Motif ID: HNF4A_NR2F1,2.p2

Z-value: 3.941


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR2F1chr5_+_929205920.485.9e-02Click!
NR2F2chr5_+_929205920.485.9e-02Click!
HNF4Achr20_+_430298650.448.5e-02Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_27370155 14.541 PIPOX
pipecolic acid oxidase
chr14_-_94855120 12.439 NM_000295
 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_31623668 10.456 NM_019101
 APOM
apolipoprotein M
chr12_+_53497273 10.428 NM_003578
 SOAT2
sterol O-acyltransferase 2
chr1_-_169555710 10.353 NM_000130
 F5
coagulation factor V (proaccelerin, labile factor)
chr1_-_230849847 10.199 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_+_31623688 10.115 APOM
apolipoprotein M
chr12_+_53497287 9.731 SOAT2
sterol O-acyltransferase 2
chr1_-_230849863 9.453 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_21266893 9.278 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_169555624 9.095 F5
coagulation factor V (proaccelerin, labile factor)
chr6_+_31982538 9.031 NM_001242823
NM_001252204
NM_007293
NM_001002029
 LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr5_-_42811959 8.433 NM_001085486
NM_001093726
NM_005410
 SEPP1


selenoprotein P, plasma, 1


chr1_-_161193190 8.040 APOA2
apolipoprotein A-II
chr10_+_102732285 7.759 NM_001203244
NM_017893
 SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr17_+_27369917 7.743 NM_016518
 PIPOX
pipecolic acid oxidase
chr11_-_116708334 7.634 NM_000039
 APOA1
apolipoprotein A-I
chr11_+_46740769 7.585 F2
coagulation factor II (thrombin)
chr11_+_46740736 7.573 NM_000506
 F2
coagulation factor II (thrombin)
chr14_-_24777184 7.511 CIDEB
cell death-inducing DFFA-like effector b

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 58 entries
Enrichment   P-value GO Accession GO Term
38.57 3.88e-02 GO:0010901 regulation of very-low-density lipoprotein particle remodeling
34.28 2.75e-03 GO:0034384 high-density lipoprotein particle clearance
29.38 6.31e-03 GO:0010873 positive regulation of cholesterol esterification
25.71 5.77e-05 GO:0034377 plasma lipoprotein particle assembly
25.71 5.77e-05 GO:0065005 protein-lipid complex assembly
25.71 1.24e-02 GO:0010872 regulation of cholesterol esterification
22.86 2.20e-02 GO:0033700 phospholipid efflux
18.00 8.15e-05 GO:0033344 cholesterol efflux
17.14 1.20e-04 GO:0034367 macromolecular complex remodeling
17.14 1.20e-04 GO:0034368 protein-lipid complex remodeling
17.14 1.20e-04 GO:0034369 plasma lipoprotein particle remodeling
16.46 2.00e-05 GO:0071825 protein-lipid complex subunit organization
16.46 2.00e-05 GO:0071827 plasma lipoprotein particle organization
16.24 1.51e-03 GO:0034381 plasma lipoprotein particle clearance
15.13 1.85e-02 GO:0043691 reverse cholesterol transport
12.18 4.62e-05 GO:0030301 cholesterol transport
12.10 2.89e-04 GO:0097006 regulation of plasma lipoprotein particle levels
11.87 5.91e-05 GO:0015918 sterol transport
9.76 1.65e-05 GO:0055088 lipid homeostasis
9.57 1.99e-03 GO:0042632 cholesterol homeostasis

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
Enrichment   P-value GO Accession GO Term
25.71 1.84e-03 GO:0034366 spherical high-density lipoprotein particle
20.00 5.13e-06 GO:0034361 very-low-density lipoprotein particle
20.00 5.13e-06 GO:0034385 triglyceride-rich lipoprotein particle
18.70 8.30e-03 GO:0034362 low-density lipoprotein particle
18.70 8.30e-03 GO:0042627 chylomicron
14.03 5.86e-04 GO:0034364 high-density lipoprotein particle
12.86 2.57e-05 GO:0032994 protein-lipid complex
12.86 2.57e-05 GO:0034358 plasma lipoprotein particle
3.10 2.78e-08 GO:0005615 extracellular space
2.58 2.20e-06 GO:0044421 extracellular region part
2.10 5.36e-06 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
Enrichment   P-value GO Accession GO Term
30.85 2.12e-02 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
17.14 1.84e-02 GO:0015248 sterol transporter activity
7.74 1.68e-08 GO:0004866 endopeptidase inhibitor activity
7.60 2.24e-08 GO:0030414 peptidase inhibitor activity
7.47 8.52e-04 GO:0004867 serine-type endopeptidase inhibitor activity
7.41 3.40e-08 GO:0061135 endopeptidase regulator activity
7.22 3.98e-03 GO:0005319 lipid transporter activity
7.20 1.42e-02 GO:0033293 monocarboxylic acid binding
6.12 7.22e-07 GO:0061134 peptidase regulator activity
5.10 1.06e-07 GO:0004857 enzyme inhibitor activity
4.73 3.60e-02 GO:0008201 heparin binding