Motif ID: ESRRA.p2

Z-value: 1.503


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ESRRAchr11_+_640730400.467.5e-02Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_39826676 4.427 NM_004877
GMFG
glia maturation factor, gamma
chr19_-_39826625 3.927 GMFG
glia maturation factor, gamma
chr10_+_81107259 2.752 PPIF
peptidylprolyl isomerase F
chr20_+_37434294 2.358 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory subunit 16B

chr10_+_81107242 2.349 PPIF
peptidylprolyl isomerase F
chr12_-_54694717 1.976 NM_001136023
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_-_54694647 1.936 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr6_-_26285726 1.896 NM_003543
HIST1H4H
histone cluster 1, H4h
chr8_+_145149985 1.826 CYC1
cytochrome c-1
chr19_-_13044459 1.661 FARSA
phenylalanyl-tRNA synthetase, alpha subunit
chr12_-_21810720 1.631 NM_001174097
LDHB
lactate dehydrogenase B
chr3_-_121379701 1.583 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr12_-_21810769 1.574 LDHB
lactate dehydrogenase B
chr12_-_21810779 1.562 NM_002300
LDHB
lactate dehydrogenase B
chr12_-_21810733 1.542 LDHB
lactate dehydrogenase B
chr12_-_21810754 1.530 LDHB
lactate dehydrogenase B
chr3_-_50649080 1.507 CISH
cytokine inducible SH2-containing protein
chr8_-_131028674 1.506 FAM49B
family with sequence similarity 49, member B
chr11_-_57194591 1.502 NM_199329
SLC43A3
solute carrier family 43, member 3
chr11_-_57194556 1.435 SLC43A3
solute carrier family 43, member 3
chr6_+_26251826 1.348 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr14_-_106174914 1.336 IGHA1
immunoglobulin heavy constant alpha 1
chr9_-_138853146 1.302 NM_016172
UBAC1
UBA domain containing 1
chr1_-_45452215 1.300 EIF2B3
eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
chr19_-_55668956 1.292 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr10_+_81107219 1.285 NM_005729
PPIF
peptidylprolyl isomerase F
chr10_+_81107228 1.278 PPIF
peptidylprolyl isomerase F
chr11_-_57194512 1.215 NM_014096
SLC43A3
solute carrier family 43, member 3
chr20_-_62130390 1.190 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr1_-_17380486 1.153 NM_003000
SDHB
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr16_+_81040515 1.145 CENPN
centromere protein N
chr4_+_44680408 1.134 NM_021927
GUF1
GUF1 GTPase homolog (S. cerevisiae)
chr22_+_23213671 1.133 IGLV4-3
immunoglobulin lambda variable 4-3
chr1_-_33502484 1.130 NM_001199199
NM_001625
NM_013411
AK2


adenylate kinase 2


chr6_-_97345760 1.126 NM_014165
NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr6_-_97345747 1.126 NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr19_-_13213973 1.104 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr8_-_131028833 1.084 FAM49B
family with sequence similarity 49, member B
chr3_-_121379757 1.073 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr9_-_130966488 1.069 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr11_-_33891485 1.048 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr15_-_78423556 1.034 NM_006383
CIB2
calcium and integrin binding family member 2
chr6_+_34206567 1.029 NM_145905
HMGA1
high mobility group AT-hook 1
chr1_+_161475200 1.022 NM_001136219
NM_021642
FCGR2A

Fc fragment of IgG, low affinity IIa, receptor (CD32)

chr11_+_65190272 1.011


chr1_-_144994839 1.006 PDE4DIP
phosphodiesterase 4D interacting protein
chr19_+_589849 0.993 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr9_-_138853007 0.984 UBAC1
UBA domain containing 1
chr6_-_97345676 0.981 NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chrX_-_15511358 0.959 PIR
pirin (iron-binding nuclear protein)
chrX_+_118602391 0.943 SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chrX_-_15511710 0.940 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr1_-_241683011 0.931 FH
fumarate hydratase
chr8_-_131028646 0.930 FAM49B
family with sequence similarity 49, member B
chr4_-_40517913 0.909 NM_019027
RBM47
RNA binding motif protein 47
chr11_-_64512265 0.904 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr12_-_117537090 0.900 NM_001168325
NM_017899
TESC

tescalcin

chr15_+_78441737 0.895 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr15_+_40453263 0.893 BUB1B
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
chr1_-_246580710 0.891 NM_022743
SMYD3
SET and MYND domain containing 3
chr19_-_2328566 0.891 NM_016199
LSM7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr15_+_78441678 0.878 NM_005530
IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr1_-_224033383 0.875 TP53BP2
tumor protein p53 binding protein, 2
chr19_+_45394642 0.873 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chrX_-_129299680 0.869 AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr1_-_33502428 0.868 AK2
adenylate kinase 2
chr1_-_27816676 0.860 NM_001201404
NM_006990
WASF2

WAS protein family, member 2

chr2_-_44223039 0.850 LRPPRC
leucine-rich PPR-motif containing
chr12_-_772525 0.829 NM_016533
NINJ2
ninjurin 2
chr17_+_79679370 0.822 NM_012140
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr11_-_57298180 0.821 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chrX_-_129299629 0.820 AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr8_+_145149936 0.815 NM_001916
CYC1
cytochrome c-1
chr2_-_176046120 0.815 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr8_+_145149978 0.807 CYC1
cytochrome c-1
chr11_+_73498913 0.800 NM_016055
MRPL48
mitochondrial ribosomal protein L48
chr17_+_30469505 0.797 RHOT1
ras homolog gene family, member T1
chr17_+_30469567 0.794 RHOT1
ras homolog gene family, member T1
chr1_+_201924618 0.790 NM_006335
TIMM17A
translocase of inner mitochondrial membrane 17 homolog A (yeast)
chr2_-_44223131 0.784 NM_133259
LRPPRC
leucine-rich PPR-motif containing
chr10_+_62538088 0.783 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr19_-_55973048 0.782 NM_001136201
NM_001136202
NM_024710
ISOC2


isochorismatase domain containing 2


chr2_+_177134122 0.777 NM_006554
MTX2
metaxin 2
chr22_+_22697538 0.774


chr3_+_158288952 0.774 NM_001130156
NM_001130157
NM_001195432
NM_001195433
NM_001195434
NM_022443
MLF1





myeloid leukemia factor 1





chr6_-_43027114 0.751 NM_015950
MRPL2
mitochondrial ribosomal protein L2
chr15_+_78441733 0.748 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr16_-_81040439 0.748 NM_020188
C16orf61
chromosome 16 open reading frame 61
chr18_-_12377248 0.747 NM_006796
AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr19_-_13044528 0.745 NM_004461
FARSA
phenylalanyl-tRNA synthetase, alpha subunit
chr1_-_144994908 0.745 PDE4DIP
phosphodiesterase 4D interacting protein
chr9_-_33264458 0.743 NM_001172415
NM_004323
BAG1

BCL2-associated athanogene

chr22_+_31518923 0.740 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chrX_-_129299803 0.739 NM_001130847
NM_004208
NM_145812
NM_145813
AIFM1



apoptosis-inducing factor, mitochondrion-associated, 1



chr16_+_21964700 0.738 UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr12_+_102091399 0.737 NM_020244
CHPT1
choline phosphotransferase 1
chr17_+_30469541 0.729 RHOT1
ras homolog gene family, member T1
chrX_+_135579670 0.724 NM_014500
HTATSF1
HIV-1 Tat specific factor 1
chr9_-_130679210 0.722 NM_175039
NM_175040
ST6GALNAC4

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

chr2_-_44223112 0.719 LRPPRC
leucine-rich PPR-motif containing
chr1_+_32757711 0.712 HDAC1
histone deacetylase 1
chr1_-_200992824 0.707 NM_001252100
NM_001252102
NM_001252103
NM_017596
KIF21B



kinesin family member 21B



chr20_-_57617836 0.705 NM_016045
SLMO2
slowmo homolog 2 (Drosophila)
chr15_+_40733302 0.701 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr2_+_198365113 0.700 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr5_-_140027167 0.693 NDUFA2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
chr15_-_41694619 0.692 NM_016013
NDUFAF1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1
chr12_-_120554453 0.690 RAB35
RAB35, member RAS oncogene family
chr3_-_183735617 0.685 NM_001023587
NM_005688
ABCC5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

chr9_-_130889993 0.684 PTGES2
prostaglandin E synthase 2
chrX_+_65382432 0.682 NM_138737
HEPH
hephaestin
chr3_+_184038050 0.681 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr8_-_61193882 0.679 NM_004056
CA8
carbonic anhydrase VIII
chr1_+_32757702 0.674 HDAC1
histone deacetylase 1
chr11_+_66624501 0.670 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr1_+_32757707 0.661 NM_004964
HDAC1
histone deacetylase 1
chr5_-_179718963 0.657 MAPK9
mitogen-activated protein kinase 9
chr1_-_29508382 0.657 SRSF4
serine/arginine-rich splicing factor 4
chr11_+_63706433 0.656 NM_024771
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr1_-_33502452 0.651 AK2
adenylate kinase 2
chr19_+_1383898 0.647 NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chr8_+_110346549 0.646 NM_001193557
NM_020189
ENY2

enhancer of yellow 2 homolog (Drosophila)

chr17_-_29151638 0.639 CRLF3
cytokine receptor-like factor 3
chr12_+_58176527 0.632 NM_001172695
NM_001172696
NM_001172697
NM_005726
TSFM



Ts translation elongation factor, mitochondrial



chr4_-_74088773 0.630 ANKRD17
ankyrin repeat domain 17
chr15_+_75494233 0.629 C15orf39
chromosome 15 open reading frame 39
chr1_+_185014449 0.629 NM_007212
RNF2
ring finger protein 2
chr10_+_22605300 0.624 NM_001204062
NM_012071
COMMD3-BMI1
COMMD3
COMMD3-BMI1 readthrough
COMM domain containing 3
chr18_-_12377168 0.624 AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr17_+_30469373 0.623 NM_001033566
NM_001033568
NM_018307
RHOT1


ras homolog gene family, member T1


chr3_+_10290357 0.619 TATDN2
TatD DNase domain containing 2
chr1_-_27732069 0.616 WASF2
WAS protein family, member 2
chr12_-_54070108 0.613 NM_005176
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr1_-_29508636 0.612 NM_005626
SRSF4
serine/arginine-rich splicing factor 4
chr17_+_79679399 0.610 SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr11_-_5275904 0.610 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr20_-_31989303 0.610 CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr9_+_130965668 0.604 DNM1
dynamin 1
chr19_+_1383904 0.602 NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chr1_-_33502470 0.602 AK2
adenylate kinase 2
chrX_-_151938194 0.601 NM_005362
MAGEA3
melanoma antigen family A, 3
chr2_+_198365012 0.599 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr19_-_55972997 0.596 ISOC2
isochorismatase domain containing 2
chr11_-_86666211 0.592 NM_012193
FZD4
frizzled family receptor 4
chr11_+_118272103 0.592 NM_006476
ATP5L
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
chr1_+_155179005 0.585 MTX1
metaxin 1
chrX_-_124097601 0.581 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1 (Drosophila)


chr19_+_1383877 0.578 NM_024407
NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chr20_-_2641476 0.574 IDH3B
isocitrate dehydrogenase 3 (NAD+) beta
chr9_+_130965666 0.574 DNM1
dynamin 1
chr19_+_57742376 0.572 NM_001015879
NM_003160
NM_001015878
AURKC


aurora kinase C


chr11_-_76091866 0.568 NM_004705
PRKRIR
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr13_-_42535066 0.567 KIAA0564
KIAA0564
chr11_+_111957533 0.560 NM_003002
SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr19_+_46850245 0.558 NM_001204284
NM_006247
PPP5C

protein phosphatase 5, catalytic subunit

chr9_+_17578952 0.556 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr1_-_1690080 0.555 NM_001198995
NADK
NAD kinase
chr2_-_198364623 0.554 NM_002156
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr16_+_21964608 0.553 NM_003366
UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr11_+_111957611 0.550 SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr22_+_44395090 0.550 NM_001003828
PARVB
parvin, beta
chr12_-_102512277 0.550 NM_024057
NUP37
nucleoporin 37kDa
chr19_-_12912602 0.546 NM_005809
NM_181738
PRDX2

peroxiredoxin 2

chr1_-_29508358 0.545 SRSF4
serine/arginine-rich splicing factor 4
chr16_+_21964677 0.536 UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr7_-_140624280 0.529 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr11_-_3862183 0.529 NM_001665
RHOG
ras homolog gene family, member G (rho G)
chr11_-_64511550 0.525 NM_001098671
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr19_-_46476556 0.525 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chr19_-_3062911 0.520 NM_198969
AES
amino-terminal enhancer of split
chr19_-_15235748 0.519 ILVBL
ilvB (bacterial acetolactate synthase)-like
chr2_-_26467501 0.515 NM_000182
HADHA
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
chr1_+_47799447 0.513 NM_001136140
NM_016308
CMPK1

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

chr17_-_29151724 0.513 NM_015986
CRLF3
cytokine receptor-like factor 3
chr10_-_35363167 0.504 NM_001198778
NM_001198779
CUL2

cullin 2

chr1_-_156786500 0.504 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr1_-_205719340 0.502 NM_022731
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr15_-_89010607 0.499 NM_022163
MRPL46
mitochondrial ribosomal protein L46
chr9_+_130965608 0.497 NM_001005336
NM_004408
DNM1

dynamin 1

chr15_+_75494196 0.493 NM_015492
C15orf39
chromosome 15 open reading frame 39
chr15_-_23378167 0.492 HERC2P2
hect domain and RLD 2 pseudogene 2
chr5_-_140027231 0.492 NM_001185012
NM_002488
NDUFA2

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa

chr19_-_55972935 0.490 ISOC2
isochorismatase domain containing 2
chr14_-_96180402 0.488 NM_001098725
NM_021966
TCL1A

T-cell leukemia/lymphoma 1A

chr2_-_26467463 0.487 HADHA
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
chr12_-_54069856 0.487 ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr16_-_28222700 0.487 XPO6
exportin 6
chr22_+_22712091 0.485 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr15_-_66790068 0.484 NM_006049
SNAPC5
small nuclear RNA activating complex, polypeptide 5, 19kDa
chr8_+_124428964 0.483 NM_018024
WDYHV1
WDYHV motif containing 1
chr10_-_75012241 0.481 NM_016065
MRPS16
mitochondrial ribosomal protein S16
chr6_+_33172418 0.480 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr1_-_33502464 0.477 AK2
adenylate kinase 2
chr9_-_130889965 0.476 PTGES2
prostaglandin E synthase 2
chr7_+_2443164 0.475 NM_001243794
NM_001243795
NM_018641
CHST12


carbohydrate (chondroitin 4) sulfotransferase 12


chr16_+_81040120 0.475 CENPN
centromere protein N
chr15_+_75494235 0.471 C15orf39
chromosome 15 open reading frame 39
chrX_-_109683457 0.469 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr10_+_94050858 0.465 NM_017824
MARCH5
membrane-associated ring finger (C3HC4) 5
chr12_-_120554551 0.464 RAB35
RAB35, member RAS oncogene family

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
23.72 2.66e-04 GO:0034728 nucleosome organization
21.77 4.08e-04 GO:0071824 protein-DNA complex subunit organization
18.05 1.03e-03 GO:0006333 chromatin assembly or disassembly
7.18 5.29e-03 GO:0034621 cellular macromolecular complex subunit organization
120.49 1.72e-02 GO:0006337 nucleosome disassembly
120.49 1.72e-02 GO:0031498 chromatin disassembly
120.49 1.72e-02 GO:0032986 protein-DNA complex disassembly
13.63 2.85e-02 GO:0071103 DNA conformation change

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
6.76 1.01e-02 GO:0005740 mitochondrial envelope
8.20 1.54e-02 GO:0005743 mitochondrial inner membrane
7.54 2.28e-02 GO:0019866 organelle inner membrane

Nothing significant found in function category.