Motif ID: MEF2{A,B,C,D}.p2

Z-value: 2.416


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MEF2Cchr5_-_881196040.552.9e-02Click!
MEF2Achr15_+_1001062140.401.2e-01Click!
MEF2Dchr1_-_1564603900.233.9e-01Click!
MEF2Bchr19_-_19281090,
chr19_-_19281062		-0.175.2e-01Click!
MEF2BNB-MEF2Bchr19_-_193029160.029.5e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_211168315 7.083 NM_079422
 MYL1
myosin, light chain 1, alkali; skeletal, fast
chrX_-_21776158 7.071 NM_014332
 SMPX
small muscle protein, X-linked
chr10_-_75415748 5.919 NM_001114133
 SYNPO2L
synaptopodin 2-like
chr1_-_116311161 5.855 CASQ2
calsequestrin 2 (cardiac muscle)
chr1_-_116311330 5.839 CASQ2
calsequestrin 2 (cardiac muscle)
chr1_-_116311398 5.692 NM_001232
 CASQ2
calsequestrin 2 (cardiac muscle)
chr2_-_190927321 5.275 NM_005259
 MSTN
myostatin
chr2_+_170366211 4.694 NM_006063
 KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr10_-_75410778 4.676 NM_024875
 SYNPO2L
synaptopodin 2-like
chr12_+_81101407 4.561 NM_002469
 MYF6
myogenic factor 6 (herculin)
chr1_-_201390845 4.421 NM_003281
 TNNI1
troponin I type 1 (skeletal, slow)
chr1_-_201346783 4.063 TNNT2
troponin T type 2 (cardiac)
chr1_-_201346804 4.001 NM_000364
NM_001001430
NM_001001431
NM_001001432
 TNNT2



troponin T type 2 (cardiac)



chr5_+_53751430 3.745 NM_006308
 HSPB3
heat shock 27kDa protein 3
chr1_-_153518265 3.616 NM_002961
NM_019554
 S100A4

S100 calcium binding protein A4

chr17_-_10325266 3.277 NM_002472
 MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr9_+_139871954 3.229 NM_000954
 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr5_+_155753755 3.186 NM_000337
NM_001128209
NM_172244
 SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr20_+_9288446 3.155 NM_000933
 PLCB4
phospholipase C, beta 4
chr2_-_211179765 3.055 NM_079420
 MYL1
myosin, light chain 1, alkali; skeletal, fast

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 20 entries
Enrichment   P-value GO Accession GO Term
59.30 5.05e-03 GO:0014743 regulation of muscle hypertrophy
37.40 1.87e-07 GO:0030049 muscle filament sliding
37.40 1.87e-07 GO:0033275 actin-myosin filament sliding
36.42 2.28e-07 GO:0070252 actin-mediated cell contraction
32.95 7.77e-06 GO:0006941 striated muscle contraction
31.22 3.95e-02 GO:0003015 heart process
31.22 3.95e-02 GO:0060047 heart contraction
27.14 1.99e-06 GO:0030048 actin filament-based movement
22.60 9.61e-03 GO:0048644 muscle organ morphogenesis
16.99 1.71e-11 GO:0007517 muscle organ development
16.76 3.94e-03 GO:0009408 response to heat
14.13 9.14e-03 GO:0090257 regulation of muscle system process
12.96 2.15e-07 GO:0003012 muscle system process
12.85 1.51e-06 GO:0006936 muscle contraction
11.99 2.08e-09 GO:0061061 muscle structure development
10.76 3.41e-02 GO:0009266 response to temperature stimulus
8.15 1.14e-04 GO:0030029 actin filament-based process
2.80 2.25e-03 GO:0048513 organ development
2.32 3.90e-03 GO:0048731 system development
2.17 8.29e-03 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
Enrichment   P-value GO Accession GO Term
84.71 3.66e-04 GO:0005861 troponin complex
45.62 2.93e-03 GO:0005865 striated muscle thin filament
43.93 1.47e-04 GO:0005859 muscle myosin complex
39.54 2.31e-04 GO:0016460 myosin II complex
29.89 2.00e-14 GO:0030017 sarcomere
29.37 1.02e-16 GO:0044449 contractile fiber part
28.52 1.62e-16 GO:0030016 myofibril
26.72 4.51e-16 GO:0043292 contractile fiber
24.72 1.64e-03 GO:0030018 Z disc
19.30 4.47e-03 GO:0031674 I band
18.31 6.24e-04 GO:0016459 myosin complex
9.94 3.35e-08 GO:0015629 actin cytoskeleton
3.13 6.91e-04 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
98.83 1.09e-02 GO:0004111 creatine kinase activity
79.07 1.82e-02 GO:0032036 myosin heavy chain binding
24.12 1.31e-04 GO:0008307 structural constituent of muscle
9.34 1.38e-02 GO:0003774 motor activity
8.04 6.54e-06 GO:0003779 actin binding
5.37 1.24e-04 GO:0008092 cytoskeletal protein binding
4.09 4.55e-03 GO:0005509 calcium ion binding