Motif ID: GTF2I.p2

Z-value: 1.493


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GTF2Ichr7_+_740720550.504.9e-02Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_148060 5.210 NM_018390
 PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chrX_+_198060 5.145 NM_018390
 PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr20_-_22564893 4.566 FOXA2
forkhead box A2
chr19_+_45452427 3.756 APOC2
apolipoprotein C-II
chr11_-_2159472 2.735 IGF2
insulin-like growth factor 2 (somatomedin A)
chr1_-_20812727 2.504 NM_018584
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr20_-_22565050 2.363 NM_021784
 FOXA2
forkhead box A2
chr12_-_115121939 2.315 NM_005996
NM_016569
 TBX3

T-box 3

chr14_-_54423448 2.228 NM_001202
NM_130850
 BMP4

bone morphogenetic protein 4

chr10_+_114709963 2.074 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
 TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr11_-_2160199 2.072 NM_000612
 IGF2
insulin-like growth factor 2 (somatomedin A)
chr8_+_97506141 2.050 SDC2
syndecan 2
chr11_-_2159925 2.049 IGF2
insulin-like growth factor 2 (somatomedin A)
chr1_-_92351476 2.036 TGFBR3
transforming growth factor, beta receptor III
chr2_-_39664430 2.032 MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr16_-_29910340 1.961 NM_001114099
NM_001114100
NM_001243332
NM_001243333
NM_012410
NM_201575
 SEZ6L2





seizure related 6 homolog (mouse)-like 2





chr2_+_128175989 1.904 NM_000312
 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr2_+_128176019 1.898 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr5_+_92918924 1.844 NM_005654
 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr5_+_92920592 1.747 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 64 entries
Enrichment   P-value GO Accession GO Term
243.25 1.13e-02 GO:0060696 regulation of phospholipid catabolic process
243.25 1.13e-02 GO:0060838 lymphatic endothelial cell fate commitment
243.25 1.13e-02 GO:0060839 endothelial cell fate commitment
243.25 1.13e-02 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment
243.25 1.13e-02 GO:0072148 epithelial cell fate commitment
162.17 3.37e-02 GO:0035117 embryonic arm morphogenesis
162.17 3.37e-02 GO:0035140 arm morphogenesis
162.17 3.37e-02 GO:0060836 lymphatic endothelial cell differentiation
121.63 8.71e-04 GO:0045662 negative regulation of myoblast differentiation
60.83 9.42e-03 GO:0045661 regulation of myoblast differentiation
60.83 9.42e-03 GO:0051148 negative regulation of muscle cell differentiation
45.63 2.37e-02 GO:0048844 artery morphogenesis
40.56 3.43e-02 GO:0060840 artery development
38.42 4.07e-02 GO:0034381 plasma lipoprotein particle clearance
36.50 4.77e-02 GO:0003158 endothelium development
33.57 3.70e-03 GO:0051153 regulation of striated muscle cell differentiation
17.90 5.41e-03 GO:0055123 digestive system development
9.31 2.74e-02 GO:0032582 negative regulation of gene-specific transcription
8.41 1.43e-04 GO:0043009 chordate embryonic development
8.29 1.62e-04 GO:0009792 embryo development ending in birth or egg hatching

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
121.63 7.63e-03 GO:0034363 intermediate-density lipoprotein particle
66.35 8.05e-04 GO:0042627 chylomicron
40.56 3.90e-03 GO:0034361 very-low-density lipoprotein particle
40.56 3.90e-03 GO:0034385 triglyceride-rich lipoprotein particle
22.82 2.28e-02 GO:0032994 protein-lipid complex
22.82 2.28e-02 GO:0034358 plasma lipoprotein particle
4.04 4.58e-03 GO:0005615 extracellular space
3.80 1.65e-03 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
12.82 2.85e-02 GO:0003704 specific RNA polymerase II transcription factor activity
7.87 2.90e-03 GO:0003702 RNA polymerase II transcription factor activity
6.47 2.57e-04 GO:0019904 protein domain specific binding
4.09 3.17e-02 GO:0043565 sequence-specific DNA binding
3.75 6.03e-03 GO:0030528 transcription regulator activity
3.51 2.36e-02 GO:0001071 nucleic acid binding transcription factor activity
3.51 2.36e-02 GO:0003700 sequence-specific DNA binding transcription factor activity