Motif ID: MSX1,2.p2

Z-value: 1.975


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MSX1chr4_+_48613710.821.1e-04Click!
MSX2chr5_+_174151531-0.292.8e-01Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_116840551 13.705 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_+_7745354 11.363 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745325 10.848 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr9_-_116840460 9.896 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_88896838 8.909 SPP1
secreted phosphoprotein 1
chr9_-_116840604 8.545 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_88896801 8.503 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr4_+_88896868 8.068 SPP1
secreted phosphoprotein 1
chr4_+_88896899 7.355 SPP1
secreted phosphoprotein 1
chrX_+_115567746 7.066 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr14_-_65409445 6.674 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr3_-_148939784 6.298 NM_000096
CP
ceruloplasmin (ferroxidase)
chr11_-_115088628 5.853 CADM1
cell adhesion molecule 1
chr4_+_71062241 5.732 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr9_-_116840545 5.689 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_+_7745341 5.225 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745284 4.633 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_+_155484131 4.631 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr3_+_52828783 4.387 NM_002217
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr17_-_64225496 4.084 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr9_-_116840673 4.026 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr12_+_7169192 3.949


chr3_-_149095458 2.915 TM4SF1
transmembrane 4 L six family member 1
chr3_-_149095517 2.843 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr1_-_108231122 2.548 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr10_+_7745229 2.413 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_+_201979747 2.032 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr12_+_51318743 1.966 METTL7A
methyltransferase like 7A
chr13_-_46679143 1.942 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr3_-_149095333 1.908 TM4SF1
transmembrane 4 L six family member 1
chr1_-_19217384 1.806 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr5_+_59784004 1.705 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr7_+_94539209 1.676 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr16_+_82068958 1.641 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr5_-_42811959 1.636 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr3_-_120401401 1.630 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr12_+_71833518 1.595 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr3_+_46616044 1.531 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr3_-_149095413 1.472 TM4SF1
transmembrane 4 L six family member 1
chr16_+_82068910 1.469 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr17_+_27370155 1.425 PIPOX
pipecolic acid oxidase
chr14_-_95599794 1.411 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr16_+_56485423 1.408 NM_018233
OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr3_-_99833348 1.405 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr4_-_155533757 1.403 FGG
fibrinogen gamma chain
chr16_+_56485435 1.361 OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr3_-_79817058 1.360 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr6_+_87969619 1.285 ZNF292
zinc finger protein 292
chr1_+_207277577 1.189 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr1_-_86043932 1.153 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr11_+_7618416 1.148 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr10_+_114133838 1.134 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr7_+_112063131 1.119 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr1_+_120254418 1.070 NM_006623
PHGDH
phosphoglycerate dehydrogenase
chr19_+_50016500 1.063 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr4_-_186733372 1.053 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr1_+_54359859 1.038 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr2_-_162929928 1.034 DPP4
dipeptidyl-peptidase 4
chr12_-_71551564 0.991 TSPAN8
tetraspanin 8
chr9_+_134305476 0.991 NM_013318
PRRC2B
proline-rich coiled-coil 2B
chr16_-_73092533 0.987 NM_001164766
ZFHX3
zinc finger homeobox 3
chr10_+_114133775 0.985 ACSL5
acyl-CoA synthetase long-chain family member 5
chr14_-_105259937 0.971 NM_005163
AKT1
v-akt murine thymoma viral oncogene homolog 1
chr4_-_89744154 0.945 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr17_+_70117168 0.924 SOX9
SRY (sex determining region Y)-box 9
chr3_+_12392993 0.876 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr2_+_163200582 0.876 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr8_+_21916858 0.875 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr7_+_120629444 0.871 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr12_+_1017011 0.837 WNK1
WNK lysine deficient protein kinase 1
chrX_+_129139163 0.824 NM_021946
BCORL1
BCL6 corepressor-like 1
chr17_+_37856253 0.806 NM_004448
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr17_+_70117154 0.782 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr2_+_65216482 0.735 NM_003038
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr5_+_139876504 0.719 ANKHD1
ankyrin repeat and KH domain containing 1
chr19_-_17375522 0.715 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr22_+_35462125 0.628 NM_001008494
ISX
intestine-specific homeobox
chr3_+_187943192 0.627 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr14_-_94759360 0.613 NM_016186
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr17_+_4854383 0.613 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr6_-_31830593 0.609 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr5_+_126859157 0.607 PRRC1
proline-rich coiled-coil 1
chr20_+_32150139 0.597 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr16_-_21289571 0.578 CRYM
crystallin, mu
chr1_+_201979689 0.567 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr2_-_165424993 0.564 GRB14
growth factor receptor-bound protein 14
chr20_-_34543280 0.554 NM_016558
SCAND1
SCAN domain containing 1
chr6_-_25930838 0.551 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr6_+_163984574 0.531 QKI
QKI, KH domain containing, RNA binding
chr2_-_162931051 0.504 NM_001935
DPP4
dipeptidyl-peptidase 4
chr10_-_73848530 0.490 NM_001244950
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr16_+_53479685 0.475 RBL2
retinoblastoma-like 2 (p130)
chr1_+_167298280 0.460 NM_001198783
POU2F1
POU class 2 homeobox 1
chr11_-_129062092 0.459 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr1_+_110560111 0.448 AHCYL1
adenosylhomocysteinase-like 1
chr2_-_238322815 0.431 COL6A3
collagen, type VI, alpha 3
chr21_-_33074101 0.431 SCAF4
SR-related CTD-associated factor 4
chr1_+_167298382 0.401 POU2F1
POU class 2 homeobox 1
chr20_-_45976626 0.391 ZMYND8
zinc finger, MYND-type containing 8
chr20_-_49253425 0.385 NM_080829
FAM65C
family with sequence similarity 65, member C
chr10_-_45474210 0.367 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr7_-_23509972 0.346 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr3_+_100238063 0.341 TMEM45A
transmembrane protein 45A
chr6_+_64231626 0.325 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr12_-_24102563 0.311 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr11_-_102323353 0.310 NM_052932
TMEM123
transmembrane protein 123
chr2_-_238322840 0.304 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chrX_+_153656977 0.296 NM_001183
ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr17_+_7743233 0.295 NM_001080424
KDM6B
lysine (K)-specific demethylase 6B
chr11_-_8832881 0.294 NM_139157
ST5
suppression of tumorigenicity 5
chr11_-_72463416 0.292 NM_001040118
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr21_-_37852387 0.288 NM_001146079
NM_144492
CLDN14

claudin 14

chr10_+_49609641 0.285 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr2_-_183387063 0.281 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr9_+_120466625 0.277 TLR4
toll-like receptor 4
chr2_+_113885137 0.276 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr5_+_109025135 0.271 NM_002372
MAN2A1
mannosidase, alpha, class 2A, member 1
chr1_+_205473683 0.265 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr11_+_101983170 0.261 NM_001195045
YAP1
Yes-associated protein 1
chr20_-_34243118 0.247 RBM12
RNA binding motif protein 12
chr10_-_116444374 0.247 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr17_+_48821106 0.244 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr1_+_153232178 0.233 NM_000427
LOR
loricrin
chr12_-_9360960 0.230 NM_002864
PZP
pregnancy-zone protein
chr17_-_4890664 0.224 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr12_-_6484557 0.221 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr2_+_113885145 0.210 IL1RN
interleukin 1 receptor antagonist
chrX_+_99839789 0.208 NM_022144
TNMD
tenomodulin
chr11_-_55703875 0.205 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr2_-_238322770 0.204 COL6A3
collagen, type VI, alpha 3
chr5_+_73109342 0.203 NM_001244364
RGNEF
190 kDa guanine nucleotide exchange factor
chr3_-_114790221 0.192 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr4_-_66536182 0.186 EPHA5
EPH receptor A5
chr17_-_4890920 0.175 NM_001171166
NM_015099
CAMTA2

calmodulin binding transcription activator 2

chr2_+_171784947 0.170 NM_001201428
NM_015530
GORASP2

golgi reassembly stacking protein 2, 55kDa

chr19_-_44079609 0.170 XRCC1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr16_+_89984286 0.169 NM_002386
MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr4_+_113970784 0.169 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr14_-_91976630 0.166 NM_032560
SMEK1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr5_-_138210992 0.163 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chrX_-_48828250 0.162 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chrX_-_110655384 0.160 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr8_+_107738239 0.160 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr10_-_98325100 0.158 TM9SF3
transmembrane 9 superfamily member 3
chr12_+_86268072 0.156 NM_006183
NTS
neurotensin
chr15_+_99645152 0.152 NM_015286
NM_145728
SYNM

synemin, intermediate filament protein

chrX_+_153657025 0.146 ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr11_+_92085261 0.146 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr8_+_66933790 0.143 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chrX_-_19988381 0.143 NM_198279
CXorf23
chromosome X open reading frame 23
chr16_-_72128214 0.142 NM_001142318
TXNL4B
thioredoxin-like 4B
chr5_-_138211054 0.141 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr17_+_37856224 0.141 ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chrX_-_24690740 0.139 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr4_+_154178525 0.136 TRIM2
tripartite motif containing 2
chr19_+_40872709 0.135 PLD3
phospholipase D family, member 3
chr3_-_137851123 0.132 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr6_-_31107110 0.128 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr1_+_36772696 0.128 NM_024676
SH3D21
SH3 domain containing 21
chr17_-_47841468 0.127 FAM117A
family with sequence similarity 117, member A
chrX_+_16668280 0.127 NM_004057
S100G
S100 calcium binding protein G
chr7_-_91764036 0.126 NM_001146152
CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
chr12_-_93323006 0.125 EEA1
early endosome antigen 1
chr4_-_89205667 0.119 PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr2_+_171034654 0.117 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chrX_+_47004619 0.116 RBM10
RNA binding motif protein 10
chr4_+_71296208 0.115 NM_001145006
MUC7
mucin 7, secreted
chr1_+_118472364 0.115 NM_006784
WDR3
WD repeat domain 3
chrX_+_153657119 0.114 ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr7_-_99717463 0.113 NM_001190415
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr2_-_25468909 0.111 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr12_-_53171104 0.110 NM_015848
KRT76
keratin 76
chr7_+_39017608 0.106 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr7_+_27282163 0.103 NM_001989
EVX1
even-skipped homeobox 1
chrX_+_47004609 0.103 NM_001204466
NM_001204467
NM_001204468
NM_005676
NM_152856
RBM10




RNA binding motif protein 10




chr1_+_110882057 0.102 RBM15
RNA binding motif protein 15
chr3_+_9944511 0.100 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr6_+_31973358 0.097 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr21_-_34185943 0.096 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr6_-_119470336 0.096 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr12_-_9760481 0.094 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr5_+_175223519 0.092 NM_006650
CPLX2
complexin 2
chr1_-_190446701 0.092 NM_199051
FAM5C
family with sequence similarity 5, member C
chrX_+_47004633 0.092 RBM10
RNA binding motif protein 10
chr5_-_148758787 0.092 NM_014443
IL17B
interleukin 17B
chr10_-_65028825 0.087 NM_004241
JMJD1C
jumonji domain containing 1C
chr12_-_14132920 0.086 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr15_-_42749710 0.083 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr12_-_91398744 0.082 EPYC
epiphycan
chr14_-_24584125 0.079 NRL
neural retina leucine zipper
chr7_-_20256942 0.076 NM_182762
MACC1
metastasis associated in colon cancer 1
chr19_+_48325098 0.075 NM_000554
CRX
cone-rod homeobox
chr4_+_71337833 0.069 NM_152291
MUC7
mucin 7, secreted
chr5_-_59783885 0.068 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_-_21567069 0.067 NM_001101672
ZNF219
zinc finger protein 219
chr11_-_6640644 0.067 TPP1
tripeptidyl peptidase I
chr19_+_4402658 0.066 NM_005483
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr8_+_75736771 0.065 NM_015886
PI15
peptidase inhibitor 15
chr4_-_76957139 0.065 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr4_+_148538508 0.063 NM_018241
TMEM184C
transmembrane protein 184C

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.04 1.24e-02 GO:0009308 amine metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.05 5.58e-03 GO:0005576 extracellular region
88.16 1.54e-02 GO:0005577 fibrinogen complex
5.72 3.94e-02 GO:0009986 cell surface

Nothing significant found in function category.