear ribonucleoprotein C-like
chr8_-_87755880 0.160 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chrX_+_110366304 0.159 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr4_-_153303663 0.159 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr17_-_29641068 0.158 EVI2B
ecotropic viral integration site 2B
chr12_+_121132677 0.157


chr10_-_104178900 0.157 NM_002779
PSD
pleckstrin and Sec7 domain containing
chr6_-_87804773 0.156 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr8_-_66701175 0.155 NM_002603
PDE7A
phosphodiesterase 7A
chr15_+_93443418 0.154 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr10_+_104179570 0.154 NM_024326
FBXL15
F-box and leucine-rich repeat protein 15
chr8_+_22844918 0.153 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr3_+_151488214 0.153 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr6_+_33043702 0.152 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr6_+_26273143 0.152 NM_003525
HIST1H2BI
histone cluster 1, H2bi
chr2_-_215896809 0.151 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr10_-_62149487 0.151 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr10_-_104179468 0.150 PSD
pleckstrin and Sec7 domain containing
chr10_+_7745284 0.149 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
52.87 7.53e-03 GO:0005882 intermediate filament
41.91 1.20e-02 GO:0045111 intermediate filament cytoskeleton
8.39 3.97e-02 GO:0044430 cytoskeletal part

Nothing significant found in function category.