Motif ID: GFI1B.p2

Z-value: 1.165


Transcription factors associated with GFI1B.p2:

Gene SymbolEntrez IDGene Name
GFI1B 8328 growth factor independent 1B transcription repressor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GFI1Bchr9_+_135854097-0.581.8e-02Click!


Activity profile for motif GFI1B.p2.

activity profile for motif GFI1B.p2


Sorted Z-values histogram for motif GFI1B.p2

Sorted Z-values for motif GFI1B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GFI1B.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_28124915 5.103 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr7_-_27205148 3.128 NM_152739
HOXA9
homeobox A9
chr7_-_27205123 3.101 HOXA9
homeobox A9
chr6_+_12290528 2.451 NM_001168319
NM_001955
EDN1

endothelin 1

chr10_-_91011516 2.040 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr21_-_27512668 2.040 NM_001136016
APP
amyloid beta (A4) precursor protein
chr2_-_113542970 1.953 NM_000575
IL1A
interleukin 1, alpha
chr17_+_70117168 1.719 SOX9
SRY (sex determining region Y)-box 9
chr10_-_91011562 1.687 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr17_-_56494930 1.576 NM_017763
RNF43
ring finger protein 43
chr5_+_102201526 1.545 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr4_-_40936640 1.499 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr5_+_66124603 1.436 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr6_-_134498973 1.420 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr1_+_101702304 1.345 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr2_-_165424993 1.345 GRB14
growth factor receptor-bound protein 14
chr17_+_70117177 1.275 SOX9
SRY (sex determining region Y)-box 9
chr1_+_27189628 1.274 NM_006142
SFN
stratifin
chr7_-_56101830 1.272 PSPH
phosphoserine phosphatase
chr2_-_113594325 1.252 NM_000576
IL1B
interleukin 1, beta
chr9_+_33624214 1.249 ANXA2P2
annexin A2 pseudogene 2
chr4_+_166248816 1.213 NM_001017369
NM_006745
MSMO1

methylsterol monooxygenase 1

chr17_-_1619473 1.000 MIR22HG
MIR22 host gene (non-protein coding)
chr1_-_153085963 0.904 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr11_+_19372270 0.897 NM_001111018
NAV2
neuron navigator 2
chr1_+_101702561 0.868 S1PR1
sphingosine-1-phosphate receptor 1
chr17_-_56494889 0.822 RNF43
ring finger protein 43
chr3_-_158390266 0.778 NM_020169
LXN
latexin
chr1_+_220701800 0.769 MARK1
MAP/microtubule affinity-regulating kinase 1
chr1_+_66797775 0.751 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chrX_-_10588458 0.744 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr4_-_186877869 0.705 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr11_-_118135197 0.698 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr11_+_5710926 0.664 TRIM22
tripartite motif containing 22
chr7_-_115670828 0.655 NM_001018058
NM_012252
TFEC

transcription factor EC

chr18_+_21452981 0.653 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_84647342 0.643 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_+_159557649 0.638 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr12_-_15038724 0.618 NM_000900
NM_001190839
MGP

matrix Gla protein

chr15_-_83953465 0.605 NM_001717
BNC1
basonuclin 1
chr7_+_116165089 0.571 CAV1
caveolin 1, caveolae protein, 22kDa
chr22_-_28315202 0.570 PITPNB
phosphatidylinositol transfer protein, beta
chr18_+_47088400 0.570 NM_006033
LIPG
lipase, endothelial
chr6_+_90272036 0.568 NM_001242811
ANKRD6
ankyrin repeat domain 6
chr3_+_159557745 0.566 SCHIP1
schwannomin interacting protein 1
chr5_+_109025135 0.559 NM_002372
MAN2A1
mannosidase, alpha, class 2A, member 1
chr16_+_69220940 0.559 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr4_+_169418167 0.559 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr4_-_186733372 0.557 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr18_+_29027731 0.557 NM_001944
DSG3
desmoglein 3
chr8_-_17555158 0.535 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr7_+_18548899 0.534 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr1_+_66798095 0.529 PDE4B
phosphodiesterase 4B, cAMP-specific
chr7_-_115670774 0.529 TFEC
transcription factor EC
chr10_-_91011586 0.515 NM_000235
NM_001127605
LIPA

lipase A, lysosomal acid, cholesterol esterase

chr21_-_47648715 0.504 NM_001001438
NM_001145436
NM_001145437
NM_002340
LSS



lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)



chr3_-_149095333 0.502 TM4SF1
transmembrane 4 L six family member 1
chr12_-_8815479 0.494 MFAP5
microfibrillar associated protein 5
chr1_-_17308072 0.493 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr3_+_133494275 0.492 TF
transferrin
chrX_+_46696346 0.477 NM_006915
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr3_+_158991035 0.470 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr12_-_6233684 0.467 NM_000552
VWF
von Willebrand factor
chr3_-_119812973 0.465 NM_001146156
NM_002093
GSK3B

glycogen synthase kinase 3 beta

chr13_-_48987247 0.455 LPAR6
lysophosphatidic acid receptor 6
chr5_+_102201713 0.441 PAM
peptidylglycine alpha-amidating monooxygenase
chrX_+_46696424 0.425 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr21_+_35014624 0.414 NM_001001132
NM_003024
ITSN1

intersectin 1 (SH3 domain protein)

chr7_+_150264457 0.412 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr6_-_47277646 0.411 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr8_+_32504250 0.408 NM_013959
NRG1
neuregulin 1
chr17_+_41052813 0.408 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr8_-_17580024 0.408 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr2_+_234580504 0.396 NM_021027
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr1_+_158979681 0.391 NM_001206567
NM_005531
IFI16

interferon, gamma-inducible protein 16

chr11_-_8892909 0.384 ST5
suppression of tumorigenicity 5
chr1_+_162760491 0.382 NM_016371
HSD17B7
hydroxysteroid (17-beta) dehydrogenase 7
chr11_+_34654010 0.381 NM_001206616
EHF
ets homologous factor
chr22_-_28315214 0.380 NM_012399
PITPNB
phosphatidylinositol transfer protein, beta
chr1_-_68697997 0.359 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr5_+_140792507 0.356 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr1_+_43766565 0.352 NM_001253357
NM_005424
TIE1

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

chr2_+_163200582 0.351 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr11_-_118134986 0.349 MPZL2
myelin protein zero-like 2
chrX_+_15518899 0.347 NM_203281
BMX
BMX non-receptor tyrosine kinase
chrX_+_100805415 0.338 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr1_+_220701547 0.337 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr5_+_134209426 0.329 NM_024715
TXNDC15
thioredoxin domain containing 15
chr3_-_133748828 0.328 NM_005630
SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr3_+_113557679 0.325 NM_017577
GRAMD1C
GRAM domain containing 1C
chr6_-_75965845 0.315 TMEM30A
transmembrane protein 30A
chr4_+_154125589 0.313 NM_015271
TRIM2
tripartite motif containing 2
chr3_-_18480203 0.299 NM_001131010
SATB1
SATB homeobox 1
chr15_+_40509628 0.297 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr21_-_47648672 0.293 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr3_-_151034514 0.292 NM_023915
GPR87
G protein-coupled receptor 87
chr17_+_20771745 0.291


chr18_+_3451589 0.291 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr2_+_204732509 0.288 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr22_-_38881529 0.285 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr22_-_41682169 0.284 RANGAP1
Ran GTPase activating protein 1
chr3_-_190040192 0.280 NM_021101
CLDN1
claudin 1
chr16_+_8806825 0.280 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr8_+_9953061 0.278 NM_001135671
NM_001199729
MSRA

methionine sulfoxide reductase A

chr3_+_142375738 0.274 NM_001172312
PLS1
plastin 1
chr2_-_190044330 0.272 NM_000393
COL5A2
collagen, type V, alpha 2
chr2_+_113033146 0.267 NM_198581
ZC3H6
zinc finger CCCH-type containing 6
chrX_+_105937067 0.264 NM_024539
RNF128
ring finger protein 128
chr15_+_32933869 0.258 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr12_+_54674531 0.257 HNRNPA1L2
HNRNPA1
heterogeneous nuclear ribonucleoprotein A1-like 2
heterogeneous nuclear ribonucleoprotein A1
chr11_+_57529233 0.255 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001206883
NM_001206884
NM_001206885
NM_001206886
NM_001206887
NM_001206888
NM_001206889
NM_001206890
NM_001206891
NM_001331
CTNND1





















catenin (cadherin-associated protein), delta 1





















chr8_-_17579729 0.238 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr22_-_41682187 0.236 NM_002883
RANGAP1
Ran GTPase activating protein 1
chr18_+_33234532 0.232 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr11_+_5710816 0.229 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr19_+_42724431 0.229 NM_133444
ZNF526
zinc finger protein 526
chr4_-_102268626 0.226 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr8_+_32579350 0.226 NM_001159996
NRG1
neuregulin 1
chr4_+_6271588 0.224 WFS1
Wolfram syndrome 1 (wolframin)
chr5_-_137071703 0.222 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr4_-_186877413 0.220 SORBS2
sorbin and SH3 domain containing 2
chr12_+_56915587 0.215 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr19_+_48281841 0.214 NM_003009
SEPW1
selenoprotein W, 1
chr2_+_183582667 0.211 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr17_+_73720775 0.208 NM_001005619
ITGB4
integrin, beta 4
chr17_-_5389480 0.207 NM_016041
DERL2
Der1-like domain family, member 2
chr13_-_48987652 0.207 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr6_-_167040700 0.203 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr4_+_6271558 0.202 NM_001145853
NM_006005
WFS1

Wolfram syndrome 1 (wolframin)

chr12_-_8815266 0.200 MFAP5
microfibrillar associated protein 5
chr2_-_161350304 0.197 NM_002897
NM_016836
RBMS1

RNA binding motif, single stranded interacting protein 1

chr22_-_39640956 0.195 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide
chr12_-_123201319 0.195 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr4_-_23891608 0.191 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chrX_-_72434623 0.190 NAP1L2
nucleosome assembly protein 1-like 2
chr1_-_116383323 0.190 NM_001111061
NHLH2
nescient helix loop helix 2
chr8_-_119123804 0.189 NM_000127
EXT1
exostosin 1
chr12_-_56756526 0.188 NM_001638
APOF
apolipoprotein F
chr1_-_163113938 0.185 RGS5
regulator of G-protein signaling 5
chr18_-_3874252 0.181 NM_001242764
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr5_-_137071462 0.180 KLHL3
kelch-like 3 (Drosophila)
chr14_-_58764805 0.180 FLJ31306
uncharacterized LOC379025
chr3_+_98451537 0.178 NM_006100
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr10_-_129924467 0.177 NM_001145966
NM_002417
MKI67

antigen identified by monoclonal antibody Ki-67

chr2_+_163200623 0.176 GCA
grancalcin, EF-hand calcium binding protein
chr1_+_24840800 0.174 NM_001251980
NM_001251982
NM_001251985
RCAN3


RCAN family member 3


chr12_-_123187842 0.174 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr1_+_26872306 0.174 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_79472360 0.169 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chrX_-_72434667 0.166 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chr19_+_41770329 0.164 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr13_-_75901897 0.164 TBC1D4
TBC1 domain family, member 4
chr14_-_75600111 0.160 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr16_+_15744082 0.159 NM_017668
NDE1
nudE nuclear distribution gene E homolog 1 (A. nidulans)
chr19_+_41770285 0.157 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr16_+_68279206 0.157 NM_012320
PLA2G15
phospholipase A2, group XV
chr11_-_58343308 0.156 NM_004811
LPXN
leupaxin
chr12_-_54673901 0.156 NM_012117
CBX5
chromobox homolog 5
chr4_-_76944585 0.156 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr8_-_19540093 0.154 NM_018371
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr6_-_31648140 0.153 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr6_+_154331630 0.153 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr16_+_15031299 0.153 NM_006985
NPIP
nuclear pore complex interacting protein
chr16_+_53479685 0.152 RBL2
retinoblastoma-like 2 (p130)
chr20_-_44485953 0.152 NM_005469
ACOT8
acyl-CoA thioesterase 8
chr2_-_86116016 0.151 NM_003896
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr7_+_115850546 0.147 NM_015641
TES
testis derived transcript (3 LIM domains)
chr11_+_18287807 0.145 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr9_-_123812535 0.145 NM_001735
C5
complement component 5
chr8_+_26150731 0.142 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr5_+_140729723 0.142 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr10_+_38645293 0.141 HSD17B7P2
hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2
chr2_+_33701678 0.139 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr2_+_62900985 0.139 NM_001142615
EHBP1
EH domain binding protein 1
chr14_-_68162419 0.138 NM_001252650
NM_016026
RDH11

retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

chr10_+_102792161 0.134 SFXN3
sideroflexin 3
chrY_+_14774201 0.130 TTTY15
testis-specific transcript, Y-linked 15 (non-protein coding)
chr4_+_6271605 0.129 WFS1
Wolfram syndrome 1 (wolframin)
chr1_+_84630575 0.128 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chrX_-_10645726 0.127 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr10_+_71211215 0.125 NM_012339
TSPAN15
tetraspanin 15
chr19_+_36545848 0.124 WDR62
WD repeat domain 62
chr1_-_108231122 0.123 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr4_-_186577858 0.122 SORBS2
sorbin and SH3 domain containing 2
chrX_+_135278912 0.122 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr1_-_152297678 0.119 NM_002016
FLG
filaggrin
chr10_-_91403630 0.119 NM_138316
NM_148978
PANK1

pantothenate kinase 1

chr2_-_165551178 0.118 COBLL1
COBL-like 1
chr10_+_104535887 0.116 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr16_+_68279297 0.114 PLA2G15
phospholipase A2, group XV
chrX_+_57618440 0.113 ZXDB
zinc finger, X-linked, duplicated B
chr18_-_3874688 0.112 NM_001242762
NM_001242763
DLGAP1

discs, large (Drosophila) homolog-associated protein 1

chr16_-_1876792 0.111 HAGH
hydroxyacylglutathione hydrolase
chr12_+_113229548 0.110 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr19_+_45449228 0.108 NM_000483
APOC2
apolipoprotein C-II
chr15_+_85923739 0.108 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr14_-_94759594 0.106 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr19_+_36545804 0.104 WDR62
WD repeat domain 62
chr5_-_146833150 0.104 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr19_+_11200124 0.103 LDLR
low density lipoprotein receptor

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
42.57 7.09e-04 GO:0045787 positive regulation of cell cycle
97.10 1.37e-03 GO:0045840 positive regulation of mitosis
97.10 1.37e-03 GO:0051785 positive regulation of nuclear division
496.06 2.11e-03 GO:0010193 response to ozone
16.37 3.25e-03 GO:0007346 regulation of mitotic cell cycle
372.06 4.22e-03 GO:0033591 response to L-ascorbic acid
7.77 4.35e-03 GO:0031328 positive regulation of cellular biosynthetic process
4.30 4.61e-03 GO:0065008 regulation of biological quality
7.64 4.89e-03 GO:0009891 positive regulation of biosynthetic process
7.36 6.24e-03 GO:0042592 homeostatic process
54.50 8.13e-03 GO:0060560 developmental growth involved in morphogenesis
12.80 1.08e-02 GO:0060429 epithelium development
5.12 1.74e-02 GO:0009653 anatomical structure morphogenesis
186.06 1.96e-02 GO:0032331 negative regulation of chondrocyte differentiation
17.46 2.46e-02 GO:0006874 cellular calcium ion homeostasis
165.39 2.52e-02 GO:0051482 elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger
17.06 2.69e-02 GO:0072503 cellular divalent inorganic cation homeostasis
16.87 2.82e-02 GO:0055074 calcium ion homeostasis
16.41 3.14e-02 GO:0072507 divalent inorganic cation homeostasis
7.14 3.75e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
135.33 3.85e-02 GO:0032874 positive regulation of stress-activated MAPK cascade
32.41 3.91e-02 GO:0048871 multicellular organismal homeostasis
5.50 4.23e-02 GO:0031325 positive regulation of cellular metabolic process
31.06 4.44e-02 GO:0007088 regulation of mitosis
31.06 4.44e-02 GO:0051783 regulation of nuclear division

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
212.63 1.37e-03 GO:0005149 interleukin-1 receptor binding