Motif ID: EP300.p2

Z-value: 2.161


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
EP300 2033 E1A binding protein p300

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EP300chr22_+_41487787-0.684.0e-03Click!


Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_140271293 7.577 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr12_+_6309475 6.316 NM_001769
CD9
CD9 molecule
chr1_-_95007139 5.991 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr10_-_126849556 5.881 NM_001083914
CTBP2
C-terminal binding protein 2
chrX_-_140271275 5.734 LDOC1
leucine zipper, down-regulated in cancer 1
chr13_-_114567040 4.162 NM_000820
GAS6
growth arrest-specific 6
chr13_-_114567011 4.057 GAS6
growth arrest-specific 6
chr13_-_114567034 4.047 GAS6
growth arrest-specific 6
chr13_-_114566951 3.892 GAS6
growth arrest-specific 6
chr7_+_116165089 2.847 CAV1
caveolin 1, caveolae protein, 22kDa
chr13_-_40177355 2.820 NM_005780
LHFP
lipoma HMGIC fusion partner
chr7_+_116164838 2.804 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr7_+_116165043 2.697 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr18_-_21977711 2.658 OSBPL1A
oxysterol binding protein-like 1A
chr2_+_71295685 2.643 NAGK
N-acetylglucosamine kinase
chr18_-_21977785 2.580 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr12_-_54813002 2.546 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr9_-_117880411 2.535 NM_002160
TNC
tenascin C
chr13_-_40177200 2.479 LHFP
lipoma HMGIC fusion partner
chr14_-_69446038 2.423 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr11_+_35160385 2.401 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
NM_001202555
NM_001202556
NM_001202557
CD44







CD44 molecule (Indian blood group)







chrX_+_135229536 2.309 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr12_-_54812936 2.270 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr14_-_69446008 2.244 ACTN1
actinin, alpha 1
chr14_-_69445978 2.237 ACTN1
actinin, alpha 1
chr1_-_108742963 2.211 NM_013386
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr10_+_121411086 2.208 BAG3
BCL2-associated athanogene 3
chr14_-_69445974 2.176 ACTN1
actinin, alpha 1
chr3_-_32023237 2.158 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr14_-_69445989 2.127 ACTN1
actinin, alpha 1
chr14_-_69445948 2.122 ACTN1
actinin, alpha 1
chr14_-_105444693 2.091 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr13_-_40177304 2.059 LHFP
lipoma HMGIC fusion partner
chr10_+_121411071 2.033 BAG3
BCL2-associated athanogene 3
chr5_+_95998678 2.026 CAST
calpastatin
chr1_-_225840660 1.847 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr4_+_75480628 1.837 NM_001657
AREG
amphiregulin
chr4_-_84256012 1.831 NM_001098540
HPSE
heparanase
chr1_-_59042827 1.767 TACSTD2
tumor-associated calcium signal transducer 2
chr2_-_190044330 1.766 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_-_20812727 1.737 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr11_+_114167197 1.727 NNMT
nicotinamide N-methyltransferase
chr4_+_75310852 1.716 NM_001657
AREG
amphiregulin
chr12_-_105629790 1.688 NM_001251904
NM_018171
APPL2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr17_+_60705051 1.657 MRC2
mannose receptor, C type 2
chr8_+_15397761 1.649 TUSC3
tumor suppressor candidate 3
chrX_+_135251454 1.635 NM_001159704
FHL1
four and a half LIM domains 1
chr8_+_31497267 1.632 NM_013962
NRG1
neuregulin 1
chr6_-_86352650 1.603 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr3_+_154797644 1.591 NM_007287
MME
membrane metallo-endopeptidase
chr10_+_102792166 1.574 SFXN3
sideroflexin 3
chr12_-_26277807 1.568 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr8_-_145013628 1.567 NM_201384
PLEC
plectin
chr19_+_16296211 1.566 NM_014077
FAM32A
family with sequence similarity 32, member A
chr1_+_223889253 1.550 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr18_-_21851816 1.548 OSBPL1A
oxysterol binding protein-like 1A
chr3_+_156392714 1.536 NM_001184717
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr1_+_26606580 1.513 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr3_+_154797435 1.503 NM_000902
MME
membrane metallo-endopeptidase
chr1_+_26606621 1.489 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr12_+_54410641 1.466 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr1_-_108742738 1.458 SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr18_-_21851646 1.455 OSBPL1A
oxysterol binding protein-like 1A
chr5_-_39425297 1.451 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr2_+_217498082 1.447 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr2_+_192109879 1.444 NM_001130158
NM_012223
NM_001161819
MYO1B


myosin IB


chr8_+_15397595 1.440 NM_006765
NM_178234
TUSC3

tumor suppressor candidate 3

chr16_+_70502824 1.429 FUK
fucokinase
chr14_-_67878859 1.419 PLEK2
pleckstrin 2
chr9_-_33447527 1.408 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr1_+_156084579 1.394 LMNA
lamin A/C
chr5_-_39424930 1.391 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr3_-_51996855 1.388 NM_033010
PCBP4
poly(rC) binding protein 4
chr1_+_26606586 1.380 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr17_+_15848230 1.372 NM_000676
ADORA2B
adenosine A2b receptor
chr1_-_156647088 1.366 NM_006617
NES
nestin
chr14_-_69445772 1.365 ACTN1
actinin, alpha 1
chr18_-_21852189 1.358 NM_018030
OSBPL1A
oxysterol binding protein-like 1A
chr15_-_23932410 1.351 NM_002487
NDN
necdin homolog (mouse)
chr9_-_88714486 1.349 NM_016548
GOLM1
golgi membrane protein 1
chr20_-_56286540 1.346 NM_199171
PMEPA1
prostate transmembrane protein, androgen induced 1
chr3_+_156392369 1.339 TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr20_+_62328002 1.336 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr8_+_32504250 1.323 NM_013959
NRG1
neuregulin 1
chr7_+_48128939 1.318 UPP1
uridine phosphorylase 1
chr3_+_156392204 1.315 NM_015508
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr19_+_50030874 1.312 NM_020650
RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr15_-_73925555 1.309 NPTN
neuroplastin
chr1_-_68697997 1.298 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr9_-_88714460 1.281 GOLM1
golgi membrane protein 1
chr11_+_35160666 1.280 CD44
CD44 molecule (Indian blood group)
chrX_+_134166318 1.274 NM_001078171
FAM127A
family with sequence similarity 127, member A
chr10_+_54074037 1.270 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr2_-_161349874 1.266 RBMS1
RNA binding motif, single stranded interacting protein 1
chr14_-_67878770 1.264 NM_016445
PLEK2
pleckstrin 2
chr1_-_153538305 1.263 NM_005978
S100A2
S100 calcium binding protein A2
chr9_+_19049417 1.262 RRAGA
Ras-related GTP binding A
chr5_+_131593388 1.256 PDLIM4
PDZ and LIM domain 4
chr9_+_19049376 1.237 RRAGA
Ras-related GTP binding A
chr12_-_54813010 1.236 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chrX_+_37208527 1.235 NM_000950
NM_001142395
NM_001173486
NM_001173489
NM_001173490
PRRG1




proline rich Gla (G-carboxyglutamic acid) 1




chr15_+_71184781 1.234 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr4_-_84255999 1.221 HPSE
heparanase
chr9_+_19049408 1.214 RRAGA
Ras-related GTP binding A
chr11_+_66824308 1.213 RHOD
ras homolog gene family, member D
chr17_+_60704747 1.209 NM_006039
MRC2
mannose receptor, C type 2
chr9_+_19049355 1.208 NM_006570
RRAGA
Ras-related GTP binding A
chr12_-_52886971 1.206 NM_005554
KRT6A
keratin 6A
chr1_+_20915440 1.205 NM_001785
CDA
cytidine deaminase
chr15_+_74218786 1.203 NM_005576
LOXL1
lysyl oxidase-like 1
chr2_-_110371404 1.195 SEPT10
septin 10
chr9_-_88714395 1.193 GOLM1
golgi membrane protein 1
chr14_-_51411118 1.189 NM_001163940
NM_002863
PYGL

phosphorylase, glycogen, liver

chr5_+_34684611 1.180 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr8_-_122653493 1.180 NM_005328
HAS2
hyaluronan synthase 2
chr6_-_110501164 1.175 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chr8_-_42065037 1.169 PLAT
plasminogen activator, tissue
chr15_+_74218794 1.164 LOXL1
lysyl oxidase-like 1
chr5_-_39425030 1.152 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr11_+_66824285 1.144 NM_014578
RHOD
ras homolog gene family, member D
chr10_-_3827205 1.142 KLF6
Kruppel-like factor 6
chr4_+_6576915 1.137 MAN2B2
mannosidase, alpha, class 2B, member 2
chr14_+_23340955 1.134 NM_014045
LRP10
low density lipoprotein receptor-related protein 10
chr8_+_95732101 1.130 NM_181787
DPY19L4
dpy-19-like 4 (C. elegans)
chr1_-_154946801 1.122 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chrX_-_3264680 1.111 NM_015419
MXRA5
matrix-remodelling associated 5
chr9_+_19049424 1.095 RRAGA
Ras-related GTP binding A
chr1_-_154946830 1.093 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr15_-_23932364 1.092


chr20_-_14318200 1.091 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr1_-_85930610 1.087 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_+_19971865 1.082 NM_001204085
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr20_+_9288446 1.075 NM_000933
PLCB4
phospholipase C, beta 4
chr1_+_157963062 1.073 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr7_+_143078358 1.069 NM_001010972
NM_003461
ZYX

zyxin

chr11_-_120008801 1.065 TRIM29
tripartite motif containing 29
chr4_-_84255895 1.064 NM_001199830
HPSE
heparanase
chr5_+_131593331 1.057 NM_001131027
NM_003687
PDLIM4

PDZ and LIM domain 4

chr6_-_110500803 1.055 WASF1
WAS protein family, member 1
chr11_+_35160832 1.048 CD44
CD44 molecule (Indian blood group)
chr10_+_88728187 1.048 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr7_+_143078395 1.042 ZYX
zyxin
chr17_+_60705042 1.041 MRC2
mannose receptor, C type 2
chr1_+_19972259 1.041 NM_001204086
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr4_+_169552752 1.035 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr9_+_33750463 1.032 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3


chr15_+_74218811 1.026 LOXL1
lysyl oxidase-like 1
chr6_-_47277646 1.026 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr2_-_110371669 1.024 NM_144710
NM_178584
SEPT10

septin 10

chr12_-_124118197 1.023 NM_001414
EIF2B1
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
chr10_+_99400441 1.017 NM_018425
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr8_-_145018057 1.013 NM_201382
PLEC
plectin
chr1_+_26606443 1.013 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr5_+_131593377 1.007 PDLIM4
PDZ and LIM domain 4
chr3_-_32022734 1.006 OSBPL10
oxysterol binding protein-like 10
chrX_-_134156488 1.002 NM_001078173
FAM127C
family with sequence similarity 127, member C
chr15_+_63334753 1.000 NM_000366
NM_001018004
NM_001018005
NM_001018006
NM_001018007
NM_001018020
TPM1





tropomyosin 1 (alpha)





chr10_+_121411042 0.993 BAG3
BCL2-associated athanogene 3
chr1_-_33168356 0.983 NM_001161708
NM_030786
SYNC

syncoilin, intermediate filament protein

chr14_-_70826393 0.982 NM_001204090
NM_016468
COX16

COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)

chr17_-_4851797 0.981 NM_005022
PFN1
profilin 1
chr1_-_154946859 0.971 NM_001130041
NM_001202859
NM_003029
SHC1


SHC (Src homology 2 domain containing) transforming protein 1


chr19_+_50031232 0.968 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chrX_+_64887510 0.965 NM_002444
MSN
moesin
chr17_-_4851827 0.959 PFN1
profilin 1
chr1_-_95392449 0.957 CNN3
calponin 3, acidic
chr9_-_34620489 0.948 NM_007234
NM_024348
DCTN3

dynactin 3 (p22)

chr8_-_119123804 0.941 NM_000127
EXT1
exostosin 1
chr15_+_74218962 0.934 LOXL1
lysyl oxidase-like 1
chr16_-_31085503 0.933 NM_024706
ZNF668
zinc finger protein 668
chr4_-_40859081 0.932 NM_001166051
NM_001166052
NM_001166053
NM_001166054
APBB2



amyloid beta (A4) precursor protein-binding, family B, member 2



chr7_+_143078457 0.928 ZYX
zyxin
chr19_+_16187315 0.919 TPM4
tropomyosin 4
chr17_-_74582144 0.919 NM_006456
ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr9_+_127631500 0.918 ARPC5L
actin related protein 2/3 complex, subunit 5-like
chr9_-_34620483 0.917 DCTN3
dynactin 3 (p22)
chr20_+_43104513 0.917 NM_001039199
NM_024331
TTPAL

tocopherol (alpha) transfer protein-like

chr1_+_156030965 0.910 NM_020387
RAB25
RAB25, member RAS oncogene family
chr10_-_3827418 0.909 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr6_-_47277511 0.904 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr12_-_21810779 0.899 NM_002300
LDHB
lactate dehydrogenase B
chr18_+_61144143 0.891 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr7_+_143078399 0.885 ZYX
zyxin
chr8_-_23261626 0.883 LOXL2
lysyl oxidase-like 2
chr7_+_143078444 0.879 ZYX
zyxin
chr9_-_34620460 0.876 DCTN3
dynactin 3 (p22)
chr9_+_132934685 0.875 NM_014286
NCS1
neuronal calcium sensor 1
chr17_-_39743085 0.874 NM_000526
KRT14
keratin 14
chr15_+_63335086 0.868 TPM1
tropomyosin 1 (alpha)
chr6_+_125474800 0.863 NM_001003396
NM_001003397
NM_003287
TPD52L1


tumor protein D52-like 1


chr2_+_71295428 0.856 NAGK
N-acetylglucosamine kinase
chr7_+_69064316 0.854 AUTS2
autism susceptibility candidate 2
chr4_-_84256304 0.854 NM_001166498
NM_006665
HPSE

heparanase

chr4_-_57976516 0.838 IGFBP7
insulin-like growth factor binding protein 7
chr12_+_21590537 0.837 NM_024854
PYROXD1
pyridine nucleotide-disulphide oxidoreductase domain 1
chr5_+_65892139 0.834 NM_001164664
NM_198828
MAST4

microtubule associated serine/threonine kinase family member 4

chr20_+_62328068 0.834 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr19_+_48828820 0.832 EMP3
epithelial membrane protein 3
chr1_-_59043165 0.823 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr1_-_120612301 0.812 NM_001200001
NM_024408
NOTCH2

notch 2


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
10.37 5.65e-04 GO:0005925 focal adhesion
9.92 7.56e-04 GO:0005924 cell-substrate adherens junction
9.52 9.97e-04 GO:0030055 cell-substrate junction
7.07 6.91e-03 GO:0005912 adherens junction
6.35 1.36e-02 GO:0070161 anchoring junction
5.21 1.76e-02 GO:0016323 basolateral plasma membrane
2.01 2.61e-02 GO:0044459 plasma membrane part

Nothing significant found in function category.