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• Activity deltas table
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Motif ID: HOXA9_MEIS1.p2

Z-value: 0.756

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chrX_-_105282714	2.428	NM_000354	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr16_+_29690464	2.160		QPRT	quinolinate phosphoribosyltransferase
chr1_+_198608216	1.935		PTPRC	protein tyrosine phosphatase, receptor type, C
chr14_-_94856926	1.695	NM_001002235 NM_001002236 NM_001127700 NM_001127701 NM_001127702 NM_001127703 NM_001127704 NM_001127705 NM_001127706 NM_001127707	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr15_-_58306185	1.295	NM_170697	ALDH1A2	aldehyde dehydrogenase 1 family, member A2
chr16_+_29690328	1.295	NM_014298	QPRT	quinolinate phosphoribosyltransferase
chr2_+_68592317	1.128	NM_002664	PLEK	pleckstrin
chr1_+_198608244	1.038		PTPRC	protein tyrosine phosphatase, receptor type, C
chrX_-_129272014	1.015	NM_001130846	AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1
chr1_+_198608136	0.967	NM_002838 NM_080921 NM_080923	PTPRC	protein tyrosine phosphatase, receptor type, C
chr1_-_169555624	0.962		F5	coagulation factor V (proaccelerin, labile factor)
chr3_-_138478184	0.883	NM_006219	PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide
chr1_-_169555710	0.753	NM_000130	F5	coagulation factor V (proaccelerin, labile factor)
chr4_+_88896899	0.738		SPP1	secreted phosphoprotein 1
chr18_+_2655885	0.685	NM_015295	SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1
chr12_-_51422012	0.665	NM_001174125	SLC11A2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr12_-_9268513	0.570		A2M	alpha-2-macroglobulin
chr2_+_68592432	0.565		PLEK	pleckstrin
chr7_+_115863004	0.559	NM_152829	TES	testis derived transcript (3 LIM domains)
chr17_-_39191100	0.545	NM_030966	KRTAP1-3	keratin associated protein 1-3
chr6_-_24936177	0.501		FAM65B	family with sequence similarity 65, member B
chr7_+_73245192	0.486	NM_001305	CLDN4	claudin 4
chr17_-_29641068	0.485		EVI2B	ecotropic viral integration site 2B
chr18_-_31628557	0.475	NM_001198549	NOL4	nucleolar protein 4
chr12_-_102591547	0.467	NM_002674	PMCH	pro-melanin-concentrating hormone
chr12_-_9268475	0.430		A2M	alpha-2-macroglobulin
chrX_-_137949716	0.424	NM_001139502	FGF13	fibroblast growth factor 13
chr10_+_35484829	0.409	NM_182721 NM_182722 NM_182723 NM_182724 NM_182725	CREM	cAMP responsive element modulator
chr16_-_73082169	0.401	NM_006885	ZFHX3	zinc finger homeobox 3
chr4_+_88896801	0.387	NM_000582 NM_001040058 NM_001040060 NM_001251829 NM_001251830	SPP1	secreted phosphoprotein 1
chrX_+_49197555	0.382	NM_012196 NM_001472 NM_001127200 NM_001098407 NM_001127212	GAGE8 GAGE2C GAGE2E GAGE12J GAGE2D GAGE2A	G antigen 8 G antigen 2C G antigen 2E G antigen 12J G antigen 2D G antigen 2A
chr11_+_63871240	0.372	NM_013280	FLRT1	fibronectin leucine rich transmembrane protein 1
chr9_+_103947316	0.372	NM_017753	LPPR1	lipid phosphate phosphatase-related protein type 1
chrX_+_49207115	0.371	NM_012196 NM_001472 NM_001127200 NM_001098407 NM_001127212	GAGE8 GAGE2C GAGE2E GAGE2D GAGE2A	G antigen 8 G antigen 2C G antigen 2E G antigen 2D G antigen 2A
chrX_+_49178508	0.371	NM_001098406	GAGE1 GAGE4 GAGE5 GAGE6 GAGE12J	G antigen 1 G antigen 4 G antigen 5 G antigen 6 G antigen 12J
chr2_+_169923531	0.358	NM_199204	DHRS9	dehydrogenase/reductase (SDR family) member 9
chr9_+_4792974	0.348		RCL1	RNA terminal phosphate cyclase-like 1
chr5_+_161275897	0.346	NM_001127646	GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_-_202130677	0.344	NM_001199797 NM_002832	PTPN7	protein tyrosine phosphatase, non-receptor type 7
chr6_-_49604524	0.341	NM_000324	RHAG	Rh-associated glycoprotein
chrX_+_49216616	0.331	NM_012196 NM_001472 NM_001474 NM_001475 NM_021123 NM_001477 NM_001127200 NM_001127212	GAGE8 GAGE1 GAGE2C GAGE4 GAGE5 GAGE6 GAGE7 GAGE12I GAGE2E GAGE12B GAGE2A	G antigen 8 G antigen 1 G antigen 2C G antigen 4 G antigen 5 G antigen 6 G antigen 7 G antigen 12I G antigen 2E G antigen 12B G antigen 2A
chr17_-_29641094	0.329	NM_006495	EVI2B	ecotropic viral integration site 2B
chr7_+_44646120	0.322	NM_001003941 NM_001165036 NM_002541	OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr6_+_64356430	0.310	NM_015153	PHF3	PHD finger protein 3
chr9_+_93589704	0.296	NM_001174167	SYK	spleen tyrosine kinase
chr1_+_33004771	0.295	NM_001040441	ZBTB8A	zinc finger and BTB domain containing 8A
chr1_+_212475147	0.293	NM_001199756	PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha
chr1_-_159046555	0.291	NM_004833	AIM2	absent in melanoma 2
chr1_+_2005424	0.289	NM_001242874	PRKCZ	protein kinase C, zeta
chr14_-_106746056	0.274
chrX_+_49354117	0.273	NM_001127212	GAGE1 GAGE2C GAGE2A	G antigen 1 G antigen 2C G antigen 2A
chr16_+_4838397	0.272	NM_001253790 NM_001253791	LOC440335	uncharacterized LOC440335
chr3_+_151985828	0.267	NM_021038 NM_207292	MBNL1	muscleblind-like (Drosophila)
chrX_+_123234462	0.258		STAG2	stromal antigen 2
chr15_-_43559054	0.251	NM_004245 NM_201631	TGM5	transglutaminase 5
chr5_-_22853435	0.248		CDH12	cadherin 12, type 2 (N-cadherin 2)
chr12_-_9268522	0.242	NM_000014	A2M	alpha-2-macroglobulin
chr17_+_39555993	0.242		GAST	gastrin
chr6_+_26597131	0.240	NM_013375	ABT1	activator of basal transcription 1
chr17_-_46608271	0.234	NM_002144	HOXB1	homeobox B1
chr5_+_132432880	0.234		HSPA4	heat shock 70kDa protein 4
chr5_+_68800003	0.233	NM_001205255	OCLN	occludin
chr5_+_128300786	0.233		SLC27A6	solute carrier family 27 (fatty acid transporter), member 6
chr14_+_95047730	0.231	NM_000624	SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr7_+_64126481	0.228	NM_001013746 NM_016220	ZNF107	zinc finger protein 107
chr17_-_29641087	0.226		EVI2B	ecotropic viral integration site 2B
chr12_-_53343607	0.219		KRT8	keratin 8
chr12_-_109027654	0.216	NM_003006	SELPLG	selectin P ligand
chr1_-_178007057	0.216		LOC730102	quinone oxidoreductase-like protein 2 pseudogene
chr12_-_9268440	0.214		A2M	alpha-2-macroglobulin
chr6_+_31913920	0.212		CFB	complement factor B
chr19_-_3772208	0.207	NM_032753	RAX2	retina and anterior neural fold homeobox 2
chr18_-_47806361	0.203	NM_001204151	MBD1	methyl-CpG binding domain protein 1
chr3_-_12941547	0.199		IQSEC1	IQ motif and Sec7 domain 1
chr17_-_41739261	0.190	NM_001040002	MEOX1	mesenchyme homeobox 1
chr18_+_55816546	0.188	NM_001144965 NM_001144968 NM_001144969 NM_001144971	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr20_-_62601140	0.184	NM_020713	ZNF512B	zinc finger protein 512B
chr11_-_47545539	0.181	NM_001172639	CELF1	CUGBP, Elav-like family member 1
chr1_-_150587879	0.178
chr3_+_111261039	0.178		CD96	CD96 molecule
chr14_-_95599794	0.175	NM_001195573	DICER1	dicer 1, ribonuclease type III
chr12_+_64798050	0.175	NM_007235	XPOT	exportin, tRNA (nuclear export receptor for tRNAs)
chr1_-_247171302	0.174		ZNF695	zinc finger protein 695
chr17_-_56492938	0.174		RNF43	ring finger protein 43
chr8_-_124408665	0.174		ATAD2	ATPase family, AAA domain containing 2
chr6_+_31913852	0.172		CFB	complement factor B
chr1_-_84326673	0.164
chr6_-_166796363	0.163		BRP44L	brain protein 44-like
chr20_-_34243118	0.162		RBM12	RNA binding motif protein 12
chr7_+_128578246	0.160	NM_032643	IRF5	interferon regulatory factor 5
chr2_+_33661392	0.156	NM_170672	RASGRP3	RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr18_-_3011944	0.155	NM_014646	LPIN2	lipin 2
chrX_+_64708614	0.154	NM_001010888	ZC3H12B	zinc finger CCCH-type containing 12B
chr6_-_28220001	0.152	NM_019110	ZKSCAN4	zinc finger with KRAB and SCAN domains 4
chr11_-_4718948	0.152	NM_030774	OR51E2	olfactory receptor, family 51, subfamily E, member 2
chr13_+_52436116	0.148	NM_031290	CCDC70	coiled-coil domain containing 70
chrX_-_32430370	0.147	NM_004011 NM_004012	DMD	dystrophin
chr12_-_71182699	0.147	NM_001207015	PTPRR	protein tyrosine phosphatase, receptor type, R
chr2_+_219724545	0.144	NM_006522	WNT6	wingless-type MMTV integration site family, member 6
chr12_-_109027615	0.141		SELPLG	selectin P ligand
chr3_-_149470254	0.139	NM_016094	COMMD2	COMM domain containing 2
chr10_-_99052358	0.139		ARHGAP19	Rho GTPase activating protein 19
chr4_-_70080448	0.139	NM_001073	UGT2B11 UGT2B10	UDP glucuronosyltransferase 2 family, polypeptide B11 UDP glucuronosyltransferase 2 family, polypeptide B10
chr2_-_2334887	0.135	NM_015025	MYT1L	myelin transcription factor 1-like
chr11_+_99426872	0.134	NM_175566	CNTN5	contactin 5
chr1_+_67632168	0.130	NM_144701	IL23R	interleukin 23 receptor
chr5_+_140261792	0.127	NM_018904 NM_031865	PCDHA13	protocadherin alpha 13
chr21_-_34185943	0.124	NM_001162495 NM_001162496 NM_019596	C21orf62	chromosome 21 open reading frame 62
chr1_-_241799101	0.122	NM_001821	CHML	choroideremia-like (Rab escort protein 2)
chr7_-_50628744	0.119	NM_000790 NM_001242886 NM_001242887 NM_001242888 NM_001242889 NM_001242890	DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr6_+_167704802	0.118	NM_001143947 NM_018974	UNC93A	unc-93 homolog A (C. elegans)
chr8_-_124408688	0.117	NM_014109	ATAD2	ATPase family, AAA domain containing 2
chr1_+_57320442	0.114	NM_000562	C8A	complement component 8, alpha polypeptide
chr17_-_56296965	0.113	NM_001165927	MKS1	Meckel syndrome, type 1
chr6_+_155538096	0.113	NM_001010927	TIAM2	T-cell lymphoma invasion and metastasis 2
chr22_+_23063107	0.112		IGLJ3	immunoglobulin lambda joining 3
chr3_-_135913276	0.108	NM_001145417	MSL2	male-specific lethal 2 homolog (Drosophila)
chr6_-_26235160	0.108	NM_005320	HIST1H1D	histone cluster 1, H1d
chr4_+_70146216	0.105	NM_001207004 NM_053039	UGT2B28	UDP glucuronosyltransferase 2 family, polypeptide B28
chr21_-_35899046	0.105	NM_203418	RCAN1	regulator of calcineurin 1
chr7_-_112727832	0.103	NM_001146265 NM_018970	GPR85	G protein-coupled receptor 85
chr1_+_13516065	0.103	NM_001099852	PRAMEF20	PRAME family member 20
chr1_-_13611532	0.102	NM_001012276	PRAMEF8 PRAMEF7	PRAME family member 8 PRAME family member 7
chr6_+_31590468	0.101
chr3_+_111260925	0.100	NM_005816 NM_198196	CD96	CD96 molecule
chr5_-_142815076	0.099	NM_001018074 NM_001018075 NM_001018077	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr5_-_137071703	0.098	NM_017415	KLHL3	kelch-like 3 (Drosophila)
chr1_+_13736906	0.096	NM_001099852	PRAMEF20	PRAME family member 20
chr8_+_17829848	0.094		PCM1	pericentriolar material 1
chr17_+_17608163	0.094
chrX_-_110654373	0.093	NM_000555	DCX	doublecortin
chr19_+_39989603	0.093		DLL3	delta-like 3 (Drosophila)
chr8_-_13372183	0.092	NM_024767 NM_182643	DLC1	deleted in liver cancer 1
chr1_-_57431620	0.090	NM_000066	C8B	complement component 8, beta polypeptide
chr3_+_121796695	0.090	NM_006889 NM_176892	CD86	CD86 molecule
chr20_-_45313122	0.090	NM_001011554 NM_001193340	SLC13A3	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
chr17_-_38210888	0.089	NM_001079518 NM_014815	MED24	mediator complex subunit 24
chr18_-_52625278	0.087	NM_001143829	CCDC68	coiled-coil domain containing 68
chr6_-_29343063	0.087	NM_030959	OR12D3	olfactory receptor, family 12, subfamily D, member 3
chr1_+_12976449	0.086	NM_001012276	PRAMEF8 PRAMEF7	PRAME family member 8 PRAME family member 7
chr1_-_9129620	0.086		SLC2A5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr7_-_84751246	0.086	NM_152754	SEMA3D	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr6_-_42946887	0.085		PEX6	peroxisomal biogenesis factor 6
chrX_-_71792610	0.085		HDAC8	histone deacetylase 8
chr8_+_123794043	0.085		ZHX2	zinc fingers and homeoboxes 2
chr17_+_16120465	0.085	NM_004278	PIGL	phosphatidylinositol glycan anchor biosynthesis, class L
chr5_-_22853730	0.084	NM_004061	CDH12	cadherin 12, type 2 (N-cadherin 2)
chr1_-_13390747	0.083	NM_001012276	PRAMEF8 PRAMEF7	PRAME family member 8 PRAME family member 7
chr9_-_8733893	0.082	NM_001040712 NM_001171025 NM_130391 NM_130392 NM_130393	PTPRD	protein tyrosine phosphatase, receptor type, D
chr18_+_72342918	0.082	NM_001146189 NM_001146190 NM_017757	ZNF407	zinc finger protein 407
chr3_-_52569021	0.081	NM_022908	NT5DC2	5'-nucleotidase domain containing 2
chr6_-_22297729	0.079	NM_000948	PRL	prolactin
chr7_+_142986680	0.078	NM_001224	CASP2	caspase 2, apoptosis-related cysteine peptidase
chr9_-_124922049	0.077	NM_014222	NDUFA8	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
chrX_-_77582979	0.077	NM_006639	CYSLTR1	cysteinyl leukotriene receptor 1
chr1_-_41625539	0.076	NM_001172222	SCMH1	sex comb on midleg homolog 1 (Drosophila)
chr19_+_39989534	0.076	NM_016941 NM_203486	DLL3	delta-like 3 (Drosophila)
chr3_-_184971815	0.074	NM_001166415 NM_001966	EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
chr1_+_43124047	0.073	NM_006347	PPIH	peptidylprolyl isomerase H (cyclophilin H)
chr16_+_69958900	0.073	NM_199424	WWP2	WW domain containing E3 ubiquitin protein ligase 2
chr6_+_73076431	0.073	NM_001168411	RIMS1	regulating synaptic membrane exocytosis 1
chr11_+_68367824	0.072		PPP6R3	protein phosphatase 6, regulatory subunit 3
chr12_-_109027565	0.072		SELPLG	selectin P ligand
chr2_-_152146373	0.072	NM_004688	NMI	N-myc (and STAT) interactor
chr16_-_24942662	0.069		ARHGAP17	Rho GTPase activating protein 17
chr3_-_149470230	0.069		COMMD2	COMM domain containing 2
chr5_-_169816637	0.067	NM_004137	KCNMB1	potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr4_-_176733413	0.067		GPM6A	glycoprotein M6A
chr6_+_27925018	0.064	NM_012367	OR2B6	olfactory receptor, family 2, subfamily B, member 6
chr12_+_56391004	0.063	NM_000456 NM_001032386 NM_001032387	SUOX	sulfite oxidase
chr3_+_148545587	0.063	NM_001871	CPB1	carboxypeptidase B1 (tissue)
chr8_+_123793988	0.063		ZHX2	zinc fingers and homeoboxes 2
chr11_-_62389376	0.063		B3GAT3	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr12_+_86268072	0.063	NM_006183	NTS	neurotensin
chrX_+_100474932	0.063	NM_001171184 NM_001939	DRP2	dystrophin related protein 2
chr21_+_40823779	0.062	NM_007341	SH3BGR	SH3 domain binding glutamic acid-rich protein
chr12_-_99548471	0.060	NM_001204068 NM_001204069 NM_001204070 NM_020140 NM_181670 NM_001204066	ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B
chr7_-_112727778	0.060		GPR85	G protein-coupled receptor 85
chr1_+_174844655	0.058	NM_001035230	RABGAP1L	RAB GTPase activating protein 1-like
chr4_+_39408472	0.058	NM_175737	KLB	klotho beta
chr3_-_150966901	0.058	NM_001081455	P2RY14	purinergic receptor P2Y, G-protein coupled, 14
chr7_+_31726630	0.058	NM_001145123 NM_006658	PPP1R17	protein phosphatase 1, regulatory subunit 17
chr15_-_65903406	0.058	NM_001207058 NM_001207059	C15orf44	chromosome 15 open reading frame 44
chr13_-_78493902	0.057	NM_001201397	EDNRB	endothelin receptor type B
chr3_-_87325611	0.056	NM_000306 NM_001122757	POU1F1	POU class 1 homeobox 1
chr18_-_60986968	0.055		BCL2	B-cell CLL/lymphoma 2
chr10_+_98740987	0.054	NM_015652	C10orf12	chromosome 10 open reading frame 12
chr1_+_153232178	0.053	NM_000427	LOR	loricrin
chr2_+_233897381	0.053	NM_005383	NEU2	sialidase 2 (cytosolic sialidase)
chr17_-_41738901	0.052	NM_004527 NM_013999	MEOX1	mesenchyme homeobox 1
chr9_-_91793681	0.052	NM_016848	SHC3	SHC (Src homology 2 domain containing) transforming protein 3
chr19_+_39989585	0.051		DLL3	delta-like 3 (Drosophila)
chr9_-_19378815	0.048		RPS6	ribosomal protein S6
chr10_+_18549583	0.047	NM_000724	CACNB2	calcium channel, voltage-dependent, beta 2 subunit
chr12_+_109577201	0.047	NM_001093	ACACB	acetyl-CoA carboxylase beta
chr1_+_171481164	0.045		PRRC2C	proline-rich coiled-coil 2C
chr12_+_94071150	0.044	NM_003805	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain
chr18_+_72166568	0.043		CNDP2	CNDP dipeptidase 2 (metallopeptidase M20 family)
chr9_-_104198045	0.043	NM_000035	ALDOB	aldolase B, fructose-bisphosphate
chr7_+_154720154	0.043		LOC100132707	uncharacterized LOC100132707

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
17.99	2.40e-03	GO:0043086	negative regulation of catalytic activity
40.66	3.17e-03	GO:0051346	negative regulation of hydrolase activity
14.76	5.26e-03	GO:0044092	negative regulation of molecular function
8.39	5.55e-03	GO:0050790	regulation of catalytic activity
14.47	5.71e-03	GO:0051336	regulation of hydrolase activity
29.77	8.09e-03	GO:0052548	regulation of endopeptidase activity
28.53	9.19e-03	GO:0052547	regulation of peptidase activity
6.89	1.46e-02	GO:0065009	regulation of molecular function
66.00	3.51e-02	GO:0033993	response to lipid
56.59	4.78e-02	GO:0010951	negative regulation of endopeptidase activity

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
51.12	8.93e-03	GO:0004867	serine-type endopeptidase inhibitor activity
27.62	3.05e-02	GO:0030414	peptidase inhibitor activity
26.92	3.21e-02	GO:0061135	endopeptidase regulator activity
22.24	4.69e-02	GO:0061134	peptidase regulator activity