Motif ID: NANOG.p2

Z-value: 1.054


Transcription factors associated with NANOG.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NANOGchr12_+_7941994-0.381.4e-01Click!


Activity profile for motif NANOG.p2.

activity profile for motif NANOG.p2


Sorted Z-values histogram for motif NANOG.p2

Sorted Z-values for motif NANOG.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_55562483 2.260 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr1_+_198608136 2.255 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr11_-_57195052 2.014 NM_017611
SLC43A3
solute carrier family 43, member 3
chr12_-_15114495 1.996 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr1_+_198608216 1.924 PTPRC
protein tyrosine phosphatase, receptor type, C
chr15_-_55563091 1.882 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr7_-_25268057 1.510 NM_022150
NPVF
neuropeptide VF precursor
chr6_+_34206567 1.504 NM_145905
HMGA1
high mobility group AT-hook 1
chr20_+_31367637 1.439 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr1_+_167298280 1.313 NM_001198783
POU2F1
POU class 2 homeobox 1
chr9_-_124989755 1.287 NM_001242334
LHX6
LIM homeobox 6
chr6_-_32497925 1.243 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr12_+_25205180 1.210 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr6_+_135502521 1.160 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr7_-_14025826 1.130 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr13_-_41593405 1.084 ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_-_26235160 1.050 NM_005320
HIST1H1D
histone cluster 1, H1d
chr13_+_109281569 1.045 NM_001198950
MYO16
myosin XVI
chr7_-_37025696 1.035 ELMO1
engulfment and cell motility 1
chr12_-_102874373 1.028 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr13_-_41593491 1.021 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_+_25205488 0.983 LRMP
lymphoid-restricted membrane protein
chr1_-_154842725 0.971 NM_001204087
NM_002249
KCNN3

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

chr11_-_118900078 0.969 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chrX_-_137821514 0.963 NM_033642
FGF13
fibroblast growth factor 13
chr9_-_124984018 0.961 NM_001242335
LHX6
LIM homeobox 6
chr6_+_34204928 0.955 HMGA1
high mobility group AT-hook 1
chr12_-_102874321 0.933 IGF1
insulin-like growth factor 1 (somatomedin C)
chr8_-_82395401 0.930 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr12_-_71148063 0.875 PTPRR
protein tyrosine phosphatase, receptor type, R
chr1_-_150738232 0.849 CTSS
cathepsin S
chr7_+_116660291 0.848 ST7
suppression of tumorigenicity 7
chr22_+_40322609 0.830 GRAP2
GRB2-related adaptor protein 2
chr12_+_50869531 0.793 LARP4
La ribonucleoprotein domain family, member 4
chr17_+_18768781 0.792 NM_001243940
PRPSAP2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr1_+_50569581 0.788 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr13_-_99910548 0.782 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr6_+_34204690 0.760 HMGA1
high mobility group AT-hook 1
chr10_+_35484829 0.758 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr9_-_86584079 0.753 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr3_+_63884074 0.746 NM_001177387
ATXN7
ataxin 7
chr1_+_167298382 0.743 POU2F1
POU class 2 homeobox 1
chr14_+_58906398 0.741 NM_001244193
KIAA0586
KIAA0586
chr6_+_34204647 0.740 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr6_-_87804773 0.739 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr3_-_121379757 0.738 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr2_+_169757749 0.727 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr6_+_87969619 0.688 ZNF292
zinc finger protein 292
chr13_-_95131718 0.667 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr12_-_102874299 0.665 IGF1
insulin-like growth factor 1 (somatomedin C)
chr6_-_32557431 0.655 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr5_-_88179278 0.644 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr6_+_32605182 0.634 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr16_+_56815703 0.629 NM_001242795
NUP93
nucleoporin 93kDa
chr14_+_92789536 0.628 NM_153647
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr3_-_124842442 0.617 SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr14_+_92788924 0.593 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr12_-_102874340 0.580 IGF1
insulin-like growth factor 1 (somatomedin C)
chr17_-_49124128 0.579 NM_001251971
SPAG9
sperm associated antigen 9
chr10_-_14372807 0.577 NM_018027
FRMD4A
FERM domain containing 4A
chr10_+_11206928 0.574 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr8_+_26150731 0.569 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr1_+_50574601 0.566 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_+_15990300 0.565


chr7_+_129015483 0.563 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr9_-_5304579 0.556 NM_005059
NM_134441
RLN2

relaxin 2

chr12_-_24103842 0.552 SOX5
SRY (sex determining region Y)-box 5
chr1_+_198608244 0.549 PTPRC
protein tyrosine phosphatase, receptor type, C
chr15_+_89631695 0.548 ABHD2
abhydrolase domain containing 2
chrX_+_119738542 0.544 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr12_+_53818864 0.541 AMHR2
anti-Mullerian hormone receptor, type II
chr3_-_121379701 0.540 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_-_152386727 0.517 NM_016190
CRNN
cornulin
chr1_+_6105980 0.510 NM_001199862
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr11_+_75526211 0.510 NM_003369
UVRAG
UV radiation resistance associated gene
chr3_-_138478184 0.506 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr5_-_88199868 0.505 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr5_+_169780880 0.501 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr20_+_2276612 0.500 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr3_+_152880024 0.496 NM_002886
RAP2B
RAP2B, member of RAS oncogene family
chr5_+_137673223 0.495 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr11_+_7618416 0.495 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr3_-_57234279 0.494 NM_003865
HESX1
HESX homeobox 1
chr4_-_123542165 0.488 NM_001207006
NM_021803
IL21

interleukin 21

chr15_+_89631731 0.488 ABHD2
abhydrolase domain containing 2
chr4_+_146031528 0.486 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr4_-_176734181 0.479 NM_201591
GPM6A
glycoprotein M6A
chr3_+_156394452 0.477 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr12_-_24103953 0.474 SOX5
SRY (sex determining region Y)-box 5
chr6_-_161694992 0.465 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr15_+_89631625 0.464 ABHD2
abhydrolase domain containing 2
chr7_+_28725597 0.462 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr3_+_121796695 0.460 NM_006889
NM_176892
CD86

CD86 molecule

chr9_+_12693385 0.459 NM_000550
TYRP1
tyrosinase-related protein 1
chr20_+_43030005 0.458 HNF4A
hepatocyte nuclear factor 4, alpha
chr12_-_102874158 0.457 IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_-_151770611 0.457 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr13_+_49684388 0.456 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr9_-_8733893 0.455 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr2_-_99279935 0.454 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr6_+_34205029 0.447 HMGA1
high mobility group AT-hook 1
chr12_-_102512277 0.442 NM_024057
NUP37
nucleoporin 37kDa
chr3_-_12941547 0.434 IQSEC1
IQ motif and Sec7 domain 1
chr4_-_174451356 0.434 NM_021973
HAND2
heart and neural crest derivatives expressed 2
chr18_-_31803514 0.430 NM_001198546
NM_001198548
NM_003787
NOL4


nucleolar protein 4


chr2_-_40657419 0.425 NM_001112800
NM_001112801
NM_001252624
NM_021097
SLC8A1



solute carrier family 8 (sodium/calcium exchanger), member 1



chr12_+_14538232 0.423 ATF7IP
activating transcription factor 7 interacting protein
chr11_+_75526236 0.422 UVRAG
UV radiation resistance associated gene
chr1_-_150738292 0.420 NM_001199739
NM_004079
CTSS

cathepsin S

chr8_-_40755328 0.419 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr12_-_16760935 0.419 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr6_+_32407618 0.417 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr1_+_50574589 0.416 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr2_-_200325200 0.414 SATB2
SATB homeobox 2
chr5_-_169724817 0.412 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr3_+_152880036 0.410 RAP2B
RAP2B, member of RAS oncogene family
chr2_+_162272619 0.408 NM_006593
TBR1
T-box, brain, 1
chr18_+_21572736 0.406 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr18_-_53089722 0.402 NM_001243233
TCF4
transcription factor 4
chr1_-_161147757 0.402 NM_001199873
NM_001199874
NM_003779
B4GALT3


UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3


chr22_+_22758538 0.400


chr22_+_22712091 0.398 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr7_+_150690838 0.397 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr10_-_13749622 0.396 FRMD4A
FERM domain containing 4A
chr12_+_52695648 0.394 NM_002284
KRT86
keratin 86
chr17_-_48785016 0.394 NM_052855
ANKRD40
ankyrin repeat domain 40
chr17_+_39240412 0.393 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr11_+_58390145 0.393 NM_000614
CNTF
ciliary neurotrophic factor
chr17_-_41739261 0.392 NM_001040002
MEOX1
mesenchyme homeobox 1
chr17_-_1248346 0.390 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr5_+_140809957 0.386 PCDHGA12
protocadherin gamma subfamily A, 12
chr21_-_40033617 0.385 NM_001243432
NM_001136154
NM_004449
ERG


v-ets erythroblastosis virus E26 oncogene homolog (avian)


chr6_+_26104103 0.384 NM_003542
HIST2H4B
HIST1H4C
histone cluster 2, H4b
histone cluster 1, H4c
chr19_+_4402658 0.380 NM_005483
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chrX_-_124097601 0.379 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1 (Drosophila)


chr10_+_82173574 0.377 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr6_-_136847078 0.377 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr20_+_43029973 0.376 HNF4A
hepatocyte nuclear factor 4, alpha
chr22_+_40573879 0.373 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr10_-_115613858 0.369 NM_014881
DCLRE1A
DNA cross-link repair 1A
chr12_-_52761254 0.368 NM_002283
KRT85
keratin 85
chr2_+_162272892 0.366 TBR1
T-box, brain, 1
chr12_-_52779362 0.366 NM_033045
KRT84
keratin 84
chr10_+_35416384 0.365 NM_181571
NM_183060
CREM

cAMP responsive element modulator

chr4_-_176733901 0.365 GPM6A
glycoprotein M6A
chr1_-_116383692 0.364 NM_005599
NHLH2
nescient helix loop helix 2
chr2_+_162272800 0.361 TBR1
T-box, brain, 1
chr20_+_42295747 0.356 MYBL2
v-myb myeloblastosis viral oncogene homolog (avian)-like 2
chr5_-_169724782 0.355 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr18_+_13611664 0.355 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr14_-_23426265 0.352 NM_001166269
NM_001166270
NM_017815
HAUS4


HAUS augmin-like complex, subunit 4


chr1_+_50575465 0.351 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr2_-_191184770 0.351 NM_014362
NM_198047
HIBCH

3-hydroxyisobutyryl-CoA hydrolase

chr4_+_114214102 0.349 ANK2
ankyrin 2, neuronal
chr14_+_101295409 0.347 MEG3
maternally expressed 3 (non-protein coding)
chr10_+_11207053 0.345 CELF2
CUGBP, Elav-like family member 2
chr12_+_86268072 0.343 NM_006183
NTS
neurotensin
chr15_-_70390229 0.342 NM_001105192
NM_005078
NM_020908
TLE3


transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)


chr6_-_26189303 0.341 NM_003539
HIST1H4D
histone cluster 1, H4d
chr4_-_26491888 0.340 NM_000730
CCKAR
cholecystokinin A receptor
chr4_-_83347222 0.338 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr5_+_176853673 0.336 NM_001004105
NM_001004106
NM_002082
GRK6


G protein-coupled receptor kinase 6


chr3_+_88188261 0.326 NM_018293
ZNF654
zinc finger protein 654
chr8_-_86290333 0.324 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr18_-_31803168 0.318 NOL4
nucleolar protein 4
chr17_-_38821286 0.317 NM_152349
KRT222
keratin 222
chr12_-_53994783 0.312 NM_001130059
ATF7
activating transcription factor 7
chr14_+_32798478 0.312 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr6_-_154677868 0.312 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr9_+_116226006 0.303 NM_017790
RGS3
regulator of G-protein signaling 3
chr4_-_41750936 0.302 NM_003924
PHOX2B
paired-like homeobox 2b
chr6_+_49467670 0.302 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr16_+_87984948 0.301 NM_001173539
NM_001173540
NM_001173541
NM_017869
NM_079837
BANP




BTG3 associated nuclear protein




chr12_-_6233684 0.297 NM_000552
VWF
von Willebrand factor
chr12_+_41831484 0.297 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr12_-_53171104 0.291 NM_015848
KRT76
keratin 76
chr6_+_34204663 0.290 HMGA1
high mobility group AT-hook 1
chr4_-_153303663 0.288 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr1_-_110155672 0.288 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr14_-_23426356 0.287 HAUS4
HAUS augmin-like complex, subunit 4
chr11_+_20620945 0.287 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr6_-_24719286 0.287 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr1_+_101003692 0.280 NM_022049
GPR88
G protein-coupled receptor 88
chr16_-_21314371 0.276 NM_001014444
NM_001888
CRYM

crystallin, mu

chr2_-_166930130 0.274 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr5_+_137673702 0.273 NM_016605
FAM53C
family with sequence similarity 53, member C
chr7_+_55433140 0.271 NM_018697
LANCL2
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr3_-_119379269 0.271 NM_022135
POPDC2
popeye domain containing 2
chr17_-_41276112 0.271 NM_007298
BRCA1
breast cancer 1, early onset
chr11_-_102496049 0.262 NM_004771
MMP20
matrix metallopeptidase 20
chr16_+_28889808 0.262 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr1_+_156119734 0.261 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr5_-_169724734 0.260 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr16_-_67517715 0.259 NM_001138
AGRP
agouti related protein homolog (mouse)
chr21_-_35899046 0.259 NM_203418
RCAN1
regulator of calcineurin 1
chr1_+_43162386 0.257 YBX1
Y box binding protein 1
chr8_-_27115935 0.252 STMN4
stathmin-like 4
chr7_+_28475233 0.252 NM_004904
CREB5
cAMP responsive element binding protein 5
chr6_-_32634287 0.252 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chr15_+_58430394 0.250 NM_020980
AQP9
aquaporin 9

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
7.48 2.74e-03 GO:0043565 sequence-specific DNA binding