Motif ID: MTF1.p2

Z-value: 3.691


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MTF1chr1_-_38325224-0.126.5e-01Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_56659679 12.131 MT1E
metallothionein 1E
chr2_-_224903933 11.911 NM_001136528
NM_006216
 SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr16_+_56659584 11.600 NM_175617
 MT1E
metallothionein 1E
chr6_+_7541863 10.633 NM_001008844
NM_004415
 DSP

desmoplakin

chr16_+_56703725 10.518 NM_005951
 MT1H
metallothionein 1H
chr16_+_56642477 9.462 NM_005953
 MT2A
metallothionein 2A
chr6_+_7541837 8.870 DSP
desmoplakin
chr1_-_225840660 8.540 NM_001008493
NM_018212
 ENAH

enabled homolog (Drosophila)

chr16_+_56716378 8.415 NM_005952
 MT1X
metallothionein 1X
chr16_+_56691854 7.156 NM_005949
 MT1F
metallothionein 1F
chr9_+_133320093 6.315 NM_000050
NM_054012
 ASS1

argininosuccinate synthase 1

chr10_+_124220990 6.309 NM_002775
 HTRA1
HtrA serine peptidase 1
chr9_+_133320247 6.061 ASS1
argininosuccinate synthase 1
chr16_+_56672577 5.681 NM_005946
 MT1A
metallothionein 1A
chr19_+_38755097 5.558 NM_001166103
NM_021102
 SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr10_-_125851850 5.503 NM_014863
NM_015892
 CHST15

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

chr1_-_151966303 5.316 S100A10
S100 calcium binding protein A10
chr6_+_7541892 5.273 DSP
desmoplakin
chr21_+_42540054 5.145 BACE2
beta-site APP-cleaving enzyme 2
chr16_-_56701904 5.120 NM_005950
 MT1G
metallothionein 1G

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 57 entries
Enrichment   P-value GO Accession GO Term
12.60 1.98e-04 GO:0048146 positive regulation of fibroblast proliferation
9.62 1.90e-03 GO:0048145 regulation of fibroblast proliferation
7.21 5.24e-03 GO:0032526 response to retinoic acid
6.82 2.57e-03 GO:0033189 response to vitamin A
6.65 3.42e-02 GO:0007229 integrin-mediated signaling pathway
5.40 1.17e-03 GO:0033273 response to vitamin
4.57 1.79e-02 GO:0031960 response to corticosteroid stimulus
4.53 4.48e-02 GO:0051384 response to glucocorticoid stimulus
3.92 1.01e-02 GO:0007584 response to nutrient
3.46 3.94e-03 GO:0031667 response to nutrient levels
3.40 2.83e-03 GO:0009991 response to extracellular stimulus
3.36 1.92e-02 GO:0061061 muscle structure development
2.92 1.50e-03 GO:0000904 cell morphogenesis involved in differentiation
2.82 2.87e-04 GO:0032989 cellular component morphogenesis
2.78 2.28e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
2.75 4.14e-02 GO:0007409 axonogenesis
2.74 2.82e-02 GO:0048812 neuron projection morphogenesis
2.70 1.48e-02 GO:0048858 cell projection morphogenesis
2.68 1.75e-02 GO:0032990 cell part morphogenesis
2.64 2.82e-03 GO:0042060 wound healing

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
3.35 9.78e-04 GO:0015629 actin cytoskeleton
3.09 1.89e-03 GO:0031012 extracellular matrix
2.32 3.68e-02 GO:0030054 cell junction
2.13 1.40e-03 GO:0044421 extracellular region part
2.06 3.19e-02 GO:0005615 extracellular space
1.86 4.80e-04 GO:0005576 extracellular region
1.73 6.84e-04 GO:0044459 plasma membrane part
1.50 1.29e-03 GO:0071944 cell periphery
1.50 2.21e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
36.53 3.10e-04 GO:0046870 cadmium ion binding
34.25 1.14e-02 GO:0005010 insulin-like growth factor receptor activity
13.70 8.84e-04 GO:0005520 insulin-like growth factor binding
4.98 3.62e-03 GO:0019838 growth factor binding
3.37 6.30e-04 GO:0003779 actin binding
2.99 4.09e-05 GO:0008092 cytoskeletal protein binding
2.89 4.17e-02 GO:0032403 protein complex binding
2.12 7.89e-03 GO:0030234 enzyme regulator activity
1.35 9.97e-06 GO:0005515 protein binding