Motif ID: HNF1A.p2

Z-value: 4.462


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HNF1Achr12_+_1214165480.978.7e-10Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_64225496 35.441 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr4_+_74301932 32.678 NM_001134
 AFP
alpha-fetoprotein
chr4_+_74269971 28.557 NM_000477
 ALB
albumin
chr14_-_94854910 28.443 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_94855120 27.871 NM_000295
 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chrX_-_105282714 27.687 NM_000354
 SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr4_-_155511838 21.621 NM_000508
NM_021871
 FGA

fibrinogen alpha chain

chr11_+_46740769 21.367 F2
coagulation factor II (thrombin)
chr4_-_110723127 21.282 CFI
complement factor I
chr8_-_17752847 20.935 NM_147203
NM_201553
NM_004467
NM_201552
 FGL1



fibrinogen-like 1



chr7_+_45927958 19.969 NM_000596
 IGFBP1
insulin-like growth factor binding protein 1
chr14_-_94789641 19.699 NM_001756
 SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr19_-_36303766 19.651 PRODH2
proline dehydrogenase (oxidase) 2
chr9_-_123812535 18.954 NM_001735
 C5
complement component 5
chr14_+_21156922 18.787 NM_001097577
NM_194431
 ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr11_+_46740736 18.545 NM_000506
 F2
coagulation factor II (thrombin)
chr19_-_36303724 18.346 PRODH2
proline dehydrogenase (oxidase) 2
chr6_+_31623688 18.188 APOM
apolipoprotein M
chr4_-_110723334 17.785 NM_000204
 CFI
complement factor I
chr6_+_31623668 17.630 NM_019101
 APOM
apolipoprotein M

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 42 entries
Enrichment   P-value GO Accession GO Term
57.50 2.99e-04 GO:0051918 negative regulation of fibrinolysis
52.27 1.61e-05 GO:0051917 regulation of fibrinolysis
38.34 2.06e-03 GO:0030194 positive regulation of blood coagulation
32.86 4.11e-03 GO:0050820 positive regulation of coagulation
24.65 9.64e-05 GO:0030195 negative regulation of blood coagulation
24.22 1.54e-02 GO:0034381 plasma lipoprotein particle clearance
23.80 1.21e-04 GO:0050819 negative regulation of coagulation
21.91 2.35e-02 GO:0034367 macromolecular complex remodeling
21.91 2.35e-02 GO:0034368 protein-lipid complex remodeling
21.91 2.35e-02 GO:0034369 plasma lipoprotein particle remodeling
21.19 2.46e-05 GO:0030193 regulation of blood coagulation
19.64 4.29e-05 GO:0050818 regulation of coagulation
18.41 4.83e-02 GO:0071825 protein-lipid complex subunit organization
18.41 4.83e-02 GO:0071827 plasma lipoprotein particle organization
17.13 1.15e-04 GO:0061041 regulation of wound healing
16.92 8.29e-03 GO:0097006 regulation of plasma lipoprotein particle levels
16.44 1.97e-05 GO:0010951 negative regulation of endopeptidase activity
15.14 1.46e-02 GO:0030301 cholesterol transport
14.75 1.66e-02 GO:0015918 sterol transport
13.42 6.45e-04 GO:0072376 protein activation cascade

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
Enrichment   P-value GO Accession GO Term
49.29 2.98e-03 GO:0005577 fibrinogen complex
20.91 4.75e-03 GO:0034364 high-density lipoprotein particle
17.98 1.01e-03 GO:0032994 protein-lipid complex
17.98 1.01e-03 GO:0034358 plasma lipoprotein particle
15.49 3.94e-05 GO:0031983 vesicle lumen
14.69 4.01e-04 GO:0031093 platelet alpha granule lumen
14.38 4.55e-04 GO:0034774 secretory granule lumen
13.81 5.82e-04 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
12.33 1.14e-03 GO:0031091 platelet alpha granule
5.48 3.84e-02 GO:0016324 apical plasma membrane
4.95 2.81e-02 GO:0045177 apical part of cell
4.50 6.59e-09 GO:0005615 extracellular space
3.72 1.93e-07 GO:0044421 extracellular region part
2.75 2.22e-06 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 10 of 10 entries
Enrichment   P-value GO Accession GO Term
31.37 1.75e-02 GO:0034185 apolipoprotein binding
14.85 9.58e-06 GO:0004867 serine-type endopeptidase inhibitor activity
14.38 2.79e-02 GO:0005504 fatty acid binding
13.38 5.74e-03 GO:0043498 cell surface binding
9.17 9.43e-05 GO:0004866 endopeptidase inhibitor activity
9.01 1.10e-04 GO:0030414 peptidase inhibitor activity
8.78 1.36e-04 GO:0061135 endopeptidase regulator activity
7.25 6.80e-04 GO:0061134 peptidase regulator activity
5.71 5.71e-04 GO:0004857 enzyme inhibitor activity
2.84 8.72e-03 GO:0030234 enzyme regulator activity