Motif ID: NFATC1..3.p2

Z-value: 1.596


Transcription factors associated with NFATC1..3.p2:

Gene SymbolEntrez IDGene Name
NFATC1 4772 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 4773 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 4775 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFATC3chr16_+_68119350,
chr16_+_68119211		-0.871.4e-05Click!
NFATC1chr18_+_77160243-0.421.1e-01Click!


Activity profile for motif NFATC1..3.p2.

activity profile for motif NFATC1..3.p2


Sorted Z-values histogram for motif NFATC1..3.p2

Sorted Z-values for motif NFATC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_13349720 9.762 EMP1
epithelial membrane protein 1
chr12_+_13349601 8.655 NM_001423
 EMP1
epithelial membrane protein 1
chr2_+_189839132 6.097 COL3A1
collagen, type III, alpha 1
chr2_+_189839078 5.266 NM_000090
 COL3A1
collagen, type III, alpha 1
chr2_-_238322840 5.228 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
 COL6A3




collagen, type VI, alpha 3




chr2_-_238322770 5.128 COL6A3
collagen, type VI, alpha 3
chr2_+_189839113 5.065 COL3A1
collagen, type III, alpha 1
chr2_-_238322815 4.692 COL6A3
collagen, type VI, alpha 3
chr4_+_169418167 4.537 NM_001166108
NM_016081
 PALLD

palladin, cytoskeletal associated protein

chr18_-_21891469 4.289 NM_001242508
 OSBPL1A
oxysterol binding protein-like 1A
chr3_+_159557745 4.272 SCHIP1
schwannomin interacting protein 1
chr6_-_128841432 3.664 NM_002844
NM_001135648
 PTPRK

protein tyrosine phosphatase, receptor type, K

chr7_+_116164838 3.616 NM_001753
 CAV1
caveolin 1, caveolae protein, 22kDa
chr12_-_91573264 3.598 NM_133503
 DCN
decorin
chr22_-_36236264 3.440 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr6_-_169654047 3.430 NM_003247
 THBS2
thrombospondin 2
chr22_-_36236421 3.135 NM_001031695
NM_001082576
NM_001082577
NM_014309
 RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr22_-_36236330 3.118 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_+_158979681 3.097 NM_001206567
NM_005531
 IFI16

interferon, gamma-inducible protein 16

chr1_-_150780705 3.053 NM_000396
 CTSK
cathepsin K

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 11 of 11 entries
Enrichment   P-value GO Accession GO Term
25.92 7.32e-03 GO:0018149 peptide cross-linking
22.68 1.28e-02 GO:0030199 collagen fibril organization
11.08 1.51e-03 GO:0030198 extracellular matrix organization
7.22 2.52e-02 GO:0043062 extracellular structure organization
3.89 6.37e-04 GO:0007155 cell adhesion
3.89 6.37e-04 GO:0022610 biological adhesion
3.67 6.86e-04 GO:0009888 tissue development
2.02 1.31e-02 GO:0048731 system development
1.93 1.75e-02 GO:0048856 anatomical structure development
1.91 1.18e-02 GO:0007275 multicellular organismal development
1.83 1.78e-02 GO:0032502 developmental process

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
Enrichment   P-value GO Accession GO Term
90.68 1.54e-02 GO:0005589 collagen type VI
49.47 8.32e-05 GO:0005583 fibrillar collagen
45.34 3.01e-03 GO:0030934 anchoring collagen
32.98 7.09e-09 GO:0005581 collagen
15.28 1.15e-08 GO:0044420 extracellular matrix part
8.89 2.23e-09 GO:0005578 proteinaceous extracellular matrix
7.82 3.80e-09 GO:0031012 extracellular matrix
4.40 2.45e-09 GO:0044421 extracellular region part
3.90 2.57e-05 GO:0005615 extracellular space
3.44 5.06e-10 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
Enrichment   P-value GO Accession GO Term
90.68 1.98e-02 GO:0004024 alcohol dehydrogenase activity, zinc-dependent
19.44 6.47e-04 GO:0005518 collagen binding
14.01 7.60e-05 GO:0005201 extracellular matrix structural constituent
9.73 9.08e-04 GO:0008201 heparin binding
8.51 5.33e-04 GO:0005539 glycosaminoglycan binding
7.89 9.33e-04 GO:0001871 pattern binding
7.89 9.33e-04 GO:0030247 polysaccharide binding
6.67 1.05e-02 GO:0061134 peptidase regulator activity
4.91 2.74e-02 GO:0004857 enzyme inhibitor activity
4.51 8.84e-03 GO:0030246 carbohydrate binding
4.04 4.59e-04 GO:0005198 structural molecule activity