Motif ID: HIF1A.p2

Z-value: 1.839


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HIF1Achr14_+_62162042,
chr14_+_62164339
-0.107.2e-01Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_13956530 4.690 GPM6B
glycoprotein M6B
chr10_+_3110818 3.367 NM_001242339
PFKP
phosphofructokinase, platelet
chr8_+_95653272 3.002 ESRP1
epithelial splicing regulatory protein 1
chr12_-_21810720 2.706 NM_001174097
LDHB
lactate dehydrogenase B
chr12_-_21810769 2.548 LDHB
lactate dehydrogenase B
chr12_-_21810754 2.529 LDHB
lactate dehydrogenase B
chr12_-_21810733 2.519 LDHB
lactate dehydrogenase B
chr12_-_21810779 2.477 NM_002300
LDHB
lactate dehydrogenase B
chrX_-_13956644 2.426 NM_001001994
GPM6B
glycoprotein M6B
chr12_-_50677238 2.337 NM_001113546
NM_016357
LIMA1

LIM domain and actin binding 1

chr8_+_31497267 2.245 NM_013962
NRG1
neuregulin 1
chr5_+_17217474 1.998 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr5_+_17217781 1.841 BASP1
brain abundant, membrane attached signal protein 1
chr11_+_69924407 1.784 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr4_-_143767603 1.750 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr1_+_233749749 1.749 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr7_+_156931631 1.738 NM_014671
UBE3C
ubiquitin protein ligase E3C
chr9_-_110252045 1.705 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr10_+_3109708 1.677 NM_002627
PFKP
phosphofructokinase, platelet
chr7_+_156931663 1.669 UBE3C
ubiquitin protein ligase E3C
chr15_-_83953465 1.644 NM_001717
BNC1
basonuclin 1
chr22_+_45148437 1.606 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr11_+_20385230 1.596 NM_006410
NM_001098521
HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

chr11_+_20385259 1.528 NM_001098520
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chrX_-_13956445 1.508


chrX_+_64887510 1.405 NM_002444
MSN
moesin
chr11_+_20385324 1.394 NM_001098522
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr1_-_159895279 1.394 NM_003564
TAGLN2
transgelin 2
chr4_+_4388804 1.353 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr3_+_156392369 1.338 TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr17_+_40985412 1.326 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr1_-_159895258 1.324 TAGLN2
transgelin 2
chrX_+_64887534 1.310 MSN
moesin
chr16_+_22825806 1.303 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr1_-_175161832 1.260 NM_001162895
NM_014656
NM_001162893
NM_001162894
KIAA0040



KIAA0040



chr7_+_55086922 1.243 EGFR
epidermal growth factor receptor
chr13_-_107187312 1.231 NM_004093
EFNB2
ephrin-B2
chr8_+_94929082 1.195 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr11_+_32851469 1.154 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr3_-_127541160 1.146 NM_007283
MGLL
monoglyceride lipase
chr1_-_43637788 1.117 EBNA1BP2
EBNA1 binding protein 2
chr4_+_4388717 1.116 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr5_+_49962920 1.077 PARP8
poly (ADP-ribose) polymerase family, member 8
chr16_+_68679229 1.046 CDH3
cadherin 3, type 1, P-cadherin (placental)
chrX_+_48367346 1.042 NM_022825
NM_203473
PORCN

porcupine homolog (Drosophila)

chr8_-_54755546 1.038 NM_213620
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr7_+_79764087 1.035 NM_002069
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr4_+_78079302 1.027 CCNG2
cyclin G2
chr6_-_159240398 1.026 EZR
ezrin
chr3_-_127541975 1.021 NM_001003794
MGLL
monoglyceride lipase
chr19_+_35646006 1.020 FXYD5
FXYD domain containing ion transport regulator 5
chr8_-_54755836 1.006 NM_015941
NM_213619
ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

chr3_-_16555128 1.004 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr1_-_144520918 1.000 LOC728855
uncharacterized LOC728855
chr19_+_39421347 0.977 NM_033362
MRPS12
mitochondrial ribosomal protein S12
chr1_-_209979388 0.972 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr5_+_49962771 0.967 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr10_+_74033676 0.954 NM_019058
DDIT4
DNA-damage-inducible transcript 4
chr6_-_159240367 0.951 EZR
ezrin
chr1_-_43637969 0.950 NM_006824
NM_001159936
EBNA1BP2

EBNA1 binding protein 2

chr8_+_48920969 0.937 NM_003350
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr22_+_45098091 0.922 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr15_-_42264749 0.921 NM_139265
EHD4
EH-domain containing 4
chr20_-_57582303 0.919 NM_001336
CTSZ
cathepsin Z
chr11_-_125366048 0.914 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr1_-_43833689 0.910 NM_022821
ELOVL1
ELOVL fatty acid elongase 1
chr21_-_45079327 0.906 NM_007031
HSF2BP
heat shock transcription factor 2 binding protein
chr12_-_42632150 0.902 NM_001190979
NM_001190980
NM_005748
YAF2


YY1 associated factor 2


chr1_-_144520987 0.901 LOC728855
uncharacterized LOC728855
chr18_-_45457454 0.897 NM_001003652
NM_001135937
SMAD2

SMAD family member 2

chr8_-_54755821 0.897 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr7_-_87849341 0.895 SRI
sorcin
chr12_-_42631982 0.893 NM_001190977
YAF2
YY1 associated factor 2
chr15_-_42264687 0.887 EHD4
EH-domain containing 4
chr3_+_156392204 0.883 NM_015508
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr12_+_131356617 0.876 RAN
RAN, member RAS oncogene family
chr7_-_27135524 0.874 NM_005522
NM_153620
HOXA1

homeobox A1

chr18_+_12308242 0.873 NM_032525
TUBB6
tubulin, beta 6 class V
chr11_-_64014140 0.862 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_-_43637958 0.859 EBNA1BP2
EBNA1 binding protein 2
chr3_-_52090090 0.857 NM_001947
DUSP7
dual specificity phosphatase 7
chr14_-_105634708 0.852 JAG2
jagged 2
chr7_+_115850546 0.846 NM_015641
TES
testis derived transcript (3 LIM domains)
chr1_+_233749917 0.846 KCNK1
potassium channel, subfamily K, member 1
chr6_-_106773290 0.844 ATG5
ATG5 autophagy related 5 homolog (S. cerevisiae)
chr1_-_43833688 0.842 ELOVL1
ELOVL fatty acid elongase 1
chr1_-_143744355 0.840 LOC100286793
FLJ39739
uncharacterized LOC100286793
uncharacterized FLJ39739
chr2_-_10588451 0.839 NM_002539
ODC1
ornithine decarboxylase 1
chr2_+_113403433 0.836 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr5_+_133861685 0.836 NM_015288
PHF15
PHD finger protein 15
chr1_+_174128547 0.833 NM_014857
RABGAP1L
RAB GTPase activating protein 1-like
chr1_-_147931877 0.830 FLJ39739
uncharacterized FLJ39739
chr20_-_57582152 0.830 CTSZ
cathepsin Z
chr3_-_16554992 0.825 RFTN1
raftlin, lipid raft linker 1
chr5_+_176560627 0.821 NM_022455
NSD1
nuclear receptor binding SET domain protein 1
chr6_-_159240399 0.815 EZR
ezrin
chr15_-_63673918 0.814 CA12
carbonic anhydrase XII
chr1_-_148176392 0.801


chr17_+_40985416 0.800 NM_005789
NM_176863
PSME3

proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)

chr1_-_43833668 0.797 ELOVL1
ELOVL fatty acid elongase 1
chr3_+_50654589 0.792 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chrX_+_16804531 0.789 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr10_+_112257624 0.784 NM_004419
DUSP5
dual specificity phosphatase 5
chrX_+_135229536 0.781 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr1_+_209848994 0.780 G0S2
G0/G1switch 2
chr22_-_17640076 0.780 CECR5
cat eye syndrome chromosome region, candidate 5
chr17_-_3599298 0.776 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr6_-_159240433 0.772 NM_001111077
EZR
ezrin
chr22_+_20105068 0.767 RANBP1
RAN binding protein 1
chr9_-_110251754 0.762 KLF4
Kruppel-like factor 4 (gut)
chr6_+_116692098 0.760 NM_013352
DSE
dermatan sulfate epimerase
chr1_-_43833605 0.760 ELOVL1
ELOVL fatty acid elongase 1
chr8_+_28351694 0.759 NM_017412
NM_145866
FZD3

frizzled family receptor 3

chr6_+_30294224 0.756


chr17_+_35849997 0.750 DUSP14
dual specificity phosphatase 14
chrX_+_64887593 0.742 MSN
moesin
chr17_+_52978022 0.733 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr2_-_96811138 0.730 NM_004418
DUSP2
dual specificity phosphatase 2
chr2_-_20424627 0.728 NM_002997
SDC1
syndecan 1
chr16_-_87903028 0.727 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr17_+_40985434 0.726 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr3_+_5229357 0.726 NM_014674
EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr16_+_68679198 0.706 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr1_+_41445402 0.705 CTPS
CTP synthase
chr3_+_50654600 0.704 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chrX_+_77359712 0.702 PGK1
phosphoglycerate kinase 1
chrX_+_77359768 0.699 PGK1
phosphoglycerate kinase 1
chr15_-_63674074 0.697 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr1_-_144521169 0.695 FAM91A2
family with sequence similarity 91, member A2
chr16_+_68771192 0.691 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr18_+_33877630 0.686 NM_025135
FHOD3
formin homology 2 domain containing 3
chr1_+_41445359 0.682 CTPS
CTP synthase
chr6_-_106773529 0.682 ATG5
ATG5 autophagy related 5 homolog (S. cerevisiae)
chr22_+_20105095 0.679 RANBP1
RAN binding protein 1
chr11_+_18416111 0.672 LDHA
lactate dehydrogenase A
chrX_+_110187468 0.672 NM_001128166
NM_001128167
PAK3

p21 protein (Cdc42/Rac)-activated kinase 3

chrX_-_149106641 0.668 NM_001013845
CXorf40B
chromosome X open reading frame 40B
chr9_-_21994414 0.667 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr8_-_23261626 0.667 LOXL2
lysyl oxidase-like 2
chr17_+_40985425 0.666 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr16_+_730425 0.664 STUB1
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
chr8_+_99129488 0.662 NM_001145860
NM_001145861
POP1

processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)

chr13_+_113951537 0.655 LAMP1
lysosomal-associated membrane protein 1
chr21_-_30257611 0.653 NM_013240
NM_182749
N6AMT1

N-6 adenine-specific DNA methyltransferase 1 (putative)

chr6_-_144385647 0.652 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr3_+_50654558 0.651 NM_001243925
NM_004635
MAPKAPK3

mitogen-activated protein kinase-activated protein kinase 3

chr5_+_176560882 0.646 NSD1
nuclear receptor binding SET domain protein 1
chr22_-_17640153 0.643 CECR5
cat eye syndrome chromosome region, candidate 5
chr7_-_87849366 0.642 NM_003130
SRI
sorcin
chr13_+_114239047 0.642 NM_007111
TFDP1
transcription factor Dp-1
chr1_-_8939150 0.642 NM_001428
ENO1
enolase 1, (alpha)
chr4_-_24586015 0.636 DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr6_-_106773607 0.633 NM_004849
ATG5
ATG5 autophagy related 5 homolog (S. cerevisiae)
chr1_-_153508463 0.631 S100A6
S100 calcium binding protein A6
chr11_+_12132063 0.631 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr5_+_176561146 0.630 NSD1
nuclear receptor binding SET domain protein 1
chr9_-_117880411 0.628 NM_002160
TNC
tenascin C
chr11_+_85956260 0.626 EED
embryonic ectoderm development
chr11_+_18416106 0.622 LDHA
lactate dehydrogenase A
chr19_-_12886421 0.614 NM_001100176
NM_013312
HOOK2

hook homolog 2 (Drosophila)

chr19_-_12886263 0.613 HOOK2
hook homolog 2 (Drosophila)
chr1_-_8938745 0.613 ENO1
enolase 1, (alpha)
chr17_+_35849950 0.609 NM_007026
DUSP14
dual specificity phosphatase 14
chr3_+_5229430 0.604 EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr6_-_144329342 0.600 NM_001080952
NM_001080953
NM_001080954
NM_001080956
NM_002656
NM_006718
PLAGL1





HYMAI
pleiomorphic adenoma gene-like 1





hydatidiform mole associated and imprinted (non-protein coding)
chr1_+_193091057 0.597 NM_024529
CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chrX_+_77359665 0.595 NM_000291
PGK1
phosphoglycerate kinase 1
chr5_+_110074740 0.589 NM_138773
SLC25A46
solute carrier family 25, member 46
chr4_-_24586145 0.585 DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr16_+_730114 0.582 NM_005861
STUB1
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
chr11_-_8985955 0.570 NM_020644
TMEM9B
TMEM9 domain family, member B
chr3_+_156392714 0.569 NM_001184717
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr17_-_3599487 0.568 NM_001204519
NM_001204520
NM_002561
NM_175080
P2RX5-TAX1BP3
P2RX5



P2RX5-TAX1BP3 readthrough
purinergic receptor P2X, ligand-gated ion channel, 5



chr5_+_110074708 0.567 SLC25A46
solute carrier family 25, member 46
chr8_-_124054491 0.566 DERL1
Der1-like domain family, member 1
chr15_+_63569748 0.565 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr11_-_8985937 0.564 TMEM9B
TMEM9 domain family, member B
chr1_-_36184392 0.562 C1orf216
chromosome 1 open reading frame 216
chr12_+_54332575 0.561 NM_017410
HOXC13
homeobox C13
chr9_-_21975131 0.560 NM_000077
NM_001195132
CDKN2A

cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

chrX_-_51239426 0.559 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr7_-_127225653 0.557 NM_024523
GCC1
GRIP and coiled-coil domain containing 1
chr4_-_24586178 0.557 NM_001358
DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr14_+_64971504 0.556 ZBTB1
zinc finger and BTB domain containing 1
chr1_+_54412007 0.555 NM_052940
LRRC42
leucine rich repeat containing 42
chr7_-_42951488 0.552 NM_001099858
NM_024054
C7orf25

chromosome 7 open reading frame 25

chr1_+_171750760 0.546 NM_001007239
NM_014955
NM_015935
METTL13


methyltransferase like 13


chr1_+_19970674 0.546 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr13_+_113951461 0.546 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chrX_+_102470003 0.546 NM_001080425
NM_001127688
BEX4

brain expressed, X-linked 4

chr10_+_75910908 0.545 NM_001202450
NM_006721
ADK

adenosine kinase

chrX_+_77359754 0.543 PGK1
phosphoglycerate kinase 1
chr3_-_45017600 0.542 NM_001135179
NM_016598
ZDHHC3

zinc finger, DHHC-type containing 3

chr15_-_52821004 0.541 NM_000259
NM_001142495
MYO5A

myosin VA (heavy chain 12, myoxin)

chr1_-_8938727 0.539 ENO1
enolase 1, (alpha)
chr22_-_17640168 0.538 NM_033070
CECR5
cat eye syndrome chromosome region, candidate 5
chr16_+_222845 0.538 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr15_+_74218962 0.536 LOXL1
lysyl oxidase-like 1
chr12_+_131356557 0.536 NM_006325
RAN
RAN, member RAS oncogene family
chr20_-_56285576 0.532 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.