Motif ID: KLF4.p3

Z-value: 3.162


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF4chr9_-_1102507070.665.4e-03Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_50143350 9.395 NM_006270
 RRAS
related RAS viral (r-ras) oncogene homolog
chr10_-_126849556 8.720 NM_001083914
 CTBP2
C-terminal binding protein 2
chrX_-_140271293 6.087 NM_012317
 LDOC1
leucine zipper, down-regulated in cancer 1
chr11_-_12030539 5.292 DKK3
dickkopf 3 homolog (Xenopus laevis)
chrX_-_140271275 5.228 LDOC1
leucine zipper, down-regulated in cancer 1
chr12_-_47473424 4.967 NM_001143668
NM_181847
 AMIGO2

adhesion molecule with Ig-like domain 2

chr22_+_43547526 4.728 NM_000714
NM_007311
 TSPO

translocator protein (18kDa)

chr17_+_48133331 4.563 NM_002204
NM_005501
 ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr13_-_110438896 4.416 NM_003749
 IRS2
insulin receptor substrate 2
chr3_+_135684463 4.383 NM_001190447
NM_002718
 PPP2R3A

protein phosphatase 2, regulatory subunit B'', alpha

chr7_+_116140097 4.322 NM_001206748
 CAV2
caveolin 2
chr11_+_65686727 4.320 NM_006442
 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr7_+_116139619 4.301 NM_001206747
NM_001233
NM_198212
 CAV2


caveolin 2


chr7_+_116166346 4.241 NM_001172896
NM_001172897
 CAV1

caveolin 1, caveolae protein, 22kDa

chr11_-_2950593 4.232 NM_003311
 PHLDA2
pleckstrin homology-like domain, family A, member 2
chr15_+_90931470 4.226 NM_003870
 IQGAP1
IQ motif containing GTPase activating protein 1
chr11_+_65686908 4.155 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chrX_+_49028183 4.074 NM_002668
 PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr11_-_12030838 4.018 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr19_+_38755422 3.998 SPINT2
serine peptidase inhibitor, Kunitz type, 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 37 entries
Enrichment   P-value GO Accession GO Term
10.19 2.56e-02 GO:0007044 cell-substrate junction assembly
6.68 2.86e-02 GO:0008064 regulation of actin polymerization or depolymerization
6.45 3.71e-02 GO:0030832 regulation of actin filament length
5.82 3.40e-03 GO:0032956 regulation of actin cytoskeleton organization
5.79 2.89e-02 GO:0002576 platelet degranulation
5.69 4.23e-03 GO:0032970 regulation of actin filament-based process
4.99 3.97e-04 GO:0051493 regulation of cytoskeleton organization
4.97 6.47e-03 GO:0034329 cell junction assembly
4.94 1.69e-02 GO:0043254 regulation of protein complex assembly
4.91 2.97e-03 GO:0034330 cell junction organization
4.26 3.10e-02 GO:0046039 GTP metabolic process
4.09 1.07e-02 GO:0006887 exocytosis
3.81 2.40e-02 GO:0044087 regulation of cellular component biogenesis
3.66 1.01e-02 GO:0030168 platelet activation
3.53 8.42e-03 GO:0030334 regulation of cell migration
3.50 9.46e-03 GO:2000145 regulation of cell motility
3.45 6.18e-03 GO:0040012 regulation of locomotion
3.40 7.72e-03 GO:0051270 regulation of cellular component movement
3.34 5.57e-03 GO:0033043 regulation of organelle organization
2.86 1.87e-02 GO:0007409 axonogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
Enrichment   P-value GO Accession GO Term
10.41 7.87e-04 GO:0042641 actomyosin
8.81 4.77e-02 GO:0001725 stress fiber
5.82 6.04e-04 GO:0005925 focal adhesion
5.57 9.31e-04 GO:0005924 cell-substrate adherens junction
5.34 1.40e-03 GO:0030055 cell-substrate junction
4.69 8.89e-04 GO:0005912 adherens junction
4.21 2.90e-03 GO:0070161 anchoring junction
3.68 1.22e-04 GO:0015629 actin cytoskeleton
3.07 4.39e-02 GO:0030659 cytoplasmic vesicle membrane
2.82 4.17e-02 GO:0044433 cytoplasmic vesicle part
2.25 1.15e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
2.20 1.68e-02 GO:0031988 membrane-bounded vesicle
2.19 1.33e-02 GO:0031410 cytoplasmic vesicle
2.18 1.05e-02 GO:0031982 vesicle
2.17 1.42e-05 GO:0005856 cytoskeleton
2.11 6.74e-03 GO:0044430 cytoskeletal part
1.59 6.45e-05 GO:0005886 plasma membrane
1.58 6.79e-05 GO:0071944 cell periphery
1.29 1.02e-02 GO:0016020 membrane
1.25 2.59e-03 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
9.51 3.67e-02 GO:0005544 calcium-dependent phospholipid binding
3.44 2.73e-02 GO:0003924 GTPase activity
3.16 4.19e-03 GO:0003779 actin binding
3.12 1.38e-05 GO:0008092 cytoskeletal protein binding
1.32 1.60e-04 GO:0005515 protein binding