Motif ID: HIC1.p2

Z-value: 3.904


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HIC1chr17_+_1958354,
chr17_+_1959512		0.185.0e-01Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_101980736 11.385 NM_001130145
NM_001195044
NM_006106
 YAP1


Yes-associated protein 1


chr2_-_224903933 11.121 NM_001136528
NM_006216
 SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr1_-_85930610 10.105 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_-_224903324 9.698 NM_001136530
 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr2_+_235860616 8.583 NM_014521
 SH3BP4
SH3-domain binding protein 4
chr1_-_85930733 7.605 NM_012137
 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_-_95392449 7.471 CNN3
calponin 3, acidic
chr13_-_110959441 7.397 NM_001845
 COL4A1
collagen, type IV, alpha 1
chr13_+_98795710 6.811 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr8_+_26435339 6.665 NM_001386
 DPYSL2
dihydropyrimidinase-like 2
chr10_+_124134206 6.530 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr11_-_12030838 6.510 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr1_-_94702916 6.484 ARHGAP29
Rho GTPase activating protein 29
chr13_+_110959592 6.477 NM_001846
 COL4A2
collagen, type IV, alpha 2
chr16_-_4166021 6.347 ADCY9
adenylate cyclase 9
chr11_-_12030882 6.287 NM_013253
 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr2_-_1748240 5.898 PXDN
peroxidasin homolog (Drosophila)
chr13_+_98795468 5.864 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr2_-_161349874 5.688 RBMS1
RNA binding motif, single stranded interacting protein 1
chr16_+_31483066 5.470 NM_001042454
NM_001164719
 TGFB1I1

transforming growth factor beta 1 induced transcript 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 69 entries
Enrichment   P-value GO Accession GO Term
5.34 6.73e-05 GO:0010769 regulation of cell morphogenesis involved in differentiation
5.29 7.73e-05 GO:0022604 regulation of cell morphogenesis
4.95 3.06e-03 GO:0010720 positive regulation of cell development
4.89 8.69e-03 GO:0030198 extracellular matrix organization
4.25 1.68e-03 GO:0043062 extracellular structure organization
4.22 1.87e-02 GO:0010975 regulation of neuron projection development
3.70 9.18e-07 GO:0007411 axon guidance
3.68 4.18e-04 GO:0050767 regulation of neurogenesis
3.61 7.55e-03 GO:0045664 regulation of neuron differentiation
3.48 3.19e-04 GO:0001568 blood vessel development
3.46 9.93e-05 GO:0060284 regulation of cell development
3.43 7.50e-04 GO:0051960 regulation of nervous system development
3.38 2.93e-04 GO:0001944 vasculature development
3.32 2.20e-06 GO:0007409 axonogenesis
3.30 1.40e-02 GO:0048514 blood vessel morphogenesis
3.27 1.66e-07 GO:0000904 cell morphogenesis involved in differentiation
3.20 5.55e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
3.15 7.83e-06 GO:0048812 neuron projection morphogenesis
3.11 2.19e-06 GO:0048858 cell projection morphogenesis
3.11 3.88e-03 GO:0040012 regulation of locomotion

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
Enrichment   P-value GO Accession GO Term
26.28 2.16e-02 GO:0005862 muscle thin filament tropomyosin
7.25 1.58e-05 GO:0005604 basement membrane
7.25 3.38e-02 GO:0005913 cell-cell adherens junction
5.05 1.45e-06 GO:0005912 adherens junction
5.01 1.64e-04 GO:0044420 extracellular matrix part
4.85 5.97e-04 GO:0005924 cell-substrate adherens junction
4.77 1.56e-06 GO:0070161 anchoring junction
4.67 2.14e-03 GO:0005925 focal adhesion
4.65 9.61e-04 GO:0030055 cell-substrate junction
4.24 1.29e-02 GO:0019898 extrinsic to membrane
3.31 1.18e-02 GO:0031252 cell leading edge
3.20 2.35e-05 GO:0031012 extracellular matrix
2.98 1.20e-03 GO:0015629 actin cytoskeleton
2.86 5.80e-03 GO:0005578 proteinaceous extracellular matrix
2.48 1.40e-02 GO:0009986 cell surface
2.40 1.42e-03 GO:0030054 cell junction
1.89 6.70e-03 GO:0044421 extracellular region part
1.69 1.77e-02 GO:0005856 cytoskeleton
1.62 8.87e-04 GO:0044459 plasma membrane part
1.53 1.02e-05 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
Enrichment   P-value GO Accession GO Term
3.62 1.19e-06 GO:0003779 actin binding
3.01 3.92e-07 GO:0008092 cytoskeletal protein binding
1.78 4.97e-02 GO:0005102 receptor binding
1.23 4.56e-03 GO:0005515 protein binding