Motif ID: NFIX.p2

Z-value: 2.548


Transcription factors associated with NFIX.p2:

Gene SymbolEntrez IDGene Name
NFIX 4784 nuclear factor I/X (CCAAT-binding transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFIXchr19_+_131353680.712.2e-03Click!


Activity profile for motif NFIX.p2.

activity profile for motif NFIX.p2


Sorted Z-values histogram for motif NFIX.p2

Sorted Z-values for motif NFIX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_151966276 11.010 S100A10
S100 calcium binding protein A10
chr10_+_124220990 8.562 NM_002775
HTRA1
HtrA serine peptidase 1
chr15_+_63336274 6.450 TPM1
tropomyosin 1 (alpha)
chr10_+_17271859 6.276 VIM
vimentin
chr10_+_17271956 6.223 VIM
vimentin
chr12_+_26348268 5.947 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr7_-_80548666 5.627 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr4_-_99579540 5.549 NM_005723
TSPAN5
tetraspanin 5
chr7_-_80548322 4.888 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr7_+_65670256 4.849 NM_003596
TPST1
tyrosylprotein sulfotransferase 1
chr1_-_151966713 4.220 NM_002966
S100A10
S100 calcium binding protein A10
chr21_-_28217692 4.025 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr10_+_88728187 3.997 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr11_-_12030128 3.974 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr9_+_124030455 3.740 GSN
gelsolin
chr10_+_102792161 3.690 SFXN3
sideroflexin 3
chr9_+_124030370 3.655 NM_001127662
NM_001127663
NM_001127664
NM_001127665
NM_001127666
NM_001127667
NM_198252
GSN






gelsolin






chr2_-_56151273 3.624 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr10_-_91011516 3.443 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr8_-_41166931 3.401 NM_003012
SFRP1
secreted frizzled-related protein 1
chr4_-_143767603 3.238 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr10_-_91011586 3.233 NM_000235
NM_001127605
LIPA

lipase A, lysosomal acid, cholesterol esterase

chr9_+_124030413 3.139 GSN
gelsolin
chr16_+_3070310 3.135 NM_016639
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr2_+_241375030 3.124 NM_002081
GPC1
glypican 1
chr10_-_91011562 3.102 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr9_+_115913227 3.021 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chrX_-_68385249 3.015 NM_001032396
NM_022368
NM_145119
PJA1


praja ring finger 1


chr1_+_43996478 2.875 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr5_+_34656595 2.837 NM_001145520
RAI14
retinoic acid induced 14
chr11_-_12030539 2.835 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr11_-_117166247 2.804 NM_001207048
NM_001207049
BACE1

beta-site APP-cleaving enzyme 1

chr3_+_154797435 2.782 NM_000902
MME
membrane metallo-endopeptidase
chr1_-_153588789 2.756 NM_020672
S100A14
S100 calcium binding protein A14
chr5_+_34656482 2.688 RAI14
retinoic acid induced 14
chr11_-_61735108 2.644 NM_002032
FTH1
ferritin, heavy polypeptide 1
chr1_+_64059479 2.621 NM_001172819
PGM1
phosphoglucomutase 1
chr13_-_77460432 2.606 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr1_-_153599969 2.604 NM_001024211
S100A13
S100 calcium binding protein A13
chr6_+_86159301 2.596 NM_001204813
NM_002526
NT5E

5'-nucleotidase, ecto (CD73)

chr5_-_157002739 2.570 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr21_-_28217272 2.488 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr12_+_75874512 2.462 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr12_+_6309475 2.456 NM_001769
CD9
CD9 molecule
chr1_+_20915440 2.394 NM_001785
CDA
cytidine deaminase
chr5_+_34656367 2.384 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr16_+_56703725 2.349 NM_005951
MT1H
metallothionein 1H
chr1_-_207205996 2.322 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr5_+_34684611 2.314 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr11_-_12030622 2.215 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr19_+_38755097 2.215 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr9_+_112810877 2.198 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr8_-_119123804 2.188 NM_000127
EXT1
exostosin 1
chr9_+_116342939 2.178 NM_021106
RGS3
regulator of G-protein signaling 3
chr4_+_38869346 2.126 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr19_-_59066477 2.065 NM_014453
CHMP2A
charged multivesicular body protein 2A
chr10_+_89419352 2.041 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr20_+_17550598 1.990 NM_001011546
NM_006870
DSTN

destrin (actin depolymerizing factor)

chr9_+_112542496 1.984 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr1_-_68697997 1.968 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr12_+_26348488 1.933 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr3_+_138067678 1.921 NM_001252092
MRAS
muscle RAS oncogene homolog
chr9_-_32526164 1.910 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_106015423 1.887 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr6_+_86159738 1.887 NT5E
5'-nucleotidase, ecto (CD73)
chr19_-_59066303 1.883 CHMP2A
charged multivesicular body protein 2A
chr9_-_113800243 1.846 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr4_+_146402704 1.814 NM_005900
SMAD1
SMAD family member 1
chr19_-_59066353 1.806 NM_198426
CHMP2A
charged multivesicular body protein 2A
chr12_+_56325788 1.803 NM_201444
NM_201445
NM_201554
DGKA


diacylglycerol kinase, alpha 80kDa


chr1_-_151966303 1.779 S100A10
S100 calcium binding protein A10
chr19_+_38755238 1.770 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr6_+_30851860 1.764 NM_001954
DDR1
discoidin domain receptor tyrosine kinase 1
chr19_+_38755422 1.751 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr15_+_67358161 1.718 SMAD3
SMAD family member 3
chr6_-_150244145 1.711 NM_001001788
RAET1G
retinoic acid early transcript 1G
chr9_+_116343169 1.694 RGS3
regulator of G-protein signaling 3
chr10_-_95241943 1.694 NM_013451
NM_133337
MYOF

myoferlin

chr3_+_138067969 1.673 NM_001252090
MRAS
muscle RAS oncogene homolog
chr1_-_153599743 1.660 NM_001024212
S100A13
S100 calcium binding protein A13
chr12_+_56324945 1.650 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chr9_+_115913266 1.619 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr5_+_150399980 1.614 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr13_+_48807307 1.595 ITM2B
integral membrane protein 2B
chr15_+_67358194 1.573 NM_005902
SMAD3
SMAD family member 3
chr5_+_150400132 1.568 GPX3
glutathione peroxidase 3 (plasma)
chr19_-_45926819 1.552 NM_202001
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chrX_-_151999259 1.550 NM_004344
CETN2
centrin, EF-hand protein, 2
chr9_-_130617009 1.549 NM_000118
NM_001114753
ENG

endoglin

chr21_-_27512668 1.547 NM_001136016
APP
amyloid beta (A4) precursor protein
chr8_+_70405080 1.539 SULF1
sulfatase 1
chr11_-_46722115 1.531 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr9_-_130616760 1.530 ENG
endoglin
chr7_+_93551015 1.529 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr1_+_228327784 1.523 NM_001242839
NM_000858
NM_001159390
NM_001242840
GUK1



guanylate kinase 1



chr15_-_77363122 1.518 TSPAN3
tetraspanin 3
chr6_+_139456240 1.516 NM_016217
HECA
headcase homolog (Drosophila)
chr22_+_38864015 1.513 NM_006855
NM_016657
KDELR3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

chr1_+_228328015 1.511 GUK1
guanylate kinase 1
chr19_-_59066458 1.503 CHMP2A
charged multivesicular body protein 2A
chr19_-_45926759 1.476 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr19_-_59066372 1.468 CHMP2A
charged multivesicular body protein 2A
chr10_-_126849556 1.467 NM_001083914
CTBP2
C-terminal binding protein 2
chr9_-_74383301 1.461 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr3_+_154797910 1.458 NM_007288
MME
membrane metallo-endopeptidase
chr11_-_46722139 1.454 ARHGAP1
Rho GTPase activating protein 1
chr3_+_130745693 1.439 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr4_-_111558150 1.423 PITX2
paired-like homeodomain 2
chr5_-_122372320 1.421 PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr1_+_228327982 1.420 GUK1
guanylate kinase 1
chr1_-_95007139 1.407 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr8_+_1772095 1.406 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr13_+_48807492 1.401 ITM2B
integral membrane protein 2B
chr1_+_228327966 1.388 GUK1
guanylate kinase 1
chr1_+_228328003 1.373 GUK1
guanylate kinase 1
chr3_-_50396892 1.368 TMEM115
transmembrane protein 115
chr11_-_46722160 1.365 ARHGAP1
Rho GTPase activating protein 1
chr10_-_100206643 1.316 HPS1
Hermansky-Pudlak syndrome 1
chr9_-_130616592 1.308 ENG
endoglin
chr1_+_77333121 1.267 ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr9_+_35605339 1.255 TESK1
testis-specific kinase 1
chr19_-_45927081 1.254 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr2_+_241375235 1.251 GPC1
glypican 1
chr11_-_61734896 1.250 FTH1
ferritin, heavy polypeptide 1
chr1_+_210502639 1.247 NM_001170580
HHAT
hedgehog acyltransferase
chr17_-_46115135 1.242 NM_016429
COPZ2
coatomer protein complex, subunit zeta 2
chr14_-_24664758 1.235 NM_001014842
NM_006405
TM9SF1

transmembrane 9 superfamily member 1

chr4_+_6576900 1.232 NM_015274
MAN2B2
mannosidase, alpha, class 2B, member 2
chr9_+_35605275 1.217 NM_006285
TESK1
testis-specific kinase 1
chr8_-_11725509 1.216 CTSB
cathepsin B
chr20_+_43344005 1.199 WISP2
WNT1 inducible signaling pathway protein 2
chr8_+_70405027 1.197 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr5_+_95998678 1.181 CAST
calpastatin
chr19_-_45927142 1.141 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr1_+_25071906 1.141 CLIC4
chloride intracellular channel 4
chr4_+_148402117 1.136 EDNRA
endothelin receptor type A
chr9_+_130911731 1.130 NM_005564
LCN2
lipocalin 2
chr19_+_48281841 1.127 NM_003009
SEPW1
selenoprotein W, 1
chr1_+_77333158 1.124 NM_030965
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr3_-_49941300 1.121 NM_001244937
NM_002447
MST1R

macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

chr1_+_68150858 1.116 NM_001199741
NM_001199742
NM_001924
GADD45A


growth arrest and DNA-damage-inducible, alpha


chr10_-_735522 1.112 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr9_-_130616957 1.105 ENG
endoglin
chr18_-_21977785 1.097 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr11_+_93862143 1.090 PANX1
pannexin 1
chr11_-_61735067 1.089 FTH1
CPSF7
ferritin, heavy polypeptide 1
cleavage and polyadenylation specific factor 7, 59kDa
chr3_-_50396930 1.086 NM_007024
TMEM115
transmembrane protein 115
chr9_+_133320093 1.081 NM_000050
NM_054012
ASS1

argininosuccinate synthase 1

chr21_+_42540092 1.066 BACE2
beta-site APP-cleaving enzyme 2
chr8_-_11725587 1.054 CTSB
cathepsin B
chr11_-_125366048 1.050 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr6_-_46459010 1.048 NM_001251974
RCAN2
regulator of calcineurin 2
chr12_+_72666462 1.034 NM_013381
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr4_+_6576915 1.013 MAN2B2
mannosidase, alpha, class 2B, member 2
chr19_+_48216600 1.010 NM_014601
EHD2
EH-domain containing 2
chr3_+_138067444 1.005 NM_001085049
NM_001252093
MRAS

muscle RAS oncogene homolog

chr1_+_210502188 0.997 NM_001170587
NM_001170588
NM_018194
HHAT


hedgehog acyltransferase


chr10_+_102792166 0.990 SFXN3
sideroflexin 3
chr16_-_89556886 0.988 NM_013275
ANKRD11
ankyrin repeat domain 11
chr17_+_37844325 0.986 NM_001005862
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr8_-_54755836 0.980 NM_015941
NM_213619
ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

chr14_+_59104736 0.980 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr1_-_27692825 0.979 MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr15_-_71184611 0.975 NM_020147
THAP10
THAP domain containing 10
chr15_+_74466887 0.974 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr17_-_80656461 0.972 NM_006822
RAB40B
RAB40B, member RAS oncogene family
chr11_+_93862060 0.971 NM_015368
PANX1
pannexin 1
chr1_-_36235422 0.971 NM_001190481
NM_022111
CLSPN

claspin

chr19_-_45926631 0.968 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr14_-_24664606 0.964 TM9SF1
transmembrane 9 superfamily member 1
chr2_-_86116016 0.963 NM_003896
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr18_+_12308236 0.961 TUBB6
tubulin, beta 6 class V
chr6_-_139695739 0.959 CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr8_+_11142314 0.953 MTMR9
myotubularin related protein 9
chr15_-_60690115 0.952 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr8_-_54755821 0.949 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr5_+_140797270 0.945 PCDHGB7
protocadherin gamma subfamily B, 7
chr9_+_34179036 0.939 UBAP1
ubiquitin associated protein 1
chr1_-_94702916 0.938 ARHGAP29
Rho GTPase activating protein 29
chr3_-_28390506 0.928 NM_001134432
NM_001134433
NM_022461
AZI2


5-azacytidine induced 2


chr15_-_59041777 0.925 ADAM10
ADAM metallopeptidase domain 10
chr13_+_48807250 0.924 NM_021999
ITM2B
integral membrane protein 2B
chr12_-_102455763 0.900 CCDC53
coiled-coil domain containing 53
chr10_+_17271302 0.893 VIM
vimentin
chr6_-_139695784 0.893 NM_006079
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr3_+_35681008 0.889 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr14_-_75078669 0.888 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr12_-_102455793 0.888 NM_016053
CCDC53
coiled-coil domain containing 53
chr4_+_15704691 0.888 BST1
bone marrow stromal cell antigen 1
chr11_-_120008801 0.885 TRIM29
tripartite motif containing 29
chr1_-_43919547 0.881 NM_001190880
NM_001243526
NM_031207
HYI


hydroxypyruvate isomerase (putative)


chr3_+_190231839 0.879 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chrX_-_101771641 0.874 NM_021992
TMSB15A
TMSB15B
thymosin beta 15a
thymosin beta 15B
chr2_+_18059923 0.871 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr12_-_102455739 0.868 CCDC53
coiled-coil domain containing 53
chr1_+_203595897 0.863 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chr8_-_11725622 0.863 CTSB
cathepsin B
chr11_+_34642651 0.858 EHF
ets homologous factor
chr9_+_133320247 0.843 ASS1
argininosuccinate synthase 1
chr2_-_85637486 0.836 NM_001747
CAPG
capping protein (actin filament), gelsolin-like

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.97 2.36e-04 GO:0009986 cell surface
1.45 1.42e-02 GO:0016020 membrane
1.67 3.30e-02 GO:0071944 cell periphery
62.01 4.61e-02 GO:0032059 bleb

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
37.21 8.10e-03 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity