Motif ID: HAND1,2.p2

Z-value: 1.628


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HAND1chr5_-_153857820-0.253.5e-01Click!
HAND2chr4_-_174451356-0.224.0e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_149792370 5.428 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr19_-_7764283 4.665 NM_001207019
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr14_-_107179043 4.533 IGHA1
immunoglobulin heavy constant alpha 1
chr5_-_149792276 4.247 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_+_6588933 3.835 NM_004271
LY86
lymphocyte antigen 86
chr22_+_23213671 3.598 IGLV4-3
immunoglobulin lambda variable 4-3
chr22_+_22723972 2.986


chr11_+_121461070 2.808 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr19_+_45452427 2.806 APOC2
apolipoprotein C-II
chr11_+_22689653 2.673 NM_177553
GAS2
growth arrest-specific 2
chr11_+_22696318 2.597 NM_005256
GAS2
growth arrest-specific 2
chr4_+_74281884 2.556 ALB
albumin
chrX_+_128913881 2.462 NM_018990
SASH3
SAM and SH3 domain containing 3
chr1_-_160681552 2.399 NM_001778
CD48
CD48 molecule
chr21_-_46340821 2.375 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr7_+_99816870 2.354 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr7_+_26403944 2.333 NM_001199838
SNX10
sorting nexin 10
chr14_+_75988838 2.307 BATF
basic leucine zipper transcription factor, ATF-like
chr4_-_40631846 2.289 NM_001098634
RBM47
RNA binding motif protein 47
chrX_+_128913897 2.228 SASH3
SAM and SH3 domain containing 3
chr14_+_75988765 2.218 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr2_+_228678556 2.178 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr14_-_107013474 2.152 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_-_53600999 1.940 NM_000889
ITGB7
integrin, beta 7
chr19_+_40194945 1.929 NM_020129
NM_203471
LGALS14

lectin, galactoside-binding, soluble, 14

chr12_-_53601051 1.874 ITGB7
integrin, beta 7
chr14_-_106746056 1.871


chr1_+_26644458 1.819 CD52
CD52 molecule
chr22_+_25003610 1.817 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr14_-_106208537 1.803


chr13_+_31309690 1.782 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr14_-_106471439 1.751 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr10_-_90712510 1.711 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr14_-_106774311 1.701 IGHA1
immunoglobulin heavy constant alpha 1
chr14_-_65409445 1.664 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr13_-_46742678 1.650 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr14_-_107078578 1.626


chr22_+_24999113 1.590 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr6_+_87969619 1.571 ZNF292
zinc finger protein 292
chr1_+_26644380 1.515 NM_001803
CD52
CD52 molecule
chr19_-_9695166 1.480 NM_001008727
ZNF121
zinc finger protein 121
chr17_+_53342356 1.479 HLF
hepatic leukemia factor
chr14_-_106518424 1.473 IGH@
IGHA1
IGHG1
IGHG2
IGHM
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chrX_-_105282714 1.441 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr11_-_2158510 1.414 IGF2
insulin-like growth factor 2 (somatomedin A)
chr3_+_112051914 1.351 NM_001004196
NM_005944
CD200

CD200 molecule

chr13_+_31309644 1.300 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr21_+_27012045 1.274 JAM2
junctional adhesion molecule 2
chr1_+_156123321 1.269 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr17_-_39092714 1.230 KRT23
keratin 23 (histone deacetylase inducible)
chr5_-_150467220 1.221 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chrX_-_33357725 1.160 NM_000109
DMD
dystrophin
chr3_+_112052020 1.158 CD200
CD200 molecule
chr14_-_106405633 1.142 IGHM
immunoglobulin heavy constant mu
chr21_-_46340776 1.118 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_+_207262211 1.113 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr1_+_161632904 1.110 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr5_-_150466696 1.096 NM_001252391
NM_001252392
TNIP1

TNFAIP3 interacting protein 1

chrX_-_32173585 1.092 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr1_+_111413820 1.069 NM_001040033
CD53
CD53 molecule
chr17_+_75446612 1.069 NM_001113496
SEPT9
septin 9
chr3_+_98250742 1.057 NM_005290
GPR15
G protein-coupled receptor 15
chr12_+_54891539 1.021 NCKAP1L
NCK-associated protein 1-like
chr6_+_33043702 1.002 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr3_+_133494275 1.002 TF
transferrin
chr6_-_112194430 0.961 FYN
FYN oncogene related to SRC, FGR, YES
chr16_-_28608367 0.949 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr17_+_53342320 0.910 NM_002126
HLF
hepatic leukemia factor
chr1_+_6105980 0.899 NM_001199862
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr8_-_103137134 0.897 NM_001040630
NCALD
neurocalcin delta
chrX_+_1455508 0.876 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr2_+_75059781 0.870 NM_000189
HK2
hexokinase 2
chr17_+_72462766 0.856 CD300A
CD300a molecule
chr19_-_10450262 0.853 NM_002162
ICAM3
intercellular adhesion molecule 3
chrY_+_1405508 0.845 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr2_-_175462428 0.840 WIPF1
WAS/WASL interacting protein family, member 1
chr22_-_37545944 0.831 NM_000878
IL2RB
interleukin 2 receptor, beta
chr6_+_167525294 0.824 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr19_-_41196419 0.819 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr14_-_106092256 0.818 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr17_+_16319087 0.814 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr8_+_28174648 0.805 NM_006228
PNOC
prepronociceptin
chr14_-_106111114 0.784 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr12_+_54891522 0.776 NCKAP1L
NCK-associated protein 1-like
chr8_-_28347733 0.775 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr7_-_20256942 0.754 NM_182762
MACC1
metastasis associated in colon cancer 1
chr14_-_106237675 0.743 IGHM
immunoglobulin heavy constant mu
chr1_+_26856259 0.734 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr21_+_34602273 0.720 IFNAR2
interferon (alpha, beta and omega) receptor 2
chr21_-_46340874 0.716 NM_000211
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr6_-_112194648 0.691 NM_002037
FYN
FYN oncogene related to SRC, FGR, YES
chr21_+_34602304 0.687 IFNAR2
interferon (alpha, beta and omega) receptor 2
chr3_-_13384746 0.685 NUP210
nucleoporin 210kDa
chr17_+_72462521 0.685 NM_007261
CD300A
CD300a molecule
chr6_+_30227335 0.672 HLA-L
major histocompatibility complex, class I, L, pseudogene
chr14_-_24777153 0.665 CIDEB
cell death-inducing DFFA-like effector b
chr11_-_70672644 0.663 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr14_-_107170400 0.663 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr14_-_107066061 0.659 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_72873739 0.655 LOC100507299
uncharacterized LOC100507299
chr1_+_87380437 0.651 HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr22_+_22712091 0.634 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr12_+_113416267 0.633 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr1_-_155904201 0.632 KIAA0907
KIAA0907
chr13_-_47012324 0.629 KIAA0226L
KIAA0226-like
chr12_+_121132677 0.621


chr1_+_207262583 0.617 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr16_-_29910340 0.607 NM_001114099
NM_001114100
NM_001243332
NM_001243333
NM_012410
NM_201575
SEZ6L2





seizure related 6 homolog (mouse)-like 2





chr14_-_106209380 0.606 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr18_+_29171729 0.604 NM_000371
TTR
transthyretin
chr14_+_65878579 0.597 FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr16_+_56995761 0.592 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chr19_-_36304200 0.588 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr1_-_160549226 0.585 CD84
CD84 molecule
chr19_+_35820069 0.572 NM_001185099
NM_001185100
NM_001185101
NM_001771
CD22



CD22 molecule



chr9_+_35829375 0.564 NM_001042590
TMEM8B
transmembrane protein 8B
chr7_+_94297448 0.550 PEG10
paternally expressed 10
chr19_+_17186569 0.539 NM_001130065
NM_004145
MYO9B

myosin IXB

chr12_+_27485767 0.535 NM_001248002
NM_001248003
NM_001248004
NM_001248005
NM_020183
ARNTL2




aryl hydrocarbon receptor nuclear translocator-like 2




chr11_-_89650877 0.530 NM_001206627
LOC399939
ring finger protein 18-like
chr3_+_50304989 0.530 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr9_-_123688352 0.527 TRAF1
TNF receptor-associated factor 1
chr14_-_107113943 0.522 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_+_54891491 0.521 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr1_-_205601999 0.504 NM_001973
NM_021795
ELK4

ELK4, ETS-domain protein (SRF accessory protein 1)

chr14_-_24423329 0.501 C14orf167
chromosome 14 open reading frame 167
chr3_-_114790221 0.498 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr5_-_138725544 0.486 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr8_+_11351509 0.485 NM_001715
BLK
B lymphoid tyrosine kinase
chr2_-_42588300 0.481 NM_004718
COX7A2L
cytochrome c oxidase subunit VIIa polypeptide 2 like
chr17_-_10372875 0.476 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr15_-_45670624 0.467 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr1_+_13736906 0.465 NM_001099852
PRAMEF20
PRAME family member 20
chr9_+_35829208 0.463 NM_016446
NM_001042589
TMEM8B

transmembrane protein 8B

chr5_-_171881421 0.459 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr14_-_24777160 0.457 CIDEB
cell death-inducing DFFA-like effector b
chr1_+_13516065 0.454 NM_001099852
PRAMEF20
PRAME family member 20
chr8_-_102803196 0.448 NCALD
neurocalcin delta
chr12_-_9913415 0.441 NM_001781
CD69
CD69 molecule
chr1_-_156399183 0.441 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr11_+_89659929 0.438 NM_001206627
LOC399939
ring finger protein 18-like
chr14_-_106494166 0.436 IGHV4-31
IGHA1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
chr19_-_8642337 0.435 MYO1F
myosin IF
chr10_+_131265500 0.433 MGMT
O-6-methylguanine-DNA methyltransferase
chr10_+_131265453 0.433 NM_002412
MGMT
O-6-methylguanine-DNA methyltransferase
chr13_-_46756295 0.430 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_-_8642297 0.429 MYO1F
myosin IF
chr1_+_36772696 0.418 NM_024676
SH3D21
SH3 domain containing 21
chr19_-_8642309 0.417 NM_012335
MYO1F
myosin IF
chr10_+_71812356 0.412 NM_018649
H2AFY2
H2A histone family, member Y2
chr11_-_116708334 0.404 NM_000039
APOA1
apolipoprotein A-I
chr22_+_23063107 0.398 IGLJ3
immunoglobulin lambda joining 3
chr21_+_34602205 0.393 NM_000874
NM_207584
NM_207585
IFNAR2


interferon (alpha, beta and omega) receptor 2


chr2_-_89513056 0.392 IGKC
immunoglobulin kappa constant
chr13_-_46756291 0.388 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr17_+_72462780 0.387 CD300A
CD300a molecule
chr6_-_41715078 0.386 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr9_+_71819926 0.380 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr13_+_113741668 0.379 MCF2L
MCF.2 cell line derived transforming sequence-like
chr13_-_46756326 0.379 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr22_-_36556781 0.373 NM_145640
APOL3
apolipoprotein L, 3
chr13_+_113812967 0.368 NM_003891
PROZ
protein Z, vitamin K-dependent plasma glycoprotein
chr6_-_55740358 0.364 NM_021073
BMP5
bone morphogenetic protein 5
chr5_+_59784004 0.362 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr13_-_41593405 0.358 ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_-_119278402 0.358 NM_005191
CD80
CD80 molecule
chr17_+_75315632 0.354 SEPT9
septin 9
chr16_+_16326478 0.352 NOMO2
NODAL modulator 2
chr3_-_196159304 0.351 NM_015562
UBXN7
UBX domain protein 7
chr17_+_37894212 0.350 GRB7
growth factor receptor-bound protein 7
chr19_+_56158953 0.347 NM_013301
CCDC106
coiled-coil domain containing 106
chr17_+_16318848 0.345 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr17_+_18380097 0.343 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr7_-_87230170 0.343 ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr17_+_1646129 0.339 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr17_+_75315590 0.336 NM_006640
SEPT9
septin 9
chr4_+_69962191 0.336 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr7_-_140714730 0.328 MRPS33
mitochondrial ribosomal protein S33
chr3_-_20227618 0.325 NM_001012409
NM_001012410
NM_001012411
NM_001012412
NM_001012413
NM_138484
NM_001199251
NM_001199252
NM_001199253
NM_001199254
NM_001199255
NM_001199256
NM_001199257
SGOL1












shugoshin-like 1 (S. pombe)












chr11_-_63330854 0.324 NM_017878
HRASLS2
HRAS-like suppressor 2
chr5_+_159626047 0.324 NM_001040442
FABP6
fatty acid binding protein 6, ileal
chr1_-_234614848 0.323 NM_005646
TARBP1
TAR (HIV-1) RNA binding protein 1
chr1_-_160832466 0.323 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr19_-_54850385 0.321 NM_012276
LILRA4
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
chr6_-_55740387 0.319 BMP5
bone morphogenetic protein 5
chr1_+_181003066 0.318 MR1
major histocompatibility complex, class I-related
chr7_+_1127722 0.317 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr2_+_169312793 0.317 NM_203463
CERS6
ceramide synthase 6
chr11_+_71927818 0.317 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr17_+_37894161 0.314 NM_005310
GRB7
growth factor receptor-bound protein 7
chr13_-_99910548 0.313 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr7_+_134832765 0.310 NM_018295
TMEM140
transmembrane protein 140
chr1_-_93342706 0.308 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr14_-_107170076 0.307 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr19_-_51875790 0.306 NM_005601
NKG7
natural killer cell group 7 sequence
chr2_+_97202463 0.306 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr14_-_106725620 0.303 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr16_-_20587625 0.302 NM_001105069
NM_182617
ACSM2B

acyl-CoA synthetase medium-chain family member 2B

chr6_-_43337125 0.295 NM_014345
ZNF318
zinc finger protein 318
chrX_-_131351917 0.294 NM_021183
RAP2C
RAP2C, member of RAS oncogene family

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
8.17 4.89e-06 GO:0050776 regulation of immune response
4.08 2.13e-04 GO:0002376 immune system process
5.40 4.48e-04 GO:0002682 regulation of immune system process
42.18 7.98e-04 GO:0030890 positive regulation of B cell proliferation
4.94 1.14e-03 GO:0006955 immune response
31.02 2.85e-03 GO:0030888 regulation of B cell proliferation
27.76 4.49e-03 GO:0050871 positive regulation of B cell activation
19.18 1.98e-02 GO:0050864 regulation of B cell activation
15.75 4.31e-02 GO:0050671 positive regulation of lymphocyte proliferation
15.52 4.56e-02 GO:0032946 positive regulation of mononuclear cell proliferation
15.30 4.83e-02 GO:0070665 positive regulation of leukocyte proliferation

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
32.96 1.66e-05 GO:0003823 antigen binding