Motif ID: GATA1..3.p2

Z-value: 2.103


Transcription factors associated with GATA1..3.p2:

Gene SymbolEntrez IDGene Name
GATA1 2623 GATA binding protein 1 (globin transcription factor 1)
GATA2 2624 GATA binding protein 2
GATA3 2625 GATA binding protein 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GATA2chr3_-_128212027-0.439.7e-02Click!
GATA1chrX_+_48644961-0.421.0e-01Click!
GATA3chr10_+_80973500.087.6e-01Click!


Activity profile for motif GATA1..3.p2.

activity profile for motif GATA1..3.p2


Sorted Z-values histogram for motif GATA1..3.p2

Sorted Z-values for motif GATA1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_190044330 6.527 NM_000393
COL5A2
collagen, type V, alpha 2
chr12_+_1738411 4.806 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr17_+_42634598 4.651 NM_001466
FZD2
frizzled family receptor 2
chr2_+_189839078 4.192 NM_000090
COL3A1
collagen, type III, alpha 1
chr2_+_189839113 4.186 COL3A1
collagen, type III, alpha 1
chr17_-_48278874 3.854 COL1A1
collagen, type I, alpha 1
chr2_+_189839132 3.787 COL3A1
collagen, type III, alpha 1
chr10_+_75673346 3.447 PLAU
plasminogen activator, urokinase
chr11_-_35547144 3.386 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr3_+_159557649 3.349 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr1_+_114522029 3.018 NM_020190
OLFML3
olfactomedin-like 3
chr2_-_216241321 2.889 FN1
fibronectin 1
chr17_-_48262900 2.815 COL1A1
collagen, type I, alpha 1
chr2_-_175869910 2.687 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr17_-_48264039 2.623 COL1A1
collagen, type I, alpha 1
chr3_-_127541160 2.507 NM_007283
MGLL
monoglyceride lipase
chr1_-_86043932 2.476 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr4_+_88928797 2.426 NM_000297
PKD2
polycystic kidney disease 2 (autosomal dominant)
chr12_+_81110689 2.419 NM_005593
MYF5
myogenic factor 5
chr12_-_50616425 2.407 NM_001113547
LIMA1
LIM domain and actin binding 1
chr3_+_159557745 2.341 SCHIP1
schwannomin interacting protein 1
chr14_+_65007418 2.262 HSPA2
heat shock 70kDa protein 2
chrX_-_10535476 2.200 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr19_-_50143350 2.180 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr8_+_22437983 2.116 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr9_-_16727887 2.113 BNC2
basonuclin 2
chr20_+_19915716 2.083 RIN2
Ras and Rab interactor 2
chr11_+_131240370 2.078 NM_001048209
NTM
neurotrimin
chr11_-_27742224 2.065 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr12_+_81101407 2.065 NM_002469
MYF6
myogenic factor 6 (herculin)
chr11_-_111782447 2.028 NM_001885
CRYAB
crystallin, alpha B
chr8_+_70405080 1.952 SULF1
sulfatase 1
chr9_+_112542496 1.950 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr13_-_107187312 1.888 NM_004093
EFNB2
ephrin-B2
chr3_-_55521567 1.886 WNT5A
wingless-type MMTV integration site family, member 5A
chr2_-_216259197 1.820 FN1
fibronectin 1
chr1_-_103573894 1.818 COL11A1
collagen, type XI, alpha 1
chr3_-_51993955 1.793 PCBP4
poly(rC) binding protein 4
chr8_+_70378858 1.784 NM_001128204
NM_015170
SULF1

sulfatase 1

chr1_-_27998700 1.767 IFI6
interferon, alpha-inducible protein 6
chr10_+_17271302 1.762 VIM
vimentin
chr10_+_17271341 1.736 VIM
vimentin
chr2_-_211168315 1.725 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr7_-_5567929 1.715 ACTB
actin, beta
chr3_-_114343791 1.711 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr1_-_27998658 1.692 IFI6
interferon, alpha-inducible protein 6
chr2_+_202899309 1.690 NM_003507
FZD7
frizzled family receptor 7
chr2_+_170366211 1.641 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr9_+_33624214 1.637 ANXA2P2
annexin A2 pseudogene 2
chr8_-_18541441 1.623 PSD3
pleckstrin and Sec7 domain containing 3
chr10_+_17271277 1.613 VIM
vimentin
chr13_+_102104941 1.597 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr10_+_17271276 1.597 VIM
vimentin
chr7_+_116165089 1.573 CAV1
caveolin 1, caveolae protein, 22kDa
chr5_+_131593388 1.569 PDLIM4
PDZ and LIM domain 4
chr5_+_82767492 1.565 NM_001126336
NM_001164097
NM_001164098
NM_004385
VCAN



versican



chr7_-_151511925 1.560 NM_001040633
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr1_-_103574051 1.545 NM_001190709
NM_001854
NM_080629
NM_080630
COL11A1



collagen, type XI, alpha 1



chr7_+_116165043 1.537 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr10_-_92681025 1.537 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chrX_-_140271293 1.504 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chrX_+_114795176 1.459 NM_005032
PLS3
plastin 3
chr2_-_217540722 1.456 IGFBP5
insulin-like growth factor binding protein 5
chr4_-_111563278 1.445 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr11_-_47470687 1.429 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr7_+_116164838 1.425 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr21_+_47545896 1.412 COL6A2
collagen, type VI, alpha 2
chr15_-_35087748 1.405 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr11_-_85469043 1.404 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chrX_+_135230736 1.403 NM_001159700
FHL1
four and a half LIM domains 1
chr12_+_79258588 1.403 SYT1
synaptotagmin I
chr16_+_31483066 1.398 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr15_+_43809805 1.387 NM_002373
MAP1A
microtubule-associated protein 1A
chr2_-_1748317 1.386 PXDN
peroxidasin homolog (Drosophila)
chr11_+_114167197 1.379 NNMT
nicotinamide N-methyltransferase
chr2_-_56150862 1.378 EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr17_-_46682333 1.356 NM_018952
HOXB6
homeobox B6
chr11_+_114167168 1.349 NNMT
nicotinamide N-methyltransferase
chr18_-_53068755 1.344 TCF4
transcription factor 4
chr4_-_57976550 1.344 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chr10_-_79397546 1.333 NM_001014797
NM_001161352
NM_001161353
NM_002247
KCNMA1



potassium large conductance calcium-activated channel, subfamily M, alpha member 1



chr8_-_108510094 1.329 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr4_-_57976516 1.319 IGFBP7
insulin-like growth factor binding protein 7
chr14_+_96722546 1.318 NM_000710
BDKRB1
bradykinin receptor B1
chr9_+_124086842 1.313 GSN
gelsolin
chr15_-_48937795 1.307 NM_000138
FBN1
fibrillin 1
chr7_+_116166346 1.297 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr10_+_102792166 1.290 SFXN3
sideroflexin 3
chr4_-_57976355 1.281 IGFBP7
insulin-like growth factor binding protein 7
chr2_-_1748240 1.279 PXDN
peroxidasin homolog (Drosophila)
chr11_-_117166247 1.277 NM_001207048
NM_001207049
BACE1

beta-site APP-cleaving enzyme 1

chr10_+_71075609 1.274 NM_033496
HK1
hexokinase 1
chrX_+_48368063 1.272 NM_203474
NM_203475
PORCN

porcupine homolog (Drosophila)

chr8_-_67525426 1.233 NM_001080416
NM_001144755
MYBL1

LOC645895
v-myb myeloblastosis viral oncogene homolog (avian)-like 1

uncharacterized LOC645895
chr1_-_155210887 1.225 GBA
glucosidase, beta, acid
chr2_-_1748285 1.218 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr10_-_79397290 1.201 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr3_-_114343052 1.198 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr5_+_17217781 1.194 BASP1
brain abundant, membrane attached signal protein 1
chr3_-_55521330 1.191 NM_003392
WNT5A
wingless-type MMTV integration site family, member 5A
chr12_+_54422193 1.189 NM_004503
HOXC6
homeobox C6
chr11_+_131780537 1.183 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr1_-_154943001 1.169 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr8_+_70405027 1.165 NM_001128205
NM_001128206
SULF1

sulfatase 1

chrX_-_13835187 1.164 GPM6B
glycoprotein M6B
chrX_-_140271275 1.159 LDOC1
leucine zipper, down-regulated in cancer 1
chr5_+_34687663 1.156 NM_001145523
RAI14
retinoic acid induced 14
chr11_+_69455938 1.155 CCND1
cyclin D1
chrX_-_10645726 1.143 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr10_+_70847817 1.141 NM_002727
SRGN
serglycin
chr1_-_68299047 1.137 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr5_+_119799898 1.127 PRR16
proline rich 16
chr11_-_12030128 1.126 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr1_-_94702916 1.102 ARHGAP29
Rho GTPase activating protein 29
chr1_+_64088886 1.102 NM_001172818
PGM1
phosphoglucomutase 1
chr13_-_33780142 1.100 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chr1_-_153508597 1.095 NM_014624
S100A6
S100 calcium binding protein A6
chr11_-_8892909 1.089 ST5
suppression of tumorigenicity 5
chr10_-_104473957 1.086 NM_004311
ARL3
ADP-ribosylation factor-like 3
chrX_-_21776158 1.085 NM_014332
SMPX
small muscle protein, X-linked
chr11_+_117070039 1.082 NM_001001522
NM_003186
TAGLN

transgelin

chr12_+_53491448 1.072 IGFBP6
insulin-like growth factor binding protein 6
chr18_-_53071225 1.068 NM_001243232
TCF4
transcription factor 4
chrX_-_48931645 1.067 NM_007213
PRAF2
PRA1 domain family, member 2
chr10_+_102792161 1.062 SFXN3
sideroflexin 3
chr7_-_81399286 1.052 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chrX_+_102611379 1.047 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr15_+_71184781 1.043 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr3_-_123339423 1.041 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr11_+_69455837 1.039 NM_053056
CCND1
cyclin D1
chr4_+_169418167 1.032 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr4_+_169753105 1.031 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr20_-_48099178 1.028 NM_004975
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr8_-_119123804 1.027 NM_000127
EXT1
exostosin 1
chr1_+_223900212 1.026 CAPN2
calpain 2, (m/II) large subunit
chr12_+_13349601 1.018 NM_001423
EMP1
epithelial membrane protein 1
chr5_+_131593377 1.017 PDLIM4
PDZ and LIM domain 4
chr5_-_141993691 1.016 NM_033137
FGF1
fibroblast growth factor 1 (acidic)
chr12_+_79258517 1.015 SYT1
synaptotagmin I
chrX_-_13835012 1.009 GPM6B
glycoprotein M6B
chrX_+_149531439 1.008 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr1_-_27998719 1.002 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr1_-_155211049 1.002 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr3_-_123339178 0.998 MYLK
myosin light chain kinase
chr3_-_107941168 0.990 NM_018010
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr13_-_38172862 0.988 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr10_-_127511832 0.988 NM_000375
UROS
uroporphyrinogen III synthase
chr10_-_92680784 0.988 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr8_-_93029864 0.982 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_-_91573264 0.975 NM_133503
DCN
decorin
chr13_-_33859835 0.973 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr12_+_49208214 0.969 NM_001206917
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr10_+_70847857 0.964 SRGN
serglycin
chr2_-_175629140 0.958 NM_000079
NM_001039523
CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr9_+_114659439 0.952 UGCG
UDP-glucose ceramide glucosyltransferase
chr21_-_27512668 0.950 NM_001136016
APP
amyloid beta (A4) precursor protein
chr13_+_111134933 0.950 COL4A2
collagen, type IV, alpha 2
chr12_-_91572328 0.949 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr2_-_238322770 0.949 COL6A3
collagen, type VI, alpha 3
chr10_+_104503724 0.942 NM_001083913
C10orf26
chromosome 10 open reading frame 26
chr1_+_145507556 0.932 NM_005105
RBM8A
RNA binding motif protein 8A
chr1_+_155829259 0.927 NM_152280
SYT11
synaptotagmin XI
chr5_+_119800004 0.922 NM_016644
PRR16
proline rich 16
chr9_+_35829208 0.912 NM_016446
NM_001042589
TMEM8B

transmembrane protein 8B

chr19_+_17420216 0.909 NM_024050
DDA1
DET1 and DDB1 associated 1
chr8_-_93107442 0.908 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr1_+_164528914 0.907 PBX1
pre-B-cell leukemia homeobox 1
chr16_+_84853585 0.900 NM_031476
CRISPLD2
cysteine-rich secretory protein LCCL domain containing 2
chr4_+_55095263 0.900 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr6_-_75994631 0.900 NM_001143958
NM_018247
TMEM30A

transmembrane protein 30A

chr22_+_31478845 0.897 NM_001207017
SMTN
smoothelin
chr8_+_37654757 0.897 GPR124
G protein-coupled receptor 124
chr17_-_48278987 0.897 NM_000088
COL1A1
collagen, type I, alpha 1
chr21_+_27012067 0.897 JAM2
junctional adhesion molecule 2
chr10_-_79397204 0.894 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr21_+_30517897 0.880 C21orf7
chromosome 21 open reading frame 7
chr20_+_9288446 0.873 NM_000933
PLCB4
phospholipase C, beta 4
chr3_-_114478117 0.870 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr5_+_140753480 0.869 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr12_+_48513012 0.869 NM_000289
PFKM
phosphofructokinase, muscle
chr6_-_112041253 0.869 NM_153047
FYN
FYN oncogene related to SRC, FGR, YES
chr4_+_72204769 0.866 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr15_+_63334753 0.866 NM_000366
NM_001018004
NM_001018005
NM_001018006
NM_001018007
NM_001018020
TPM1





tropomyosin 1 (alpha)





chr5_+_86564727 0.862 NM_022650
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr12_+_79258448 0.860 NM_005639
SYT1
synaptotagmin I
chr19_+_41725259 0.856 AXL
AXL receptor tyrosine kinase
chr2_-_238322840 0.851 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr11_+_69455978 0.845 CCND1
cyclin D1
chr1_-_42965948 0.841 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr11_-_14380591 0.837 NM_012250
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr19_+_41725131 0.832 AXL
AXL receptor tyrosine kinase
chr6_-_75994477 0.830 TMEM30A
transmembrane protein 30A
chr6_-_32095993 0.829 NM_001136153
NM_004381
ATF6B

activating transcription factor 6 beta

chr5_+_131593331 0.826 NM_001131027
NM_003687
PDLIM4

PDZ and LIM domain 4

chr8_-_29207795 0.825 NM_001394
DUSP4
dual specificity phosphatase 4
chr4_+_83956238 0.823 NM_016129
COPS4
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
chr9_+_35829375 0.820 NM_001042590
TMEM8B
transmembrane protein 8B
chrX_-_106243442 0.818 NM_001085354
NM_024657
MORC4

MORC family CW-type zinc finger 4

chr6_-_75994496 0.818 TMEM30A
transmembrane protein 30A
chrX_+_135278912 0.816 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.88 1.91e-05 GO:0032501 multicellular organismal process
3.04 2.55e-05 GO:0009653 anatomical structure morphogenesis
2.19 4.54e-05 GO:0048856 anatomical structure development
2.26 6.88e-05 GO:0048731 system development
1.98 2.66e-04 GO:0032502 developmental process
2.05 3.45e-04 GO:0007275 multicellular organismal development
2.56 3.59e-04 GO:0048513 organ development
11.43 3.70e-04 GO:0030198 extracellular matrix organization
7.54 6.44e-04 GO:0007517 muscle organ development
25.59 9.84e-04 GO:0030199 collagen fibril organization
3.50 1.26e-03 GO:0009888 tissue development
2.41 1.42e-03 GO:0048869 cellular developmental process
5.86 2.16e-03 GO:0061061 muscle structure development
21.94 2.22e-03 GO:0071295 cellular response to vitamin
2.39 2.53e-03 GO:0030154 cell differentiation
4.35 2.98e-03 GO:0072358 cardiovascular system development
4.35 2.98e-03 GO:0072359 circulatory system development
18.07 6.04e-03 GO:0031670 cellular response to nutrient
7.45 9.44e-03 GO:0043062 extracellular structure organization
3.67 1.02e-02 GO:0042060 wound healing
25.86 1.18e-02 GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway
23.40 1.80e-02 GO:0071300 cellular response to retinoic acid
22.34 2.19e-02 GO:0071299 cellular response to vitamin A
4.94 2.76e-02 GO:0001944 vasculature development
6.39 2.89e-02 GO:0006936 muscle contraction
9.58 3.01e-02 GO:0031669 cellular response to nutrient levels
7.55 3.13e-02 GO:0016055 Wnt receptor signaling pathway
7.42 3.50e-02 GO:0060537 muscle tissue development
19.66 3.72e-02 GO:0035567 non-canonical Wnt receptor signaling pathway
4.71 4.12e-02 GO:0001501 skeletal system development
6.07 4.14e-02 GO:0042327 positive regulation of phosphorylation
3.43 4.36e-02 GO:0032989 cellular component morphogenesis
2.47 4.69e-02 GO:0009966 regulation of signal transduction
5.96 4.72e-02 GO:0010562 positive regulation of phosphorus metabolic process
5.96 4.72e-02 GO:0045937 positive regulation of phosphate metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
6.65 2.52e-07 GO:0031012 extracellular matrix
7.03 1.40e-06 GO:0005578 proteinaceous extracellular matrix
3.38 2.39e-05 GO:0044421 extracellular region part
44.66 1.75e-04 GO:0005583 fibrillar collagen
3.52 1.90e-04 GO:0005615 extracellular space
2.51 2.56e-04 GO:0005576 extracellular region
7.85 1.53e-02 GO:0005924 cell-substrate adherens junction
14.89 1.89e-02 GO:0005581 collagen
7.53 1.93e-02 GO:0030055 cell-substrate junction
7.53 1.93e-02 GO:0044420 extracellular matrix part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
14.46 1.00e-05 GO:0005201 extracellular matrix structural constituent