Motif ID: NFKB1_REL_RELA.p2

Z-value: 3.287


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFKB1chr4_+_1034227300.862.1e-05Click!
RELchr2_+_611087020.775.4e-04Click!
RELAchr11_-_654302140.116.8e-01Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_4229494 9.771 NM_005755
 EBI3
Epstein-Barr virus induced 3
chr5_-_149792276 7.089 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_32551993 6.932 HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr22_+_22758538 6.696


chr11_+_102188180 6.532 NM_001165
NM_182962
 BIRC3

baculoviral IAP repeat containing 3

chr19_-_6591012 6.249 CD70
CD70 molecule
chr5_-_149792370 5.950 NM_001025158
NM_001025159
NM_004355
 CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr6_+_32605182 5.718 NM_002122
 HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr2_-_163174816 5.518 NM_022168
 IFIH1
interferon induced with helicase C domain 1
chr6_-_31324975 5.470 NM_005514
 HLA-B
major histocompatibility complex, class I, B
chr22_-_37545944 5.407 NM_000878
 IL2RB
interleukin 2 receptor, beta
chr14_-_35873823 5.397 NM_020529
 NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr12_+_7055736 5.072 NM_080548
 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr22_+_23134980 5.050


chr6_+_14117486 5.006 NM_001251901
 CD83
CD83 molecule
chr20_+_44746889 4.853 NM_001250
NM_152854
 CD40

CD40 molecule, TNF receptor superfamily member 5

chr1_+_111770280 4.811 NM_001025197
NM_004000
 CHI3L2

chitinase 3-like 2

chr7_+_69064316 4.808 AUTS2
autism susceptibility candidate 2
chr6_-_31324955 4.774 HLA-B
major histocompatibility complex, class I, B
chr16_+_85932766 4.663 NM_002163
 IRF8
interferon regulatory factor 8

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 122 entries
Enrichment   P-value GO Accession GO Term
44.23 2.80e-02 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
37.91 4.85e-02 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin
27.65 6.90e-04 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
23.08 1.64e-04 GO:0002712 regulation of B cell mediated immunity
23.08 1.64e-04 GO:0002889 regulation of immunoglobulin mediated immune response
21.23 2.83e-04 GO:0032655 regulation of interleukin-12 production
19.66 4.30e-02 GO:0046631 alpha-beta T cell activation
17.02 9.49e-03 GO:0032088 negative regulation of NF-kappaB transcription factor activity
16.39 1.15e-02 GO:0032480 negative regulation of type I interferon production
16.39 1.15e-02 GO:0050830 defense response to Gram-positive bacterium
14.08 5.59e-04 GO:0032649 regulation of interferon-gamma production
12.87 1.73e-04 GO:0050864 regulation of B cell activation
12.07 9.45e-03 GO:0032479 regulation of type I interferon production
11.91 1.81e-03 GO:0019882 antigen processing and presentation
11.61 3.96e-04 GO:0060333 interferon-gamma-mediated signaling pathway
11.38 8.62e-05 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
11.26 2.67e-03 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
11.06 1.11e-04 GO:0002250 adaptive immune response
11.06 3.02e-03 GO:0002819 regulation of adaptive immune response
10.62 2.01e-02 GO:0042108 positive regulation of cytokine biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
88.45 1.67e-02 GO:0033257 Bcl3/NF-kappaB2 complex
70.77 1.02e-05 GO:0033256 I-kappaB/NF-kappaB complex
31.60 4.17e-05 GO:0042613 MHC class II protein complex
17.70 1.17e-04 GO:0042611 MHC protein complex
7.08 2.62e-02 GO:0009898 internal side of plasma membrane
5.53 1.32e-02 GO:0009897 external side of plasma membrane
1.76 2.38e-04 GO:0071944 cell periphery
1.72 7.78e-04 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
Enrichment   P-value GO Accession GO Term
11.06 1.32e-02 GO:0003823 antigen binding
5.30 3.12e-03 GO:0005125 cytokine activity
1.34 1.69e-02 GO:0005515 protein binding