Motif ID: IKZF1.p2

Z-value: 1.842


Transcription factors associated with IKZF1.p2:

Gene SymbolEntrez IDGene Name
IKZF1 10320 IKAROS family zinc finger 1 (Ikaros)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IKZF1chr7_+_50344255-0.233.8e-01Click!


Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_51456159 2.499 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr16_-_11680146 2.486 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr1_-_209825797 2.438 NM_000228
LAMB3
laminin, beta 3
chr2_-_113594325 2.337 NM_000576
IL1B
interleukin 1, beta
chr1_+_26856252 2.320 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr4_-_155533850 2.236 FGG
fibrinogen gamma chain
chr12_-_58160823 2.226 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr12_+_52626953 2.164 NM_005556
KRT7
keratin 7
chr4_-_155533800 2.148 FGG
fibrinogen gamma chain
chr4_-_155533882 2.121 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr1_+_26856240 2.102 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_209825673 2.071 NM_001127641
LAMB3
laminin, beta 3
chr1_-_209979388 2.054 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr19_+_38755422 2.048 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr12_+_66218141 2.046 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr12_+_52627007 2.008 KRT7
keratin 7
chr1_+_26856259 2.007 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr19_+_38755097 1.969 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr2_+_47596286 1.886 NM_002354
EPCAM
epithelial cell adhesion molecule
chr19_-_10697907 1.869 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr4_-_155533757 1.838 FGG
fibrinogen gamma chain
chr15_+_41136178 1.834 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr2_+_17721806 1.820 NM_003385
VSNL1
visinin-like 1
chr2_-_21266915 1.790 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr20_+_56136136 1.759 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr2_-_21266893 1.745 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_-_24036939 1.730 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr2_+_17721983 1.694 VSNL1
visinin-like 1
chr12_-_110939877 1.685 NM_016226
NM_057180
VPS29

vacuolar protein sorting 29 homolog (S. cerevisiae)

chr18_+_55714457 1.595 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_+_131157231 1.575 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr8_+_101170510 1.504 NM_003114
SPAG1
sperm associated antigen 1
chr1_+_27189628 1.477 NM_006142
SFN
stratifin
chr16_-_68269948 1.471 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr1_+_155099935 1.443 EFNA1
ephrin-A1
chr1_+_35247838 1.413 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr12_-_52867521 1.412 NM_173086
KRT6C
keratin 6C
chr19_+_38755238 1.377 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr2_-_21266809 1.376 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_+_32042122 1.335 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr2_+_102608305 1.282 NM_004633
IL1R2
interleukin 1 receptor, type II
chr1_+_32042085 1.279 NM_001204414
NM_022164
TINAGL1

tubulointerstitial nephritis antigen-like 1

chr1_+_183155173 1.278 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr1_+_32042125 1.273 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr14_-_24037266 1.255 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr8_-_17743062 1.254 FGL1
fibrinogen-like 1
chr11_+_62649160 1.239 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr2_-_165424993 1.220 GRB14
growth factor receptor-bound protein 14
chr1_+_32043745 1.178 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr3_+_171758289 1.175 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr2_-_99279935 1.135 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr18_-_28681885 1.119 NM_004949
NM_024422
DSC2

desmocollin 2

chr11_+_22689653 1.119 NM_177553
GAS2
growth arrest-specific 2
chr1_+_1981902 1.114 NM_002744
PRKCZ
protein kinase C, zeta
chr17_-_27401216 1.088 TIAF1
TGFB1-induced anti-apoptotic factor 1
chr22_+_38201113 1.063 NM_005318
H1F0
H1 histone family, member 0
chr17_-_27401590 1.057 TIAF1
TGFB1-induced anti-apoptotic factor 1
chr17_+_48712115 1.053 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr1_+_39456887 1.037 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr16_-_23652477 1.030 NM_024675
PALB2
partner and localizer of BRCA2
chr18_-_19284622 1.016 ABHD3
abhydrolase domain containing 3
chr15_+_99192696 1.015 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr22_+_38201232 1.008 H1F0
H1 histone family, member 0
chr2_-_238499317 1.005 RAB17
RAB17, member RAS oncogene family
chr17_-_7493389 0.987 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr16_+_56659679 0.968 MT1E
metallothionein 1E
chr19_+_33865429 0.964 NM_001252296
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr7_+_48128939 0.963 UPP1
uridine phosphorylase 1
chr3_+_193853930 0.946 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr8_-_146202727 0.943 ZNF252
zinc finger protein 252
chr16_+_56659584 0.939 NM_175617
MT1E
metallothionein 1E
chr2_-_238499713 0.929 NM_022449
RAB17
RAB17, member RAS oncogene family
chr5_+_76114832 0.924 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr11_-_111250156 0.918 NM_006235
POU2AF1
POU class 2 associating factor 1
chr3_+_193853937 0.914 HES1
hairy and enhancer of split 1, (Drosophila)
chr11_+_46740769 0.911 F2
coagulation factor II (thrombin)
chr8_+_95653340 0.882 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr1_-_153588789 0.866 NM_020672
S100A14
S100 calcium binding protein A14
chr14_+_65171149 0.866 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr18_+_56338678 0.858 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr7_+_47694841 0.855 NM_001123065
C7orf65
chromosome 7 open reading frame 65
chr19_+_496453 0.853 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr17_+_27369917 0.851 NM_016518
PIPOX
pipecolic acid oxidase
chr9_-_74383301 0.849 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr20_-_23618382 0.848 NM_000099
CST3
cystatin C
chr9_+_130911731 0.840 NM_005564
LCN2
lipocalin 2
chr19_+_35739282 0.840 LSR
lipolysis stimulated lipoprotein receptor
chr13_-_111213865 0.840 NM_017817
RAB20
RAB20, member RAS oncogene family
chr3_-_119812973 0.834 NM_001146156
NM_002093
GSK3B

glycogen synthase kinase 3 beta

chr8_-_125740650 0.833 NM_014751
MTSS1
metastasis suppressor 1
chr11_-_111249902 0.822 POU2AF1
POU class 2 associating factor 1
chr3_+_190231839 0.817 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr5_+_66124603 0.817 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr18_+_56338818 0.812 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr3_+_50192420 0.811 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr8_+_126442557 0.802 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr12_-_53298765 0.799 NM_002273
KRT8
keratin 8
chr8_+_95653399 0.795 ESRP1
epithelial splicing regulatory protein 1
chrX_+_115567746 0.780 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chrX_-_71792610 0.778 HDAC8
histone deacetylase 8
chr19_-_51504799 0.777 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr11_-_35440514 0.772 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr20_+_44441334 0.761 UBE2C
ubiquitin-conjugating enzyme E2C
chr8_+_95653272 0.760 ESRP1
epithelial splicing regulatory protein 1
chr18_+_3451589 0.751 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr17_-_39768939 0.747 NM_005557
KRT16
keratin 16
chr3_-_69435223 0.743 FRMD4B
FERM domain containing 4B
chr16_-_87903028 0.737 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr10_-_52645384 0.733 A1CF
APOBEC1 complementation factor
chr1_-_117210301 0.730 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr11_-_35441099 0.726 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_-_35441501 0.721 NM_001195728
NM_001252652
SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr8_+_22224786 0.714 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr11_+_22696318 0.710 NM_005256
GAS2
growth arrest-specific 2
chr3_+_46619075 0.702 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr10_-_52645430 0.701 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr18_+_56338617 0.701 NM_006785
NM_173844
MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1

chr18_+_20513766 0.688 NM_203291
NM_203292
RBBP8

retinoblastoma binding protein 8

chr19_+_45312294 0.685 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr10_+_47746919 0.682 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr11_+_73357222 0.677 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr6_-_76203256 0.676 NM_015687
FILIP1
filamin A interacting protein 1
chr18_+_56338783 0.676 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr8_+_37887990 0.674 NM_004095
EIF4EBP1
eukaryotic translation initiation factor 4E binding protein 1
chr2_-_43453146 0.670 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr8_+_22224758 0.666 NM_001128431
NM_001135154
NM_015359
SLC39A14


solute carrier family 39 (zinc transporter), member 14


chr16_+_27325244 0.664 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr17_+_4675175 0.663 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr16_+_56703725 0.662 NM_005951
MT1H
metallothionein 1H
chr2_-_39347562 0.662 NM_005633
SOS1
son of sevenless homolog 1 (Drosophila)
chr9_+_115913266 0.656 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr1_+_209848659 0.652 NM_015714
G0S2
G0/G1switch 2
chr9_+_115913227 0.650 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr1_-_201368434 0.641 LAD1
ladinin 1
chr4_-_40631846 0.626 NM_001098634
RBM47
RNA binding motif protein 47
chr20_+_44441247 0.618 NM_007019
NM_181799
NM_181800
NM_181802
NM_181803
UBE2C




ubiquitin-conjugating enzyme E2C




chr11_-_18258315 0.616 SAA4
serum amyloid A4, constitutive
chr10_+_48255223 0.616 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr3_-_69435429 0.614 NM_015123
FRMD4B
FERM domain containing 4B
chr1_-_160990862 0.612 F11R
F11 receptor
chr17_+_48610045 0.610 NM_017957
EPN3
epsin 3
chr3_+_53195214 0.609 NM_006254
NM_212539
PRKCD

protein kinase C, delta

chr7_+_89783688 0.600 NM_012449
STEAP1
six transmembrane epithelial antigen of the prostate 1
chr14_-_24777184 0.597 CIDEB
cell death-inducing DFFA-like effector b
chr13_+_113760101 0.593 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr5_+_76114881 0.581 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr1_-_200638996 0.578 DDX59
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
chr14_-_24423329 0.576 C14orf167
chromosome 14 open reading frame 167
chr22_+_38599026 0.575 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr19_-_45909566 0.569 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr19_-_19052032 0.561 NM_004838
HOMER3
homer homolog 3 (Drosophila)
chr17_+_2699731 0.558 NM_001100398
NM_015085
RAP1GAP2

RAP1 GTPase activating protein 2

chr6_-_32821743 0.557 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_-_43453737 0.557 NM_006887
ZFP36L2
zinc finger protein 36, C3H type-like 2
chrX_+_30671456 0.554 NM_000167
NM_001128127
NM_001205019
NM_203391
GK



glycerol kinase



chr12_-_56881901 0.550 NM_013267
GLS2
glutaminase 2 (liver, mitochondrial)
chr1_+_155100304 0.547 NM_004428
NM_182685
EFNA1

ephrin-A1

chr8_+_26435339 0.543 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr1_+_6845381 0.541 NM_001195563
NM_001242701
NM_015215
CAMTA1


calmodulin binding transcription activator 1


chr19_-_19051899 0.539 HOMER3
homer homolog 3 (Drosophila)
chr9_-_21994379 0.538 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr19_-_11688508 0.535 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr4_+_159690208 0.528 FNIP2
folliculin interacting protein 2
chr10_+_124134206 0.522 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr8_+_26435920 0.521 NM_001244604
DPYSL2
dihydropyrimidinase-like 2
chr10_+_124145584 0.521 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr2_+_163200582 0.519 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr14_+_24505620 0.512 NM_001082488
DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 1
chr15_-_52587851 0.508 NM_018728
MYO5C
myosin VC
chr2_-_172290435 0.506 METTL8
methyltransferase like 8
chr5_-_125930604 0.502 NM_001182
NM_001201377
NM_001202404
ALDH7A1


aldehyde dehydrogenase 7 family, member A1


chr18_+_20513277 0.501 NM_002894
RBBP8
retinoblastoma binding protein 8
chr16_+_27325269 0.501 IL4R
interleukin 4 receptor
chr4_+_124317884 0.500 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr19_+_10381763 0.494 ICAM1
intercellular adhesion molecule 1
chr19_+_10381516 0.493 NM_000201
ICAM1
intercellular adhesion molecule 1
chr14_+_65171243 0.486 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr2_-_220436010 0.484 OBSL1
obscurin-like 1
chr6_+_31126114 0.482 NM_001077511
NM_007109
TCF19

transcription factor 19

chr5_+_49962920 0.481 PARP8
poly (ADP-ribose) polymerase family, member 8
chrY_-_21154560 0.470 NM_013230
CD24
CD24P4
CD24 molecule
CD24 molecule pseudogene 4
chr4_-_153456152 0.468 NM_033632
FBXW7
F-box and WD repeat domain containing 7
chr8_-_81083660 0.467 NM_001025253
NM_005079
TPD52

tumor protein D52

chr2_+_96931988 0.466 CIAO1
cytosolic iron-sulfur protein assembly 1
chr11_+_119039415 0.465 NM_024618
NM_170722
NLRX1

NLR family member X1

chr6_+_292033 0.463 NM_020185
DUSP22
dual specificity phosphatase 22
chr3_-_38178581 0.460 NM_001130410
NM_001607
ACAA1

acetyl-CoA acyltransferase 1

chr1_-_230849863 0.458 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_+_16174358 0.457 NM_015001
SPEN
spen homolog, transcriptional regulator (Drosophila)
chr3_-_149688638 0.450 NM_002628
NM_053024
PFN2

profilin 2

chr19_+_33864574 0.445 NM_001806
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr10_+_54074037 0.445 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr4_-_15939949 0.443 FGFBP1
fibroblast growth factor binding protein 1
chr6_-_32821592 0.442 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr12_+_41086189 0.436 NM_001843
NM_175038
CNTN1

contactin 1

chr2_+_163200623 0.434 GCA
grancalcin, EF-hand calcium binding protein
chr3_+_42201658 0.433 NM_014965
TRAK1
trafficking protein, kinesin binding 1
chr16_+_15737123 0.429 NM_001143979
NDE1
nudE nuclear distribution gene E homolog 1 (A. nidulans)
chr4_-_69817478 0.426 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr22_-_45608232 0.424 KIAA0930
KIAA0930

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
45.85 1.36e-02 GO:0046627 negative regulation of insulin receptor signaling pathway

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
274.98 1.22e-03 GO:0005610 laminin-5 complex

Nothing significant found in function category.