Motif ID: FOXD3.p2

Z-value: 1.052


Transcription factors associated with FOXD3.p2:

Gene SymbolEntrez IDGene Name
FOXD3 27022 forkhead box D3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXD3chr1_+_637887290.019.7e-01Click!


Activity profile for motif FOXD3.p2.

activity profile for motif FOXD3.p2


Sorted Z-values histogram for motif FOXD3.p2

Sorted Z-values for motif FOXD3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXD3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_19870209 4.290 NM_018993
RIN2
Ras and Rab interactor 2
chr7_-_87849341 3.430 SRI
sorcin
chr8_+_54764367 3.065 NM_170587
RGS20
regulator of G-protein signaling 20
chr20_+_19915716 2.866 RIN2
Ras and Rab interactor 2
chr16_+_68678150 2.851 NM_001793
CDH3
cadherin 3, type 1, P-cadherin (placental)
chr21_-_27512668 2.331 NM_001136016
APP
amyloid beta (A4) precursor protein
chr6_+_121756744 2.253 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr4_-_90759446 2.187 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr10_-_126849010 2.114 CTBP2
C-terminal binding protein 2
chr18_+_29027731 1.985 NM_001944
DSG3
desmoglein 3
chr14_-_61748510 1.817 NM_001017970
TMEM30B
transmembrane protein 30B
chr9_-_88715024 1.760 NM_177937
GOLM1
golgi membrane protein 1
chr3_-_189838673 1.739 LEPREL1
leprecan-like 1
chr9_+_75766777 1.674 NM_000700
ANXA1
annexin A1
chr9_+_75766794 1.577 ANXA1
annexin A1
chr12_+_48513012 1.526 NM_000289
PFKM
phosphofructokinase, muscle
chr4_+_89299874 1.473 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr7_-_87849366 1.473 NM_003130
SRI
sorcin
chr3_-_189838907 1.464 NM_018192
LEPREL1
leprecan-like 1
chr3_-_15382874 1.445 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr3_+_135741576 1.403 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr5_+_96212167 1.321 ERAP2
endoplasmic reticulum aminopeptidase 2
chr9_+_79115548 1.307 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr1_+_183155173 1.304 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr1_-_170038055 1.304 NM_001204517
KIFAP3
kinesin-associated protein 3
chr2_-_151344145 1.279 NM_005168
RND3
Rho family GTPase 3
chr4_+_89299980 1.275 HERC6
hect domain and RLD 6
chr12_+_27175482 1.256 NM_004264
MED21
mediator complex subunit 21
chr5_+_140771482 1.255 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr13_-_110802708 1.231 COL4A1
collagen, type IV, alpha 1
chr13_+_50070096 1.213 PHF11
PHD finger protein 11
chr10_+_48255223 1.206 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr2_-_56151273 1.204 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr10_+_47746919 1.170 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr10_-_47173917 1.148 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr12_+_13043955 1.140 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr1_+_84630575 1.130 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr17_+_7942351 1.102 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr1_-_170043608 1.091 NM_001204514
NM_001204516
NM_014970
KIFAP3


kinesin-associated protein 3


chr12_+_56915587 1.059 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr6_+_83072922 1.058 NM_006670
TPBG
trophoblast glycoprotein
chr18_+_61554938 1.051 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr9_-_110252045 1.045 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr7_+_134576187 1.037 CALD1
caldesmon 1
chr2_-_175712276 1.033 NM_001206602
CHN1
chimerin (chimaerin) 1
chr6_+_29855349 1.026 HLA-H
major histocompatibility complex, class I, H (pseudogene)
chr10_-_126849066 1.024 NM_001329
CTBP2
C-terminal binding protein 2
chr9_-_14086901 1.006 NFIB
nuclear factor I/B
chr21_+_39628869 1.004 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chrX_-_114252132 0.998 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr1_+_220701547 0.996 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr1_+_150480486 0.961 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr19_-_4831711 0.959 NM_182919
TICAM1
toll-like receptor adaptor molecule 1
chr22_+_45148437 0.937 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr18_+_61254533 0.935 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr10_+_124145584 0.932 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr20_-_14318200 0.930 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr2_-_85637486 0.926 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr12_+_27175501 0.906 MED21
mediator complex subunit 21
chr18_+_61420276 0.904 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr5_+_140247767 0.894 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr15_-_63674074 0.889 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr3_-_149086884 0.883 TM4SF1
transmembrane 4 L six family member 1
chr18_-_47814691 0.877 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr6_+_150263120 0.861 NM_025217
ULBP2
UL16 binding protein 2
chr3_+_122044010 0.849 NM_005213
CSTA
cystatin A (stefin A)
chr11_+_67351276 0.841 GSTP1
glutathione S-transferase pi 1
chr15_-_72501017 0.833 PKM2
pyruvate kinase, muscle
chr19_+_13134782 0.826 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr8_+_132991171 0.824 EFR3A
EFR3 homolog A (S. cerevisiae)
chr3_+_62305395 0.822 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr17_-_29641087 0.809 EVI2B
ecotropic viral integration site 2B
chr2_+_201473942 0.807 AOX1
aldehyde oxidase 1
chr11_-_17191287 0.805 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr19_+_1026271 0.799 NM_004368
NM_201277
CNN2

calponin 2

chr15_-_63673918 0.798 CA12
carbonic anhydrase XII
chr12_+_32832272 0.786 DNM1L
dynamin 1-like
chr12_-_28124915 0.781 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr1_+_15764934 0.765 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr17_-_29641094 0.752 NM_006495
EVI2B
ecotropic viral integration site 2B
chr1_+_84630374 0.737 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr21_+_37442298 0.735 CBR1
carbonyl reductase 1
chrX_-_10535476 0.733 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr12_+_32832209 0.729 DNM1L
dynamin 1-like
chr3_-_126327397 0.725 NM_001039783
TXNRD3NB
thioredoxin reductase 3 neighbor
chr15_+_32933869 0.696 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr6_-_159240398 0.692 EZR
ezrin
chr6_-_159240399 0.683 EZR
ezrin
chr4_-_153303663 0.679 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr2_-_190044330 0.675 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_-_108786663 0.672 NM_001143989
NBPF4
NBPF6
neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6
chr1_+_81771844 0.671 LPHN2
latrophilin 2
chr2_-_86948244 0.669 NM_001198954
RNF103-CHMP3
RNF103-CHMP3 readthrough
chr18_-_61329113 0.664 NM_006919
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr7_+_134576150 0.655 NM_033139
NM_033140
CALD1

caldesmon 1

chr10_+_71561687 0.651 COL13A1
collagen, type XIII, alpha 1
chr11_-_102651321 0.651 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr22_+_23054862 0.649 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr11_-_108464344 0.649 NM_015065
EXPH5
exophilin 5
chr12_+_32832128 0.646 NM_005690
NM_012062
NM_012063
DNM1L


dynamin 1-like


chr6_-_159240367 0.640 EZR
ezrin
chr4_+_55095263 0.629 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr16_+_82660390 0.628 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr3_+_11267666 0.624 NM_001098211
HRH1
histamine receptor H1
chr14_+_23305792 0.622 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr17_-_29641068 0.599 EVI2B
ecotropic viral integration site 2B
chrX_+_12994286 0.598 TMSB4X
thymosin beta 4, X-linked
chr4_-_102268626 0.596 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr1_-_42965948 0.594 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr1_+_223889253 0.594 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr13_+_111134933 0.590 COL4A2
collagen, type IV, alpha 2
chr12_-_15114495 0.575 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr14_+_23305816 0.573 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr7_+_89783688 0.571 NM_012449
STEAP1
six transmembrane epithelial antigen of the prostate 1
chr1_-_161207879 0.567 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr5_+_140810126 0.565 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr19_+_11200037 0.564 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr6_-_159240433 0.561 NM_001111077
EZR
ezrin
chr3_+_132036210 0.560 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr16_+_82660573 0.559 CDH13
cadherin 13, H-cadherin (heart)
chr11_+_67351065 0.550 NM_000852
GSTP1
glutathione S-transferase pi 1
chrX_+_118714297 0.549 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A
chr1_+_84609941 0.546 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr5_+_141346401 0.545 NM_001201365
NM_183399
RNF14

ring finger protein 14

chr19_+_3136026 0.544 NM_002068
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr3_-_111314181 0.540 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr4_+_47487230 0.537 NM_020453
ATP10D
ATPase, class V, type 10D
chr9_-_95298251 0.535 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr13_-_37679800 0.528 NM_145203
CSNK1A1L
casein kinase 1, alpha 1-like
chr15_+_58430394 0.519 NM_020980
AQP9
aquaporin 9
chr22_-_17646176 0.518 NM_017829
CECR5
cat eye syndrome chromosome region, candidate 5
chr4_-_70826712 0.513 NM_001891
CSN2
casein beta
chr9_-_110251754 0.506 KLF4
Kruppel-like factor 4 (gut)
chr21_+_39628663 0.504 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_+_29913400 0.500


chr10_-_33623771 0.492 NM_001024628
NM_001024629
NM_001244972
NM_001244973
NM_003873
NRP1




neuropilin 1




chr10_+_71561643 0.492 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr3_+_132316080 0.487 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr22_-_43036606 0.484 NM_001165877
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr14_-_60632019 0.483 DHRS7
dehydrogenase/reductase (SDR family) member 7
chr2_-_215896809 0.482 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr3_-_69037498 0.481 C3orf64
chromosome 3 open reading frame 64
chr1_-_150978879 0.479 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr11_+_114167168 0.478 NNMT
nicotinamide N-methyltransferase
chr8_-_80993009 0.478 NM_001025252
TPD52
tumor protein D52
chr3_-_189840225 0.476 NM_001134418
LEPREL1
leprecan-like 1
chr2_-_161056762 0.473 ITGB6
integrin, beta 6
chr9_-_14398981 0.466 NM_001190738
NFIB
nuclear factor I/B
chr9_-_117880411 0.463 NM_002160
TNC
tenascin C
chr3_+_159557649 0.456 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr19_-_14785626 0.456 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr18_+_61442611 0.453 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr8_-_95274520 0.450 GEM
GTP binding protein overexpressed in skeletal muscle
chr2_-_219031646 0.447 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr7_+_89783789 0.447 STEAP1
six transmembrane epithelial antigen of the prostate 1
chr4_-_102267952 0.445 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr11_+_101983170 0.442 NM_001195045
YAP1
Yes-associated protein 1
chr12_+_29302132 0.440 FAR2
fatty acyl CoA reductase 2
chr5_+_173472692 0.440 NM_015980
HMP19
HMP19 protein
chr3_+_159557745 0.439 SCHIP1
schwannomin interacting protein 1
chr7_+_90338711 0.436 NM_012395
CDK14
cyclin-dependent kinase 14
chr3_-_169587598 0.434 NM_024727
LRRC31
leucine rich repeat containing 31
chr6_+_26501448 0.433 NM_001732
BTN1A1
butyrophilin, subfamily 1, member A1
chr15_+_94841429 0.432 NM_001159643
NM_018349
MCTP2

multiple C2 domains, transmembrane 2

chr19_+_14491920 0.432 NM_001025160
NM_001784
NM_078481
CD97


CD97 molecule


chr1_+_84630014 0.431 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr8_-_6420454 0.431 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr1_-_152297678 0.429 NM_002016
FLG
filaggrin
chr16_+_68771192 0.427 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr11_-_88070840 0.427 CTSC
cathepsin C
chr12_+_79258517 0.425 SYT1
synaptotagmin I
chr1_+_74701070 0.424 NM_015978
TNNI3K
TNNI3 interacting kinase
chr19_-_4400470 0.424 NM_001199943
NM_003025
SH3GL1

SH3-domain GRB2-like 1

chr6_-_32784727 0.423 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr12_-_50595303 0.422 NM_001243775
LIMA1
LIM domain and actin binding 1
chrX_-_63005212 0.420 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr7_+_76026819 0.420 NM_007155
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr21_+_37442221 0.419 NM_001757
CBR1
carbonyl reductase 1
chr9_-_14314036 0.419 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr3_+_158787040 0.418 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr1_-_85742586 0.416 NM_003921
BCL10
B-cell CLL/lymphoma 10
chr10_+_124151818 0.414 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr11_-_102668892 0.414 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr1_-_153363544 0.414 NM_002964
S100A8
S100 calcium binding protein A8
chr15_-_60690115 0.411 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr8_-_27941387 0.410 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr4_-_187644983 0.409 NM_005245
FAT1
FAT tumor suppressor homolog 1 (Drosophila)
chr1_+_35220647 0.409 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr5_+_102201526 0.408 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr19_+_35645640 0.408 NM_144779
NM_001164605
FXYD5

FXYD domain containing ion transport regulator 5

chr12_+_13349720 0.408 EMP1
epithelial membrane protein 1
chr19_-_11689765 0.405 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr16_+_81812899 0.405 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr8_-_95274540 0.402 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr16_+_81812897 0.400 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr15_+_64680002 0.400 NM_016213
TRIP4
thyroid hormone receptor interactor 4
chr19_+_35645614 0.399 NM_014164
FXYD5
FXYD domain containing ion transport regulator 5
chr14_-_60632058 0.399 NM_016029
DHRS7
dehydrogenase/reductase (SDR family) member 7
chr2_-_56150862 0.397 EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr1_-_152009440 0.395 S100A11
S100 calcium binding protein A11

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
48.21 9.08e-05 GO:0005544 calcium-dependent phospholipid binding
5.66 4.68e-04 GO:0005509 calcium ion binding
3.73 3.71e-02 GO:0030234 enzyme regulator activity