Motif ID: IRF1,2,7.p3

Z-value: 5.243


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRF7chr11_-_615998,
chr11_-_615649		0.926.3e-07Click!
IRF1chr5_-_1318264260.835.9e-05Click!
IRF2chr4_-_1853956160.774.9e-04Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_79086087 28.820 NM_006820
 IFI44L
interferon-induced protein 44-like
chr10_+_91152321 19.980 NM_001548
 IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr21_+_42792441 18.988 NM_001144925
 MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr1_+_948846 18.825 NM_005101
 ISG15
ISG15 ubiquitin-like modifier
chr1_-_27998719 18.824 NM_002038
NM_022872
NM_022873
 IFI6


interferon, alpha-inducible protein 6


chr1_-_27998658 17.795 IFI6
interferon, alpha-inducible protein 6
chr1_-_27998700 17.751 IFI6
interferon, alpha-inducible protein 6
chr11_-_615920 17.647 IRF7
interferon regulatory factor 7
chr11_-_615998 17.338 NM_001572
NM_004029
 IRF7

interferon regulatory factor 7

chr21_+_42733916 15.532 NM_002463
 LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr12_+_25205488 12.829 LRMP
lymphoid-restricted membrane protein
chr4_+_89378234 12.665 NM_016323
 HERC5
hect domain and RLD 5
chr1_+_158979681 12.575 NM_001206567
NM_005531
 IFI16

interferon, gamma-inducible protein 16

chr12_+_113416267 12.444 NM_001032731
NM_002535
NM_016817
 OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr6_+_32821924 12.244 NM_002800
 PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr4_-_169239816 12.136 NM_017631
 DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr1_+_79115476 11.330 NM_006417
 IFI44
interferon-induced protein 44
chr2_-_89165652 11.028


chr11_+_5710816 11.013 NM_001199573
NM_006074
 TRIM22

tripartite motif containing 22

chr1_+_174843523 10.798 NM_001243763
 RABGAP1L
RAB GTPase activating protein 1-like

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 57 entries
Enrichment   P-value GO Accession GO Term
38.33 3.44e-02 GO:0002478 antigen processing and presentation of exogenous peptide antigen
38.33 3.44e-02 GO:0002483 antigen processing and presentation of endogenous peptide antigen
38.33 3.44e-02 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
36.51 1.83e-03 GO:0019883 antigen processing and presentation of endogenous antigen
29.49 1.98e-05 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
24.73 5.73e-25 GO:0060337 type I interferon-mediated signaling pathway
24.73 5.73e-25 GO:0071357 cellular response to type I interferon
24.34 9.13e-25 GO:0034340 response to type I interferon
23.54 8.21e-06 GO:0048002 antigen processing and presentation of peptide antigen
14.67 3.58e-10 GO:0060333 interferon-gamma-mediated signaling pathway
14.20 2.84e-03 GO:0032480 negative regulation of type I interferon production
13.35 1.43e-09 GO:0071346 cellular response to interferon-gamma
13.28 3.77e-11 GO:0034341 response to interferon-gamma
12.78 3.41e-02 GO:0030890 positive regulation of B cell proliferation
11.62 2.24e-22 GO:0019221 cytokine-mediated signaling pathway
11.62 3.15e-04 GO:0032479 regulation of type I interferon production
11.28 1.18e-02 GO:0030888 regulation of B cell proliferation
11.06 8.89e-05 GO:0019882 antigen processing and presentation
10.49 6.35e-21 GO:0071345 cellular response to cytokine stimulus
9.13 4.26e-11 GO:0009615 response to virus

Gene overrepresentation in compartment category:

Showing 1 to 1 of 1 entries
Enrichment   P-value GO Accession GO Term
4.50 2.28e-02 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
Enrichment   P-value GO Accession GO Term
27.38 2.21e-02 GO:0015197 peptide transporter activity
23.96 3.49e-02 GO:0016175 superoxide-generating NADPH oxidase activity
19.66 6.50e-03 GO:0050664 oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor
12.78 2.70e-05 GO:0003823 antigen binding