Motif ID: EOMES.p2

Z-value: 0.966


Transcription factors associated with EOMES.p2:

Gene SymbolEntrez IDGene Name
EOMES 8320 eomesodermin



Activity profile for motif EOMES.p2.

activity profile for motif EOMES.p2


Sorted Z-values histogram for motif EOMES.p2

Sorted Z-values for motif EOMES.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EOMES.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_75568232 2.862 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr1_-_85930610 2.653 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr10_-_92680784 2.565 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_-_186732208 1.956 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr9_-_75567915 1.902 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr4_-_186732047 1.814 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chrX_+_99899162 1.683 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chrX_+_99899388 1.635 SRPX2
sushi-repeat containing protein, X-linked 2
chr10_-_92681025 1.618 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_-_186578122 1.300 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr16_+_30386097 1.238 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr12_-_6233684 1.223 NM_000552
VWF
von Willebrand factor
chr15_-_35087748 1.117 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr1_-_116311161 1.071 CASQ2
calsequestrin 2 (cardiac muscle)
chr4_-_186577858 1.032 SORBS2
sorbin and SH3 domain containing 2
chr7_-_50772997 0.932 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr2_-_56151273 0.910 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr14_+_105941061 0.895 NM_001312
CRIP2
cysteine-rich protein 2
chr3_-_99833348 0.868 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr1_+_150245182 0.797 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr4_+_124317884 0.790 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr12_+_56473944 0.778 ERBB3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr14_+_95078713 0.774 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr2_+_228678556 0.752 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr9_-_16727887 0.741 BNC2
basonuclin 2
chr2_-_192711651 0.734 SDPR
serum deprivation response
chr10_+_70847817 0.732 NM_002727
SRGN
serglycin
chr8_-_82395401 0.703 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chrX_-_15873094 0.691 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr11_+_46402333 0.672 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr9_-_79520878 0.671 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chrX_-_15872938 0.671 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr11_-_27743604 0.667 NM_170731
BDNF
brain-derived neurotrophic factor
chr6_-_112041253 0.663 NM_153047
FYN
FYN oncogene related to SRC, FGR, YES
chr9_-_130616592 0.646 ENG
endoglin
chr10_+_70847857 0.638 SRGN
serglycin
chr2_-_190044330 0.628 NM_000393
COL5A2
collagen, type V, alpha 2
chr11_-_33913835 0.612 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr7_+_150264457 0.573 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr11_+_73358593 0.569 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr4_+_86396251 0.568 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr17_+_8214139 0.555 NM_025014
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr12_+_69742130 0.545 NM_000239
LYZ
lysozyme
chr2_-_39664430 0.528 MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr19_-_44831907 0.525 ZFP112
zinc finger protein 112 homolog (mouse)
chr8_+_40010986 0.521 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr12_+_69742140 0.515 LYZ
lysozyme
chr1_-_153600714 0.506 NM_005979
S100A13
S100 calcium binding protein A13
chr20_-_23062786 0.497 CD93
CD93 molecule
chr2_-_39664291 0.494 MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr10_-_15413054 0.464 NM_001010924
FAM171A1
family with sequence similarity 171, member A1
chr7_-_99766238 0.455 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr5_-_95158365 0.454 GLRX
glutaredoxin (thioltransferase)
chr3_-_114478117 0.446 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr18_+_72922725 0.437 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr7_-_99766191 0.437 GAL3ST4
galactose-3-O-sulfotransferase 4
chr3_+_158991035 0.436 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr15_+_63336274 0.431 TPM1
tropomyosin 1 (alpha)
chr19_-_46285752 0.429 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr5_-_16742336 0.415 MYO10
myosin X
chrX_-_15872921 0.410 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr10_-_75410778 0.409 NM_024875
SYNPO2L
synaptopodin 2-like
chr14_+_55034633 0.404 SAMD4A
sterile alpha motif domain containing 4A
chr12_-_111358353 0.401 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr5_-_111093792 0.399 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr2_-_179672056 0.394 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr17_+_8213555 0.391 NM_173728
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr11_-_2182408 0.391 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough
chrX_+_70443055 0.388 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr2_-_175869910 0.383 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr9_+_34652125 0.379 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr1_-_173174611 0.378 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr3_-_187463474 0.375 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr1_-_169555624 0.372 F5
coagulation factor V (proaccelerin, labile factor)
chr17_-_10452939 0.367 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr5_-_95158465 0.366 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr10_+_7745229 0.362 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr9_+_34990715 0.362 DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr11_-_65314049 0.355 LTBP3
latent transforming growth factor beta binding protein 3
chr8_-_11705259 0.348


chrX_-_15872905 0.348


chr1_+_46379258 0.346 MAST2
microtubule associated serine/threonine kinase 2
chr21_-_39870303 0.340 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr5_-_168271852 0.339


chr2_-_211179765 0.336 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr11_-_2159472 0.335 IGF2
insulin-like growth factor 2 (somatomedin A)
chr13_-_36429798 0.330 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr2_-_56150862 0.328 EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr6_-_31619481 0.327


chr11_-_86666211 0.325 NM_012193
FZD4
frizzled family receptor 4
chr5_-_94224601 0.325 MCTP1
multiple C2 domains, transmembrane 1
chr22_+_38598065 0.324 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr6_-_46293628 0.314 NM_005822
RCAN2
regulator of calcineurin 2
chr11_+_19734821 0.313 NM_001244963
NM_145117
NM_182964
NAV2


neuron navigator 2


chr7_-_27224762 0.309 NM_005523
HOXA11
homeobox A11
chr1_+_84630575 0.308 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr13_+_102104941 0.307 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr14_+_55034329 0.303 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr1_+_84630374 0.300 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_-_151344145 0.297 NM_005168
RND3
Rho family GTPase 3
chr6_+_39760148 0.297 NM_001201427
DAAM2
dishevelled associated activator of morphogenesis 2
chr16_-_52581713 0.296 NM_001146188
TOX3
TOX high mobility group box family member 3
chr3_-_50360109 0.294 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr9_+_34990266 0.294 NM_001135005
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr9_+_134378353 0.294 POMT1
protein-O-mannosyltransferase 1
chr11_-_6676851 0.292 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr2_-_192711923 0.288 NM_004657
SDPR
serum deprivation response
chr1_+_38022514 0.280 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr6_-_31620142 0.278 NM_001098534
BAG6
BCL2-associated athanogene 6
chr16_+_31484497 0.276 NM_015927
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr15_-_90349819 0.274 ANPEP
alanyl (membrane) aminopeptidase
chr3_-_49459870 0.272 AMT
aminomethyltransferase
chr12_+_7169192 0.271


chrX_-_21776158 0.270 NM_014332
SMPX
small muscle protein, X-linked
chr14_-_75078669 0.269 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr3_-_49726081 0.267 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr2_+_178257371 0.266 NM_003659
AGPS
alkylglycerone phosphate synthase
chr6_-_46459710 0.262 NM_001251973
RCAN2
regulator of calcineurin 2
chr2_+_178257488 0.261 AGPS
alkylglycerone phosphate synthase
chr3_-_171528227 0.258 NM_001130081
NM_002662
PLD1

phospholipase D1, phosphatidylcholine-specific

chr10_+_7745325 0.258 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_-_161193190 0.258 APOA2
apolipoprotein A-II
chr1_-_169555710 0.258 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr22_-_43042976 0.257 NM_001129819
NM_001171661
NM_007326
CYB5R3


cytochrome b5 reductase 3


chr4_-_186733372 0.253 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr4_+_90816002 0.251 NM_007351
MMRN1
multimerin 1
chr6_+_107811272 0.250 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr16_+_69220940 0.249 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr10_+_7745341 0.248 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr9_+_134378335 0.247 POMT1
protein-O-mannosyltransferase 1
chr12_+_26348488 0.244 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr10_-_29754478 0.240 SVIL
supervillin
chr10_+_31607419 0.238 ZEB1
zinc finger E-box binding homeobox 1
chr11_+_112831968 0.238 NM_000615
NM_001076682
NM_001242607
NM_001242608
NM_181351
NCAM1




neural cell adhesion molecule 1




chr20_+_44518782 0.237 CTSA
cathepsin A
chr9_+_134378334 0.235 POMT1
protein-O-mannosyltransferase 1
chr2_-_39664129 0.231 NM_003618
MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr1_-_160313353 0.231 NM_001098398
NM_004371
COPA

coatomer protein complex, subunit alpha

chr12_+_75874512 0.229 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr1_+_160313172 0.226 NCSTN
nicastrin
chr3_-_66551341 0.224 LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr21_-_27253197 0.222 APP
amyloid beta (A4) precursor protein
chr2_+_28616346 0.221 FOSL2
FOS-like antigen 2
chr16_+_57702156 0.221 NM_170776
GPR97
G protein-coupled receptor 97
chrX_+_66763868 0.220 NM_000044
AR
androgen receptor
chr18_-_53255361 0.214 TCF4
transcription factor 4
chr10_+_7745284 0.210 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr22_+_38597938 0.210 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr12_-_6055397 0.209 NM_020373
ANO2
anoctamin 2
chr8_-_134584012 0.204 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr7_+_134576187 0.204 CALD1
caldesmon 1
chrX_-_135749436 0.203 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr2_+_71295685 0.203 NAGK
N-acetylglucosamine kinase
chr3_-_187463227 0.201 BCL6
B-cell CLL/lymphoma 6
chr16_+_85645014 0.199 NM_001134473
KIAA0182
KIAA0182
chr6_+_131894343 0.199 NM_000045
NM_001244438
ARG1

arginase, liver

chr3_+_49506079 0.198 NM_001177643
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr16_-_88717395 0.198 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr6_+_142622797 0.195 NM_001032394
NM_001032395
NM_020455
NM_198569
GPR126



G protein-coupled receptor 126



chr1_+_27101217 0.192 ARID1A
AT rich interactive domain 1A (SWI-like)
chr16_-_18937722 0.192 NM_015092
SMG1
smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr9_+_116327301 0.191 NM_134427
RGS3
regulator of G-protein signaling 3
chr1_-_203155827 0.190 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr1_+_17846818 0.190 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr2_-_211168315 0.190 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr2_-_133428480 0.189 NM_144586
LYPD1
LY6/PLAUR domain containing 1
chr3_-_133748828 0.187 NM_005630
SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr2_+_219283809 0.186 NM_007127
VIL1
villin 1
chr5_-_132112887 0.184 NM_001098811
NM_001098812
NM_015146
SEPT8


septin 8


chr16_+_72088507 0.183 NM_001126102
NM_005143
HP

haptoglobin

chr3_-_133748727 0.182 SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr5_+_176513819 0.181 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr1_-_12677347 0.180 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr9_+_139871954 0.179 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr2_-_133429069 0.179 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr1_+_153600859 0.176 NM_006271
S100A1
S100 calcium binding protein A1
chr11_+_63448868 0.175 NM_006054
NM_201428
NM_201429
NM_201430
RTN3



reticulon 3



chrX_+_23685658 0.175 PRDX4
peroxiredoxin 4
chrX_-_133119475 0.173 GPC3
glypican 3
chr20_-_24973410 0.171 NM_020531
C20orf3
chromosome 20 open reading frame 3
chr1_-_203155745 0.170 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr9_-_74979625 0.169 ZFAND5
zinc finger, AN1-type domain 5
chr9_+_17134974 0.167 NM_001114395
NM_017738
CNTLN

centlein, centrosomal protein

chr2_-_96956458 0.166 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr20_+_34680569 0.164 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chrX_-_10645726 0.163 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr1_+_55007927 0.162 ACOT11
acyl-CoA thioesterase 11
chr17_-_76836852 0.161 NM_025090
USP36
ubiquitin specific peptidase 36
chr12_+_26348268 0.160 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr10_+_7745354 0.160 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chrX_+_152770083 0.159 BGN
biglycan
chr16_+_6069094 0.156 NM_001142333
NM_018723
RBFOX1

RNA binding protein, fox-1 homolog (C. elegans) 1

chr14_+_21156922 0.155 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chrX_-_70473941 0.155 ZMYM3
zinc finger, MYM-type 3
chr10_+_114135965 0.154 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_52456292 0.154 NM_002867
RAB3B
RAB3B, member RAS oncogene family
chr3_+_35721115 0.152 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr5_-_54281345 0.152 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr4_+_8951476 0.152 NM_001040071
LOC650293
seven transmembrane helix receptor
chrX_-_70474402 0.151 NM_001171163
NM_005096
ZMYM3

zinc finger, MYM-type 3


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
50.19 1.50e-05 GO:0044449 contractile fiber part
45.68 2.19e-05 GO:0043292 contractile fiber
92.65 8.31e-05 GO:0031674 I band
44.22 7.85e-04 GO:0030017 sarcomere
36.58 1.39e-03 GO:0030016 myofibril
14.75 2.06e-02 GO:0015629 actin cytoskeleton

Nothing significant found in function category.