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• Mean activities

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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: NFE2.p2

Z-value: 1.299

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_-_38721701	6.680	NM_001838	CCR7	chemokine (C-C motif) receptor 7
chr22_+_23040394	5.202		IGL@	immunoglobulin lambda locus
chr22_+_23010757	5.033
chr22_+_22723972	3.709
chr22_+_23165273	3.351
chr12_-_15114495	3.313	NM_001175	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr13_-_99959649	3.237	NM_004951	GPR183	G protein-coupled receptor 183
chr1_+_174844655	3.181	NM_001035230	RABGAP1L	RAB GTPase activating protein 1-like
chr22_+_22569155	3.161
chr4_+_41258941	2.923		UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chrX_-_154563735	2.863	NM_001289	CLIC2	chloride intracellular channel 2
chr5_+_150020201	2.786	NM_001109974 NM_007286	SYNPO	synaptopodin
chrX_+_12993224	2.752	NM_021109	TMSB4X	thymosin beta 4, X-linked
chr6_+_33043702	2.609	NM_002121	HLA-DPB1	major histocompatibility complex, class II, DP beta 1
chr11_+_20385324	2.397	NM_001098522	HTATIP2	HIV-1 Tat interactive protein 2, 30kDa
chr11_+_20385230	2.261	NM_006410 NM_001098521	HTATIP2	HIV-1 Tat interactive protein 2, 30kDa
chr11_+_20385259	2.255	NM_001098520	HTATIP2	HIV-1 Tat interactive protein 2, 30kDa
chr22_+_22758538	2.161
chr10_-_6019880	2.109	NM_001243539	IL15RA	interleukin 15 receptor, alpha
chr9_-_123688352	2.100		TRAF1	TNF receptor-associated factor 1
chrX_-_100641143	2.094	NM_000061	BTK	Bruton agammaglobulinemia tyrosine kinase
chr11_+_67351276	2.094		GSTP1	glutathione S-transferase pi 1
chr11_+_67351065	2.092	NM_000852	GSTP1	glutathione S-transferase pi 1
chr17_-_28618836	1.975		BLMH	bleomycin hydrolase
chr17_-_29641087	1.973		EVI2B	ecotropic viral integration site 2B
chr16_+_57392694	1.967	NM_002990	CCL22	chemokine (C-C motif) ligand 22
chr1_+_150122246	1.965		PLEKHO1	pleckstrin homology domain containing, family O member 1
chr22_+_22712091	1.959		IGLV1-44 IGL@	immunoglobulin lambda variable 1-44 immunoglobulin lambda locus
chr22_+_23134980	1.950
chr1_+_150122415	1.949		PLEKHO1	pleckstrin homology domain containing, family O member 1
chr5_-_141061798	1.888	NM_022481	ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr10_-_6019454	1.853	NM_002189 NM_172200	IL15RA	interleukin 15 receptor, alpha
chr6_-_84140758	1.837		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr22_+_22697538	1.828
chr3_-_98241357	1.815		CLDND1	claudin domain containing 1
chr17_-_29641068	1.801		EVI2B	ecotropic viral integration site 2B
chr1_+_150122095	1.791	NM_016274	PLEKHO1	pleckstrin homology domain containing, family O member 1
chr10_+_30723050	1.779		MAP3K8	mitogen-activated protein kinase kinase kinase 8
chr19_-_7764283	1.769	NM_001207019	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)
chr10_+_17270257	1.744	NM_003380	VIM	vimentin
chr6_-_84140744	1.691		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr22_+_22735134	1.630		CYAT1	immunoglobulin lambda light chain-like
chr3_+_183894736	1.619		AP2M1	adaptor-related protein complex 2, mu 1 subunit
chr17_+_30771520	1.569		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chrX_+_99899162	1.560	NM_014467	SRPX2	sushi-repeat containing protein, X-linked 2
chr11_-_102668892	1.554	NM_001145938 NM_002421	MMP1	matrix metallopeptidase 1 (interstitial collagenase)
chr10_+_30722856	1.545	NM_001244134 NM_005204	MAP3K8	mitogen-activated protein kinase kinase kinase 8
chr5_-_141061749	1.539		ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr22_+_22786283	1.518
chr17_-_29641094	1.516	NM_006495	EVI2B	ecotropic viral integration site 2B
chr17_+_32582295	1.514	NM_002982	CCL2	chemokine (C-C motif) ligand 2
chr11_+_20385686	1.507	NM_001098523	HTATIP2	HIV-1 Tat interactive protein 2, 30kDa
chr6_-_84140854	1.492	NM_002395	ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr8_-_82395401	1.486	NM_001442	FABP4	fatty acid binding protein 4, adipocyte
chr7_+_90339146	1.482		CDK14	cyclin-dependent kinase 14
chr11_-_102668822	1.463		MMP1	matrix metallopeptidase 1 (interstitial collagenase)
chr15_+_89182038	1.461	NM_002201	ISG20	interferon stimulated exonuclease gene 20kDa
chrX_+_99899388	1.461		SRPX2	sushi-repeat containing protein, X-linked 2
chr18_-_53068755	1.423		TCF4	transcription factor 4
chr3_+_49027281	1.387	NM_177938 NM_177939	P4HTM	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr11_+_128563772	1.371	NM_001167681 NM_002017	FLI1	Friend leukemia virus integration 1
chr10_+_17270469	1.359		VIM	vimentin
chr11_-_9025531	1.306	NM_020645	NRIP3	nuclear receptor interacting protein 3
chr3_+_48507209	1.306	NM_016381 NM_033629	TREX1	three prime repair exonuclease 1
chr19_+_4229494	1.295	NM_005755	EBI3	Epstein-Barr virus induced 3
chrX_-_15511710	1.292	NM_001018109 NM_003662	PIR	pirin (iron-binding nuclear protein)
chr3_+_48507621	1.270		TREX1	three prime repair exonuclease 1
chr22_+_22676814	1.250
chr4_-_76944585	1.250	NM_001565	CXCL10	chemokine (C-X-C motif) ligand 10
chr17_-_28619183	1.222	NM_000386	BLMH	bleomycin hydrolase
chrX_+_65382627	1.214		HEPH	hephaestin
chr3_-_58200397	1.202	NM_004944	DNASE1L3	deoxyribonuclease I-like 3
chrX_+_65382432	1.180	NM_138737	HEPH	hephaestin
chr5_-_169724734	1.180		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr3_-_98241683	1.177		CLDND1	claudin domain containing 1
chr12_+_7060433	1.161	NM_002831 NM_080549	PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr18_-_53303129	1.147	NM_001243226	TCF4	transcription factor 4
chr19_+_36203829	1.145	NM_014383	ZBTB32	zinc finger and BTB domain containing 32
chr5_-_169724817	1.135	NM_005565	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_-_24877453	1.124	NM_015864	FAM65B	family with sequence similarity 65, member B
chr2_-_89292396	1.101		IGKC	immunoglobulin kappa constant
chr5_-_169724782	1.101		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chrX_+_9431314	1.069	NM_001139466 NM_001139467 NM_001139468	TBL1X	transducin (beta)-like 1X-linked
chr18_-_53177999	1.063	NM_001243231	TCF4	transcription factor 4
chr4_-_16900348	1.057	NM_001130834 NM_001290	LDB2	LIM domain binding 2
chr7_+_150434435	1.055	NM_018384	GIMAP5	GTPase, IMAP family member 5
chr1_+_155853546	1.054		SYT11	synaptotagmin XI
chr12_-_91573264	1.050	NM_133503	DCN	decorin
chr9_+_4985082	1.026		JAK2	Janus kinase 2
chr12_-_8765438	1.019	NM_020661	AICDA	activation-induced cytidine deaminase
chr17_-_45899133	1.019	NM_145798	OSBPL7	oxysterol binding protein-like 7
chr11_-_3862137	1.014		RHOG	ras homolog gene family, member G (rho G)
chr22_-_37545944	1.011	NM_000878	IL2RB	interleukin 2 receptor, beta
chr22_+_22735207	1.003		IGLJ3	immunoglobulin lambda joining 3
chr11_+_128563993	1.000		FLI1	Friend leukemia virus integration 1
chr6_+_44195008	0.996		SLC29A1	solute carrier family 29 (nucleoside transporters), member 1
chr8_-_42623928	0.995	NM_001199279 NM_004198	CHRNA6	cholinergic receptor, nicotinic, alpha 6
chr3_+_69915374	0.969	NM_198177	MITF	microphthalmia-associated transcription factor
chr3_-_98241748	0.953		CLDND1	claudin domain containing 1
chr2_+_152214105	0.933	NM_007115	TNFAIP6	tumor necrosis factor, alpha-induced protein 6
chr1_-_225616556	0.927	NM_194442	LBR	lamin B receptor
chr19_-_56348127	0.923	NM_145007	NLRP11	NLR family, pyrin domain containing 11
chrX_-_15511358	0.914		PIR	pirin (iron-binding nuclear protein)
chr16_-_89043215	0.905	NM_005187	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr7_+_23286390	0.904		GPNMB	glycoprotein (transmembrane) nmb
chr1_-_159046555	0.896	NM_004833	AIM2	absent in melanoma 2
chr3_+_50284325	0.895	NM_001166425	GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr15_+_44829373	0.882		EIF3J	eukaryotic translation initiation factor 3, subunit J
chr1_-_246580710	0.859	NM_022743	SMYD3	SET and MYND domain containing 3
chr5_-_137071462	0.853		KLHL3	kelch-like 3 (Drosophila)
chr7_+_23286386	0.846		GPNMB	glycoprotein (transmembrane) nmb
chr11_+_10476665	0.833	NM_001025389	AMPD3	adenosine monophosphate deaminase 3
chr7_+_23286277	0.830	NM_001005340 NM_002510	GPNMB	glycoprotein (transmembrane) nmb
chr6_-_31550065	0.821	NM_002341 NM_009588	LTB	lymphotoxin beta (TNF superfamily, member 3)
chr7_+_22766765	0.821	NM_000600	IL6	interleukin 6 (interferon, beta 2)
chrX_-_129244422	0.817		ELF4	E74-like factor 4 (ets domain transcription factor)
chr19_-_10450262	0.813	NM_002162	ICAM3	intercellular adhesion molecule 3
chr14_+_103801160	0.810	NM_183004	EIF5	eukaryotic translation initiation factor 5
chr17_-_45899118	0.808		OSBPL7	oxysterol binding protein-like 7
chr1_+_12123433	0.804	NM_001243	TNFRSF8	tumor necrosis factor receptor superfamily, member 8
chr11_-_62474666	0.796		BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chrX_-_129244471	0.794	NM_001421	ELF4	E74-like factor 4 (ets domain transcription factor)
chr17_-_34207308	0.794	NM_002985	CCL5	chemokine (C-C motif) ligand 5
chr3_+_119316694	0.790	NM_001206960 NM_001206961 NM_015900	PLA1A	phospholipase A1 member A
chr22_+_23222897	0.790		CYAT1	immunoglobulin lambda light chain-like
chr7_+_150688143	0.785	NM_000603	NOS3	nitric oxide synthase 3 (endothelial cell)
chr11_-_3862183	0.781	NM_001665	RHOG	ras homolog gene family, member G (rho G)
chrX_-_135749436	0.763		ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr22_-_39268214	0.755		CBX6	chromobox homolog 6
chr2_-_175462428	0.739		WIPF1	WAS/WASL interacting protein family, member 1
chr10_-_94333721	0.738		IDE	insulin-degrading enzyme
chr16_-_1429612	0.733	NM_001193389 NM_023076	UNKL	unkempt homolog (Drosophila)-like
chr6_-_84140651	0.729		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr11_-_6676851	0.714	NM_003737	DCHS1	dachsous 1 (Drosophila)
chr10_+_71075609	0.710	NM_033496	HK1	hexokinase 1
chr3_-_98241722	0.709		CLDND1	claudin domain containing 1
chr10_-_94333828	0.696		IDE	insulin-degrading enzyme
chr17_-_73150769	0.684	NM_001002032 NM_001002033 NM_016185	HN1	hematological and neurological expressed 1
chr1_+_14075861	0.682	NM_001007257	PRDM2	PR domain containing 2, with ZNF domain
chr11_-_102714240	0.682	NM_002422	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr3_+_141043054	0.681	NM_001080412	ZBTB38	zinc finger and BTB domain containing 38
chr12_-_102591547	0.681	NM_002674	PMCH	pro-melanin-concentrating hormone
chr9_+_4985243	0.677	NM_004972	JAK2	Janus kinase 2
chr10_-_21462987	0.671		NEBL	nebulette
chr1_-_183559463	0.667		NCF2	neutrophil cytosolic factor 2
chr9_-_34662629	0.664	NM_006664	CCL27	chemokine (C-C motif) ligand 27
chr6_+_106546736	0.664	NM_182907	PRDM1	PR domain containing 1, with ZNF domain
chr6_-_32908583	0.662	NM_002118	HLA-DMB	major histocompatibility complex, class II, DM beta
chr3_+_11178778	0.661	NM_001098213	HRH1	histamine receptor H1
chr12_+_10365415	0.660	NM_031412	GABARAPL1	GABA(A) receptor-associated protein like 1
chr5_-_137071703	0.656	NM_017415	KLHL3	kelch-like 3 (Drosophila)
chr8_-_70745624	0.655	NM_001146008	SLCO5A1	solute carrier organic anion transporter family, member 5A1
chr11_+_10477480	0.627	NM_001025390	AMPD3	adenosine monophosphate deaminase 3
chr11_-_62474869	0.624		BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr17_+_30771494	0.620	NM_002815	PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_-_115880851	0.612	NM_002506	NGF	nerve growth factor (beta polypeptide)
chr2_+_33359607	0.610	NM_000627 NM_001166264 NM_001166265 NM_001166266	LTBP1	latent transforming growth factor beta binding protein 1
chr16_+_58534045	0.605	NM_001242833 NM_001242834 NM_001242835 NM_001242836	NDRG4	NDRG family member 4
chr15_+_101459459	0.604	NM_024652	LRRK1	leucine-rich repeat kinase 1
chr9_+_2015218	0.604	NM_003070 NM_139045	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_-_109969058	0.599	NM_001199772 NM_002790 NM_001199773 NM_001199774	PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5
chr14_-_106691698	0.597
chr19_-_41859253	0.586		TGFB1	transforming growth factor, beta 1
chr14_-_106092256	0.585		IGHG4	immunoglobulin heavy constant gamma 4 (G4m marker)
chr10_-_101769640	0.581	NM_015221	DNMBP	dynamin binding protein
chr10_-_94333847	0.579	NM_004969	IDE	insulin-degrading enzyme
chrX_-_16730669	0.579	NM_175859 NM_019857	CTPS2	CTP synthase II
chr7_-_134854225	0.578	NM_001243753 NM_001243755	C7orf49	chromosome 7 open reading frame 49
chr4_-_159092509	0.575		FAM198B	family with sequence similarity 198, member B
chr4_+_170581212	0.574	NM_001243374	CLCN3	chloride channel 3
chr17_+_30771532	0.574		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr10_+_35484829	0.560	NM_182721 NM_182722 NM_182723 NM_182724 NM_182725	CREM	cAMP responsive element modulator
chrX_-_72434623	0.559		NAP1L2	nucleosome assembly protein 1-like 2
chr1_+_40735749	0.556		ZMPSTE24	zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr1_-_109969044	0.554		PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5
chr3_-_93782066	0.553	NM_001195643	DHFRL1	dihydrofolate reductase-like 1
chr5_-_169724614	0.552		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_-_46293404	0.551		RCAN2	regulator of calcineurin 2
chr14_-_106111114	0.548		IGHG2	immunoglobulin heavy constant gamma 2 (G2m marker)
chr7_+_23286420	0.547		GPNMB	glycoprotein (transmembrane) nmb
chr15_+_86220267	0.535	NM_144767	AKAP13	A kinase (PRKA) anchor protein 13
chr12_+_69202796	0.533		MDM2	Mdm2 p53 binding protein homolog (mouse)
chr17_+_30771522	0.529		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_+_154966061	0.525	NM_018655	LENEP	lens epithelial protein
chr1_-_160832466	0.524	NM_001166663 NM_001166664 NM_016382	CD244	CD244 molecule, natural killer cell receptor 2B4
chrX_-_72434656	0.521		NAP1L2	nucleosome assembly protein 1-like 2
chr5_+_72143929	0.520	NM_153188	TNPO1	transportin 1
chr18_+_21572736	0.518	NM_153211	TTC39C	tetratricopeptide repeat domain 39C
chr17_+_30771485	0.518		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr21_+_30517897	0.513		C21orf7	chromosome 21 open reading frame 7
chr3_+_132373289	0.510	NM_198329	UBA5	ubiquitin-like modifier activating enzyme 5
chr7_+_150434679	0.503		GIMAP5	GTPase, IMAP family member 5
chr14_-_106237675	0.495		IGHM	immunoglobulin heavy constant mu
chr7_+_130794854	0.493	NM_001145354	MKLN1	muskelin 1, intracellular mediator containing kelch motifs
chr22_+_22764094	0.490
chr1_-_183559669	0.486	NM_000433 NM_001190789 NM_001190794	NCF2	neutrophil cytosolic factor 2
chr6_-_159239269	0.485	NM_003379	EZR	ezrin
chr6_-_159239198	0.484		EZR	ezrin
chr1_-_109968951	0.484		PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5
chr6_+_34206567	0.484	NM_145905	HMGA1	high mobility group AT-hook 1

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
4.08	2.72e-05	GO:0002376	immune system process
4.85	3.12e-04	GO:0006955	immune response
10.10	5.45e-04	GO:0019221	cytokine-mediated signaling pathway
9.12	1.18e-03	GO:0071345	cellular response to cytokine stimulus
9.26	4.85e-03	GO:0050867	positive regulation of cell activation
10.42	1.14e-02	GO:0050870	positive regulation of T cell activation
1.75	1.27e-02	GO:0050896	response to stimulus
6.57	1.32e-02	GO:0034097	response to cytokine stimulus
5.23	2.37e-02	GO:0002684	positive regulation of immune system process
4.17	2.52e-02	GO:0002682	regulation of immune system process
7.05	2.84e-02	GO:0050865	regulation of cell activation
147.95	3.12e-02	GO:0051772	regulation of nitric-oxide synthase 2 biosynthetic process
8.66	3.24e-02	GO:0051251	positive regulation of lymphocyte activation
8.50	3.60e-02	GO:0050863	regulation of T cell activation
2.27	4.21e-02	GO:0048518	positive regulation of biological process
8.09	4.74e-02	GO:0002696	positive regulation of leukocyte activation

Nothing significant found in compartment category.

Nothing significant found in function category.