Motif ID: HMX1.p2

Z-value: 1.208


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HMX1chr4_-_8873453-0.601.4e-02Click!


Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_49028183 2.534 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr14_-_105634708 2.110 JAG2
jagged 2
chr1_-_59042827 1.732 TACSTD2
tumor-associated calcium signal transducer 2
chr13_+_42031690 1.653 C13orf15
chromosome 13 open reading frame 15
chr13_+_42031679 1.640 C13orf15
chromosome 13 open reading frame 15
chr13_+_42031525 1.637 NM_014059
C13orf15
chromosome 13 open reading frame 15
chr22_-_37640287 1.585 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr5_-_81046858 1.406 SSBP2
single-stranded DNA binding protein 2
chr17_-_62097937 1.381 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr11_-_33890931 1.292 LMO2
LIM domain only 2 (rhombotin-like 1)
chr4_-_177713664 1.288 NM_005429
VEGFC
vascular endothelial growth factor C
chr11_-_33891258 1.279 LMO2
LIM domain only 2 (rhombotin-like 1)
chr5_-_81046943 1.184 NM_012446
SSBP2
single-stranded DNA binding protein 2
chrX_-_140271275 1.067 LDOC1
leucine zipper, down-regulated in cancer 1
chr19_+_38755238 1.037 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr4_+_41258941 1.036 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chrX_-_140271293 1.028 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr19_+_38755097 1.024 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr6_+_7727010 1.016 NM_001718
BMP6
bone morphogenetic protein 6
chr9_+_116263706 1.016 NM_130795
RGS3
regulator of G-protein signaling 3
chr14_-_105635114 0.995 NM_002226
NM_145159
JAG2

jagged 2

chr1_+_168195257 0.994 SFT2D2
SFT2 domain containing 2
chr21_-_40032563 0.967 NM_001243428
ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr17_-_7166263 0.956 NM_001185023
NM_001307
CLDN7

claudin 7

chr6_-_41909386 0.955 NM_001136125
NM_001760
CCND3

cyclin D3

chrX_-_100914816 0.939 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr9_-_130616760 0.915 ENG
endoglin
chr22_-_37640187 0.911 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr9_-_130617009 0.900 NM_000118
NM_001114753
ENG

endoglin

chr7_-_131241321 0.882 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr1_+_168195248 0.869 NM_199344
SFT2D2
SFT2 domain containing 2
chr15_+_83776323 0.866 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chr5_-_41870702 0.842 NM_000436
OXCT1
3-oxoacid CoA transferase 1
chr18_-_500583 0.833 NM_130386
COLEC12
collectin sub-family member 12
chr9_-_130616957 0.830 ENG
endoglin
chr1_-_201476241 0.816 CSRP1
cysteine and glycine-rich protein 1
chr1_-_201475966 0.814 NM_001193571
CSRP1
cysteine and glycine-rich protein 1
chr2_-_152146133 0.799 NMI
N-myc (and STAT) interactor
chr11_-_33744272 0.795 NM_001127223
NM_001127225
NM_001127226
CD59


CD59 molecule, complement regulatory protein


chr11_-_417324 0.771 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr3_+_151986731 0.738 MBNL1
muscleblind-like (Drosophila)
chr1_-_183604850 0.735 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr9_-_130616592 0.718 ENG
endoglin
chr1_-_183604793 0.714 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr1_-_201476218 0.712 CSRP1
cysteine and glycine-rich protein 1
chr8_-_29207795 0.709 NM_001394
DUSP4
dual specificity phosphatase 4
chr4_+_41258895 0.706 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr1_+_183605207 0.695 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr9_+_33624214 0.682 ANXA2P2
annexin A2 pseudogene 2
chr6_-_7910716 0.681 NM_030810
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chrX_-_78622711 0.669 ITM2A
integral membrane protein 2A
chr1_-_183604885 0.664 NM_005717
ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr2_+_217498205 0.663 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr17_-_34313685 0.662 NM_032962
NM_032963
CCL14

chemokine (C-C motif) ligand 14

chr4_+_41258909 0.658 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr17_-_3627073 0.658 ITGAE
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
chr17_-_7165788 0.651 CLDN7
claudin 7
chr4_+_86396251 0.650 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr19_+_38755422 0.649 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr11_-_19262424 0.647 NM_024680
E2F8
E2F transcription factor 8
chr12_-_50677238 0.644 NM_001113546
NM_016357
LIMA1

LIM domain and actin binding 1

chr2_-_133427624 0.644 LYPD1
LY6/PLAUR domain containing 1
chr22_-_17640076 0.630 CECR5
cat eye syndrome chromosome region, candidate 5
chr11_-_67275549 0.630 CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr5_+_76114881 0.625 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr10_+_17271956 0.614 VIM
vimentin
chr12_-_49318663 0.604 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr11_+_61129831 0.600 TMEM138
transmembrane protein 138
chr10_+_17271859 0.585 VIM
vimentin
chr4_-_90758126 0.566 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr7_+_134331530 0.565 NM_001724
NM_199186
BPGM

2,3-bisphosphoglycerate mutase

chr5_+_76114832 0.558 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr8_+_31497267 0.546 NM_013962
NRG1
neuregulin 1
chr15_-_58306185 0.545 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr6_+_16238780 0.538 NM_006877
GMPR
guanosine monophosphate reductase
chr18_-_21977785 0.531 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr11_+_19138639 0.525 NM_001001483
NM_019028
ZDHHC13

zinc finger, DHHC-type containing 13

chr17_+_5973640 0.523 NM_015253
WSCD1
WSC domain containing 1
chr1_+_183155393 0.520 LAMC2
laminin, gamma 2
chr18_-_21851816 0.519 OSBPL1A
oxysterol binding protein-like 1A
chr18_-_53303129 0.519 NM_001243226
TCF4
transcription factor 4
chr18_-_21977711 0.509 OSBPL1A
oxysterol binding protein-like 1A
chr14_+_90422260 0.504 TDP1
tyrosyl-DNA phosphodiesterase 1
chr4_-_84256304 0.498 NM_001166498
NM_006665
HPSE

heparanase

chr8_+_37654833 0.495 GPR124
G protein-coupled receptor 124
chr1_-_62190740 0.494 TM2D1
TM2 domain containing 1
chr3_-_120169493 0.493 NM_007085
FSTL1
follistatin-like 1
chrX_-_134185978 0.487 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B

chr5_-_41870500 0.483 OXCT1
3-oxoacid CoA transferase 1
chr6_+_76458970 0.473 MYO6
myosin VI
chr18_-_21851646 0.467 OSBPL1A
oxysterol binding protein-like 1A
chr1_+_236305831 0.463 NM_003272
GPR137B
G protein-coupled receptor 137B
chr17_-_8151373 0.463 NM_025099
CTC1
CTS telomere maintenance complex component 1
chr1_+_26606580 0.460 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr8_-_93115453 0.460 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr1_+_26606586 0.456 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr13_+_77566043 0.453 NM_006493
CLN5
ceroid-lipofuscinosis, neuronal 5
chr1_+_26606621 0.453 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr13_+_58207858 0.444 PCDH17
protocadherin 17
chr12_-_15114495 0.439 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr22_+_29702950 0.435 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr9_+_82186846 0.429 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr11_-_61658853 0.429 NM_021727
FADS3
fatty acid desaturase 3
chr3_+_11196213 0.428 NM_001098212
HRH1
histamine receptor H1
chrX_-_78623006 0.426 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr14_+_58666818 0.426 NM_018477
ACTR10
actin-related protein 10 homolog (S. cerevisiae)
chr10_+_99258615 0.426 NM_024954
UBTD1
ubiquitin domain containing 1
chr14_+_90422236 0.425 NM_001008744
NM_018319
TDP1

tyrosyl-DNA phosphodiesterase 1

chr1_+_155278538 0.425 NM_001135822
NM_001242824
NM_001242825
NM_002004
FDPS



farnesyl diphosphate synthase



chr17_-_8151353 0.425 CTC1
CTS telomere maintenance complex component 1
chr19_+_55587220 0.418 NM_133180
EPS8L1
EPS8-like 1
chr6_+_76458888 0.418 NM_004999
MYO6
myosin VI
chr3_-_18466759 0.417 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr1_+_168195241 0.416 SFT2D2
SFT2 domain containing 2
chr7_+_22766765 0.409 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr1_+_82266081 0.409 NM_012302
LPHN2
latrophilin 2
chr1_+_221052845 0.408 HLX
H2.0-like homeobox
chr12_+_4430346 0.400 NM_020375
C12orf5
chromosome 12 open reading frame 5
chr14_+_105941061 0.398 NM_001312
CRIP2
cysteine-rich protein 2
chr7_+_128470462 0.395 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr1_+_12227050 0.395 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr1_+_155278727 0.393 FDPS
farnesyl diphosphate synthase
chr17_-_3704487 0.390 NM_002208
ITGAE
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
chr7_+_22767101 0.388 IL6
interleukin 6 (interferon, beta 2)
chr17_-_3704437 0.386 ITGAE
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
chr19_-_49314177 0.386 NM_001164773
NM_001190
BCAT2

branched chain amino-acid transaminase 2, mitochondrial

chr10_-_33623771 0.382 NM_001024628
NM_001024629
NM_001244972
NM_001244973
NM_003873
NRP1




neuropilin 1




chr8_+_32405727 0.380 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr6_-_13486382 0.371 NM_001242628
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr7_-_37488554 0.371 NM_014800
ELMO1
engulfment and cell motility 1
chr8_-_126104004 0.370 KIAA0196
KIAA0196
chr1_+_155278677 0.366 NM_001135821
FDPS
farnesyl diphosphate synthase
chr1_-_62190803 0.363 TM2D1
TM2 domain containing 1
chr19_-_47354060 0.363 NM_004069
NM_021575
AP2S1

adaptor-related protein complex 2, sigma 1 subunit

chr11_-_67276101 0.362 NM_005851
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr1_-_28241233 0.361 NM_002946
RPA2
replication protein A2, 32kDa
chr3_-_107941168 0.361 NM_018010
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr8_-_126103926 0.359 KIAA0196
KIAA0196
chr22_-_19511777 0.359 CLDN5
claudin 5
chr1_+_86046434 0.359 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr13_+_76123885 0.356 NM_006002
UCHL3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr9_-_130639939 0.350 NM_000476
AK1
adenylate kinase 1
chr10_+_8097350 0.350 GATA3
GATA binding protein 3
chr7_+_50344255 0.350 NM_001220765
NM_001220766
NM_001220767
NM_001220768
NM_001220769
NM_001220770
NM_001220771
NM_001220772
NM_001220773
NM_001220774
NM_001220775
NM_001220776
NM_006060
IKZF1












IKAROS family zinc finger 1 (Ikaros)












chr1_-_155210887 0.347 GBA
glucosidase, beta, acid
chr7_+_44240606 0.347 YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr8_-_126104021 0.345 KIAA0196
KIAA0196
chr17_-_1619473 0.343 MIR22HG
MIR22 host gene (non-protein coding)
chr8_-_126104045 0.343 NM_014846
KIAA0196
KIAA0196
chr3_+_52529370 0.338 STAB1
stabilin 1
chr5_-_37371198 0.338 NUP155
nucleoporin 155kDa
chr1_+_26606443 0.336 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr17_+_40440481 0.333 STAT5A
signal transducer and activator of transcription 5A
chr12_+_53645369 0.332 NM_001170790
MFSD5
major facilitator superfamily domain containing 5
chr8_-_126104007 0.331 KIAA0196
KIAA0196
chr7_+_44240555 0.325 YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr12_-_54813002 0.325 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr1_+_224544590 0.324 NM_014184
CNIH4
cornichon homolog 4 (Drosophila)
chr7_-_37488408 0.323 ELMO1
engulfment and cell motility 1
chr7_+_12726910 0.322 NM_001195396
NM_005738
ARL4A

ADP-ribosylation factor-like 4A

chr1_-_109584589 0.319 NM_001142550
NM_001142551
NM_014969
WDR47


WD repeat domain 47


chr16_+_58497548 0.318 NM_020465
NDRG4
NDRG family member 4
chr6_-_13486986 0.317 GFOD1
glucose-fructose oxidoreductase domain containing 1
chr5_-_37371182 0.317 NM_153485
NUP155
nucleoporin 155kDa
chr1_-_28240953 0.316 RPA2
replication protein A2, 32kDa
chr17_-_31203889 0.315 NM_015194
MYO1D
myosin ID
chr12_-_54812936 0.312 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr5_-_94620277 0.305 NM_024717
MCTP1
multiple C2 domains, transmembrane 1
chr10_+_11059854 0.303 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr1_+_224544597 0.302 CNIH4
cornichon homolog 4 (Drosophila)
chr1_+_224544550 0.302 CNIH4
cornichon homolog 4 (Drosophila)
chr19_+_57752051 0.301 NM_001023563
NM_001145078
ZNF805

zinc finger protein 805

chr1_-_207095198 0.300 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr17_-_76183074 0.300 NM_003258
TK1
thymidine kinase 1, soluble
chr11_+_59522905 0.295 STX3
syntaxin 3
chr2_-_219925237 0.291 NM_002181
IHH
Indian hedgehog
chr2_-_192015733 0.288 STAT4
signal transducer and activator of transcription 4
chr1_-_53793743 0.288 NM_001018054
NM_004631
NM_017522
NM_033300
LRP8



low density lipoprotein receptor-related protein 8, apolipoprotein e receptor



chr2_+_217498082 0.287 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr22_-_36681757 0.286 MYH9
myosin, heavy chain 9, non-muscle
chr10_+_11060105 0.285 CELF2
CUGBP, Elav-like family member 2
chr8_-_126103873 0.284 KIAA0196
KIAA0196
chr14_+_23341360 0.284 LRP10
low density lipoprotein receptor-related protein 10
chr3_-_16554992 0.284 RFTN1
raftlin, lipid raft linker 1
chr11_-_64014140 0.283 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_-_62191094 0.282 NM_032027
TM2D1
TM2 domain containing 1
chr9_-_126692184 0.277 NM_020946
NM_024820
DENND1A

DENN/MADD domain containing 1A

chr1_-_26233367 0.277 NM_203399
STMN1
stathmin 1
chr19_-_14316980 0.277 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr6_+_30294224 0.276


chr3_+_101546833 0.276 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr17_-_78450247 0.273 NM_002522
NPTX1
neuronal pentraxin I
chr6_+_89855745 0.273 NM_001010853
PM20D2
peptidase M20 domain containing 2
chr14_+_101300806 0.271 MEG3
maternally expressed 3 (non-protein coding)
chr18_-_53257033 0.270 NM_001243227
NM_001243228
TCF4

transcription factor 4

chr12_+_85673884 0.270 NM_006982
ALX1
ALX homeobox 1
chr4_-_10118444 0.269 WDR1
WD repeat domain 1
chrX_+_102611379 0.268 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr2_+_219082119 0.262 NM_005731
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr8_+_95653272 0.261 ESRP1
epithelial splicing regulatory protein 1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.