Motif ID: HAND1,2.p2

Z-value: 1.628


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HAND1chr5_-_153857820-0.253.5e-01Click!
HAND2chr4_-_174451356-0.224.0e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_149792370 5.428 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr19_-_7764283 4.665 NM_001207019
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr14_-_107179043 4.533 IGHA1
immunoglobulin heavy constant alpha 1
chr5_-_149792276 4.247 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_+_6588933 3.835 NM_004271
LY86
lymphocyte antigen 86
chr22_+_23213671 3.598 IGLV4-3
immunoglobulin lambda variable 4-3
chr22_+_22723972 2.986


chr11_+_121461070 2.808 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr19_+_45452427 2.806 APOC2
apolipoprotein C-II
chr11_+_22689653 2.673 NM_177553
GAS2
growth arrest-specific 2
chr11_+_22696318 2.597 NM_005256
GAS2
growth arrest-specific 2
chr4_+_74281884 2.556 ALB
albumin
chrX_+_128913881 2.462 NM_018990
SASH3
SAM and SH3 domain containing 3
chr1_-_160681552 2.399 NM_001778
CD48
CD48 molecule
chr21_-_46340821 2.375 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr7_+_99816870 2.354 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr7_+_26403944 2.333 NM_001199838
SNX10
sorting nexin 10
chr14_+_75988838 2.307 BATF
basic leucine zipper transcription factor, ATF-like
chr4_-_40631846 2.289 NM_001098634
RBM47
RNA binding motif protein 47
chrX_+_128913897 2.228 SASH3
SAM and SH3 domain containing 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 11 of 11 entries
Enrichment   P-value GO Accession GO Term
42.18 7.98e-04 GO:0030890 positive regulation of B cell proliferation
31.02 2.85e-03 GO:0030888 regulation of B cell proliferation
27.76 4.49e-03 GO:0050871 positive regulation of B cell activation
19.18 1.98e-02 GO:0050864 regulation of B cell activation
15.75 4.31e-02 GO:0050671 positive regulation of lymphocyte proliferation
15.52 4.56e-02 GO:0032946 positive regulation of mononuclear cell proliferation
15.30 4.83e-02 GO:0070665 positive regulation of leukocyte proliferation
8.17 4.89e-06 GO:0050776 regulation of immune response
5.40 4.48e-04 GO:0002682 regulation of immune system process
4.94 1.14e-03 GO:0006955 immune response
4.08 2.13e-04 GO:0002376 immune system process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
Enrichment   P-value GO Accession GO Term
32.96 1.66e-05 GO:0003823 antigen binding